RU2696892C2 - САЙТЫ АНТИТЕЛ, СПЕЦИФИЧНО СВЯЗЫВАЮЩИЕ EGFRvIII - Google Patents

САЙТЫ АНТИТЕЛ, СПЕЦИФИЧНО СВЯЗЫВАЮЩИЕ EGFRvIII Download PDF

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RU2696892C2
RU2696892C2 RU2016106577A RU2016106577A RU2696892C2 RU 2696892 C2 RU2696892 C2 RU 2696892C2 RU 2016106577 A RU2016106577 A RU 2016106577A RU 2016106577 A RU2016106577 A RU 2016106577A RU 2696892 C2 RU2696892 C2 RU 2696892C2
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egfrviii
seq
binding
binding protein
cells
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RU2016106577A
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RU2016106577A (ru
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Кристина ЭЛЛВАНГЕР
Уве РОЙШ
Ивица ФУЦЕК
Стефан КНАКМУС
Вера МОЛКЕНТИН
Мелвин ЛИТЛ
Евгений ЖУКОВСКИ
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Аффимед Гмбх
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    • C07ORGANIC CHEMISTRY
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
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    • C07K2317/622Single chain antibody (scFv)
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    • C07K2317/626Diabody or triabody
    • CCHEMISTRY; METALLURGY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
RU2016106577A 2013-08-07 2014-08-07 САЙТЫ АНТИТЕЛ, СПЕЦИФИЧНО СВЯЗЫВАЮЩИЕ EGFRvIII RU2696892C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP13179630 2013-08-07
EP13179630.2 2013-08-07
EP13189599.7 2013-10-21
EP13189599 2013-10-21
PCT/EP2014/002177 WO2015018527A1 (en) 2013-08-07 2014-08-07 ANTIBODY BINDING SITES SPECIFIC FOR EGFRvIII

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RU2016106577A RU2016106577A (ru) 2017-09-14
RU2696892C2 true RU2696892C2 (ru) 2019-08-07

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US (1) US10273309B2 (enExample)
EP (1) EP3030581B1 (enExample)
JP (1) JP6529498B2 (enExample)
CN (1) CN105555804B (enExample)
AU (1) AU2014304930B2 (enExample)
CA (1) CA2920173C (enExample)
DK (1) DK3030581T3 (enExample)
HR (1) HRP20210561T1 (enExample)
HU (1) HUE054057T2 (enExample)
LT (1) LT3030581T (enExample)
RU (1) RU2696892C2 (enExample)
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Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106459199B (zh) * 2014-03-11 2021-01-01 瑞泽恩制药公司 抗-egfrviii抗体及其用途
US9212225B1 (en) * 2014-07-01 2015-12-15 Amphivena Therapeutics, Inc. Bispecific CD33 and CD3 binding proteins
EP2982693A1 (en) * 2014-08-07 2016-02-10 Affimed Therapeutics AG CD3 binding domain
CN107108735B (zh) * 2014-11-25 2021-05-04 药物抗体公司 新型egfrviii抗体和包含所述抗体的组合物
CN114652827A (zh) 2015-05-29 2022-06-24 安普希韦纳治疗公司 双特异性cd33和cd3结合蛋白质的使用方法
CA2988768A1 (en) 2015-06-09 2016-12-15 Memorial Sloan Kettering Cancer Center T cell receptor-like antibody agents specific for ebv latent membrane protein 2a peptide presented by human hla
EP3310811B1 (en) * 2015-06-16 2021-06-16 Genentech, Inc. Anti-cd3 antibodies and methods of use
TWI744242B (zh) * 2015-07-31 2021-11-01 德商安美基研究(慕尼黑)公司 Egfrviii及cd3抗體構築體
TWI829617B (zh) 2015-07-31 2024-01-21 德商安美基研究(慕尼黑)公司 Flt3及cd3抗體構築體
EA039859B1 (ru) 2015-07-31 2022-03-21 Эмджен Рисерч (Мюник) Гмбх Биспецифические конструкты антител, связывающие egfrviii и cd3
TWI796283B (zh) 2015-07-31 2023-03-21 德商安美基研究(慕尼黑)公司 Msln及cd3抗體構築體
DK3405490T3 (da) 2016-01-21 2022-01-10 Pfizer Mono- og bispecifikke antistoffer mod epidermal vækstfaktorreceptor variant iii og cd3 og anvendelser deraf
EP3405481B1 (en) 2016-01-21 2023-01-18 Pfizer Inc. Chimeric antigen receptors targeting epidermal growth factor receptor variant iii
HUE060504T2 (hu) 2016-02-03 2023-03-28 Amgen Res Munich Gmbh PSMA és CD3 bispecifikus T-sejthez kötõ ellenanyag-konstrukciók
CN107556386A (zh) * 2016-06-30 2018-01-09 中国科学院深圳先进技术研究院 抗EGFRvIII和CD3特异性双靶向抗体、含双靶向抗体表达盒的微环DNA及应用
RU2721582C1 (ru) * 2016-08-05 2020-05-20 И-Байолоджикс Инк. Антитела против лиганда-1 запрограммированной смерти (PD-L1) и их применение
UA125395C2 (uk) 2016-08-05 2022-03-02 І-Байолоджікс Інк. Антитіло проти білка-1 запрограмованої клітинної смерті (pd-1) і його застосування
CN106501518A (zh) * 2017-01-06 2017-03-15 北京弘润天源生物技术股份有限公司 一种检测EGFRvⅢ的免疫组化抗体试剂及检测方法
EP3589655B1 (en) * 2017-02-28 2022-10-26 Affimed GmbH Tandem-diabody for cd16a-directed nk-cell engagement
AR115360A1 (es) 2018-02-08 2021-01-13 Genentech Inc Moléculas de unión al antígeno y métodos de uso
CN111971090B (zh) * 2018-03-14 2024-02-23 阿菲姆德股份有限公司 双特异性egfr/cd16抗原结合蛋白
WO2020127619A1 (en) * 2018-12-21 2020-06-25 F. Hoffmann-La Roche Ag Antibodies binding to cd3
CN113164626A (zh) * 2019-01-14 2021-07-23 南京传奇生物科技有限公司 嵌合受体多肽及其用途
US11845799B2 (en) 2019-12-13 2023-12-19 Genentech, Inc. Anti-Ly6G6D antibodies and methods of use
EP4154910A4 (en) * 2020-06-30 2024-09-11 Harbour Biomed (Shanghai) Co., Ltd Binding protein having h2l2 and hcab structures
US20240101646A1 (en) * 2021-01-22 2024-03-28 Vanderbilt University Sars-cov-2 coronavirus antibodies and uses thereof
JP2023546368A (ja) 2021-05-14 2023-11-02 ジェネンテック, インコーポレイテッド モスネツズマブおよびポラツズマブベドチンを用いたcd20陽性増殖性障害の処置のための方法
WO2023287941A2 (en) * 2021-07-16 2023-01-19 Medical Guidance Systems, Llc Anti-tax interacting protein-1 (tip1) binding molecules
CN116375868A (zh) * 2021-12-31 2023-07-04 康源博创生物科技(北京)有限公司 一种抗cd3的人源化抗体及其在制备双特异性抗体中的应用
UY40783A (es) 2023-06-12 2024-12-31 Amgen Inc Proteínas de unión a agonistas del receptor beta de linfotoxina

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2317999C2 (ru) * 2000-02-25 2008-02-27 Те Гавернмент Оф Те Юнайтед Стейтс, Эз Репризентед Бай Те Секретари Оф Те Департмент Оф Хелт Энд Хьюман Сервисез SCFV ПРОТИВ EGFRvIII С УЛУЧШЕННОЙ ЦИТОТОКСИЧНОСТЬЮ И ВЫХОДОМ, ИММУНОТОКСИНЫ НА ИХ ОСНОВЕ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
EP2457586A1 (en) * 2003-06-27 2012-05-30 Amgen Fremont Inc. Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19819846B4 (de) * 1998-05-05 2016-11-24 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Multivalente Antikörper-Konstrukte
US20100056762A1 (en) * 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2317999C2 (ru) * 2000-02-25 2008-02-27 Те Гавернмент Оф Те Юнайтед Стейтс, Эз Репризентед Бай Те Секретари Оф Те Департмент Оф Хелт Энд Хьюман Сервисез SCFV ПРОТИВ EGFRvIII С УЛУЧШЕННОЙ ЦИТОТОКСИЧНОСТЬЮ И ВЫХОДОМ, ИММУНОТОКСИНЫ НА ИХ ОСНОВЕ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
EP2457586A1 (en) * 2003-06-27 2012-05-30 Amgen Fremont Inc. Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHOI B.D. et al., Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma, PNAS, 2013, vol. 110, no. 1, p.270-275. *

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JP6529498B2 (ja) 2019-06-12
BR112016002610A2 (pt) 2017-09-12
DK3030581T3 (da) 2021-04-12
CN105555804B (zh) 2020-12-25
SI3030581T1 (sl) 2021-07-30
AU2014304930B2 (en) 2019-11-21
AU2014304930A1 (en) 2016-02-25
HK1218552A1 (zh) 2017-02-24
WO2015018527A1 (en) 2015-02-12
CA2920173C (en) 2021-08-10
CN105555804A (zh) 2016-05-04
US20160152728A1 (en) 2016-06-02
LT3030581T (lt) 2021-05-25
EP3030581B1 (en) 2021-01-20
US10273309B2 (en) 2019-04-30
JP2016536322A (ja) 2016-11-24
HUE054057T2 (hu) 2021-08-30
CA2920173A1 (en) 2015-02-12
HRP20210561T1 (hr) 2021-05-14
BR112016002610A8 (pt) 2018-01-23
RU2016106577A (ru) 2017-09-14
EP3030581A1 (en) 2016-06-15

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