RU2697251C2 - Способы получения 1, 3-бензодиоксольных гетероциклических соединений - Google Patents
Способы получения 1, 3-бензодиоксольных гетероциклических соединений Download PDFInfo
- Publication number
- RU2697251C2 RU2697251C2 RU2017101808A RU2017101808A RU2697251C2 RU 2697251 C2 RU2697251 C2 RU 2697251C2 RU 2017101808 A RU2017101808 A RU 2017101808A RU 2017101808 A RU2017101808 A RU 2017101808A RU 2697251 C2 RU2697251 C2 RU 2697251C2
- Authority
- RU
- Russia
- Prior art keywords
- formula
- compound
- defined above
- compounds
- chlorine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14173397.2 | 2014-06-23 | ||
| EP14173397 | 2014-06-23 | ||
| PCT/EP2015/063942 WO2015197534A2 (en) | 2014-06-23 | 2015-06-22 | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2017101808A RU2017101808A (ru) | 2018-07-27 |
| RU2017101808A3 RU2017101808A3 (enExample) | 2019-01-22 |
| RU2697251C2 true RU2697251C2 (ru) | 2019-08-13 |
Family
ID=50980952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017101808A RU2697251C2 (ru) | 2014-06-23 | 2015-06-22 | Способы получения 1, 3-бензодиоксольных гетероциклических соединений |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9908894B2 (enExample) |
| EP (1) | EP3157930B1 (enExample) |
| JP (1) | JP6785666B2 (enExample) |
| KR (1) | KR20170016894A (enExample) |
| CN (1) | CN106459081B (enExample) |
| AU (1) | AU2015279428B2 (enExample) |
| BR (1) | BR112016029510A2 (enExample) |
| CA (1) | CA2953284A1 (enExample) |
| DK (1) | DK3157930T3 (enExample) |
| ES (1) | ES2702451T3 (enExample) |
| IL (1) | IL249336A0 (enExample) |
| MX (1) | MX2016016378A (enExample) |
| PL (1) | PL3157930T3 (enExample) |
| PT (1) | PT3157930T (enExample) |
| RU (1) | RU2697251C2 (enExample) |
| TW (1) | TW201613934A (enExample) |
| WO (1) | WO2015197534A2 (enExample) |
| ZA (1) | ZA201608442B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX385592B (es) * | 2015-12-18 | 2025-03-18 | Union Therapeutics As | Metodos para preparacion de compuestos heterociclicos de 1,3-benzodioxol. |
| CN118344381A (zh) | 2017-06-20 | 2024-07-16 | 联合疗法公司 | 用于制备1,3-苯并二氧杂环戊烯杂环化合物的方法 |
| CN111727191B (zh) | 2017-12-15 | 2024-01-05 | 联合疗法公司 | 取代的氮杂环丁烷二氢噻吩并吡啶类化合物及其作为磷酸二酯酶抑制剂的用途 |
| USD914676S1 (en) | 2018-05-11 | 2021-03-30 | Samsung Electronics Co., Ltd. | Notebook computer |
| DK3911304T3 (da) | 2019-01-15 | 2023-10-02 | Union Therapeutics As | Tabletformuleringer med modificeret frigivelse indeholdende phosphodiesterase-hæmmere |
| EP4313043A1 (en) | 2021-03-22 | 2024-02-07 | UNION therapeutics A/S | Treatment of hidradenitis suppurativa with orismilast |
| GB202205715D0 (en) | 2022-04-19 | 2022-06-01 | Union Therapeutics As | Treatment of neutrophilic dermatoses |
| GB202306663D0 (en) | 2023-05-05 | 2023-06-21 | Union Therapeutics As | Combination therapy |
| GB202306662D0 (en) | 2023-05-05 | 2023-06-21 | Union Therapeutics As | Dosage regimen |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996036624A1 (en) * | 1995-05-19 | 1996-11-21 | Kyowa Hakko Kogyo Co., Ltd. | Oxygen-containing heterocyclic compounds |
| WO2011160632A1 (en) * | 2010-06-24 | 2011-12-29 | Leo Pharma A/S | Benzodioxole or benzodioxepine heterocyclic compounds phosphodiesterase inhibitors |
| RU2495043C2 (ru) * | 2007-02-28 | 2013-10-10 | Лео Фарма А/С | Новые ингибиторы фосфодиэстераз |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6514996B2 (en) * | 1995-05-19 | 2003-02-04 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of benzofuran or benzodioxole |
| DE10205274A1 (de) * | 2002-02-08 | 2003-08-21 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen enthaltend neben Anticholinergika heterocyclische Verbindungen |
| CA2491464A1 (en) * | 2002-07-03 | 2004-01-15 | Kyowa Hakko Kogyo Co., Ltd. | Process for preparation of 1,3-benzodioxole-2-spiro- cycloalkane derivatives |
| EP2044023B1 (en) * | 2006-07-14 | 2011-01-19 | CHIESI FARMACEUTICI S.p.A. | Derivatives of 1-phenyl-2-pyridynyl alkylene alcohols as phosphodiesterase inhibitors |
| BRPI0721113A2 (pt) | 2006-12-22 | 2014-10-07 | Leo Pharma As | Composto, composição farmacêutica, uso de um composto, e, método para prevenir, tratar ou melhorar doenças ou condições dérmicas ou distúrbios |
| ZA200905371B (en) * | 2007-02-28 | 2010-10-27 | Leo Pharma As | Novel phosphodiesterase Inhibitors |
| WO2014096018A1 (en) * | 2012-12-19 | 2014-06-26 | Leo Pharma A/S | Methods for the preparation of substituted acetophenones |
| MX385592B (es) * | 2015-12-18 | 2025-03-18 | Union Therapeutics As | Metodos para preparacion de compuestos heterociclicos de 1,3-benzodioxol. |
-
2015
- 2015-06-22 CN CN201580033483.8A patent/CN106459081B/zh active Active
- 2015-06-22 TW TW104120096A patent/TW201613934A/zh unknown
- 2015-06-22 US US15/320,227 patent/US9908894B2/en active Active
- 2015-06-22 PL PL15730183T patent/PL3157930T3/pl unknown
- 2015-06-22 WO PCT/EP2015/063942 patent/WO2015197534A2/en not_active Ceased
- 2015-06-22 CA CA2953284A patent/CA2953284A1/en not_active Abandoned
- 2015-06-22 MX MX2016016378A patent/MX2016016378A/es unknown
- 2015-06-22 JP JP2016572800A patent/JP6785666B2/ja active Active
- 2015-06-22 DK DK15730183.9T patent/DK3157930T3/en active
- 2015-06-22 ES ES15730183T patent/ES2702451T3/es active Active
- 2015-06-22 BR BR112016029510A patent/BR112016029510A2/pt not_active IP Right Cessation
- 2015-06-22 EP EP15730183.9A patent/EP3157930B1/en active Active
- 2015-06-22 RU RU2017101808A patent/RU2697251C2/ru active
- 2015-06-22 KR KR1020167037002A patent/KR20170016894A/ko not_active Withdrawn
- 2015-06-22 PT PT15730183T patent/PT3157930T/pt unknown
- 2015-06-22 AU AU2015279428A patent/AU2015279428B2/en not_active Ceased
-
2016
- 2016-12-01 IL IL249336A patent/IL249336A0/en unknown
- 2016-12-07 ZA ZA2016/08442A patent/ZA201608442B/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996036624A1 (en) * | 1995-05-19 | 1996-11-21 | Kyowa Hakko Kogyo Co., Ltd. | Oxygen-containing heterocyclic compounds |
| RU2495043C2 (ru) * | 2007-02-28 | 2013-10-10 | Лео Фарма А/С | Новые ингибиторы фосфодиэстераз |
| WO2011160632A1 (en) * | 2010-06-24 | 2011-12-29 | Leo Pharma A/S | Benzodioxole or benzodioxepine heterocyclic compounds phosphodiesterase inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3157930B1 (en) | 2018-10-17 |
| ZA201608442B (en) | 2018-05-30 |
| JP2017520547A (ja) | 2017-07-27 |
| US9908894B2 (en) | 2018-03-06 |
| ES2702451T3 (es) | 2019-03-01 |
| AU2015279428B2 (en) | 2018-02-15 |
| JP6785666B2 (ja) | 2020-11-18 |
| RU2017101808A3 (enExample) | 2019-01-22 |
| CN106459081B (zh) | 2019-09-10 |
| CN106459081A (zh) | 2017-02-22 |
| PL3157930T3 (pl) | 2019-04-30 |
| US20170137438A1 (en) | 2017-05-18 |
| WO2015197534A3 (en) | 2016-03-17 |
| PT3157930T (pt) | 2018-12-24 |
| IL249336A0 (en) | 2017-02-28 |
| AU2015279428A1 (en) | 2017-01-05 |
| MX2016016378A (es) | 2017-10-16 |
| KR20170016894A (ko) | 2017-02-14 |
| WO2015197534A2 (en) | 2015-12-30 |
| CA2953284A1 (en) | 2015-12-30 |
| BR112016029510A2 (pt) | 2017-08-22 |
| TW201613934A (en) | 2016-04-16 |
| EP3157930A2 (en) | 2017-04-26 |
| RU2017101808A (ru) | 2018-07-27 |
| DK3157930T3 (en) | 2019-01-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC41 | Official registration of the transfer of exclusive right |
Effective date: 20211019 |