JP6389236B2 - 酸化還元製剤 - Google Patents

酸化還元製剤 Download PDF

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Publication number
JP6389236B2
JP6389236B2 JP2016502262A JP2016502262A JP6389236B2 JP 6389236 B2 JP6389236 B2 JP 6389236B2 JP 2016502262 A JP2016502262 A JP 2016502262A JP 2016502262 A JP2016502262 A JP 2016502262A JP 6389236 B2 JP6389236 B2 JP 6389236B2
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JP
Japan
Prior art keywords
antibody
formulation
protein
oxidation
compound
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JP2016502262A
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English (en)
Japanese (ja)
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JP2016520521A (ja
JP2016520521A5 (enExample
Inventor
スリードハラ アラバタム，
スリードハラ アラバタム，
メアリー マレイニー，
メアリー マレイニー，
パービー グレウォール，
パービー グレウォール，
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Genentech Inc
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Genentech Inc
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Publication of JP2016520521A publication Critical patent/JP2016520521A/ja
Publication of JP2016520521A5 publication Critical patent/JP2016520521A5/ja
Application granted granted Critical
Publication of JP6389236B2 publication Critical patent/JP6389236B2/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Lubricants (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2016502262A 2013-03-13 2014-03-13 酸化還元製剤 Active JP6389236B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361780845P 2013-03-13 2013-03-13
US61/780,845 2013-03-13
US201361909813P 2013-11-27 2013-11-27
US61/909,813 2013-11-27
PCT/US2014/026841 WO2014160495A1 (en) 2013-03-13 2014-03-13 Formulations with reduced oxidation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018083450A Division JP2018150317A (ja) 2013-03-13 2018-04-24 酸化還元製剤

Publications (3)

Publication Number Publication Date
JP2016520521A JP2016520521A (ja) 2016-07-14
JP2016520521A5 JP2016520521A5 (enExample) 2018-06-14
JP6389236B2 true JP6389236B2 (ja) 2018-09-12

Family

ID=51625442

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016502262A Active JP6389236B2 (ja) 2013-03-13 2014-03-13 酸化還元製剤
JP2018083450A Withdrawn JP2018150317A (ja) 2013-03-13 2018-04-24 酸化還元製剤
JP2020091966A Pending JP2020164531A (ja) 2013-03-13 2020-05-27 酸化還元製剤

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2018083450A Withdrawn JP2018150317A (ja) 2013-03-13 2018-04-24 酸化還元製剤
JP2020091966A Pending JP2020164531A (ja) 2013-03-13 2020-05-27 酸化還元製剤

Country Status (23)

Country Link
EP (1) EP2968466B1 (enExample)
JP (3) JP6389236B2 (enExample)
KR (1) KR102237885B1 (enExample)
CN (2) CN110075293A (enExample)
AU (3) AU2014243700B2 (enExample)
CA (2) CA3113172A1 (enExample)
DK (1) DK2968466T3 (enExample)
ES (1) ES2688895T3 (enExample)
HR (1) HRP20181504T1 (enExample)
HU (1) HUE039948T2 (enExample)
IL (2) IL269947B (enExample)
LT (1) LT2968466T (enExample)
MX (2) MX369671B (enExample)
MY (2) MY174679A (enExample)
NZ (1) NZ711566A (enExample)
PL (1) PL2968466T3 (enExample)
PT (1) PT2968466T (enExample)
RS (1) RS57813B1 (enExample)
RU (1) RU2707092C2 (enExample)
SG (2) SG11201507043SA (enExample)
SI (1) SI2968466T1 (enExample)
WO (1) WO2014160495A1 (enExample)
ZA (2) ZA201506876B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016513667A (ja) * 2013-03-13 2016-05-16 ジェネンテック， インコーポレイテッド 酸化還元製剤

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AR095399A1 (es) 2013-03-13 2015-10-14 Genentech Inc Formulaciones con oxidación reducida, método
AR095398A1 (es) 2013-03-13 2015-10-14 Genentech Inc Formulaciones con oxidación reducida
AR103173A1 (es) 2014-12-22 2017-04-19 Novarits Ag Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17
SG10201912369QA (en) 2016-06-27 2020-02-27 Morphosys Ag Anti-cd19 antibody formulations
CN111194233A (zh) * 2017-10-13 2020-05-22 株式会社田村特科 有害物质处理方法及臭氧产生装置
EP3833389A1 (en) 2018-08-08 2021-06-16 Genentech, Inc. Use of tryptophan derivatives and l-methionine for protein formulation

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016513667A (ja) * 2013-03-13 2016-05-16 ジェネンテック， インコーポレイテッド 酸化還元製剤

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IL240933B (en) 2019-10-31
ES2688895T3 (es) 2018-11-07
LT2968466T (lt) 2018-10-10
RU2707092C2 (ru) 2019-11-22
MX2019013560A (es) 2020-01-20
BR112015022484A2 (pt) 2017-07-18
ZA201506876B (en) 2019-12-18
PT2968466T (pt) 2018-10-22
EP2968466B1 (en) 2018-07-25
SG11201507043SA (en) 2015-10-29
WO2014160495A1 (en) 2014-10-02
CA2904166C (en) 2021-05-18
JP2016520521A (ja) 2016-07-14
HUE039948T2 (hu) 2019-02-28
HK1211219A1 (en) 2016-05-20
CN104968362A (zh) 2015-10-07
DK2968466T3 (en) 2018-10-22
MY199135A (en) 2023-10-17
SG10201705525VA (en) 2017-08-30
JP2020164531A (ja) 2020-10-08
SI2968466T1 (sl) 2018-10-30
IL269947A (enExample) 2019-12-31
JP2018150317A (ja) 2018-09-27
EP2968466A4 (en) 2016-10-26
IL240933A0 (en) 2015-11-30
AU2021201366A1 (en) 2021-03-18
NZ711566A (en) 2020-06-26
AU2014243700B2 (en) 2019-01-24
CN110075293A (zh) 2019-08-02
MX2015011432A (es) 2016-04-27
EP2968466A1 (en) 2016-01-20
HRP20181504T1 (hr) 2018-11-02
PL2968466T3 (pl) 2018-11-30
AU2019202464B2 (en) 2020-12-10
MY174679A (en) 2020-05-06
RU2015143548A (ru) 2017-04-20
KR102237885B1 (ko) 2021-04-07
NZ751543A (en) 2020-09-25
MX369671B (es) 2019-11-15
RS57813B1 (sr) 2018-12-31
AU2014243700A1 (en) 2015-10-08
ZA201906057B (en) 2022-04-28
AU2019202464A1 (en) 2019-05-02
CA3113172A1 (en) 2014-10-02
IL269947B (en) 2022-08-01
CA2904166A1 (en) 2014-10-02
KR20150130397A (ko) 2015-11-23
CN104968362B (zh) 2018-12-14

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