JP7187490B2 - 寄生虫症の治療のための５，６－縮合二環式化合物及び組成物 - Google Patents

寄生虫症の治療のための５，６－縮合二環式化合物及び組成物 Download PDF

Info

Publication number
JP7187490B2
JP7187490B2 JP2019565535A JP2019565535A JP7187490B2 JP 7187490 B2 JP7187490 B2 JP 7187490B2 JP 2019565535 A JP2019565535 A JP 2019565535A JP 2019565535 A JP2019565535 A JP 2019565535A JP 7187490 B2 JP7187490 B2 JP 7187490B2
Authority
JP
Japan
Prior art keywords
alkyl
compound
independently selected
unsubstituted
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2019565535A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020521775A (ja
JP2020521775A5 (https=
Inventor
ジリセック，ジャン
ケー． レラリオ，イザベル
リアン，ファン
リウ，シャオドン
モルテニ，バレンティーナ
スレッシュ ネーグル，アドベイト
パーリー ウン，シュイ
ラトニコフ，マキシム
エム． スミス，ジェフリー
シエ，ヨンピン
Original Assignee
ノバルティス アーゲー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ノバルティス アーゲー filed Critical ノバルティス アーゲー
Publication of JP2020521775A publication Critical patent/JP2020521775A/ja
Publication of JP2020521775A5 publication Critical patent/JP2020521775A5/ja
Application granted granted Critical
Publication of JP7187490B2 publication Critical patent/JP7187490B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2019565535A 2017-05-31 2018-05-29 寄生虫症の治療のための５，６－縮合二環式化合物及び組成物 Active JP7187490B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762513211P 2017-05-31 2017-05-31
US62/513,211 2017-05-31
US201762581919P 2017-11-06 2017-11-06
US62/581,919 2017-11-06
PCT/IB2018/053818 WO2018220531A1 (en) 2017-05-31 2018-05-29 5,6-fused-bicyclic compounds and compositions for the treatment of parasitic diseases

Publications (3)

Publication Number Publication Date
JP2020521775A JP2020521775A (ja) 2020-07-27
JP2020521775A5 JP2020521775A5 (https=) 2021-07-26
JP7187490B2 true JP7187490B2 (ja) 2022-12-12

Family

ID=62749123

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019565535A Active JP7187490B2 (ja) 2017-05-31 2018-05-29 寄生虫症の治療のための５，６－縮合二環式化合物及び組成物

Country Status (26)

Country Link
US (2) US11384078B2 (https=)
EP (1) EP3630771B1 (https=)
JP (1) JP7187490B2 (https=)
KR (1) KR20200010275A (https=)
CN (1) CN110678468B (https=)
AR (1) AR111826A1 (https=)
AU (1) AU2018276190B2 (https=)
BR (1) BR112019024804A2 (https=)
CA (1) CA3060990A1 (https=)
CL (1) CL2019003467A1 (https=)
CO (1) CO2019013254A2 (https=)
CR (1) CR20190545A (https=)
CU (1) CU24543B1 (https=)
DO (1) DOP2019000299A (https=)
EC (1) ECSP19084722A (https=)
ES (1) ES2927207T3 (https=)
IL (1) IL270927B (https=)
JO (1) JOP20190278A1 (https=)
MA (1) MA50495A (https=)
MX (1) MX389106B (https=)
PE (1) PE20201148A1 (https=)
PH (1) PH12019502652A1 (https=)
RU (1) RU2738647C1 (https=)
TW (1) TW201902894A (https=)
UY (1) UY37745A (https=)
WO (1) WO2018220531A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20190278A1 (ar) * 2017-05-31 2019-11-28 Novartis Ag مركبات 5، 6-ثنائية الحلقة مندمجة وتركيبات لعلاج الأمراض الطفيلية
EP4136066A1 (en) * 2020-04-17 2023-02-22 DSM IP Assets B.V. A process for preparation of substituted enamine compounds
WO2021259163A1 (zh) * 2020-06-23 2021-12-30 上海美悦生物科技发展有限公司 一种稠和吡唑类化合物的制备方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013067302A1 (en) 2011-11-04 2013-05-10 Glaxosmithkline Intellectual Property (No. 2) Limited Method of treatment
WO2013106254A1 (en) 2012-01-11 2013-07-18 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
WO2014151784A1 (en) 2013-03-15 2014-09-25 Irm Llc Compounds and compositions for the treatment of parasitic diseases
WO2014151729A1 (en) 2013-03-15 2014-09-25 Irm Llc Compounds and compositions for the treatment of parasitic diseases
WO2016193111A1 (en) 2015-05-29 2016-12-08 Glaxosmithkline Intellectual Property Development Limited Imidazo[1,2-b][1,2,4]triazine derivatives as antiparasitic agents
JP2017501177A (ja) 2013-12-19 2017-01-12 ノバルティス アーゲー リーシュマニア症などの寄生虫病を処置するための原生動物のプロテアソーム阻害剤としての［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体
WO2017025416A1 (en) 2015-08-07 2017-02-16 Glaxosmithkline Intellectual Property Development Limited Compounds
JP2019519484A (ja) 2016-05-03 2019-07-11 バイエル・ファルマ・アクティエンゲゼルシャフト 芳香族スルホンアミド誘導体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10053275A1 (de) * 2000-10-27 2002-05-02 Dresden Arzneimittel Neue 7-Azaindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
KR101312736B1 (ko) 2003-02-27 2013-09-27 팔라우 파르마 에스에이 피라졸로피리딘 유도체
TW201238487A (en) 2011-02-25 2012-10-01 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
CN105164124B (zh) 2012-11-19 2017-03-15 诺华股份有限公司 用于治疗寄生虫疾病的化合物和组合物
EP3227288B1 (de) 2014-12-02 2018-08-29 Bayer CropScience AG Bicyclische verbindungen als schädlingsbekämpfungsmittel
CN112608300B (zh) 2015-03-11 2024-04-26 Fmc公司 杂环取代的二环唑杀有害生物剂
JOP20190278A1 (ar) * 2017-05-31 2019-11-28 Novartis Ag مركبات 5، 6-ثنائية الحلقة مندمجة وتركيبات لعلاج الأمراض الطفيلية

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013067302A1 (en) 2011-11-04 2013-05-10 Glaxosmithkline Intellectual Property (No. 2) Limited Method of treatment
WO2013106254A1 (en) 2012-01-11 2013-07-18 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
WO2014151784A1 (en) 2013-03-15 2014-09-25 Irm Llc Compounds and compositions for the treatment of parasitic diseases
WO2014151729A1 (en) 2013-03-15 2014-09-25 Irm Llc Compounds and compositions for the treatment of parasitic diseases
JP2017501177A (ja) 2013-12-19 2017-01-12 ノバルティス アーゲー リーシュマニア症などの寄生虫病を処置するための原生動物のプロテアソーム阻害剤としての［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体
WO2016193111A1 (en) 2015-05-29 2016-12-08 Glaxosmithkline Intellectual Property Development Limited Imidazo[1,2-b][1,2,4]triazine derivatives as antiparasitic agents
WO2017025416A1 (en) 2015-08-07 2017-02-16 Glaxosmithkline Intellectual Property Development Limited Compounds
JP2019519484A (ja) 2016-05-03 2019-07-11 バイエル・ファルマ・アクティエンゲゼルシャフト 芳香族スルホンアミド誘導体

Also Published As

Publication number Publication date
KR20200010275A (ko) 2020-01-30
US20220324863A1 (en) 2022-10-13
IL270927B (en) 2022-01-01
CU20190095A7 (es) 2020-10-20
US11384078B2 (en) 2022-07-12
JP2020521775A (ja) 2020-07-27
ES2927207T3 (es) 2022-11-03
JOP20190278A1 (ar) 2019-11-28
BR112019024804A2 (pt) 2020-06-09
CU24543B1 (es) 2021-08-06
DOP2019000299A (es) 2019-12-15
AU2018276190B2 (en) 2020-05-14
CO2019013254A2 (es) 2020-01-17
EP3630771A1 (en) 2020-04-08
MX389106B (es) 2025-03-20
AU2018276190A1 (en) 2019-11-07
US20200109142A1 (en) 2020-04-09
ECSP19084722A (es) 2019-12-27
IL270927A (en) 2020-01-30
AR111826A1 (es) 2019-08-21
EP3630771B1 (en) 2022-06-29
CN110678468A (zh) 2020-01-10
UY37745A (es) 2019-01-02
PH12019502652A1 (en) 2020-07-13
WO2018220531A1 (en) 2018-12-06
CA3060990A1 (en) 2018-12-06
TW201902894A (zh) 2019-01-16
CR20190545A (es) 2020-01-15
CN110678468B (zh) 2022-07-29
CL2019003467A1 (es) 2020-03-13
MA50495A (fr) 2021-04-28
RU2738647C1 (ru) 2020-12-15
MX2019014321A (es) 2020-02-05
PE20201148A1 (es) 2020-10-26

Similar Documents

Publication Publication Date Title
CN108349940B (zh) 布鲁顿酪氨酸激酶抑制剂
CN114728926A (zh) 一种rock抑制剂及其制备方法和用途
CN117355299A (zh) 取代的2-(2,6-二氧代哌啶-3-基)-5-(1-哌啶-4-基)异吲哚啉-1,3-二酮衍生物及其用途
EP2970324A1 (en) Compounds and compositions for the treatment of parasitic diseases
TWI755255B (zh) 胺基吡啶衍生物及其作為選擇性alk-2抑制劑之用途
CN109071548A (zh) 可用于治疗尤其是癌症的吡咯并咪唑衍生物或其类似物
TW202341987A (zh) 一種Polθ抑制劑
JP7187490B2 (ja) 寄生虫症の治療のための５，６－縮合二環式化合物及び組成物
WO2019189555A1 (ja) 複素環化合物
JP2024533787A (ja) ピリド六員環構造を有するｓｏｓ１阻害剤
KR20210022646A (ko) 시아노트리아졸 화합물 및 이의 용도
JP2023512208A (ja) トール様受容体７（ＴＬＲ７）アゴニストとしての１Ｈ－ピラゾロ［４，３－ｄ］ピリミジン化合物
TWI894448B (zh) Ctla-4小分子降解劑及其應用
TW202434590A (zh) 稠合雙環化合物
CN115232109A (zh) Pd-1/pd-l1类小分子抑制剂及其在药物中的应用
TWI862653B (zh) 雜環化合物
TW202506658A (zh) 用於調節erk活性的化合物和組成物
JP2026502170A (ja) リガンド標的ｉｒａｋ３分解剤としての置換イミダゾ系化合物
EA039324B1 (ru) 5,6–конденсированные бициклические соединения и композиции для лечения паразитарных заболеваний
HK40067793B (zh) 含三环结构的芳香杂环化合物，及其制备方法和应用
HK40067854A (en) Rock inhibitor, preparation method therefor and use thereof
HK40067799B (zh) 芳香杂环衍生物作为免疫调节剂的制备及其应用
HK40067795B (zh) 新型三环芳香杂环化合物，及其制备方法、药物组合物和应用

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210519

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210519

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20220421

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220510

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220805

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20221122

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20221130

R150 Certificate of patent or registration of utility model

Ref document number: 7187490

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150