RU2752700C2 - Способы и композиции для днк-профилирования - Google Patents

Способы и композиции для днк-профилирования Download PDF

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RU2752700C2
RU2752700C2 RU2019138698A RU2019138698A RU2752700C2 RU 2752700 C2 RU2752700 C2 RU 2752700C2 RU 2019138698 A RU2019138698 A RU 2019138698A RU 2019138698 A RU2019138698 A RU 2019138698A RU 2752700 C2 RU2752700 C2 RU 2752700C2
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primers
dna
nucleic acid
amplification
isnpl
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RU2019138698A
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RU2019138698A (ru
RU2019138698A3 (enExample
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Кэтрин М. СТЕФЕНС
Сидне ХОЛТ
Кэри ДЭВИС
Анне ЯГЕР
Паулина ВАЛИХЕВИЧ
Йонми ХАН
Дэвид СИЛВА
Минь-Цзюи Ричард ШЭНЬ
Сасан АМИНИ
Фрэнк СТИМЕРС
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Иллумина, Инк.
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RU2019138698A 2014-02-18 2015-02-13 Способы и композиции для днк-профилирования RU2752700C2 (ru)

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US201461940942P 2014-02-18 2014-02-18
US61/940,942 2014-02-18
US201462043060P 2014-08-28 2014-08-28
US62/043,060 2014-08-28
US201562103524P 2015-01-14 2015-01-14
US62/103,524 2015-01-14

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Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20190672T1 (hr) * 2013-03-15 2019-08-23 AbbVie Deutschland GmbH & Co. KG Konjugirane formulacije anti-egfr protutijelo-lijek
RS61976B1 (sr) * 2014-02-18 2021-07-30 Illumina Inc Postupci i kompozicije za određivanje dnk profila
US9859394B2 (en) 2014-12-18 2018-01-02 Agilome, Inc. Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids
EP3235010A4 (en) 2014-12-18 2018-08-29 Agilome, Inc. Chemically-sensitive field effect transistor
US9618474B2 (en) 2014-12-18 2017-04-11 Edico Genome, Inc. Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids
US10020300B2 (en) 2014-12-18 2018-07-10 Agilome, Inc. Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids
US9857328B2 (en) 2014-12-18 2018-01-02 Agilome, Inc. Chemically-sensitive field effect transistors, systems and methods for manufacturing and using the same
US10006910B2 (en) 2014-12-18 2018-06-26 Agilome, Inc. Chemically-sensitive field effect transistors, systems, and methods for manufacturing and using the same
CN114250274A (zh) * 2015-04-24 2022-03-29 阿提拉生物系统公司 利用有限核苷酸组成的引物扩增
CN105755129B (zh) * 2016-03-21 2020-03-31 北京市理化分析测试中心 基于新一代测序的基因座d8s1179的str分型方法
WO2017196720A1 (en) * 2016-05-13 2017-11-16 Colorado State University Research Foundation High throughput method to genotype plants
WO2017201081A1 (en) 2016-05-16 2017-11-23 Agilome, Inc. Graphene fet devices, systems, and methods of using the same for sequencing nucleic acids
US10822647B2 (en) * 2016-07-12 2020-11-03 Biodynamics S.R.L. Methods for using long ssDNA polynucleotides as primers (superprimers) in PCR assays
ES2870639T3 (es) 2016-10-24 2021-10-27 Geneinfosec Inc Ocultación de información presente en los ácidos nucleicos
JP7256748B2 (ja) * 2017-03-23 2023-04-12 ユニヴァーシティ オブ ワシントン エラーが訂正された核酸配列決定への適用を伴う標的化核酸配列濃縮のための方法
CN106835292B (zh) * 2017-04-05 2019-04-09 北京泛生子基因科技有限公司 一步法快速构建扩增子文库的方法
GB2577214B (en) 2017-05-05 2021-10-06 Scipio Bioscience Methods for trapping and barcoding discrete biological units in hydrogel
MX2019013993A (es) * 2017-05-23 2020-07-28 Harvard College Amplificación de etiquetado extremo múltiple de ácidos nucleicos.
EP3642362B1 (en) * 2017-06-20 2025-10-15 Illumina, Inc. Methods for addressing inefficiencies in amplification reactions
AU2018313286B2 (en) 2017-08-11 2024-09-12 Atila Biosystems Incorporated Digital amplification with primers of limited nucleotide composition
CN107868837B (zh) * 2017-12-12 2019-03-01 苏州普瑞森基因科技有限公司 一种用于分析肠道微生物的引物组合物及其应用
CN109988826A (zh) * 2017-12-30 2019-07-09 安诺优达基因科技(北京)有限公司 一种基于str计算混合样本嵌合比例的方法以及系统
EP3517629A1 (en) * 2018-01-30 2019-07-31 Myway Genetics S.r.L. Use of cfdna fragments as biomarkers in patients after organ transplantation
CN108342469A (zh) * 2018-02-27 2018-07-31 广州中安基因科技有限公司 一种皮肤基因检测的基因芯片
CN112189055B (zh) * 2018-03-22 2024-07-19 哈佛学院院长及董事 用于分子认证的方法和组合物
JP6646120B1 (ja) * 2018-10-01 2020-02-14 日本ソフトウェアマネジメント株式会社 分解されたｄｎａで個体識別可能なｄｎａ鑑定方法
KR102097721B1 (ko) * 2019-01-24 2020-04-06 주식회사 시선바이오머티리얼스 태그서열 snp를 이용한 단일 검출 프로브 기반 다중 표적 검출방법
CN111485024B (zh) * 2019-01-29 2024-04-26 深圳华大法医科技有限公司 用于个体特征确认的引物组合、及其应用
KR102351579B1 (ko) * 2019-06-25 2022-01-17 대한민국 상염색체 str 좌위를 포함한 ngs 패널 및 다중증폭 시스템
CN120796438A (zh) * 2019-09-11 2025-10-17 帕兰卡有限公司 一种制备测序文库的多重方法
US20230138540A1 (en) * 2020-03-31 2023-05-04 Personal Genome Diagnostics Inc. Compositions and Methods for Nucleic Acid Quality Determination
CN112592981B (zh) * 2020-12-01 2023-06-20 广州精科医学检验所有限公司 用于dna档案建库的引物组、试剂盒和方法
CN112342303A (zh) * 2020-12-04 2021-02-09 郑州高新生物技术有限公司 一种基于ngs的人类y染色体str和snp遗传标记联合检测体系及检测方法
CN112852970A (zh) * 2020-12-31 2021-05-28 百特元生物科技（北京）有限公司 一种同时扩增人37个y-str基因座的引物组、试剂盒及其应用
EP4291680A4 (en) * 2021-02-12 2024-12-25 Verogen, Inc. METHODS AND COMPOSITIONS FOR DNA-BASED KINSHIP ANALYSIS
CN113293205B (zh) * 2021-05-24 2024-11-26 深圳市真迈生物科技有限公司 测序方法
KR102337267B1 (ko) * 2021-06-01 2021-12-08 주식회사 다우진유전자연구소 유전자 감식을 위한 24개의 str 유전자 마커를 이용한 pcr 다중증폭 시스템
CN113930490B (zh) * 2021-09-27 2024-09-10 江汉大学 二代测序平台中利用分子特异性条形码评估str滑脱的方法及其应用
EP4416734A4 (en) * 2021-10-13 2025-08-27 Verogen Inc METHODS AND COMPOSITIONS FOR IMPROVING THE ACCURACY OF DNA-BASED KINSHIP ANALYSIS
EP4272764A1 (en) 2022-05-03 2023-11-08 Scipio Bioscience Method of complexing biological units with particles
CA3263398A1 (en) 2022-08-16 2024-02-22 Verogen Inc METHODS AND SYSTEMS FOR ASSESSING KINSHIP RELATIONSHIPS FOR MISSING PERSONS AND VICTIMS OF DISASTER/CONFLICT
WO2024086805A2 (en) * 2022-10-21 2024-04-25 Watchmaker Genomics, Inc. Methods and compositions for sequencing library normalization
EP4603595A1 (en) * 2024-02-13 2025-08-20 ImmuneDiscover Sweden AB A method for typing the immune genes and the allelic variants thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006004659A1 (en) * 2004-06-30 2006-01-12 Applera Corporation Methods for analyzing short tandem repeats and single nucleotide polymorphisms

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991006678A1 (en) 1989-10-26 1991-05-16 Sri International Dna sequencing
US5846719A (en) 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US5750341A (en) 1995-04-17 1998-05-12 Lynx Therapeutics, Inc. DNA sequencing by parallel oligonucleotide extensions
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
GB9626815D0 (en) 1996-12-23 1997-02-12 Cemu Bioteknik Ab Method of sequencing DNA
ATE364718T1 (de) 1997-04-01 2007-07-15 Solexa Ltd Verfahren zur vervielfältigung von nukleinsäure
US6969488B2 (en) 1998-05-22 2005-11-29 Solexa, Inc. System and apparatus for sequential processing of analytes
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
US6274320B1 (en) 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
GB9929381D0 (en) * 1999-12-10 2000-02-09 Pyrosequencing Ab A method of assessing the amount of nucleic acid in a sample
US7001792B2 (en) 2000-04-24 2006-02-21 Eagle Research & Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
JP2004513619A (ja) 2000-07-07 2004-05-13 ヴィジゲン　バイオテクノロジーズ　インコーポレイテッド リアルタイム配列決定
WO2002044425A2 (en) 2000-12-01 2002-06-06 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
US7078168B2 (en) * 2001-02-27 2006-07-18 Biotage Ab Method for determining allele frequencies
JP4210769B2 (ja) 2001-11-22 2009-01-21 独立行政法人産業技術総合研究所 Ｇａｔｅｗａｙエントリークローンの作製方法
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
SI3363809T1 (sl) 2002-08-23 2020-08-31 Illumina Cambridge Limited Modificirani nukleotidi za polinukleotidno sekvenciranje
GB0321306D0 (en) 2003-09-11 2003-10-15 Solexa Ltd Modified polymerases for improved incorporation of nucleotide analogues
JP2007525571A (ja) 2004-01-07 2007-09-06 ソレクサ リミテッド 修飾分子アレイ
US20060057595A1 (en) * 2004-09-16 2006-03-16 Applera Corporation Compositions, methods, and kits for identifying and quantitating small RNA molecules
WO2006044078A2 (en) 2004-09-17 2006-04-27 Pacific Biosciences Of California, Inc. Apparatus and method for analysis of molecules
EP1828412B2 (en) 2004-12-13 2019-01-09 Illumina Cambridge Limited Improved method of nucleotide detection
WO2006120433A1 (en) 2005-05-10 2006-11-16 Solexa Limited Improved polymerases
GB0514936D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Preparation of templates for nucleic acid sequencing
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
SG170802A1 (en) 2006-03-31 2011-05-30 Solexa Inc Systems and devices for sequence by synthesis analysis
WO2008111990A1 (en) * 2006-06-14 2008-09-18 Cellpoint Diagnostics, Inc. Rare cell analysis using sample splitting and dna tags
AU2007309504B2 (en) 2006-10-23 2012-09-13 Pacific Biosciences Of California, Inc. Polymerase enzymes and reagents for enhanced nucleic acid sequencing
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
AU2007334393A1 (en) 2006-12-14 2008-06-26 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
US9434997B2 (en) * 2007-08-24 2016-09-06 Lawrence Livermore National Security, Llc Methods, compounds and systems for detecting a microorganism in a sample
US20090163366A1 (en) * 2007-12-24 2009-06-25 Helicos Biosciences Corporation Two-primer sequencing for high-throughput expression analysis
EP2271772B1 (en) * 2008-03-11 2014-07-16 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US10662474B2 (en) 2010-01-19 2020-05-26 Verinata Health, Inc. Identification of polymorphic sequences in mixtures of genomic DNA by whole genome sequencing
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
WO2012155084A1 (en) * 2011-05-12 2012-11-15 Netbio, Inc. Methods and compositions for rapid multiplex amplification of str loci
PT3623481T (pt) 2011-09-23 2021-10-15 Illumina Inc Composições para sequenciação de ácidos nucleicos
IN2014DN07992A (enExample) 2012-04-03 2015-05-01 Illumina Inc
JP6382189B2 (ja) 2012-06-29 2018-08-29 ゼネラル・エレクトリック・カンパニイ Ｒｎａテンプレートから開始する等温ｄｎａ増幅用のキット
RS61976B1 (sr) * 2014-02-18 2021-07-30 Illumina Inc Postupci i kompozicije za određivanje dnk profila

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006004659A1 (en) * 2004-06-30 2006-01-12 Applera Corporation Methods for analyzing short tandem repeats and single nucleotide polymorphisms

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Sanchez J. J. et al. Forensic typing of autosomal SNPs with a 29 SNP-multiplex—Results of a collaborative EDNAP exercise //Forensic Science International: Genetics. - 2008, Т. 2, No. 3, pp. 176-183. *
WO2006004659 (A1) - 2006-01-12. Sanchez J. J. et al. Forensic typing of autosomal SNPs with a 29 SNP-multiplex—Results of a collaborative EDNAP exercise //Forensic Science International: Genetics. - 2008, Т. 2, No. 3, pp. 176-183. Копа Ю., Момыналиев К., ДНК-макроматрицы и транскрипционное профилирование, Наноиндустрия, 2007, номер. 1, стр. 28-33. *
Копа Ю., Момыналиев К., ДНК-макроматрицы и транскрипционное профилирование, Наноиндустрия, 2007, номер. 1, стр. 28-33. *

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