RU2715734C2 - Схема дозирования модулятора s1p с немедленным высвобождением - Google Patents

Схема дозирования модулятора s1p с немедленным высвобождением Download PDF

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RU2715734C2
RU2715734C2 RU2016143979A RU2016143979A RU2715734C2 RU 2715734 C2 RU2715734 C2 RU 2715734C2 RU 2016143979 A RU2016143979 A RU 2016143979A RU 2016143979 A RU2016143979 A RU 2016143979A RU 2715734 C2 RU2715734 C2 RU 2715734C2
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siponimod
dosage form
patients
day
per day
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RU2016143979A
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Russian (ru)
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RU2016143979A3 (enExample
RU2016143979A (ru
Inventor
Эрик ЛЕГАНЬНЕ
Эрик Валлстрём
Филипп Мишель Рене Буйо
Эмерик Рейно
Франк ДАЛЬКЕ
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Новартис Аг
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2016143979A 2014-04-10 2015-04-08 Схема дозирования модулятора s1p с немедленным высвобождением RU2715734C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461977816P 2014-04-10 2014-04-10
US61/977,816 2014-04-10
PCT/IB2015/052550 WO2015155709A1 (en) 2014-04-10 2015-04-08 S1p modulator immediate release dosage regimen

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2020107732A Division RU2020107732A (ru) 2014-04-10 2015-04-08 Схема дозирования модулятора s1p с немедленным высвобождением

Publications (3)

Publication Number Publication Date
RU2016143979A RU2016143979A (ru) 2018-05-14
RU2016143979A3 RU2016143979A3 (enExample) 2018-11-12
RU2715734C2 true RU2715734C2 (ru) 2020-03-03

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Family Applications (2)

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RU2016143979A RU2715734C2 (ru) 2014-04-10 2015-04-08 Схема дозирования модулятора s1p с немедленным высвобождением
RU2020107732A RU2020107732A (ru) 2014-04-10 2015-04-08 Схема дозирования модулятора s1p с немедленным высвобождением

Family Applications After (1)

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RU2020107732A RU2020107732A (ru) 2014-04-10 2015-04-08 Схема дозирования модулятора s1p с немедленным высвобождением

Country Status (16)

Country Link
US (4) US20170027907A1 (enExample)
EP (3) EP3831378A1 (enExample)
JP (1) JP6674903B2 (enExample)
KR (2) KR20220156981A (enExample)
CN (2) CN106456552A (enExample)
AU (2) AU2015246036A1 (enExample)
CA (1) CA2943598C (enExample)
CL (1) CL2016002562A1 (enExample)
IL (2) IL305337A (enExample)
MX (1) MX2016013245A (enExample)
PH (1) PH12016501965A1 (enExample)
RU (2) RU2715734C2 (enExample)
SG (1) SG11201607894RA (enExample)
TW (1) TW201622721A (enExample)
WO (1) WO2015155709A1 (enExample)
ZA (1) ZA201606519B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO2699580T3 (enExample) 2014-01-24 2018-02-24
EP3831378A1 (en) * 2014-04-10 2021-06-09 Novartis AG Siponimod immediate release dosage regimen for treating autoimmune diseases
US11629124B2 (en) 2017-03-09 2023-04-18 Novartis Ag Solid forms comprising an oxime ether compound, compositions and methods of use thereof
US11434200B2 (en) 2017-03-09 2022-09-06 Novartis Ag Solid forms comprising an oxime ether compound and a coformer, compositions and methods of use thereof
CA3074416A1 (en) * 2017-09-29 2019-04-04 Novartis Ag Dosing regimen of siponimod
MX2020007268A (es) * 2017-09-29 2020-08-17 Novartis Ag Regimen de dosificacion de siponimod.
FI3758708T3 (fi) * 2018-03-01 2025-02-18 Astrazeneca Ab (2s)-{(1s)-1-syano-2-[4-(3-metyyli-2-okso-2,3-dihydro-1,3-bentsoksatsol-5-yyli)fenyyli]etyyli}-1,4-oksatsepaani-2-karboksamidia käsittäviä farmaseuttisia koostumuksia
KR20210032431A (ko) 2018-07-17 2021-03-24 인스메드 인코포레이티드 루푸스 신염을 치료하기 위한 특정 (2s)-n-[(1s)-1-시아노-2-페닐에틸]-1,4-옥사제판-2-카복스아미드
CN109908095A (zh) * 2019-04-08 2019-06-21 肇庆学院 一种西尼莫德片剂及制备方法
TW202131921A (zh) 2019-10-31 2021-09-01 瑞士商愛杜西亞製藥有限公司 Cxcr7拮抗劑與s1p1受體調節劑之組合
WO2021158838A1 (en) * 2020-02-07 2021-08-12 Argentum Pharmaceuticals Llc Dosage regimen of an s1p receptor modulator
EP4646265A1 (en) 2023-01-06 2025-11-12 Insmed Incorporated Novel, reversible dpp1 inhibitors and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010072703A1 (en) * 2008-12-22 2010-07-01 Novartis Ag Dosage regimen of an s1p receptor agonist
WO2012093161A1 (en) * 2011-01-07 2012-07-12 Novartis Ag Immunosuppressant formulations

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS53041B (sr) * 2008-12-18 2014-04-30 Novartis Ag Hemifumaratna so 1-[4-[1-(4-cikloheksil-3-trifluorometil-benziloksiimino)-etil]-2-etil-benzil]-azetidin-3-karboksilne kiseline
PL2379067T3 (pl) * 2008-12-22 2016-02-29 Novartis Ag Schemat dawkowania fingolimodu w leczeniu stwardnienia rozsianego
EP3061449A1 (en) * 2009-09-29 2016-08-31 Novartis AG Dosage regimen of an s1p receptor modulator
WO2012095853A1 (en) * 2011-01-10 2012-07-19 Novartis Pharma Ag Modified release formulations comprising sip receptor modulators
US20150218090A1 (en) * 2011-10-21 2015-08-06 Novartis Ag Dosage regimen for an s1p receptor modulator or agonist
EP3831378A1 (en) * 2014-04-10 2021-06-09 Novartis AG Siponimod immediate release dosage regimen for treating autoimmune diseases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010072703A1 (en) * 2008-12-22 2010-07-01 Novartis Ag Dosage regimen of an s1p receptor agonist
WO2012093161A1 (en) * 2011-01-07 2012-07-12 Novartis Ag Immunosuppressant formulations

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KAPPOS L. et ak. Siponimod (BAF312) for the Treatmebt of Secondary Progressive Multiple Sclerosis: Design of the phase 3 EXPAND trial. // Neurology, 2013, 80:1, Abstract, найдено он-лайн в базе данных Embase. *
KRZYSZTOF SELMAJ ET AL, "Siponimod for patients with relapsing-remitting multiple sclerosis (BOLD): an adaptive, dose-ranging, randomised, phase 2 study", THE LANCET NEUROLOGY, (20130801), vol. 12, no. 8, pages 756-767, abstrast. *

Also Published As

Publication number Publication date
AU2015246036A1 (en) 2016-10-13
EP4074312C0 (en) 2026-02-25
MX2016013245A (es) 2017-01-16
US20220016076A1 (en) 2022-01-20
CN106456552A (zh) 2017-02-22
IL247986A0 (en) 2016-11-30
EP4074312A1 (en) 2022-10-19
PH12016501965A1 (en) 2017-01-09
AU2020203107B2 (en) 2021-10-21
US20250041266A1 (en) 2025-02-06
CA2943598C (en) 2023-03-07
RU2020107732A (ru) 2020-03-30
RU2016143979A3 (enExample) 2018-11-12
US20190054065A1 (en) 2019-02-21
EP4074312B1 (en) 2026-02-25
WO2015155709A1 (en) 2015-10-15
TW201622721A (zh) 2016-07-01
EP3129020A1 (en) 2017-02-15
JP6674903B2 (ja) 2020-04-01
CN116650467A (zh) 2023-08-29
CA2943598A1 (en) 2015-10-15
AU2020203107A1 (en) 2020-05-28
KR20160141841A (ko) 2016-12-09
JP2017510607A (ja) 2017-04-13
IL305337A (en) 2023-10-01
KR20220156981A (ko) 2022-11-28
EP3831378A1 (en) 2021-06-09
US20170027907A1 (en) 2017-02-02
ZA201606519B (en) 2017-11-29
SG11201607894RA (en) 2016-10-28
CL2016002562A1 (es) 2017-07-28
RU2016143979A (ru) 2018-05-14

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FA92 Acknowledgement of application withdrawn (lack of supplementary materials submitted)

Effective date: 20190312

FZ9A Application not withdrawn (correction of the notice of withdrawal)

Effective date: 20190523