RU2720808C2 - Термостабильные препараты вакцин и микроиглы - Google Patents
Термостабильные препараты вакцин и микроиглы Download PDFInfo
- Publication number
- RU2720808C2 RU2720808C2 RU2016111354A RU2016111354A RU2720808C2 RU 2720808 C2 RU2720808 C2 RU 2720808C2 RU 2016111354 A RU2016111354 A RU 2016111354A RU 2016111354 A RU2016111354 A RU 2016111354A RU 2720808 C2 RU2720808 C2 RU 2720808C2
- Authority
- RU
- Russia
- Prior art keywords
- vaccine composition
- influenza
- maltodextrin
- vaccine
- antigen
- Prior art date
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- 239000000427 antigen Substances 0.000 claims abstract description 101
- 102000036639 antigens Human genes 0.000 claims abstract description 101
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- 239000000243 solution Substances 0.000 claims abstract description 34
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Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0402131D0 (en) | 2004-01-30 | 2004-03-03 | Isis Innovation | Delivery method |
| EP2765927B1 (en) | 2011-10-12 | 2021-02-24 | Vaxxas Pty Limited | Delivery device |
| KR20160147960A (ko) | 2014-04-25 | 2016-12-23 | 아지노모토 가부시키가이샤 | 면역자극제 |
| EP4218892A1 (en) | 2015-02-02 | 2023-08-02 | Vaxxas Pty Limited | Microprojection array applicator |
| US20160296149A1 (en) * | 2015-04-08 | 2016-10-13 | Sandia Corporation | In Vivo Extraction of Interstitial Fluid Using Hollow Microneedles |
| CN104984357B (zh) * | 2015-06-02 | 2018-01-30 | 长春百克生物科技股份公司 | 不含明胶的疫苗保护剂组合物及流感减毒活疫苗 |
| US11103259B2 (en) | 2015-09-18 | 2021-08-31 | Vaxxas Pty Limited | Microprojection arrays with microprojections having large surface area profiles |
| AU2016333148B2 (en) | 2015-09-28 | 2021-10-14 | Vaxxas Pty Limited | Microprojection arrays with enhanced skin penetrating properties and methods thereof |
| HK1254838A1 (zh) * | 2015-10-06 | 2019-07-26 | Janssen Vaccines & Prevention B.V. | 用於预防生物制品的塑料诱导降解的方法 |
| EP3368508A1 (en) | 2015-10-28 | 2018-09-05 | Ajinomoto Co., Inc. | Immunostimulating agent |
| TW201722478A (zh) * | 2015-11-27 | 2017-07-01 | Nitto Denko Corp | 流感疫苗乾燥製劑、及流感疫苗乾燥製劑之製造方法 |
| US10744197B2 (en) * | 2015-11-27 | 2020-08-18 | Nitto Denko Corporation | Vaccine pharmaceutical composition for oral administration and method for manufacturing vaccine pharmaceutical composition for oral administration |
| TW201720426A (zh) * | 2015-11-27 | 2017-06-16 | Nitto Denko Corp | 流感疫苗乾燥製劑、及流感疫苗乾燥製劑之製造方法 |
| AU2017207744A1 (en) | 2016-01-11 | 2018-07-26 | Verndari, Inc. | Microneedle compositions and methods of using same |
| JP7101121B2 (ja) | 2016-03-01 | 2022-07-14 | ジョージア テック リサーチ コーポレイション | マイクロニードル粒子、組成物、治療方法、及び目的の物質の送達方法 |
| CN115923337A (zh) | 2017-03-31 | 2023-04-07 | 瓦克萨斯私人有限公司 | 用于涂覆表面的设备和方法 |
| WO2018227246A1 (en) | 2017-06-13 | 2018-12-20 | Vaxxas Pty Limited | Quality control of substrate coatings |
| US11464957B2 (en) | 2017-08-04 | 2022-10-11 | Vaxxas Pty Limited | Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP) |
| AU2018315629B2 (en) * | 2017-08-10 | 2025-06-26 | Vaxxas Pty Limited | Differential coating of microprojections and microneedles on arrays |
| CN110870913A (zh) * | 2018-08-31 | 2020-03-10 | 成都夸常奥普医疗科技有限公司 | 氨基酸类营养素作为疫苗佐剂的应用以及包含氨基酸营养素作为佐剂的疫苗 |
| JP7660514B2 (ja) * | 2019-02-15 | 2025-04-11 | セラム インスティチュート オブ インディア プライベイト リミテッド | 弱毒生インフルエンザワクチン組成物及びその調製プロセス |
| TW202100197A (zh) * | 2019-03-28 | 2021-01-01 | 日商富士軟片股份有限公司 | 含有流感疫苗的微針陣列及微針陣列之製造方法 |
| AU2020255670B2 (en) * | 2019-03-29 | 2025-12-11 | Vaxxas Pty Ltd | Vaccination using high-density microprojection array patch |
| US12005220B2 (en) * | 2019-11-22 | 2024-06-11 | Veradermics Incorporated | Microneedle patch for immunostimulatory drug delivery |
| CN111154833B (zh) * | 2020-01-03 | 2022-08-23 | 浙江夸克生物科技有限公司 | 一种α-L-岩藻糖苷酶测定试剂盒 |
| US20230233373A1 (en) * | 2020-06-11 | 2023-07-27 | Aquavit Pharmaceuticals, Inc. | Methods and compositions for delivering bioactive compositions to ocular tissue using microneedle devices |
| CA3212891A1 (en) * | 2021-03-23 | 2022-09-29 | Veradermics Incorporated | Perilesional treatment of skin conditions |
| AU2022398370A1 (en) * | 2021-11-25 | 2024-05-30 | Orexo Ab | Pharmaceutical composition comprising biopharmaceutical drug compounds |
| WO2025013783A1 (ja) * | 2023-07-07 | 2025-01-16 | ナガセヴィータ株式会社 | タンパク質の変性抑制用組成物 |
| US20250325286A1 (en) * | 2024-04-17 | 2025-10-23 | Micron Biomedical, Inc. | Methods and Microneedle Devices for Vaccinations with Enhanced Delivery and Acceptance |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080286369A1 (en) * | 2004-07-27 | 2008-11-20 | University Of Strathclyde | Process for Preparing Microcrystals |
| US20090232894A1 (en) * | 2008-03-05 | 2009-09-17 | Sanofi Pasteur | Process for Stabilizing an Adjuvant Containing Vaccine Composition |
| US20110081380A1 (en) * | 2009-10-07 | 2011-04-07 | Sanofi Pasteur | Stabilizing Excipient for Inactivated Whole Virus Vaccine |
| WO2012145739A1 (en) * | 2011-04-21 | 2012-10-26 | Trustees Of Tufts College | Compositions and methods for stabilization of active agents |
| WO2013082418A1 (en) * | 2011-11-30 | 2013-06-06 | 3M Innovative Properties Company | Microneedle device having a peptide therapeutic agent and an amino acid, methods of making and using the same |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999064580A1 (en) | 1998-06-10 | 1999-12-16 | Georgia Tech Research Corporation | Microneedle devices and methods of manufacture and use thereof |
| US6503231B1 (en) | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
| US6743211B1 (en) | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
| US6623457B1 (en) | 1999-09-22 | 2003-09-23 | Becton, Dickinson And Company | Method and apparatus for the transdermal administration of a substance |
| WO2002064193A2 (en) | 2000-12-14 | 2002-08-22 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
| US6887484B2 (en) * | 2001-07-31 | 2005-05-03 | Posco | Vaccine composition containing a promoter peptide |
| US6945952B2 (en) | 2002-06-25 | 2005-09-20 | Theraject, Inc. | Solid solution perforator for drug delivery and other applications |
| US8062573B2 (en) | 2002-09-16 | 2011-11-22 | Theraject, Inc. | Solid micro-perforators and methods of use |
| US7314613B2 (en) | 2002-11-18 | 2008-01-01 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
| EP1633250A2 (en) | 2003-06-04 | 2006-03-15 | Georgia Tech Research Corporation | Drilling microneedle device |
| US9744227B2 (en) | 2004-06-02 | 2017-08-29 | Universal Stabilization Technologies, Inc. | Compositions containing ambient-temperature stable, inactivated but therapeutically active biopharmaceuticals and methods for formulation thereof |
| US20080269666A1 (en) | 2005-05-25 | 2008-10-30 | Georgia Tech Research Corporation | Microneedles and Methods for Microinfusion |
| WO2006138719A2 (en) | 2005-06-17 | 2006-12-28 | Georgia Tech Research Corporation | Coated microstructures and method of manufacture thereof |
| SI1954308T1 (sl) | 2005-09-16 | 2011-12-30 | Merial Ltd | Stabilizatorji za liofilizirana cepiva |
| US20090182306A1 (en) | 2006-07-21 | 2009-07-16 | Georgia Tech Research Corporation | Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal |
| UA97391C2 (ru) | 2007-03-09 | 2012-02-10 | Оцука Фармасьютикал Ко., Лтд. | Лиофилизированный препарат, содержащий гриппозную вакцину, и способ его получения |
| WO2009048607A1 (en) | 2007-10-10 | 2009-04-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
| GB0725018D0 (en) | 2007-12-21 | 2008-01-30 | Univ Cardiff | Monitoring system for microneedle delivery |
| CA2716546A1 (en) | 2008-02-25 | 2009-09-03 | Novavax, Inc. | Sugar glassified virus like particles (vlps) |
| TWI489994B (zh) | 2008-03-17 | 2015-07-01 | Baxter Healthcare Sa | 供免疫球蛋白及玻尿酸酶之皮下投藥之用的組合及方法 |
| US9028463B2 (en) | 2008-06-30 | 2015-05-12 | Hisamitsu Pharmaceutical Co., Inc. | Microneedle device, and method for enhancing the efficacy of influenza vaccine by using microneedle device |
| PT2410981T (pt) * | 2009-03-26 | 2017-05-25 | Pulmatrix Inc | Formulações em pó seco e métodos para tratar doenças pulmonares |
| US8865182B2 (en) * | 2009-07-31 | 2014-10-21 | Paxvax, Inc. | Adenoviral-based vectors |
| US20110243988A1 (en) | 2009-10-01 | 2011-10-06 | Aridis Pharmaceuticals | Methods and Compositions for Stabilization of a Virus Vaccine |
| US10206960B2 (en) | 2010-03-31 | 2019-02-19 | Stabilitech Biopharma Ltd | Stabilisation of viral particles |
| US9687536B2 (en) | 2010-04-15 | 2017-06-27 | Shin Nippon Biomedical Laboratories, Ltd. | Methods and compositions for intranasal delivery |
| GB201007207D0 (en) | 2010-04-29 | 2010-06-16 | Univ Cork | Method |
| AU2011262312B2 (en) | 2010-06-01 | 2015-05-28 | Novartis Ag | Concentration and lyophilization of influenza vaccine antigens |
| WO2011156641A2 (en) | 2010-06-09 | 2011-12-15 | Kaspar Roger L | Microneedle arrays for active agent delivery |
| JP5808102B2 (ja) | 2010-07-22 | 2015-11-10 | コスメディ製薬株式会社 | 抗原を含有する経皮免疫製剤およびその製造方法 |
| US9517205B2 (en) | 2010-08-20 | 2016-12-13 | Seqirus UK Limited | Soluble needle arrays for delivery of influenza vaccines |
| JP5558311B2 (ja) | 2010-10-27 | 2014-07-23 | 株式会社バイオセレンタック | ワクチン抗原表皮デリバリー用溶解性3層マイクロニードル・アレイ・パッチ |
| US9089677B2 (en) | 2011-01-25 | 2015-07-28 | The Regents Of The University Of California | Transcutaneous multimodal delivery system (TMDS) |
| AU2012255132B2 (en) | 2011-05-17 | 2017-05-25 | Soligenix, Inc. | Thermostable vaccine compositions and methods of preparing same |
| US20130096532A1 (en) | 2011-10-17 | 2013-04-18 | Rutgers, The State University Of New Jersey | Polymer-Based Micro-Needle Array Designs, Fabrication Processes, and Methods of Use Thereof for Drug Delivery |
| JP2015515474A (ja) | 2012-04-03 | 2015-05-28 | セラジェクト, インコーポレイテッド | ワクチンの経頬送達のための溶解性微小針アレイ |
| US20130345638A1 (en) | 2012-06-25 | 2013-12-26 | Flugen, Inc. | Multiple drug delivery device |
| EP2968162B1 (en) | 2013-03-15 | 2020-12-02 | Incube Labs, Llc | Multi-stage biodegradable drug delivery platform |
| US10010499B2 (en) | 2014-11-03 | 2018-07-03 | Merial Inc. | Methods of using microneedle vaccine formulations to elicit in animals protective immunity against rabies virus |
-
2014
- 2014-09-03 CN CN201480052624.6A patent/CN105579059B/zh active Active
- 2014-09-03 WO PCT/US2014/053902 patent/WO2015034924A1/en not_active Ceased
- 2014-09-03 ES ES14843082T patent/ES2897659T3/es active Active
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- 2014-09-03 CA CA2923010A patent/CA2923010C/en active Active
- 2014-09-03 US US14/916,417 patent/US10736840B2/en active Active
- 2014-09-03 JP JP2016540347A patent/JP6611720B2/ja active Active
-
2019
- 2019-04-23 JP JP2019082137A patent/JP7358068B2/ja active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080286369A1 (en) * | 2004-07-27 | 2008-11-20 | University Of Strathclyde | Process for Preparing Microcrystals |
| US20090232894A1 (en) * | 2008-03-05 | 2009-09-17 | Sanofi Pasteur | Process for Stabilizing an Adjuvant Containing Vaccine Composition |
| US20110081380A1 (en) * | 2009-10-07 | 2011-04-07 | Sanofi Pasteur | Stabilizing Excipient for Inactivated Whole Virus Vaccine |
| WO2012145739A1 (en) * | 2011-04-21 | 2012-10-26 | Trustees Of Tufts College | Compositions and methods for stabilization of active agents |
| WO2013082418A1 (en) * | 2011-11-30 | 2013-06-06 | 3M Innovative Properties Company | Microneedle device having a peptide therapeutic agent and an amino acid, methods of making and using the same |
Non-Patent Citations (1)
| Title |
|---|
| KIM, YC et al. Microneedles for Drug and Vaccine Delivery. Advanced drug delivery reviews., vol. 64, no. 1 4)., 2012, p.1547 - 1568. * |
Also Published As
| Publication number | Publication date |
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| EP3041504B1 (en) | 2021-08-25 |
| EP3041504A1 (en) | 2016-07-13 |
| JP2019163271A (ja) | 2019-09-26 |
| JP2016535065A (ja) | 2016-11-10 |
| CN105579059A (zh) | 2016-05-11 |
| RU2016111354A (ru) | 2017-10-09 |
| JP7358068B2 (ja) | 2023-10-10 |
| RU2016111354A3 (enExample) | 2018-07-16 |
| ES2897659T3 (es) | 2022-03-02 |
| US10736840B2 (en) | 2020-08-11 |
| EP3041504A4 (en) | 2018-02-21 |
| JP6611720B2 (ja) | 2019-11-27 |
| CA2923010A1 (en) | 2015-03-12 |
| CN105579059B (zh) | 2020-07-31 |
| US20160220483A1 (en) | 2016-08-04 |
| CA2923010C (en) | 2022-08-30 |
| WO2015034924A1 (en) | 2015-03-12 |
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