TWI699206B - Ｎ-(５-氰基-４-((２-甲氧乙基)胺基)吡啶-２-基)-７-甲醯基-６-((４-甲基-２-側氧基哌-１-基)甲基)-３,４-二氫-１,８-萘啶-１(２ｈ)-甲醯胺之顆粒 - Google Patents
Ｎ-(５-氰基-４-((２-甲氧乙基)胺基)吡啶-２-基)-７-甲醯基-６-((４-甲基-２-側氧基哌-１-基)甲基)-３,４-二氫-１,８-萘啶-１(２ｈ)-甲醯胺之顆粒 Download PDFInfo
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- TWI699206B TWI699206B TW105109283A TW105109283A TWI699206B TW I699206 B TWI699206 B TW I699206B TW 105109283 A TW105109283 A TW 105109283A TW 105109283 A TW105109283 A TW 105109283A TW I699206 B TWI699206 B TW I699206B
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- methyl
- amino
- naphthyridine
- methoxyethyl
- dihydro
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- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
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| CN113234072B (zh) * | 2016-05-20 | 2022-11-04 | 江苏豪森药业集团有限公司 | Fgfr4抑制剂、其制备方法和应用 |
| CN107619388A (zh) | 2016-07-13 | 2018-01-23 | 南京天印健华医药科技有限公司 | 作为fgfr抑制剂的杂环化合物 |
| CA3075720A1 (en) * | 2017-10-02 | 2019-04-11 | Novartis Ag | Method for preparing a pharmaceutical product |
| CN110234649B (zh) * | 2017-10-31 | 2021-10-15 | 江苏豪森药业集团有限公司 | Fgfr4抑制剂的盐、晶体、制备方法及其用途 |
| WO2019085860A1 (zh) * | 2017-10-31 | 2019-05-09 | 江苏豪森药业集团有限公司 | Fgfr4抑制剂晶型及其制备方法 |
| CN109745321B (zh) * | 2017-11-08 | 2022-04-29 | 上海翰森生物医药科技有限公司 | 包含fgfr4抑制剂的药物组合物 |
| AU2020298246A1 (en) * | 2019-06-21 | 2022-01-27 | Terns Pharmaceuticals Inc. | Compounds for inhibiting FGFR4 |
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| BRPI0620408B8 (pt) | 2005-12-21 | 2021-05-25 | Novartis Ag | derivados de pirimidinil aril uréia sendo inibidores de fgf, seus usos, e preparação farmacêutica |
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| AP2013007153A0 (en) | 2011-03-18 | 2013-09-30 | Lupin Ltd | Benzo [B] [1,4] oxazin derivatives as calcium sensing receptor modulators |
| GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
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| WO2014059214A1 (en) | 2012-10-12 | 2014-04-17 | Bristol-Myers Squibb Company | Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
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2016
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Non-Patent Citations (1)
| Title |
|---|
| Wenjun Zhou, "A Structure-Guided Approach to Creating Covalent FGFR Inhibitors" , Chemistry & Biology, Volume 17, Issue 3, 26 March 2010, Pages 285-295. * |
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