CN106459081B - 1,3-苯并二氧杂环戊烯杂环化合物的制备方法 - Google Patents

1,3-苯并二氧杂环戊烯杂环化合物的制备方法 Download PDF

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Publication number
CN106459081B
CN106459081B CN201580033483.8A CN201580033483A CN106459081B CN 106459081 B CN106459081 B CN 106459081B CN 201580033483 A CN201580033483 A CN 201580033483A CN 106459081 B CN106459081 B CN 106459081B
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formula
compound
chlorine
hydrogen
alkyl
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Chinese (zh)
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CN106459081A (zh
Inventor
B·梅茨勒
A·费尔特
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Combination Therapy Co
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Leo Pharma AS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201580033483.8A 2014-06-23 2015-06-22 1,3-苯并二氧杂环戊烯杂环化合物的制备方法 Active CN106459081B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14173397.2 2014-06-23
EP14173397 2014-06-23
PCT/EP2015/063942 WO2015197534A2 (en) 2014-06-23 2015-06-22 Methods for the preparation of 1,3-benzodioxole heterocyclic compounds

Publications (2)

Publication Number Publication Date
CN106459081A CN106459081A (zh) 2017-02-22
CN106459081B true CN106459081B (zh) 2019-09-10

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ID=50980952

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CN201580033483.8A Active CN106459081B (zh) 2014-06-23 2015-06-22 1,3-苯并二氧杂环戊烯杂环化合物的制备方法

Country Status (18)

Country Link
US (1) US9908894B2 (enExample)
EP (1) EP3157930B1 (enExample)
JP (1) JP6785666B2 (enExample)
KR (1) KR20170016894A (enExample)
CN (1) CN106459081B (enExample)
AU (1) AU2015279428B2 (enExample)
BR (1) BR112016029510A2 (enExample)
CA (1) CA2953284A1 (enExample)
DK (1) DK3157930T3 (enExample)
ES (1) ES2702451T3 (enExample)
IL (1) IL249336A0 (enExample)
MX (1) MX2016016378A (enExample)
PL (1) PL3157930T3 (enExample)
PT (1) PT3157930T (enExample)
RU (1) RU2697251C2 (enExample)
TW (1) TW201613934A (enExample)
WO (1) WO2015197534A2 (enExample)
ZA (1) ZA201608442B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3390407T (pt) * 2015-12-18 2023-11-03 Union Therapeutics As Métodos para a preparação de compostos heterocíclicos de 1,3-benzodioxole
MX394835B (es) * 2017-06-20 2025-03-24 Union Therapeutics As Metodos para la preparacion de compuestos heterociclicos de 1,3-benzodioxol.
ES2935615T3 (es) 2017-12-15 2023-03-08 Union Therapeutics As Azetidina dihidrotienopiridinas sustituidas y su uso como inhibidores de la fosfodiesterasa
USD914676S1 (en) 2018-05-11 2021-03-30 Samsung Electronics Co., Ltd. Notebook computer
SG11202107372QA (en) 2019-01-15 2021-08-30 Union Therapeutics As Modified release tablet formulations containing phosphodiesterase inhibitors
BR112023019309A2 (pt) 2021-03-22 2023-10-31 Union Therapeutics As Tratamento de hidradenite supurativa com orismilaste
GB202205715D0 (en) 2022-04-19 2022-06-01 Union Therapeutics As Treatment of neutrophilic dermatoses
GB202306662D0 (en) 2023-05-05 2023-06-21 Union Therapeutics As Dosage regimen
GB202306663D0 (en) 2023-05-05 2023-06-21 Union Therapeutics As Combination therapy

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101631792A (zh) * 2007-02-28 2010-01-20 利奥制药有限公司 新的磷酸二酯酶抑制剂
WO2011160632A1 (en) * 2010-06-24 2011-12-29 Leo Pharma A/S Benzodioxole or benzodioxepine heterocyclic compounds phosphodiesterase inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6514996B2 (en) * 1995-05-19 2003-02-04 Kyowa Hakko Kogyo Co., Ltd. Derivatives of benzofuran or benzodioxole
ES2258775T3 (es) * 1995-05-19 2006-09-01 Kyowa Hakko Kogyo Co., Ltd. Compuestos heterociclicos que contienen oxigeno.
DE10205274A1 (de) * 2002-02-08 2003-08-21 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen enthaltend neben Anticholinergika heterocyclische Verbindungen
EP1535920A4 (en) * 2002-07-03 2007-03-21 Kyowa Hakko Kogyo Kk PROCESS FOR PREPARING 1,3-BENZODIOXOL-2-SPIRO-CYCLOALKANE DERIVATIVES
WO2008006509A1 (en) * 2006-07-14 2008-01-17 Chiesi Farmaceutici S.P.A. Derivatives of 1-phenyl-2-pyridynyl alkylene alcohols as phosphodiesterase inhibitors
CA2673370C (en) * 2006-12-22 2015-11-17 Leo Pharma A/S Substituted acetophenones useful as pde4 inhibitors
HRP20140585T1 (hr) * 2007-02-28 2014-09-12 Leo Pharma A/S Inovativni inhibitori fosfodiesteraze
WO2014096018A1 (en) * 2012-12-19 2014-06-26 Leo Pharma A/S Methods for the preparation of substituted acetophenones
PT3390407T (pt) * 2015-12-18 2023-11-03 Union Therapeutics As Métodos para a preparação de compostos heterocíclicos de 1,3-benzodioxole

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101631792A (zh) * 2007-02-28 2010-01-20 利奥制药有限公司 新的磷酸二酯酶抑制剂
WO2011160632A1 (en) * 2010-06-24 2011-12-29 Leo Pharma A/S Benzodioxole or benzodioxepine heterocyclic compounds phosphodiesterase inhibitors

Also Published As

Publication number Publication date
KR20170016894A (ko) 2017-02-14
MX2016016378A (es) 2017-10-16
WO2015197534A2 (en) 2015-12-30
IL249336A0 (en) 2017-02-28
DK3157930T3 (en) 2019-01-21
AU2015279428B2 (en) 2018-02-15
PL3157930T3 (pl) 2019-04-30
CN106459081A (zh) 2017-02-22
RU2697251C2 (ru) 2019-08-13
RU2017101808A (ru) 2018-07-27
EP3157930B1 (en) 2018-10-17
US9908894B2 (en) 2018-03-06
ZA201608442B (en) 2018-05-30
CA2953284A1 (en) 2015-12-30
BR112016029510A2 (pt) 2017-08-22
PT3157930T (pt) 2018-12-24
EP3157930A2 (en) 2017-04-26
TW201613934A (en) 2016-04-16
RU2017101808A3 (enExample) 2019-01-22
ES2702451T3 (es) 2019-03-01
AU2015279428A1 (en) 2017-01-05
JP2017520547A (ja) 2017-07-27
WO2015197534A3 (en) 2016-03-17
US20170137438A1 (en) 2017-05-18
JP6785666B2 (ja) 2020-11-18

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