RU2692775C2 - Производные нафтиридина в качестве антагонистов альфа v бета 6 интегрина для лечения, в частности, фиброзных заболеваний - Google Patents

Производные нафтиридина в качестве антагонистов альфа v бета 6 интегрина для лечения, в частности, фиброзных заболеваний Download PDF

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RU2692775C2
RU2692775C2 RU2017114355A RU2017114355A RU2692775C2 RU 2692775 C2 RU2692775 C2 RU 2692775C2 RU 2017114355 A RU2017114355 A RU 2017114355A RU 2017114355 A RU2017114355 A RU 2017114355A RU 2692775 C2 RU2692775 C2 RU 2692775C2
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methyl
pyrazol
pharmaceutically acceptable
acceptable salt
mmol
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RU2017114355A
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Нилл Эндрю АНДЕРСОН
Ян Бакстер КЭМПБЕЛЛ
Мэттью Говард Джеймс КЭМПБЕЛЛ-КРОУФОРД
Эшли Пол ХЭНКОК
Сибл ЛЕММА
Саймон Джон Фосетт Макдоналд
Джон Мартин Притчард
Панайетис Александроу ПРОКОПИОУ
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Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002Heterocyclic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RU2017114355A 2014-09-26 2015-09-22 Производные нафтиридина в качестве антагонистов альфа v бета 6 интегрина для лечения, в частности, фиброзных заболеваний RU2692775C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1417094.8 2014-09-26
GBGB1417094.8A GB201417094D0 (en) 2014-09-26 2014-09-26 Novel compounds
PCT/EP2015/071782 WO2016046230A1 (en) 2014-09-26 2015-09-22 Naphthyridine derivatives as alpha v beta 6 integrin antagonists for the treatment of e.g. fibrotic diseases

Publications (3)

Publication Number Publication Date
RU2017114355A RU2017114355A (ru) 2018-10-29
RU2017114355A3 RU2017114355A3 (https=) 2019-01-14
RU2692775C2 true RU2692775C2 (ru) 2019-06-27

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RU2017114355A RU2692775C2 (ru) 2014-09-26 2015-09-22 Производные нафтиридина в качестве антагонистов альфа v бета 6 интегрина для лечения, в частности, фиброзных заболеваний

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US (2) US10144733B2 (https=)
EP (1) EP3197894B1 (https=)
JP (1) JP6657196B2 (https=)
KR (1) KR20170053638A (https=)
CN (1) CN107074851B (https=)
AU (1) AU2015320863B2 (https=)
BR (1) BR112017006242A2 (https=)
CA (1) CA2962321A1 (https=)
ES (1) ES2811119T3 (https=)
GB (1) GB201417094D0 (https=)
RU (1) RU2692775C2 (https=)
WO (1) WO2016046230A1 (https=)

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SI3538528T1 (sl) 2016-11-08 2021-03-31 Bristol-Myers Squibb Company Pirol amidi kot alfa v integrin inhibitorji
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MX2019005234A (es) 2016-11-08 2019-08-12 Squibb Bristol Myers Co Amidas y aminas de azol como inhibidores de integrina alfa v.
WO2018089353A1 (en) 2016-11-08 2018-05-17 Bristol-Myers Squibb Company 3-substituted propionic acids as alpha v integrin inhibitors
KR102506327B1 (ko) 2016-11-08 2023-03-03 브리스톨-마이어스 스큅 컴퍼니 αV 인테그린 길항제로서의 인다졸 유도체
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MA47697A (fr) 2017-02-28 2020-01-08 Morphic Therapeutic Inc Inhibiteurs de l'(alpha-v)(bêta-6) intégrine
MA52117A (fr) 2017-02-28 2022-04-06 Morphic Therapeutic Inc Inhibiteurs de l'intégrine (alpha-v) (bêta-6)
ES2904645T3 (es) 2017-11-07 2022-04-05 Bristol Myers Squibb Co Derivados de pirrolopirazina como inhibidores de integrina alfa v
FI3844162T3 (fi) * 2018-08-29 2025-03-27 Morphic Therapeutic Inc Alfa v beeta6 -integriinin estäjiä
EP4086254B1 (en) 2018-08-29 2024-12-18 Morphic Therapeutic, Inc. Integrin inhibitors
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CN120731091A (zh) 2022-12-14 2025-09-30 阿尔尼拉姆医药品有限公司 用于肝外递送的α-Vβ-6(αvβ6)整合素配体
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WO2025259747A2 (en) 2024-06-12 2025-12-18 Alnylam Pharmaceuticals, Inc. Dystrophy myotonic protein kinase (dmpk) irna compositions and methods of use thereof

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RU2296764C2 (ru) * 2001-11-05 2007-04-10 Новартис Аг Производные нафтиридина, способ их получения и применение
WO2005082889A1 (en) * 2004-02-18 2005-09-09 Janssen Pharmaceutica N.V. Piperidinyl targeting compounds that selectively bind integrins
RU2481347C2 (ru) * 2007-08-01 2013-05-10 Валеант Фармасьютикалс Интернэшнл Производные нафтиридина в качестве модуляторов калиевых каналов

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US10513517B2 (en) 2019-12-24
CN107074851B (zh) 2020-01-10
WO2016046230A1 (en) 2016-03-31
JP6657196B2 (ja) 2020-03-04
RU2017114355A3 (https=) 2019-01-14
JP2017528504A (ja) 2017-09-28
BR112017006242A2 (pt) 2017-12-12
CN107074851A (zh) 2017-08-18
US20190048005A1 (en) 2019-02-14
KR20170053638A (ko) 2017-05-16
ES2811119T3 (es) 2021-03-10
EP3197894A1 (en) 2017-08-02
AU2015320863A1 (en) 2017-03-09
US20170291899A1 (en) 2017-10-12
EP3197894B1 (en) 2020-06-03
US10144733B2 (en) 2018-12-04
GB201417094D0 (en) 2014-11-12
RU2017114355A (ru) 2018-10-29
AU2015320863B2 (en) 2018-09-06
CA2962321A1 (en) 2016-03-31

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Effective date: 20200923