RU2738647C1 - 5,6-конденсированные бициклические соединения и композиции для лечения паразитарных заболеваний - Google Patents

5,6-конденсированные бициклические соединения и композиции для лечения паразитарных заболеваний Download PDF

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Publication number
RU2738647C1
RU2738647C1 RU2019138326A RU2019138326A RU2738647C1 RU 2738647 C1 RU2738647 C1 RU 2738647C1 RU 2019138326 A RU2019138326 A RU 2019138326A RU 2019138326 A RU2019138326 A RU 2019138326A RU 2738647 C1 RU2738647 C1 RU 2738647C1
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RU
Russia
Prior art keywords
pyridin
pyrazolo
carboxamide
fluoro
phenyl
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RU2019138326A
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English (en)
Russian (ru)
Inventor
Ян Йирицек
Изабелль К. Лерарио
Фан Лян
Сяодун Лю
Валентина Мольтени
Адваит Суреш Нэгл
Шуи Пирли Нг
Максим Ратников
Джеффри М. Смит
Юнпин Се
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Новартис Аг
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/417Imidazole-alkylamines, e.g. histamine, phentolamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541Non-condensed thiazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/555Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
RU2019138326A 2017-05-31 2018-05-29 5,6-конденсированные бициклические соединения и композиции для лечения паразитарных заболеваний RU2738647C1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762513211P 2017-05-31 2017-05-31
US62/513,211 2017-05-31
US201762581919P 2017-11-06 2017-11-06
US62/581,919 2017-11-06
PCT/IB2018/053818 WO2018220531A1 (en) 2017-05-31 2018-05-29 5,6-fused-bicyclic compounds and compositions for the treatment of parasitic diseases

Publications (1)

Publication Number Publication Date
RU2738647C1 true RU2738647C1 (ru) 2020-12-15

Family

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Family Applications (1)

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RU2019138326A RU2738647C1 (ru) 2017-05-31 2018-05-29 5,6-конденсированные бициклические соединения и композиции для лечения паразитарных заболеваний

Country Status (26)

Country Link
US (2) US11384078B2 (https=)
EP (1) EP3630771B1 (https=)
JP (1) JP7187490B2 (https=)
KR (1) KR20200010275A (https=)
CN (1) CN110678468B (https=)
AR (1) AR111826A1 (https=)
AU (1) AU2018276190B2 (https=)
BR (1) BR112019024804A2 (https=)
CA (1) CA3060990A1 (https=)
CL (1) CL2019003467A1 (https=)
CO (1) CO2019013254A2 (https=)
CR (1) CR20190545A (https=)
CU (1) CU24543B1 (https=)
DO (1) DOP2019000299A (https=)
EC (1) ECSP19084722A (https=)
ES (1) ES2927207T3 (https=)
IL (1) IL270927B (https=)
JO (1) JOP20190278A1 (https=)
MA (1) MA50495A (https=)
MX (1) MX389106B (https=)
PE (1) PE20201148A1 (https=)
PH (1) PH12019502652A1 (https=)
RU (1) RU2738647C1 (https=)
TW (1) TW201902894A (https=)
UY (1) UY37745A (https=)
WO (1) WO2018220531A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20190278A1 (ar) * 2017-05-31 2019-11-28 Novartis Ag مركبات 5، 6-ثنائية الحلقة مندمجة وتركيبات لعلاج الأمراض الطفيلية
CN115397807B (zh) * 2020-04-17 2024-08-13 帝斯曼知识产权资产管理有限公司 用于制备取代的烯胺化合物的方法
EP4155302A4 (en) * 2020-06-23 2023-11-22 Shanghai Meiyue Biotech Development Co., Ltd. METHOD FOR PRODUCING A CONDENSED PYRAZOLE COMPOUND

Citations (4)

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RU2268887C2 (ru) * 2000-10-27 2006-01-27 Элбион Аг 7-азаиндолы, их применение в качестве ингибиторов фосфодиэстеразы 4 и способ их получения
WO2015095477A1 (en) * 2013-12-19 2015-06-25 Irm Llc [1,2,4]triazolo[1,5-a]pyrimidine derivatives as protozoan proteasome inhibitors for the treatment of parasitic diseases such as leishmaniasis
WO2016193111A1 (en) * 2015-05-29 2016-12-08 Glaxosmithkline Intellectual Property Development Limited Imidazo[1,2-b][1,2,4]triazine derivatives as antiparasitic agents
WO2017025416A1 (en) * 2015-08-07 2017-02-16 Glaxosmithkline Intellectual Property Development Limited Compounds

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US7468376B2 (en) 2003-02-27 2008-12-23 Palau Pharma, S.A. Pyrazolopyridine derivates
US20120220453A1 (en) 2011-02-25 2012-08-30 Dow Agrosciences Llc Pesticidal compostions and processes related thereto
WO2013067302A1 (en) * 2011-11-04 2013-05-10 Glaxosmithkline Intellectual Property (No. 2) Limited Method of treatment
WO2013106254A1 (en) * 2012-01-11 2013-07-18 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
LT2925757T (lt) 2012-11-19 2017-12-27 Novartis Ag Junginiai ir kompozicijos, skirti parazitinių ligų gydymui
WO2014151729A1 (en) * 2013-03-15 2014-09-25 Irm Llc Compounds and compositions for the treatment of parasitic diseases
UY35400A (es) * 2013-03-15 2014-10-31 Novartis Ag Compuestos y composiciones para el tratamiento de enfermedades parasitarias
US20170260183A1 (en) 2014-12-02 2017-09-14 Bayer Cropscience Aktiengesellschaft Bicyclic compounds as pest control agents
CN112679467B (zh) 2015-03-11 2024-11-01 Fmc公司 杂环取代的二环唑杀有害生物剂
PL3458443T3 (pl) * 2016-05-03 2021-03-08 Bayer Pharma Aktiengesellschaft Aromatyczne pochodne sulfonamidowe
JOP20190278A1 (ar) * 2017-05-31 2019-11-28 Novartis Ag مركبات 5، 6-ثنائية الحلقة مندمجة وتركيبات لعلاج الأمراض الطفيلية

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
RU2268887C2 (ru) * 2000-10-27 2006-01-27 Элбион Аг 7-азаиндолы, их применение в качестве ингибиторов фосфодиэстеразы 4 и способ их получения
WO2015095477A1 (en) * 2013-12-19 2015-06-25 Irm Llc [1,2,4]triazolo[1,5-a]pyrimidine derivatives as protozoan proteasome inhibitors for the treatment of parasitic diseases such as leishmaniasis
WO2016193111A1 (en) * 2015-05-29 2016-12-08 Glaxosmithkline Intellectual Property Development Limited Imidazo[1,2-b][1,2,4]triazine derivatives as antiparasitic agents
WO2017025416A1 (en) * 2015-08-07 2017-02-16 Glaxosmithkline Intellectual Property Development Limited Compounds

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Also Published As

Publication number Publication date
DOP2019000299A (es) 2019-12-15
CO2019013254A2 (es) 2020-01-17
UY37745A (es) 2019-01-02
ES2927207T3 (es) 2022-11-03
CN110678468A (zh) 2020-01-10
US20220324863A1 (en) 2022-10-13
JP7187490B2 (ja) 2022-12-12
US20200109142A1 (en) 2020-04-09
TW201902894A (zh) 2019-01-16
MA50495A (fr) 2021-04-28
AU2018276190B2 (en) 2020-05-14
MX2019014321A (es) 2020-02-05
CU24543B1 (es) 2021-08-06
ECSP19084722A (es) 2019-12-27
JOP20190278A1 (ar) 2019-11-28
CU20190095A7 (es) 2020-10-20
EP3630771B1 (en) 2022-06-29
CR20190545A (es) 2020-01-15
PE20201148A1 (es) 2020-10-26
IL270927A (en) 2020-01-30
KR20200010275A (ko) 2020-01-30
IL270927B (en) 2022-01-01
MX389106B (es) 2025-03-20
AU2018276190A1 (en) 2019-11-07
JP2020521775A (ja) 2020-07-27
PH12019502652A1 (en) 2020-07-13
AR111826A1 (es) 2019-08-21
CA3060990A1 (en) 2018-12-06
BR112019024804A2 (pt) 2020-06-09
US11384078B2 (en) 2022-07-12
CL2019003467A1 (es) 2020-03-13
WO2018220531A1 (en) 2018-12-06
EP3630771A1 (en) 2020-04-08
CN110678468B (zh) 2022-07-29

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