RU2715866C2 - Мезенхимальные стромальные клетки для лечения синдрома сепсиса - Google Patents

Мезенхимальные стромальные клетки для лечения синдрома сепсиса Download PDF

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RU2715866C2
RU2715866C2 RU2016151738A RU2016151738A RU2715866C2 RU 2715866 C2 RU2715866 C2 RU 2715866C2 RU 2016151738 A RU2016151738 A RU 2016151738A RU 2016151738 A RU2016151738 A RU 2016151738A RU 2715866 C2 RU2715866 C2 RU 2715866C2
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cells
sepsis
asc
stromal cells
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RU2016151738A
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RU2016151738A3 (Direct
RU2016151738A (ru
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Вилфрид ДАЛЕМАНС
Элеутерио ЛОМБАРДО
Роберт ДЕККЕР
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Тихеникс С.А.У.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0031Rectum, anus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
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  • Engineering & Computer Science (AREA)
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  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dispersion Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
RU2016151738A 2014-06-30 2015-06-30 Мезенхимальные стромальные клетки для лечения синдрома сепсиса RU2715866C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14175095.0 2014-06-30
EP14175095 2014-06-30
PCT/IB2015/054923 WO2016001846A1 (en) 2014-06-30 2015-06-30 Mesenchymal stromal cells for treating sepsis

Publications (3)

Publication Number Publication Date
RU2016151738A RU2016151738A (ru) 2018-07-30
RU2016151738A3 RU2016151738A3 (Direct) 2019-01-30
RU2715866C2 true RU2715866C2 (ru) 2020-03-03

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RU2016151738A RU2715866C2 (ru) 2014-06-30 2015-06-30 Мезенхимальные стромальные клетки для лечения синдрома сепсиса

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US (2) US20170151284A1 (Direct)
EP (1) EP3160481B1 (Direct)
JP (1) JP6722599B2 (Direct)
KR (1) KR102213527B1 (Direct)
CN (1) CN106573017B (Direct)
AU (1) AU2015283662B2 (Direct)
BR (1) BR112016030758B8 (Direct)
CA (1) CA2953884C (Direct)
IL (1) IL249814B (Direct)
MX (1) MX381544B (Direct)
NZ (1) NZ727950A (Direct)
RU (1) RU2715866C2 (Direct)
SG (1) SG11201610844PA (Direct)
WO (1) WO2016001846A1 (Direct)

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JP6714932B2 (ja) * 2015-12-01 2020-07-01 株式会社AdipoSeeds 脊椎動物の脂肪組織由来間葉系細胞株の製造方法
US11701389B2 (en) 2016-03-09 2023-07-18 Emory University Methods of preserving mesenchymal stem cells
GB201604304D0 (en) * 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
EP3589298B1 (fr) 2017-02-28 2022-06-22 Université de Lorraine Cellules souches mesenchymateuses issues de la gelée de wharton pour le traitement du sepsis
US11524000B2 (en) 2017-10-26 2022-12-13 Emory University Targeting Mcl-1 to enhance DNA replication stress sensitivity for cancer therapy
CA3100466A1 (en) * 2018-06-05 2019-12-12 Medipost Co., Ltd. Pharmaceutical composition comprising hyaluronic acid and stem cells for treating cartilage damage-associated disease
JP7372982B2 (ja) * 2018-10-29 2023-11-01 オタワ ホスピタル リサーチ インスティチュート Aoahを過剰発現する遺伝子組換え間葉系幹細胞及びその使用
WO2021153719A1 (ja) * 2020-01-30 2021-08-05 Jcrファーマ株式会社 歯髄由来細胞を含む医薬組成物
AU2022273715A1 (en) * 2021-05-13 2023-11-30 Primegen Us, Inc. Methods and compositions for treating liver disease
CN113398150A (zh) * 2021-06-18 2021-09-17 卡替(上海)生物技术有限公司 牙髓间充质干细胞在脓毒症治疗中的应用

Citations (2)

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WO2005093044A1 (en) * 2004-03-22 2005-10-06 Osiris Therapeutics, Inc. Mesenchymal stem cells and uses therefor
WO2010015929A2 (en) * 2008-08-04 2010-02-11 Cellerix Sa Uses of mesenchymal stem cells

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US6051429A (en) 1995-06-07 2000-04-18 Life Technologies, Inc. Peptide-enhanced cationic lipid transfections
JP4335310B2 (ja) 1995-06-07 2009-09-30 ザ ユニバーシティ オブ ブリティッシュ コロンビア 疎水性脂質−核酸複合中間体を通して調製される脂質−核酸粒子、及び遺伝子移送のための使用
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Also Published As

Publication number Publication date
MX381544B (es) 2025-03-12
CA2953884A1 (en) 2016-01-07
CA2953884C (en) 2022-12-06
BR112016030758B8 (pt) 2022-10-25
EP3160481A1 (en) 2017-05-03
RU2016151738A3 (Direct) 2019-01-30
AU2015283662B2 (en) 2020-09-24
BR112016030758A2 (Direct) 2017-08-22
IL249814B (en) 2020-02-27
AU2015283662A1 (en) 2017-01-19
US20170151284A1 (en) 2017-06-01
CN106573017B (zh) 2021-06-11
SG11201610844PA (en) 2017-01-27
RU2016151738A (ru) 2018-07-30
JP6722599B2 (ja) 2020-07-15
IL249814A0 (en) 2017-03-30
CN106573017A (zh) 2017-04-19
US20200376038A1 (en) 2020-12-03
NZ727950A (en) 2022-07-01
KR20170021343A (ko) 2017-02-27
JP2017520583A (ja) 2017-07-27
BR112016030758B1 (pt) 2021-10-13
WO2016001846A1 (en) 2016-01-07
KR102213527B1 (ko) 2021-02-09
MX2017000142A (es) 2017-07-28
EP3160481B1 (en) 2020-09-09

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