RU2714733C2 - Технологии мультимеризации - Google Patents
Технологии мультимеризации Download PDFInfo
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- RU2714733C2 RU2714733C2 RU2015143166A RU2015143166A RU2714733C2 RU 2714733 C2 RU2714733 C2 RU 2714733C2 RU 2015143166 A RU2015143166 A RU 2015143166A RU 2015143166 A RU2015143166 A RU 2015143166A RU 2714733 C2 RU2714733 C2 RU 2714733C2
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- Prior art keywords
- ser
- gly
- thr
- gln
- tyr
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| JP2021508477A (ja) | 2017-12-29 | 2021-03-11 | オンコラス， インコーポレイテッド | 治療用ポリペプチドの腫瘍溶解性ウイルス送達 |
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| JP2022510218A (ja) * | 2018-11-30 | 2022-01-26 | メモリアル スローン ケタリング キャンサー センター | ヘテロ二量体四価特異性抗体およびこれらの使用 |
| KR20210128399A (ko) * | 2019-02-20 | 2021-10-26 | 더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 | 암-표적화되고, 바이러스-암호화된, 조절 가능한 t 세포 (catvert) 또는 nk 세포 (catvern) 링커 |
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| BR112021022682A2 (pt) | 2019-05-14 | 2022-02-22 | Provention Bio Inc | Métodos e composições para prevenir diabetes do tipo 1 |
| US12006366B2 (en) | 2020-06-11 | 2024-06-11 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
| JP2023532973A (ja) * | 2020-07-03 | 2023-08-01 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | 多官能直交タンパク質キメラ |
| WO2023023055A1 (en) | 2021-08-16 | 2023-02-23 | Renagade Therapeutics Management Inc. | Compositions and methods for optimizing tropism of delivery systems for rna |
| TW202328067A (zh) | 2021-09-14 | 2023-07-16 | 美商雷納嘉德醫療管理公司 | 環狀脂質及其使用方法 |
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| WO2023122752A1 (en) | 2021-12-23 | 2023-06-29 | Renagade Therapeutics Management Inc. | Constrained lipids and methods of use thereof |
| CA3255619A1 (en) | 2022-04-07 | 2023-10-12 | Renagade Therapeutics Management Inc. | CYCLIC LIPIDS AND LIPID NANOPARTICLES (LPNs) FOR THE SUPPLY OF NUCLEIC ACIDS OR PEPTIDES INTENDED FOR USE IN VACCINATION AGAINST INFECTIOUS AGENTS |
| KR20250054843A (ko) * | 2022-07-25 | 2025-04-23 | 바이로넥시스 바이오테라퓨틱스 인코포레이티드 | 아데노-관련 바이러스 벡터 및 전이 위험을 감소시키고 치료 및 예방하기 위한 이들의 사용 방법 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2228202C2 (ru) * | 1998-04-21 | 2004-05-10 | Микромет Аг | Cd19xcd3-специфические полипептиды и их применение |
| US20060228300A1 (en) * | 2005-04-06 | 2006-10-12 | Ibc Pharmaceuticals, Inc. | Stably tethered structures of defined compositions with multiple functions or binding specificities |
| US20070298041A1 (en) * | 2002-06-28 | 2007-12-27 | Tomlinson Ian M | Ligands That Enhance Endogenous Compounds |
| EP2050764A1 (en) * | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
Family Cites Families (8)
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| GB0230202D0 (en) * | 2002-12-27 | 2003-02-05 | Domantis Ltd | Ligand |
| EP1293514B1 (en) * | 2001-09-14 | 2006-11-29 | Affimed Therapeutics AG | Multimeric single chain tandem Fv-antibodies |
| EP1600459A3 (en) * | 2002-06-28 | 2005-12-07 | Domantis Limited | Ligand |
| WO2006009901A2 (en) * | 2004-06-18 | 2006-01-26 | Ambrx, Inc. | Novel antigen-binding polypeptides and their uses |
| AU2006232310B9 (en) * | 2005-04-06 | 2011-07-21 | Ibc Pharmaceuticals, Inc. | Improved stably tethered structures of defined compositions with multiple functions or binding specificities |
| AU2011268110B2 (en) * | 2010-06-19 | 2016-05-19 | Memorial Sloan-Kettering Cancer Center | Anti-GD2 antibodies |
| CA2902561C (en) | 2013-03-15 | 2022-08-02 | Memorial Sloan-Kettering Cancer Center | Multimerization technologies |
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2014
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2228202C2 (ru) * | 1998-04-21 | 2004-05-10 | Микромет Аг | Cd19xcd3-специфические полипептиды и их применение |
| US20070298041A1 (en) * | 2002-06-28 | 2007-12-27 | Tomlinson Ian M | Ligands That Enhance Endogenous Compounds |
| US20060228300A1 (en) * | 2005-04-06 | 2006-10-12 | Ibc Pharmaceuticals, Inc. | Stably tethered structures of defined compositions with multiple functions or binding specificities |
| EP2050764A1 (en) * | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
Non-Patent Citations (2)
| Title |
|---|
| YANKELEVICH M. et al. "Anti-CD3 × Anti-GD2 Bispecific Antibody Redirects T-Cell Cytolytic Activity to Neuroblastoma Targets", Pediatr Blood Cancer, 2012, Vol. 59, Is. 7, pp. 1198-1205. * |
| YANKELEVICH M. et al. "Anti-CD3 × Anti-GD2 Bispecific Antibody Redirects T-Cell Cytolytic Activity to Neuroblastoma Targets", Pediatr Blood Cancer, 2012, Vol. 59, Is. 7, pp. 1198-1205. * |
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| BR112015022978A2 (pt) | 2017-11-14 |
| CN105530959A (zh) | 2016-04-27 |
| JP6480907B2 (ja) | 2019-03-13 |
| WO2014144573A2 (en) | 2014-09-18 |
| CA2902561C (en) | 2022-08-02 |
| EP2968547A4 (en) | 2016-11-09 |
| CN105530959B (zh) | 2021-09-17 |
| BR112015022978A8 (pt) | 2018-01-23 |
| US20180251503A1 (en) | 2018-09-06 |
| KR20150132420A (ko) | 2015-11-25 |
| RU2015143166A (ru) | 2017-04-20 |
| US20160168211A1 (en) | 2016-06-16 |
| US9802995B2 (en) | 2017-10-31 |
| HK1216145A1 (en) | 2016-10-21 |
| WO2014144573A3 (en) | 2015-10-29 |
| EP2968547A2 (en) | 2016-01-20 |
| AU2014228962A1 (en) | 2015-09-10 |
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