JP2004535203A5 - - Google Patents
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- Publication number
- JP2004535203A5 JP2004535203A5 JP2003514077A JP2003514077A JP2004535203A5 JP 2004535203 A5 JP2004535203 A5 JP 2004535203A5 JP 2003514077 A JP2003514077 A JP 2003514077A JP 2003514077 A JP2003514077 A JP 2003514077A JP 2004535203 A5 JP2004535203 A5 JP 2004535203A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- temperature
- cells
- poxvirus
- mva
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000700605 Viruses Species 0.000 claims description 104
- 210000004027 cell Anatomy 0.000 claims description 66
- 238000000034 method Methods 0.000 claims description 60
- 230000002238 attenuated effect Effects 0.000 claims description 12
- 229960005486 vaccine Drugs 0.000 claims description 12
- 241000287828 Gallus gallus Species 0.000 claims description 8
- 210000002950 fibroblast Anatomy 0.000 claims description 7
- 238000001415 gene therapy Methods 0.000 claims description 7
- 210000001161 mammalian embryo Anatomy 0.000 claims description 7
- 239000013598 vector Substances 0.000 claims description 5
- 150000002632 lipids Chemical class 0.000 claims description 4
- 241000271566 Aves Species 0.000 claims description 3
- 239000001963 growth medium Substances 0.000 claims description 3
- 239000004094 surface-active agent Substances 0.000 claims description 2
- 238000002474 experimental method Methods 0.000 description 36
- 241001183012 Modified Vaccinia Ankara virus Species 0.000 description 24
- 241000700618 Vaccinia virus Species 0.000 description 16
- 208000015181 infectious disease Diseases 0.000 description 16
- 238000004519 manufacturing process Methods 0.000 description 12
- 241000700647 Variola virus Species 0.000 description 10
- 230000003321 amplification Effects 0.000 description 10
- 238000003199 nucleic acid amplification method Methods 0.000 description 10
- 241001465754 Metazoa Species 0.000 description 9
- 238000012258 culturing Methods 0.000 description 7
- 238000011534 incubation Methods 0.000 description 7
- 230000003612 virological effect Effects 0.000 description 7
- 241000282412 Homo Species 0.000 description 6
- 230000036760 body temperature Effects 0.000 description 6
- 235000013330 chicken meat Nutrition 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 238000002255 vaccination Methods 0.000 description 6
- 241000700663 Avipoxvirus Species 0.000 description 5
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 5
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 5
- 238000004113 cell culture Methods 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 229920001993 poloxamer 188 Polymers 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 239000003381 stabilizer Substances 0.000 description 5
- 238000004448 titration Methods 0.000 description 5
- 241000700629 Orthopoxvirus Species 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 208000005585 Poxviridae Infections Diseases 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000008014 freezing Effects 0.000 description 3
- 238000007710 freezing Methods 0.000 description 3
- 230000035772 mutation Effects 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 3
- 229920000053 polysorbate 80 Polymers 0.000 description 3
- 241001430294 unidentified retrovirus Species 0.000 description 3
- 230000029812 viral genome replication Effects 0.000 description 3
- 241001135961 Amsacta moorei entomopoxvirus Species 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 2
- 229930182816 L-glutamine Natural products 0.000 description 2
- 241000700568 Suipoxvirus Species 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 2
- 230000000843 anti-fungal effect Effects 0.000 description 2
- 229940121375 antifungal agent Drugs 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 239000003026 cod liver oil Substances 0.000 description 2
- 235000012716 cod liver oil Nutrition 0.000 description 2
- 201000003740 cowpox Diseases 0.000 description 2
- 230000008029 eradication Effects 0.000 description 2
- 244000144972 livestock Species 0.000 description 2
- 229940041323 measles vaccine Drugs 0.000 description 2
- 238000010899 nucleation Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000001850 reproductive effect Effects 0.000 description 2
- 229940083538 smallpox vaccine Drugs 0.000 description 2
- 241000894007 species Species 0.000 description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 241001137864 Camelpox virus Species 0.000 description 1
- 241000700664 Capripoxvirus Species 0.000 description 1
- 108090000994 Catalytic RNA Proteins 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- 201000006082 Chickenpox Diseases 0.000 description 1
- 241000700628 Chordopoxvirinae Species 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- 241000450599 DNA viruses Species 0.000 description 1
- 241001112691 Goatpox virus Species 0.000 description 1
- 206010061598 Immunodeficiency Diseases 0.000 description 1
- 241000700559 Molluscipoxvirus Species 0.000 description 1
- 241000700639 Parapoxvirus Species 0.000 description 1
- 229940124939 Pox vaccine Drugs 0.000 description 1
- 241000700625 Poxviridae Species 0.000 description 1
- 241000700665 Sheeppox virus Species 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- 206010046865 Vaccinia virus infection Diseases 0.000 description 1
- 206010046980 Varicella Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 241000700574 Yatapoxvirus Species 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- CJPQIRJHIZUAQP-MRXNPFEDSA-N benalaxyl-M Chemical compound CC=1C=CC=C(C)C=1N([C@H](C)C(=O)OC)C(=O)CC1=CC=CC=C1 CJPQIRJHIZUAQP-MRXNPFEDSA-N 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 210000000991 chicken egg Anatomy 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 230000004090 etiopathogenesis Effects 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000002055 immunohistochemical effect Effects 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 238000012768 mass vaccination Methods 0.000 description 1
- 210000004779 membrane envelope Anatomy 0.000 description 1
- 150000007523 nucleic acids Chemical group 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 241000700570 unidentified entomopoxvirus Species 0.000 description 1
- 208000007089 vaccinia Diseases 0.000 description 1
- 210000003501 vero cell Anatomy 0.000 description 1
- 108700026220 vif Genes Proteins 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200101122 | 2001-07-18 | ||
| DKPA200101122 | 2001-07-18 | ||
| PCT/EP2002/007280 WO2003008533A2 (en) | 2001-07-18 | 2002-07-02 | Method for virus propagation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010259770A Division JP5154632B2 (ja) | 2001-07-18 | 2010-11-22 | ウイルス増殖法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004535203A JP2004535203A (ja) | 2004-11-25 |
| JP2004535203A5 true JP2004535203A5 (enExample) | 2011-01-20 |
| JP4700907B2 JP4700907B2 (ja) | 2011-06-15 |
Family
ID=8160630
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003514077A Expired - Fee Related JP4700907B2 (ja) | 2001-07-18 | 2002-07-02 | ウイルス増殖方法 |
| JP2010259770A Expired - Fee Related JP5154632B2 (ja) | 2001-07-18 | 2010-11-22 | ウイルス増殖法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010259770A Expired - Fee Related JP5154632B2 (ja) | 2001-07-18 | 2010-11-22 | ウイルス増殖法 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6924137B2 (enExample) |
| EP (1) | EP1412486B1 (enExample) |
| JP (2) | JP4700907B2 (enExample) |
| KR (1) | KR100908377B1 (enExample) |
| CN (1) | CN100513560C (enExample) |
| AU (1) | AU2002314201B2 (enExample) |
| BR (2) | BRPI0211276B1 (enExample) |
| CA (1) | CA2450206C (enExample) |
| DE (1) | DE60223812T2 (enExample) |
| DK (1) | DK1412486T3 (enExample) |
| EA (1) | EA006628B1 (enExample) |
| HU (1) | HUP0400393A3 (enExample) |
| IL (2) | IL158927A0 (enExample) |
| MX (1) | MXPA04000326A (enExample) |
| NO (1) | NO339056B1 (enExample) |
| NZ (1) | NZ529914A (enExample) |
| PL (1) | PL205926B1 (enExample) |
| UA (1) | UA82466C2 (enExample) |
| WO (1) | WO2003008533A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1335987T4 (en) * | 2000-11-23 | 2016-09-19 | Bavarian Nordic As | Modified variant of vaccinia virus Ankara |
| WO2004022729A1 (en) * | 2002-09-05 | 2004-03-18 | Bavarian Nordic A/S | Method for the cultivation of primary cells and for the amplification of viruses under serum free conditions |
| US7445924B2 (en) | 2000-11-23 | 2008-11-04 | Bavarian Nordic A/S | Modified Vaccinia Ankara virus variant and cultivation method |
| US8691502B2 (en) | 2008-10-31 | 2014-04-08 | Tremrx, Inc. | T-cell vaccination with viral vectors via mechanical epidermal disruption |
| TWI638829B (zh) | 2012-07-10 | 2018-10-21 | 法商傳斯堅公司 | 分枝桿菌抗原疫苗 |
| WO2014009433A1 (en) | 2012-07-10 | 2014-01-16 | Transgene Sa | Mycobacterium resuscitation promoting factor for use as adjuvant |
| US10765731B2 (en) | 2014-01-09 | 2020-09-08 | Transgene Sa | Fusion of heterooligomeric mycobacterial antigens |
| ES3011733T3 (en) | 2015-02-13 | 2025-04-08 | Transgene | Immunotherapeutic vaccine and antibody combination therapy |
| WO2016131945A1 (en) | 2015-02-20 | 2016-08-25 | Transgene Sa | Combination product with autophagy modulator |
| FR3042121A1 (fr) | 2015-10-08 | 2017-04-14 | Jean-Marc Limacher | Composition anti-tumorale |
| CA3023022A1 (en) | 2016-05-04 | 2017-11-09 | Transgene Sa | Combination therapy with cpg tlr9 ligand |
| US10913063B2 (en) * | 2016-07-12 | 2021-02-09 | EMULATE, Inc. | Removing bubbles in a microfluidic device |
| WO2018069316A2 (en) | 2016-10-10 | 2018-04-19 | Transgene Sa | Immunotherapeutic product and mdsc modulator combination therapy |
| SG11201912429RA (en) | 2017-06-21 | 2020-01-30 | Transgene Sa | Personalized vaccine |
| EP3842065A1 (en) | 2019-12-23 | 2021-06-30 | Transgene | Process for designing a recombinant poxvirus for a therapeutic vaccine |
| WO2023213763A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Poxvirus encoding a binding agent comprising an anti- pd-l1 sdab |
| WO2023213764A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Fusion polypeptide comprising an anti-pd-l1 sdab and a member of the tnfsf |
| AU2024241503A1 (en) | 2023-03-17 | 2025-08-14 | Albert-Ludwigs-Universität Freiburg | Hbv antigen formulation for treating hepatitis b |
| WO2025172435A1 (en) | 2024-02-13 | 2025-08-21 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Hbv antigen formulation for treating hepatitis b |
| FR3160186A1 (fr) | 2024-03-13 | 2025-09-19 | Odimma Therapeutics | Vecteur non-viral pour transcription augmentee |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2384845A1 (fr) * | 1976-08-05 | 1978-10-20 | Anvar | Vaccin contre la myxomatose et nouvelle souche virale utilisee |
| JPS60202827A (ja) * | 1984-03-28 | 1985-10-14 | Chibaken | 弱毒痘そうワクチン株 |
| CA1341245C (en) * | 1988-01-12 | 2001-06-05 | F. Hoffmann-La Roche Ag | Recombinant vaccinia virus mva |
| DE4405841C1 (de) * | 1994-02-23 | 1995-01-05 | Mayr Anton Prof Dr Med Vet Dr | Multipotente Paramunitätsinducer auf der Basis von Kombinationen von Pockenviruskomponenten, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US5616487A (en) * | 1994-09-15 | 1997-04-01 | Aastrom Biosciences, Inc. | Stabilized retrovirus compositions |
| WO1997012032A1 (en) * | 1995-09-27 | 1997-04-03 | The Government Of The United States Of America, As Represented By The Department Of Health And Human Services | Production of infectious respiratory syncytial virus from cloned nucleotide sequences |
| EP0912724B1 (en) * | 1996-07-15 | 2009-12-09 | The Government of The United States of America, as represented by The Department of Health and Human Services | Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences |
| DK1335987T4 (en) * | 2000-11-23 | 2016-09-19 | Bavarian Nordic As | Modified variant of vaccinia virus Ankara |
-
2002
- 2002-02-07 UA UA2004010355A patent/UA82466C2/uk unknown
- 2002-07-02 HU HU0400393A patent/HUP0400393A3/hu unknown
- 2002-07-02 JP JP2003514077A patent/JP4700907B2/ja not_active Expired - Fee Related
- 2002-07-02 WO PCT/EP2002/007280 patent/WO2003008533A2/en not_active Ceased
- 2002-07-02 CA CA2450206A patent/CA2450206C/en not_active Expired - Fee Related
- 2002-07-02 AU AU2002314201A patent/AU2002314201B2/en not_active Ceased
- 2002-07-02 EA EA200400195A patent/EA006628B1/ru not_active IP Right Cessation
- 2002-07-02 US US10/483,707 patent/US6924137B2/en not_active Expired - Lifetime
- 2002-07-02 NZ NZ529914A patent/NZ529914A/en not_active IP Right Cessation
- 2002-07-02 CN CNB02814421XA patent/CN100513560C/zh not_active Expired - Fee Related
- 2002-07-02 DE DE60223812T patent/DE60223812T2/de not_active Expired - Lifetime
- 2002-07-02 MX MXPA04000326A patent/MXPA04000326A/es active IP Right Grant
- 2002-07-02 DK DK02740758T patent/DK1412486T3/da active
- 2002-07-02 BR BRPI0211276A patent/BRPI0211276B1/pt unknown
- 2002-07-02 KR KR1020047000786A patent/KR100908377B1/ko not_active Expired - Fee Related
- 2002-07-02 EP EP02740758A patent/EP1412486B1/en not_active Revoked
- 2002-07-02 IL IL15892702A patent/IL158927A0/xx unknown
- 2002-07-02 BR BR0211276-0A patent/BR0211276A/pt not_active IP Right Cessation
- 2002-07-02 PL PL366897A patent/PL205926B1/pl unknown
-
2003
- 2003-11-18 IL IL158927A patent/IL158927A/en not_active IP Right Cessation
-
2004
- 2004-01-13 NO NO20040158A patent/NO339056B1/no not_active IP Right Cessation
-
2010
- 2010-11-22 JP JP2010259770A patent/JP5154632B2/ja not_active Expired - Fee Related
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