RU2720456C2 - Частицы n-(5-циано-4-((2-метоксиэтил)амино)пиридин-2-ил)-7-формил-6-((4-метил-2-оксопиперазин-1-ил)метил)-3,4-дигидро-1,8-нафтиридин-1(2h)-карбоксамида - Google Patents
Частицы n-(5-циано-4-((2-метоксиэтил)амино)пиридин-2-ил)-7-формил-6-((4-метил-2-оксопиперазин-1-ил)метил)-3,4-дигидро-1,8-нафтиридин-1(2h)-карбоксамида Download PDFInfo
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- RU2720456C2 RU2720456C2 RU2017133243A RU2017133243A RU2720456C2 RU 2720456 C2 RU2720456 C2 RU 2720456C2 RU 2017133243 A RU2017133243 A RU 2017133243A RU 2017133243 A RU2017133243 A RU 2017133243A RU 2720456 C2 RU2720456 C2 RU 2720456C2
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- methyl
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- amino
- methoxyethyl
- pyridin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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- C07B2200/13—Crystalline forms, e.g. polymorphs
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| PCT/IB2016/051633 WO2016151500A1 (en) | 2015-03-25 | 2016-03-23 | Particles of n-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2- oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2h)-carboxamide |
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| CN113234072B (zh) * | 2016-05-20 | 2022-11-04 | 江苏豪森药业集团有限公司 | Fgfr4抑制剂、其制备方法和应用 |
| CN107619388A (zh) | 2016-07-13 | 2018-01-23 | 南京天印健华医药科技有限公司 | 作为fgfr抑制剂的杂环化合物 |
| CA3075720A1 (en) * | 2017-10-02 | 2019-04-11 | Novartis Ag | Method for preparing a pharmaceutical product |
| CN110234649B (zh) * | 2017-10-31 | 2021-10-15 | 江苏豪森药业集团有限公司 | Fgfr4抑制剂的盐、晶体、制备方法及其用途 |
| WO2019085860A1 (zh) * | 2017-10-31 | 2019-05-09 | 江苏豪森药业集团有限公司 | Fgfr4抑制剂晶型及其制备方法 |
| CN109745321B (zh) * | 2017-11-08 | 2022-04-29 | 上海翰森生物医药科技有限公司 | 包含fgfr4抑制剂的药物组合物 |
| AU2020298246A1 (en) * | 2019-06-21 | 2022-01-27 | Terns Pharmaceuticals Inc. | Compounds for inhibiting FGFR4 |
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| WO2013061080A1 (en) * | 2011-10-28 | 2013-05-02 | Astex Therapeutics Limited | Anticancer pyridopyrazines via the inhibition of fgfr kinases |
| EA028819B1 (ru) * | 2013-10-25 | 2018-01-31 | Новартис Аг | Производные бициклического пиридила с конденсированными кольцами в качестве ингибиторов fgfr4 |
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| AR015514A1 (es) | 1998-02-10 | 2001-05-02 | Novartis Ag | Compuesto de amida, proceso para su preparacion y composicion farmaceutica que lo contiene |
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| JPWO2003068753A1 (ja) | 2002-02-14 | 2005-06-02 | 小野薬品工業株式会社 | Ｎ−カルバモイル窒素含有縮合環化合物およびその化合物を有効成分として含有する薬剤 |
| US20060004010A1 (en) | 2002-07-10 | 2006-01-05 | Hiromu Habashita | Ccr4 antagonist and medical use thereof |
| AU2003303231A1 (en) | 2002-12-20 | 2004-07-14 | Warner-Lambert Company Llc | Benzoxazines and derivatives thereof as inhibitors of pi3ks |
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-
2016
- 2016-03-18 US US15/073,766 patent/US9802917B2/en active Active
- 2016-03-23 WO PCT/IB2016/051633 patent/WO2016151500A1/en not_active Ceased
- 2016-03-23 KR KR1020177026470A patent/KR102606643B1/ko active Active
- 2016-03-23 PL PL16712082T patent/PL3274349T3/pl unknown
- 2016-03-23 EP EP16712082.3A patent/EP3274349B1/en active Active
- 2016-03-23 AU AU2016238437A patent/AU2016238437B2/en active Active
- 2016-03-23 RU RU2017133243A patent/RU2720456C2/ru active
- 2016-03-23 ES ES16712082T patent/ES2803028T3/es active Active
- 2016-03-23 JP JP2017549754A patent/JP6696995B2/ja active Active
- 2016-03-23 CA CA2977326A patent/CA2977326C/en active Active
- 2016-03-23 MX MX2017012293A patent/MX2017012293A/es active IP Right Grant
- 2016-03-23 AR ARP160100792A patent/AR104060A1/es unknown
- 2016-03-23 CN CN201680018234.6A patent/CN107406448B/zh active Active
- 2016-03-24 TW TW105109283A patent/TWI699206B/zh active
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2019
- 2019-02-07 AU AU2019200936A patent/AU2019200936A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013061080A1 (en) * | 2011-10-28 | 2013-05-02 | Astex Therapeutics Limited | Anticancer pyridopyrazines via the inhibition of fgfr kinases |
| EA028819B1 (ru) * | 2013-10-25 | 2018-01-31 | Новартис Аг | Производные бициклического пиридила с конденсированными кольцами в качестве ингибиторов fgfr4 |
Non-Patent Citations (1)
| Title |
|---|
| Zhou W et al. A Structure-Guided Approach to Creating Covalent FGFR Inhibitors, CHEMISTRY AND BIOLOGY, 17, 3, стр. 285 - 295, 2010. * |
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| TWI699206B (zh) | 2020-07-21 |
| RU2017133243A3 (https=) | 2019-07-29 |
| EP3274349B1 (en) | 2020-04-22 |
| AU2019200936A1 (en) | 2019-02-28 |
| AU2016238437A1 (en) | 2017-08-17 |
| CA2977326A1 (en) | 2016-09-29 |
| AR104060A1 (es) | 2017-06-21 |
| BR112017016991A2 (pt) | 2018-04-10 |
| CN107406448B (zh) | 2021-03-09 |
| AU2016238437B2 (en) | 2018-11-08 |
| KR20170129758A (ko) | 2017-11-27 |
| EP3274349A1 (en) | 2018-01-31 |
| TW201641106A (zh) | 2016-12-01 |
| MX2017012293A (es) | 2018-01-09 |
| PL3274349T3 (pl) | 2020-10-05 |
| CA2977326C (en) | 2023-08-29 |
| JP2018509446A (ja) | 2018-04-05 |
| KR102606643B1 (ko) | 2023-11-28 |
| WO2016151500A1 (en) | 2016-09-29 |
| US9802917B2 (en) | 2017-10-31 |
| JP6696995B2 (ja) | 2020-05-20 |
| ES2803028T3 (es) | 2021-01-22 |
| RU2017133243A (ru) | 2019-04-05 |
| US20160304489A1 (en) | 2016-10-20 |
| CN107406448A (zh) | 2017-11-28 |
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