RU2704485C2 - Стабильные жидкие препараты вируса осповакцины - Google Patents
Стабильные жидкие препараты вируса осповакцины Download PDFInfo
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- RU2704485C2 RU2704485C2 RU2017121019A RU2017121019A RU2704485C2 RU 2704485 C2 RU2704485 C2 RU 2704485C2 RU 2017121019 A RU2017121019 A RU 2017121019A RU 2017121019 A RU2017121019 A RU 2017121019A RU 2704485 C2 RU2704485 C2 RU 2704485C2
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- smallpox
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| CN110669739A (zh) * | 2019-09-30 | 2020-01-10 | 长春生物制品研究所有限责任公司 | 一种新型甲型肝炎病毒抗原制备方法 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3915794A (en) * | 1973-02-09 | 1975-10-28 | Rit Rech Ind Therapeut | Stabilizing compositions for cell-free viruses and cell-free virus preparations containing them |
| RU2126269C1 (ru) * | 1992-06-04 | 1999-02-20 | Мерк Энд Ко., Инк. | Способ получения вакцины, способ получения свободной от клеток вакцины, способ культивирования клеток, питательная среда |
| WO2005066333A1 (en) * | 2003-12-30 | 2005-07-21 | Aventis Pasteur, Inc. | Stabilizing compositions for recombinant viruses |
Family Cites Families (35)
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|---|---|---|---|---|
| JPS5255054Y2 (enExample) * | 1973-01-12 | 1977-12-13 | ||
| US4675187A (en) | 1983-05-16 | 1987-06-23 | Bristol-Myers Company | BBM-1675, a new antibiotic complex |
| DK331087A (da) * | 1986-06-30 | 1987-12-31 | Smith Kline Rit | Stabilisator for levende vaccine |
| JPS6314729U (enExample) * | 1986-07-14 | 1988-01-30 | ||
| FR2643817B1 (fr) | 1989-03-06 | 1993-12-17 | Transgene Sa | Composition pharmaceutique, utile a titre preventif ou curatif contre les tumeurs induites par les papillomavirus |
| GB8705477D0 (en) | 1987-03-09 | 1987-04-15 | Carlton Med Prod | Drug delivery systems |
| GB9001641D0 (en) | 1990-01-24 | 1990-03-21 | Imp Cancer Res Tech | Compounds |
| FR2668064B1 (fr) | 1990-10-23 | 1994-12-16 | Transgene Sa | Composition pharmaceutique pour le traitement ou la prevention d'une tumeur maligne. |
| US6241989B1 (en) * | 1991-07-09 | 2001-06-05 | Cornell Research Foundation, Inc. | Recombinant multivalent viral vaccine |
| FR2710536B1 (fr) | 1993-09-29 | 1995-12-22 | Transgene Sa | Usage anti-cancéreux d'un vecteur viral comportant un gène modulateur de la réponse immunitaire et/ou inflammatoire. |
| FR2751879B1 (fr) | 1996-07-30 | 1998-10-30 | Transgene Sa | Composition pharmaceutique contre les tumeurs et infections a papillomavirus |
| US5672485A (en) | 1996-08-13 | 1997-09-30 | Regents Of The University Of Minnesota | Immortalized cell lines for virus growth |
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| FR2777570A1 (fr) | 1998-04-17 | 1999-10-22 | Transgene Sa | Mutant ayant une activite phosphoribosyl transferase |
| US7456009B2 (en) | 2000-03-07 | 2008-11-25 | Merck & Co., Inc. | Adenovirus formulations |
| US7094412B2 (en) | 2001-12-10 | 2006-08-22 | Bavarian Nordic A/S | Poxvirus containing formulations and process for preparing stable poxvirus containing compositions |
| CN101804202B (zh) | 2003-02-25 | 2014-06-18 | 米迪缪尼有限公司 | 制备流感疫苗组合物的方法 |
| FR2855758B1 (fr) | 2003-06-05 | 2005-07-22 | Biomerieux Sa | Composition comprenant la polyproteine ns3/ns4 et le polypeptide ns5b du vhc, vecteurs d'expression incluant les sequences nucleiques correspondantes et leur utilisation en therapeutique |
| US7790445B2 (en) | 2003-07-21 | 2010-09-07 | Transgene S.A. | Polypeptide having an improved cytosine deaminase activity |
| ATE467678T1 (de) | 2003-07-22 | 2010-05-15 | Vivalis | Produktion von poxviren mit adhärenten oder nicht adhärenten vogelzellinien |
| MX2007005379A (es) | 2004-11-05 | 2007-07-04 | Wellstat Biologics Corp | Formulaciones de virus envueltos estables y filtrables. |
| KR101772375B1 (ko) | 2005-09-07 | 2017-08-29 | 신라젠(주) | Gm-csf를 발현하는 폭스바이러스를 사용한 전이성 및/또는 전신 파종성 암의 전신 치료법 |
| AU2007204024B2 (en) | 2006-01-05 | 2012-01-19 | Transgene S.A. | Avian telomerase reverse transcriptase |
| MX2008013489A (es) | 2006-04-21 | 2008-10-30 | Transgene Sa | Vacuna de virus de papiloma basado en hpv-18 (virus de papiloma humano 18). |
| DK2029756T3 (en) | 2006-06-20 | 2017-02-13 | Transgene Sa | PROCEDURE FOR PREPARING POXVIRA AND POXVIRUS COMPOSITIONS |
| KR20080084528A (ko) | 2007-03-15 | 2008-09-19 | 제네렉스 바이오테라퓨틱스 인크. | 종양살상형 백시니아 바이러스 암 치료 |
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| MX2010005273A (es) | 2007-11-19 | 2010-08-31 | Transgene Sa | Vectores oncoliticos poxvirales. |
| US7998488B2 (en) * | 2008-11-14 | 2011-08-16 | Baxter International Inc. | Vaccine formulations and uses thereof |
| BRPI1007744A2 (pt) * | 2009-05-12 | 2017-06-27 | Transgene Sa | método para a produção e purificação de um ortopoxvírus do tipo selvagem, ortopoxvírus do tipo selvagem, composição farmacêutica, uso de um ortopoxvírus do tipo selvagem e uso de uma linhagem de células aviárias imortalizadas |
| WO2014009433A1 (en) | 2012-07-10 | 2014-01-16 | Transgene Sa | Mycobacterium resuscitation promoting factor for use as adjuvant |
| TWI638829B (zh) | 2012-07-10 | 2018-10-21 | 法商傳斯堅公司 | 分枝桿菌抗原疫苗 |
| US9314519B2 (en) | 2012-08-21 | 2016-04-19 | Intervet Inc. | Liquid stable virus vaccines |
| TWI690322B (zh) * | 2012-10-02 | 2020-04-11 | 法商傳斯堅公司 | 含病毒的調配物及其使用 |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3915794A (en) * | 1973-02-09 | 1975-10-28 | Rit Rech Ind Therapeut | Stabilizing compositions for cell-free viruses and cell-free virus preparations containing them |
| RU2126269C1 (ru) * | 1992-06-04 | 1999-02-20 | Мерк Энд Ко., Инк. | Способ получения вакцины, способ получения свободной от клеток вакцины, способ культивирования клеток, питательная среда |
| WO2005066333A1 (en) * | 2003-12-30 | 2005-07-21 | Aventis Pasteur, Inc. | Stabilizing compositions for recombinant viruses |
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| EP3226894B1 (en) | 2019-08-07 |
| US20170326230A1 (en) | 2017-11-16 |
| JP2017537910A (ja) | 2017-12-21 |
| CN107206063B (zh) | 2021-09-28 |
| AU2015357225B2 (en) | 2020-04-09 |
| ES2753364T3 (es) | 2020-04-08 |
| AU2015357225A1 (en) | 2017-06-15 |
| JP6655618B2 (ja) | 2020-02-26 |
| KR20170091653A (ko) | 2017-08-09 |
| KR102507483B1 (ko) | 2023-03-07 |
| RU2017121019A (ru) | 2019-01-09 |
| EP3226894A1 (en) | 2017-10-11 |
| WO2016087457A1 (en) | 2016-06-09 |
| IL252512A0 (en) | 2017-07-31 |
| CN107206063A (zh) | 2017-09-26 |
| MX2017007178A (es) | 2017-08-28 |
| IL252512B (en) | 2020-05-31 |
| CA2969034A1 (en) | 2016-06-09 |
| DK3226894T3 (da) | 2019-10-21 |
| MX378901B (es) | 2025-03-10 |
| US10517943B2 (en) | 2019-12-31 |
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