RU2742691C2 - Cd3-связывающий домен - Google Patents
Cd3-связывающий домен Download PDFInfo
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- RU2742691C2 RU2742691C2 RU2017105120A RU2017105120A RU2742691C2 RU 2742691 C2 RU2742691 C2 RU 2742691C2 RU 2017105120 A RU2017105120 A RU 2017105120A RU 2017105120 A RU2017105120 A RU 2017105120A RU 2742691 C2 RU2742691 C2 RU 2742691C2
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- ser
- gly
- antigen
- thr
- ala
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| US11773166B2 (en) | 2014-11-04 | 2023-10-03 | Ichnos Sciences SA | CD3/CD38 T cell retargeting hetero-dimeric immunoglobulins and methods of their production |
| IL319047A (en) | 2015-08-28 | 2025-04-01 | Amunix Operating Inc | Chimeric polypeptide composition and methods for its preparation and use |
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| TW201834688A (zh) | 2017-02-24 | 2018-10-01 | 日商中外製藥股份有限公司 | 藥學組成物、抗原結合分子、治療方法以及篩選方法 |
| EP3366704A1 (en) | 2017-02-28 | 2018-08-29 | Affimed GmbH | Antibodies specific for mmp1/hla-a2 complex |
| CN110770255B (zh) | 2017-04-11 | 2025-07-01 | 因荷布瑞克斯生物科学公司 | 具有受限cd3结合的多特异性多肽构建体及其使用方法 |
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| CN110691789A (zh) * | 2017-06-05 | 2020-01-14 | 努玛治疗有限公司 | 新型抗cd3抗体 |
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| KR101973060B1 (ko) * | 2017-10-20 | 2019-04-26 | 주식회사 녹십자 | 항-cd3 항체 및 이를 포함하는 암 치료용 약학적 조성물 |
| EP3502140A1 (en) * | 2017-12-21 | 2019-06-26 | F. Hoffmann-La Roche AG | Combination therapy of tumor targeted icos agonists with t-cell bispecific molecules |
| WO2019160007A1 (ja) | 2018-02-14 | 2019-08-22 | 中外製薬株式会社 | 抗原結合分子および組合せ |
| CN120399075A (zh) * | 2018-03-14 | 2025-08-01 | 诺维莫尼公司 | 抗-CD3ε抗体及其应用方法 |
| SG11202009804RA (en) | 2018-04-11 | 2020-11-27 | Inhibrx Inc | Multispecific polypeptide constructs having constrained cd3 binding and related methods and uses |
| SMT202500221T1 (it) * | 2018-05-24 | 2025-07-22 | Janssen Biotech Inc | Anticorpi anti-cd3 e usi di essi |
| WO2020023553A1 (en) * | 2018-07-24 | 2020-01-30 | Inhibrx, Inc. | Multispecific polypeptide constructs containing a constrained cd3 binding domain and a receptor binding region and methods of using the same |
| AU2019325565B2 (en) | 2018-08-23 | 2025-09-04 | Regeneron Pharmaceuticals, Inc. | Anti-Fc epsilon-R1 alpha (FceR1a) antibodies, bispecific antigen-binding molecules that bind FceR1a and CD3, and uses thereof |
| TW202028245A (zh) | 2018-10-11 | 2020-08-01 | 美商英伊布里克斯公司 | Dll3單域抗體及其治療性組合物 |
| JP7698581B2 (ja) * | 2019-03-29 | 2025-06-25 | グリーン・クロス・コーポレイション | 抗メソテリン抗体、抗ｃｄ３抗体又は抗ｅｇｆｒ抗体を含む融合タンパク質、それを含む二重特異性又は三重特異性抗体、及びその使用 |
| CN115380047A (zh) | 2020-01-29 | 2022-11-22 | 印希比股份有限公司 | Cd28单结构域抗体及其多价和多特异性构建体 |
| TWI888487B (zh) * | 2020-02-14 | 2025-07-01 | 日商協和麒麟股份有限公司 | 與ｃｄ３結合之雙特異性抗體 |
| WO2021240388A1 (en) | 2020-05-27 | 2021-12-02 | Janssen Biotech, Inc. | Proteins comprising cd3 antigen binding domains and uses thereof |
| EP4223777A4 (en) * | 2020-09-29 | 2025-01-08 | Fortvita Biologics (Singapore) Pte. Ltd. | ANTI-CD3 ANTIBODY AND ITS USES |
| EP4329800A1 (en) | 2021-04-30 | 2024-03-06 | F. Hoffmann-La Roche AG | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibody |
| KR20240005691A (ko) | 2021-04-30 | 2024-01-12 | 에프. 호프만-라 로슈 아게 | 항-cd20/항-cd3 이중특이적 항체 및 항-cd79b 항체 약물 접합체를 이용한 병용 치료를 위한 투약 |
| JP2024523033A (ja) | 2021-06-17 | 2024-06-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規の三重特異的結合分子 |
| CN116375868A (zh) * | 2021-12-31 | 2023-07-04 | 康源博创生物科技(北京)有限公司 | 一种抗cd3的人源化抗体及其在制备双特异性抗体中的应用 |
| AU2022424142A1 (en) | 2021-12-31 | 2024-08-08 | Kyinno Biotechnology Co., Ltd. | Anti-gprc5d antibody and use thereof |
| JP2025512785A (ja) | 2022-03-23 | 2025-04-22 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 抗ｃｄ２０／抗ｃｄ３二重特異性抗体及び化学療法の併用処置 |
| KR20250004776A (ko) | 2022-04-13 | 2025-01-08 | 에프. 호프만-라 로슈 아게 | 항-cd20/항-cd3 이중특이성 항체의 약학 조성물 및 사용 방법 |
| WO2024088987A1 (en) | 2022-10-26 | 2024-05-02 | F. Hoffmann-La Roche Ag | Combination therapy for the treatment of cancer |
| WO2024152963A1 (zh) * | 2023-01-18 | 2024-07-25 | 贝达药业股份有限公司 | 抗cd3的人源化抗体及其应用 |
| WO2025224084A1 (en) | 2024-04-22 | 2025-10-30 | Engimmune Therapeutics Ag | Proteins comprising t cell receptor constant domains |
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| DE60124912T2 (de) | 2001-09-14 | 2007-06-14 | Affimed Therapeutics Ag | Multimerische, einzelkettige, Tandem-Fv-Antikörper |
| CA2555503C (en) | 2004-02-16 | 2018-03-27 | Micromet Ag | Humanized anti-cd3 bispecific binding molecules having reduced immunogenicity, uses and compositions relating thereto |
| TWI653333B (zh) | 2010-04-01 | 2019-03-11 | 安進研究（慕尼黑）有限責任公司 | 跨物種專一性之ＰＳＭＡｘＣＤ３雙專一性單鏈抗體 |
| SMT201900239T1 (it) * | 2011-05-21 | 2019-05-10 | Macrogenics Inc | Molecole di legame a cd3 in grado di legare cd3 umano e non umano |
| HK1216894A1 (zh) * | 2012-12-28 | 2016-12-09 | Abbvie Inc. | 多價結合蛋白組合物 |
| US10131710B2 (en) | 2013-01-14 | 2018-11-20 | Xencor, Inc. | Optimized antibody variable regions |
| EP2948475A2 (en) | 2013-01-23 | 2015-12-02 | AbbVie Inc. | Methods and compositions for modulating an immune response |
| RU2696892C2 (ru) * | 2013-08-07 | 2019-08-07 | Аффимед Гмбх | САЙТЫ АНТИТЕЛ, СПЕЦИФИЧНО СВЯЗЫВАЮЩИЕ EGFRvIII |
| US9212225B1 (en) * | 2014-07-01 | 2015-12-15 | Amphivena Therapeutics, Inc. | Bispecific CD33 and CD3 binding proteins |
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- 2015-08-05 JP JP2017506890A patent/JP6669722B2/ja active Active
- 2015-08-05 CN CN201580054757.1A patent/CN107001468B/zh active Active
- 2015-08-05 WO PCT/EP2015/068070 patent/WO2016020444A1/en not_active Ceased
- 2015-08-05 CA CA2957462A patent/CA2957462C/en active Active
- 2015-08-05 EP EP15756850.2A patent/EP3177646B1/en active Active
- 2015-08-05 HR HRP20202024TT patent/HRP20202024T1/hr unknown
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- 2015-08-05 LT LTEP15756850.2T patent/LT3177646T/lt unknown
- 2015-08-05 SI SI201531457T patent/SI3177646T1/sl unknown
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100015087A1 (en) * | 1997-12-01 | 2010-01-21 | Istituto Superiore Di Sanita | Hiv-1 tat, or derivatives thereof for prophylactic and therapeutic vaccination |
| EP2295577A2 (en) * | 1999-03-09 | 2011-03-16 | ZymoGenetics, Inc. | Human cytokine as ligand of the z-alpha receptor and uses thereof |
| RU2506275C2 (ru) * | 2007-11-01 | 2014-02-10 | Астеллас Фарма Инк. | Иммуносупрессорные полипептиды и нуклеиновые кислоты |
| EP2698431A1 (en) * | 2011-03-30 | 2014-02-19 | Chugai Seiyaku Kabushiki Kaisha | Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2982693A1 (en) | 2016-02-10 |
| WO2016020444A1 (en) | 2016-02-11 |
| BR112017002422B1 (pt) | 2024-02-20 |
| SI3177646T1 (sl) | 2021-04-30 |
| CA2957462A1 (en) | 2016-02-11 |
| LT3177646T (lt) | 2021-01-11 |
| CN107001468B (zh) | 2021-04-09 |
| US20160039934A1 (en) | 2016-02-11 |
| BR112017002422A2 (pt) | 2017-11-28 |
| DK3177646T3 (da) | 2020-12-07 |
| RU2017105120A3 (enExample) | 2019-02-20 |
| CA2957462C (en) | 2023-10-17 |
| EP3177646B1 (en) | 2020-10-07 |
| CN107001468A (zh) | 2017-08-01 |
| HRP20202024T1 (hr) | 2021-02-19 |
| AU2015299039B2 (en) | 2021-01-21 |
| JP2017529067A (ja) | 2017-10-05 |
| HUE051919T2 (hu) | 2021-04-28 |
| EP3177646A1 (en) | 2017-06-14 |
| US10066015B2 (en) | 2018-09-04 |
| JP6669722B2 (ja) | 2020-03-18 |
| AU2015299039A1 (en) | 2017-03-02 |
| RU2017105120A (ru) | 2018-09-10 |
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