RU2745506C2 - Кодирующие фактор viii варианты с пониженным содержанием cpg, композиции и способы и применение в лечении нарушений гемостаза - Google Patents

Кодирующие фактор viii варианты с пониженным содержанием cpg, композиции и способы и применение в лечении нарушений гемостаза Download PDF

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RU2745506C2
RU2745506C2 RU2018119710A RU2018119710A RU2745506C2 RU 2745506 C2 RU2745506 C2 RU 2745506C2 RU 2018119710 A RU2018119710 A RU 2018119710A RU 2018119710 A RU2018119710 A RU 2018119710A RU 2745506 C2 RU2745506 C2 RU 2745506C2
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aav
nucleic acid
vector
fviii
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Хавьер АНГЕЛА
Сам Хсиен-и СЕН
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Спарк Терапьютикс, Инк.
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RU2018119710A 2015-10-30 2016-10-31 Кодирующие фактор viii варианты с пониженным содержанием cpg, композиции и способы и применение в лечении нарушений гемостаза RU2745506C2 (ru)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201562249001P 2015-10-30 2015-10-30
US62/249,001 2015-10-30
US201662331872P 2016-05-04 2016-05-04
US62/331,872 2016-05-04
US201662349532P 2016-06-13 2016-06-13
US62/349,532 2016-06-13
US201662357874P 2016-07-01 2016-07-01
US62/357,874 2016-07-01
PCT/US2016/059793 WO2017075619A1 (en) 2015-10-30 2016-10-31 Cpg reduced factor viii variants, compositions and methods and uses for treatment of hemostasis disorders

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RU2018119710A RU2018119710A (ru) 2019-12-06
RU2018119710A3 RU2018119710A3 (enExample) 2020-04-02
RU2745506C2 true RU2745506C2 (ru) 2021-03-25

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CN (1) CN108368164A (enExample)
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PE (2) PE20231949A1 (enExample)
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CN120166940A (zh) * 2022-08-31 2025-06-17 流体基因治疗有限公司 流体动力学基因递送的方法和组合物
CN115948408A (zh) * 2022-09-23 2023-04-11 上海信致医药科技有限公司 改进的人凝血因子viii基因表达盒及其应用
WO2025164792A1 (ja) * 2024-02-02 2025-08-07 学校法人自治医科大学 高比活性／高分泌発現型の第ｖｉｉｉ因子改変体、高発現型の第ｖｉｉｉ因子コード核酸及びそれらの用途

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