CA2902561C - Multimerization technologies - Google Patents
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- CA2902561C CA2902561C CA2902561A CA2902561A CA2902561C CA 2902561 C CA2902561 C CA 2902561C CA 2902561 A CA2902561 A CA 2902561A CA 2902561 A CA2902561 A CA 2902561A CA 2902561 C CA2902561 C CA 2902561C
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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- Proteomics, Peptides & Aminoacids (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| PCT/US2014/029041 WO2014144573A2 (en) | 2013-03-15 | 2014-03-14 | Multimerization technologies |
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| CA2902561A1 CA2902561A1 (en) | 2014-09-18 |
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| EP (1) | EP2968547B1 (enExample) |
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| AU2014228772B2 (en) * | 2013-03-15 | 2019-02-28 | Memorial Sloan Kettering Cancer Center | High affinity anti-GD2 antibodies |
| IL319092A (en) | 2013-05-06 | 2025-04-01 | Scholar Rock Inc | Compositions and methods for growth factor modulation |
| US10370776B2 (en) * | 2013-09-25 | 2019-08-06 | Idea Orchard, Llc | Antibody like protein |
| US9879087B2 (en) | 2014-11-12 | 2018-01-30 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
| EP3218005B1 (en) | 2014-11-12 | 2023-01-04 | Seagen Inc. | Glycan-interacting compounds and methods of use |
| WO2017055385A1 (en) * | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Anti-cd3xgd2 bispecific t cell activating antigen binding molecules |
| HK1253049A1 (zh) | 2015-11-12 | 2019-06-06 | Seagen Inc. | 糖基相互作用化合物及其使用方法 |
| CA3038504A1 (en) * | 2016-10-14 | 2018-04-19 | Dana-Farber Cancer Institute, Inc. | Modular tetrameric bispecific antibody platform |
| US11401330B2 (en) * | 2016-11-17 | 2022-08-02 | Seagen Inc. | Glycan-interacting compounds and methods of use |
| TWI667253B (zh) * | 2016-12-30 | 2019-08-01 | 博晟生醫股份有限公司 | 重組多肽、核酸分子及其組合物以及製造、使用之方法 |
| US11046768B2 (en) * | 2017-01-27 | 2021-06-29 | Memorial Sloan Kettering Cancer Center | Bispecific HER2 and CD3 binding molecules |
| US20200231700A1 (en) * | 2017-02-20 | 2020-07-23 | Dragonfly Therapeutics, Inc. | Proteins binding gd2, nkg2d and cd16 |
| KR102653141B1 (ko) | 2017-03-03 | 2024-04-01 | 씨젠 인크. | 글리칸-상호작용 화합물 및 사용 방법 |
| CN108690138A (zh) * | 2017-04-12 | 2018-10-23 | 鸿运华宁（杭州）生物医药有限公司 | 一种能与人cd19或cd20和人cd3结合的双特异性抗体及其应用 |
| JP2021508477A (ja) | 2017-12-29 | 2021-03-11 | オンコラス， インコーポレイテッド | 治療用ポリペプチドの腫瘍溶解性ウイルス送達 |
| JPWO2020071554A1 (ja) * | 2018-10-05 | 2021-09-09 | 北海道公立大学法人 札幌医科大学 | がん幹細胞特異的抗体 |
| JP2022510218A (ja) * | 2018-11-30 | 2022-01-26 | メモリアル スローン ケタリング キャンサー センター | ヘテロ二量体四価特異性抗体およびこれらの使用 |
| KR20210128399A (ko) * | 2019-02-20 | 2021-10-26 | 더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 | 암-표적화되고, 바이러스-암호화된, 조절 가능한 t 세포 (catvert) 또는 nk 세포 (catvern) 링커 |
| EP3966227A1 (en) | 2019-05-07 | 2022-03-16 | Voyager Therapeutics, Inc. | Compositions and methods for the vectored augmentation of protein destruction, expression and/or regulation |
| BR112021022682A2 (pt) | 2019-05-14 | 2022-02-22 | Provention Bio Inc | Métodos e composições para prevenir diabetes do tipo 1 |
| US12006366B2 (en) | 2020-06-11 | 2024-06-11 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
| JP2023532973A (ja) * | 2020-07-03 | 2023-08-01 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | 多官能直交タンパク質キメラ |
| WO2023023055A1 (en) | 2021-08-16 | 2023-02-23 | Renagade Therapeutics Management Inc. | Compositions and methods for optimizing tropism of delivery systems for rna |
| TW202328067A (zh) | 2021-09-14 | 2023-07-16 | 美商雷納嘉德醫療管理公司 | 環狀脂質及其使用方法 |
| WO2023044343A1 (en) | 2021-09-14 | 2023-03-23 | Renagade Therapeutics Management Inc. | Acyclic lipids and methods of use thereof |
| WO2023122752A1 (en) | 2021-12-23 | 2023-06-29 | Renagade Therapeutics Management Inc. | Constrained lipids and methods of use thereof |
| CA3255619A1 (en) | 2022-04-07 | 2023-10-12 | Renagade Therapeutics Management Inc. | CYCLIC LIPIDS AND LIPID NANOPARTICLES (LPNs) FOR THE SUPPLY OF NUCLEIC ACIDS OR PEPTIDES INTENDED FOR USE IN VACCINATION AGAINST INFECTIOUS AGENTS |
| KR20250054843A (ko) * | 2022-07-25 | 2025-04-23 | 바이로넥시스 바이오테라퓨틱스 인코포레이티드 | 아데노-관련 바이러스 벡터 및 전이 위험을 감소시키고 치료 및 예방하기 위한 이들의 사용 방법 |
| CU20230043A7 (es) * | 2023-09-08 | 2025-04-04 | Ct Inmunologia Molecular | Anticuerpos biespecíficos que unen cd3 y el gangliósido ngcgm3 |
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| WO1999054440A1 (en) * | 1998-04-21 | 1999-10-28 | Micromet Gesellschaft Für Biomedizinische Forschung Mbh | CD19xCD3 SPECIFIC POLYPEPTIDES AND USES THEREOF |
| GB0015119D0 (en) | 2000-06-20 | 2000-08-09 | Angeletti P Ist Richerche Bio | Methods and means for regulation of gene expression |
| GB0230202D0 (en) * | 2002-12-27 | 2003-02-05 | Domantis Ltd | Ligand |
| EP1293514B1 (en) * | 2001-09-14 | 2006-11-29 | Affimed Therapeutics AG | Multimeric single chain tandem Fv-antibodies |
| US20070298041A1 (en) * | 2002-06-28 | 2007-12-27 | Tomlinson Ian M | Ligands That Enhance Endogenous Compounds |
| EP1600459A3 (en) * | 2002-06-28 | 2005-12-07 | Domantis Limited | Ligand |
| WO2006107617A2 (en) * | 2005-04-06 | 2006-10-12 | Ibc Pharmaceuticals, Inc. | Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses |
| WO2006009901A2 (en) * | 2004-06-18 | 2006-01-26 | Ambrx, Inc. | Novel antigen-binding polypeptides and their uses |
| AU2006232310B9 (en) * | 2005-04-06 | 2011-07-21 | Ibc Pharmaceuticals, Inc. | Improved stably tethered structures of defined compositions with multiple functions or binding specificities |
| EP2050764A1 (en) * | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| AU2011268110B2 (en) * | 2010-06-19 | 2016-05-19 | Memorial Sloan-Kettering Cancer Center | Anti-GD2 antibodies |
| CA2902561C (en) | 2013-03-15 | 2022-08-02 | Memorial Sloan-Kettering Cancer Center | Multimerization technologies |
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| EP2968547B1 (en) | 2019-08-07 |
| KR102090356B1 (ko) | 2020-03-18 |
| AU2014228962B2 (en) | 2019-03-14 |
| JP2016516049A (ja) | 2016-06-02 |
| CA2902561A1 (en) | 2014-09-18 |
| BR112015022978A2 (pt) | 2017-11-14 |
| CN105530959A (zh) | 2016-04-27 |
| JP6480907B2 (ja) | 2019-03-13 |
| WO2014144573A2 (en) | 2014-09-18 |
| RU2714733C2 (ru) | 2020-02-19 |
| EP2968547A4 (en) | 2016-11-09 |
| CN105530959B (zh) | 2021-09-17 |
| BR112015022978A8 (pt) | 2018-01-23 |
| US20180251503A1 (en) | 2018-09-06 |
| KR20150132420A (ko) | 2015-11-25 |
| RU2015143166A (ru) | 2017-04-20 |
| US20160168211A1 (en) | 2016-06-16 |
| US9802995B2 (en) | 2017-10-31 |
| HK1216145A1 (en) | 2016-10-21 |
| WO2014144573A3 (en) | 2015-10-29 |
| EP2968547A2 (en) | 2016-01-20 |
| AU2014228962A1 (en) | 2015-09-10 |
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