RU2742691C2 - Cd3-связывающий домен - Google Patents
Cd3-связывающий домен Download PDFInfo
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- RU2742691C2 RU2742691C2 RU2017105120A RU2017105120A RU2742691C2 RU 2742691 C2 RU2742691 C2 RU 2742691C2 RU 2017105120 A RU2017105120 A RU 2017105120A RU 2017105120 A RU2017105120 A RU 2017105120A RU 2742691 C2 RU2742691 C2 RU 2742691C2
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- ser
- gly
- antigen
- thr
- ala
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| EP3765520A1 (en) | 2018-03-14 | 2021-01-20 | NovImmune SA | Anti-cd3 epsilon antibodies and methods of use thereof |
| SG11202009804RA (en) | 2018-04-11 | 2020-11-27 | Inhibrx Inc | Multispecific polypeptide constructs having constrained cd3 binding and related methods and uses |
| BR112020023508A2 (pt) * | 2018-05-24 | 2021-03-30 | Janssen Biotech, Inc. | Anticorpos anti-cd3 e usos dos mesmos |
| TW202035451A (zh) * | 2018-07-24 | 2020-10-01 | 美商英伊布里克斯公司 | 含有受限cd3結合域及受體結合區之多重特異性多肽構築體及其使用方法 |
| CN112888482B (zh) | 2018-08-23 | 2024-06-25 | 里珍纳龙药品有限公司 | 抗Fcε-R1α(FCER1A)抗体，结合FCER1A和CD3的双特异性抗原结合分子及其用途 |
| CA3115089A1 (en) | 2018-10-11 | 2020-04-16 | Inhibrx, Inc. | Dll3 single domain antibodies and therapeutic compositions thereof |
| KR102899856B1 (ko) * | 2019-03-29 | 2025-12-15 | 주식회사 녹십자 | 항-메소텔린 항체, 항-cd3 항체 또는 항-egfr 항체를 포함하는 융합 단백질 및 이를 포함하는 이중 특이적 또는 삼중 특이적 항체 및 이의 용도 |
| BR112022014667A2 (pt) | 2020-01-29 | 2022-09-20 | Inhibrx Inc | Anticorpos de domínio único de cd28 e construtos multivalentes e multiespecíficos dos mesmos |
| TWI888487B (zh) * | 2020-02-14 | 2025-07-01 | 日商協和麒麟股份有限公司 | 與ｃｄ３結合之雙特異性抗體 |
| MX2022014938A (es) | 2020-05-27 | 2023-03-06 | Janssen Biotech Inc | Proteínas que comprenden dominios de unión al antígeno de cd3 y usos de éstas. |
| CN116261590B (zh) * | 2020-09-29 | 2025-10-17 | 信达生物制药(苏州)有限公司 | 抗cd3抗体以及其用途 |
| KR20240005691A (ko) | 2021-04-30 | 2024-01-12 | 에프. 호프만-라 로슈 아게 | 항-cd20/항-cd3 이중특이적 항체 및 항-cd79b 항체 약물 접합체를 이용한 병용 치료를 위한 투약 |
| KR20240005722A (ko) | 2021-04-30 | 2024-01-12 | 에프. 호프만-라 로슈 아게 | 항-cd20/항-cd3 이중특이적 항체를 사용한 치료를 위한 투약 |
| AR126161A1 (es) | 2021-06-17 | 2023-09-27 | Boehringer Lngelheim Int Gmbh | Moléculas de fijación triespecíficas novedosas |
| WO2023125729A1 (zh) * | 2021-12-31 | 2023-07-06 | 康源博创生物科技(北京)有限公司 | 一种抗cd3的人源化抗体及其在制备双特异性抗体中的应用 |
| JP2025503573A (ja) | 2021-12-31 | 2025-02-04 | キィノ バイオテクノロジー カンパニー リミテッド | 抗ｇｐｒｃ５ｄ抗体及びその応用 |
| AU2023238766A1 (en) | 2022-03-23 | 2024-07-25 | F. Hoffmann-La Roche Ag | Combination treatment of an anti-cd20/anti-cd3 bispecific antibody and chemotherapy |
| JP7701982B2 (ja) | 2022-04-13 | 2025-07-02 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 抗ｃｄ２０／抗ｃｄ３二重特異性抗体の薬学的組成物及び使用方法 |
| WO2024088987A1 (en) | 2022-10-26 | 2024-05-02 | F. Hoffmann-La Roche Ag | Combination therapy for the treatment of cancer |
| WO2024152963A1 (zh) * | 2023-01-18 | 2024-07-25 | 贝达药业股份有限公司 | 抗cd3的人源化抗体及其应用 |
| WO2025224084A1 (en) | 2024-04-22 | 2025-10-30 | Engimmune Therapeutics Ag | Proteins comprising t cell receptor constant domains |
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| ES2276735T3 (es) | 2001-09-14 | 2007-07-01 | Affimed Therapeutics Ag | Anticuerpos fv multimericos de cadena sencilla en tandem. |
| SI1716178T1 (sl) | 2004-02-16 | 2010-11-30 | Micromet Ag | Manj imunogene vezne molekule |
| TWI653333B (zh) | 2010-04-01 | 2019-03-11 | 安進研究（慕尼黑）有限責任公司 | 跨物種專一性之ＰＳＭＡｘＣＤ３雙專一性單鏈抗體 |
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| WO2014106004A2 (en) * | 2012-12-28 | 2014-07-03 | Abbvie, Inc. | High-throughput system and method for identifying antibodies having specific antigen binding activities |
| US10131710B2 (en) | 2013-01-14 | 2018-11-20 | Xencor, Inc. | Optimized antibody variable regions |
| WO2014116846A2 (en) | 2013-01-23 | 2014-07-31 | Abbvie, Inc. | Methods and compositions for modulating an immune response |
| DK3030581T3 (da) * | 2013-08-07 | 2021-04-12 | Affimed Gmbh | Antistofbindingssteder, der er specifikke for egfrviii |
| US9212225B1 (en) * | 2014-07-01 | 2015-12-15 | Amphivena Therapeutics, Inc. | Bispecific CD33 and CD3 binding proteins |
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- 2015-08-05 RU RU2017105120A patent/RU2742691C2/ru active
- 2015-08-05 HR HRP20202024TT patent/HRP20202024T1/hr unknown
- 2015-08-05 HU HUE15756850A patent/HUE051919T2/hu unknown
- 2015-08-05 JP JP2017506890A patent/JP6669722B2/ja active Active
- 2015-08-05 WO PCT/EP2015/068070 patent/WO2016020444A1/en not_active Ceased
- 2015-08-05 DK DK15756850.2T patent/DK3177646T3/da active
- 2015-08-05 SI SI201531457T patent/SI3177646T1/sl unknown
- 2015-08-05 CN CN201580054757.1A patent/CN107001468B/zh active Active
- 2015-08-05 CA CA2957462A patent/CA2957462C/en active Active
- 2015-08-05 LT LTEP15756850.2T patent/LT3177646T/lt unknown
- 2015-08-06 US US14/820,462 patent/US10066015B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100015087A1 (en) * | 1997-12-01 | 2010-01-21 | Istituto Superiore Di Sanita | Hiv-1 tat, or derivatives thereof for prophylactic and therapeutic vaccination |
| EP2295577A2 (en) * | 1999-03-09 | 2011-03-16 | ZymoGenetics, Inc. | Human cytokine as ligand of the z-alpha receptor and uses thereof |
| RU2506275C2 (ru) * | 2007-11-01 | 2014-02-10 | Астеллас Фарма Инк. | Иммуносупрессорные полипептиды и нуклеиновые кислоты |
| EP2698431A1 (en) * | 2011-03-30 | 2014-02-19 | Chugai Seiyaku Kabushiki Kaisha | Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2017105120A (ru) | 2018-09-10 |
| BR112017002422B1 (pt) | 2024-02-20 |
| CA2957462A1 (en) | 2016-02-11 |
| CN107001468B (zh) | 2021-04-09 |
| HUE051919T2 (hu) | 2021-04-28 |
| US20160039934A1 (en) | 2016-02-11 |
| SI3177646T1 (sl) | 2021-04-30 |
| EP3177646B1 (en) | 2020-10-07 |
| LT3177646T (lt) | 2021-01-11 |
| RU2017105120A3 (show.php) | 2019-02-20 |
| AU2015299039A1 (en) | 2017-03-02 |
| HRP20202024T1 (hr) | 2021-02-19 |
| EP2982693A1 (en) | 2016-02-10 |
| DK3177646T3 (da) | 2020-12-07 |
| EP3177646A1 (en) | 2017-06-14 |
| WO2016020444A1 (en) | 2016-02-11 |
| JP2017529067A (ja) | 2017-10-05 |
| CA2957462C (en) | 2023-10-17 |
| JP6669722B2 (ja) | 2020-03-18 |
| US10066015B2 (en) | 2018-09-04 |
| CN107001468A (zh) | 2017-08-01 |
| BR112017002422A2 (pt) | 2017-11-28 |
| AU2015299039B2 (en) | 2021-01-21 |
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