AU2015279428B2 - Methods for the preparation of 1,3-benzodioxole heterocyclic compounds - Google Patents

Methods for the preparation of 1,3-benzodioxole heterocyclic compounds Download PDF

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Publication number
AU2015279428B2
AU2015279428B2 AU2015279428A AU2015279428A AU2015279428B2 AU 2015279428 B2 AU2015279428 B2 AU 2015279428B2 AU 2015279428 A AU2015279428 A AU 2015279428A AU 2015279428 A AU2015279428 A AU 2015279428A AU 2015279428 B2 AU2015279428 B2 AU 2015279428B2
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AU
Australia
Prior art keywords
formula
compound
defined above
chloro
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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AU2015279428A
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English (en)
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AU2015279428A1 (en
Inventor
Andre Faldt
Bjorn Metzler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
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Leo Pharma AS
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Publication of AU2015279428A1 publication Critical patent/AU2015279428A1/en
Application granted granted Critical
Publication of AU2015279428B2 publication Critical patent/AU2015279428B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2015279428A 2014-06-23 2015-06-22 Methods for the preparation of 1,3-benzodioxole heterocyclic compounds Ceased AU2015279428B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14173397 2014-06-23
EP14173397.2 2014-06-23
PCT/EP2015/063942 WO2015197534A2 (en) 2014-06-23 2015-06-22 Methods for the preparation of 1,3-benzodioxole heterocyclic compounds

Publications (2)

Publication Number Publication Date
AU2015279428A1 AU2015279428A1 (en) 2017-01-05
AU2015279428B2 true AU2015279428B2 (en) 2018-02-15

Family

ID=50980952

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015279428A Ceased AU2015279428B2 (en) 2014-06-23 2015-06-22 Methods for the preparation of 1,3-benzodioxole heterocyclic compounds

Country Status (18)

Country Link
US (1) US9908894B2 (enExample)
EP (1) EP3157930B1 (enExample)
JP (1) JP6785666B2 (enExample)
KR (1) KR20170016894A (enExample)
CN (1) CN106459081B (enExample)
AU (1) AU2015279428B2 (enExample)
BR (1) BR112016029510A2 (enExample)
CA (1) CA2953284A1 (enExample)
DK (1) DK3157930T3 (enExample)
ES (1) ES2702451T3 (enExample)
IL (1) IL249336A0 (enExample)
MX (1) MX2016016378A (enExample)
PL (1) PL3157930T3 (enExample)
PT (1) PT3157930T (enExample)
RU (1) RU2697251C2 (enExample)
TW (1) TW201613934A (enExample)
WO (1) WO2015197534A2 (enExample)
ZA (1) ZA201608442B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3390407T3 (da) 2015-12-18 2023-11-06 Union Therapeutics As Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser
AU2018286964B2 (en) 2017-06-20 2022-04-14 UNION therapeutics A/S Methods for the preparation of 1,3-benzodioxole heterocyclic compounds
WO2019115776A1 (en) 2017-12-15 2019-06-20 Leo Pharma A/S Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors
USD914676S1 (en) 2018-05-11 2021-03-30 Samsung Electronics Co., Ltd. Notebook computer
KR20210117300A (ko) 2019-01-15 2021-09-28 유니온 테라퓨틱스 에이/에스 포스포디에스테라제 억제제를 함유하는 변형 방출 정제 제형
KR20230159485A (ko) 2021-03-22 2023-11-21 유니온 테라퓨틱스 에이/에스 오리스밀라스트를 사용한 화농땀샘염의 치료
GB202205715D0 (en) 2022-04-19 2022-06-01 Union Therapeutics As Treatment of neutrophilic dermatoses
GB202306663D0 (en) 2023-05-05 2023-06-21 Union Therapeutics As Combination therapy
GB202306662D0 (en) 2023-05-05 2023-06-21 Union Therapeutics As Dosage regimen

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008104175A2 (en) * 2007-02-28 2008-09-04 Leo Pharma A/S Novel phosphodiesterase inhibitors
WO2011160632A1 (en) * 2010-06-24 2011-12-29 Leo Pharma A/S Benzodioxole or benzodioxepine heterocyclic compounds phosphodiesterase inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1000785A1 (en) * 1995-05-19 2006-06-30 Kyowa Hakko Kogyo Co., Ltd Oxygen-containing heterocyclic compounds
US6514996B2 (en) * 1995-05-19 2003-02-04 Kyowa Hakko Kogyo Co., Ltd. Derivatives of benzofuran or benzodioxole
DE10205274A1 (de) * 2002-02-08 2003-08-21 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen enthaltend neben Anticholinergika heterocyclische Verbindungen
AU2003252467A1 (en) * 2002-07-03 2004-01-23 Kyowa Hakko Kogyo Co., Ltd. Process for preparation of 1,3-benzodioxole-2-spiro- cycloalkane derivatives
DE602007012105D1 (de) * 2006-07-14 2011-03-03 Chiesi Farma Spa Derivate von 1-phenyl-2-pyridinylalkylenalkohole als phosphodiesteraseinhibitoren
US8148537B2 (en) 2006-12-22 2012-04-03 Leo Pharma A/S Substituted acetophenones useful as PDE4 inhibitors
ZA200905371B (en) * 2007-02-28 2010-10-27 Leo Pharma As Novel phosphodiesterase Inhibitors
WO2014096018A1 (en) * 2012-12-19 2014-06-26 Leo Pharma A/S Methods for the preparation of substituted acetophenones
DK3390407T3 (da) * 2015-12-18 2023-11-06 Union Therapeutics As Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008104175A2 (en) * 2007-02-28 2008-09-04 Leo Pharma A/S Novel phosphodiesterase inhibitors
WO2011160632A1 (en) * 2010-06-24 2011-12-29 Leo Pharma A/S Benzodioxole or benzodioxepine heterocyclic compounds phosphodiesterase inhibitors

Also Published As

Publication number Publication date
CN106459081B (zh) 2019-09-10
US20170137438A1 (en) 2017-05-18
WO2015197534A3 (en) 2016-03-17
ES2702451T3 (es) 2019-03-01
PT3157930T (pt) 2018-12-24
IL249336A0 (en) 2017-02-28
EP3157930B1 (en) 2018-10-17
ZA201608442B (en) 2018-05-30
TW201613934A (en) 2016-04-16
RU2017101808A3 (enExample) 2019-01-22
JP6785666B2 (ja) 2020-11-18
CA2953284A1 (en) 2015-12-30
JP2017520547A (ja) 2017-07-27
DK3157930T3 (en) 2019-01-21
WO2015197534A2 (en) 2015-12-30
EP3157930A2 (en) 2017-04-26
MX2016016378A (es) 2017-10-16
RU2697251C2 (ru) 2019-08-13
US9908894B2 (en) 2018-03-06
RU2017101808A (ru) 2018-07-27
BR112016029510A2 (pt) 2017-08-22
PL3157930T3 (pl) 2019-04-30
KR20170016894A (ko) 2017-02-14
CN106459081A (zh) 2017-02-22
AU2015279428A1 (en) 2017-01-05

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired