RU2707092C2 - Составы со сниженным окислением - Google Patents

Составы со сниженным окислением Download PDF

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Publication number
RU2707092C2
RU2707092C2 RU2015143548A RU2015143548A RU2707092C2 RU 2707092 C2 RU2707092 C2 RU 2707092C2 RU 2015143548 A RU2015143548 A RU 2015143548A RU 2015143548 A RU2015143548 A RU 2015143548A RU 2707092 C2 RU2707092 C2 RU 2707092C2
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Russia
Prior art keywords
antibody
composition
oxidation
antibodies
protein
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RU2015143548A
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English (en)
Russian (ru)
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RU2015143548A (ru
RU2015143548A3 (enExample
Inventor
Сридхара Алаваттам
Мэри МЭЛЛЭНИ
Парбир ГРЕВАЛ
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Дженентек, Инк.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Biochemistry (AREA)
  • Lubricants (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2015143548A 2013-03-13 2014-03-13 Составы со сниженным окислением RU2707092C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361780845P 2013-03-13 2013-03-13
US61/780,845 2013-03-13
US201361909813P 2013-11-27 2013-11-27
US61/909,813 2013-11-27
PCT/US2014/026841 WO2014160495A1 (en) 2013-03-13 2014-03-13 Formulations with reduced oxidation

Publications (3)

Publication Number Publication Date
RU2015143548A RU2015143548A (ru) 2017-04-20
RU2015143548A3 RU2015143548A3 (enExample) 2018-02-06
RU2707092C2 true RU2707092C2 (ru) 2019-11-22

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RU2015143548A RU2707092C2 (ru) 2013-03-13 2014-03-13 Составы со сниженным окислением

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EP (1) EP2968466B1 (enExample)
JP (3) JP6389236B2 (enExample)
KR (1) KR102237885B1 (enExample)
CN (2) CN110075293A (enExample)
AU (3) AU2014243700B2 (enExample)
CA (2) CA2904166C (enExample)
DK (1) DK2968466T3 (enExample)
ES (1) ES2688895T3 (enExample)
HR (1) HRP20181504T1 (enExample)
HU (1) HUE039948T2 (enExample)
IL (2) IL269947B (enExample)
LT (1) LT2968466T (enExample)
MX (2) MX369671B (enExample)
MY (2) MY174679A (enExample)
NZ (1) NZ711566A (enExample)
PL (1) PL2968466T3 (enExample)
PT (1) PT2968466T (enExample)
RS (1) RS57813B1 (enExample)
RU (1) RU2707092C2 (enExample)
SG (2) SG11201507043SA (enExample)
SI (1) SI2968466T1 (enExample)
WO (1) WO2014160495A1 (enExample)
ZA (2) ZA201506876B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2858996C2 (ru) * 2021-02-19 2026-03-25 Инхибркс Байосайенсиз, Инк. Составы dr5-связывающих полипептидов

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US20140314778A1 (en) 2013-03-13 2014-10-23 Genentech, Inc. Formulations with reduced oxidation
HK1212613A1 (zh) * 2013-03-13 2016-06-17 豪夫迈‧罗氏有限公司 具有降低的氧化的配制物
US10653779B2 (en) 2013-03-13 2020-05-19 Genentech, Inc. Formulations with reduced oxidation
AR103173A1 (es) 2014-12-22 2017-04-19 Novarits Ag Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17
SMT202100317T1 (it) 2016-06-27 2021-07-12 Morphosys Ag Formulazioni di anticorpi anti-cd19
EP3695886A4 (en) * 2017-10-13 2021-07-28 Tamura Teco Co., Ltd. PROCESS FOR TREATING A HARMFUL SUBSTANCE GENERATING OZONE
IL280525B2 (en) * 2018-08-08 2024-11-01 Genentech Inc Use of tryptophan derivatives and l-methionine for protein formulation

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
RU2858996C2 (ru) * 2021-02-19 2026-03-25 Инхибркс Байосайенсиз, Инк. Составы dr5-связывающих полипептидов

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BR112015022484A2 (pt) 2017-07-18
JP2016520521A (ja) 2016-07-14
NZ751543A (en) 2020-09-25
CN110075293A (zh) 2019-08-02
SI2968466T1 (sl) 2018-10-30
RU2015143548A (ru) 2017-04-20
EP2968466A1 (en) 2016-01-20
MY174679A (en) 2020-05-06
ZA201506876B (en) 2019-12-18
HUE039948T2 (hu) 2019-02-28
JP2020164531A (ja) 2020-10-08
ZA201906057B (en) 2022-04-28
SG10201705525VA (en) 2017-08-30
IL269947B (en) 2022-08-01
IL240933A0 (en) 2015-11-30
AU2021201366A1 (en) 2021-03-18
JP2018150317A (ja) 2018-09-27
KR102237885B1 (ko) 2021-04-07
EP2968466B1 (en) 2018-07-25
DK2968466T3 (en) 2018-10-22
CA2904166A1 (en) 2014-10-02
ES2688895T3 (es) 2018-11-07
CA3113172A1 (en) 2014-10-02
LT2968466T (lt) 2018-10-10
AU2019202464A1 (en) 2019-05-02
KR20150130397A (ko) 2015-11-23
MY199135A (en) 2023-10-17
HK1211219A1 (en) 2016-05-20
CN104968362A (zh) 2015-10-07
EP2968466A4 (en) 2016-10-26
IL240933B (en) 2019-10-31
CN104968362B (zh) 2018-12-14
AU2014243700B2 (en) 2019-01-24
RS57813B1 (sr) 2018-12-31
JP6389236B2 (ja) 2018-09-12
AU2019202464B2 (en) 2020-12-10
HRP20181504T1 (hr) 2018-11-02
NZ711566A (en) 2020-06-26
SG11201507043SA (en) 2015-10-29
MX2015011432A (es) 2016-04-27
IL269947A (enExample) 2019-12-31
AU2014243700A1 (en) 2015-10-08
MX369671B (es) 2019-11-15
WO2014160495A1 (en) 2014-10-02
MX2019013560A (es) 2020-01-20
PL2968466T3 (pl) 2018-11-30
CA2904166C (en) 2021-05-18
PT2968466T (pt) 2018-10-22

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