RU2692775C2 - Производные нафтиридина в качестве антагонистов альфа v бета 6 интегрина для лечения, в частности, фиброзных заболеваний - Google Patents

Производные нафтиридина в качестве антагонистов альфа v бета 6 интегрина для лечения, в частности, фиброзных заболеваний Download PDF

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RU2692775C2
RU2692775C2 RU2017114355A RU2017114355A RU2692775C2 RU 2692775 C2 RU2692775 C2 RU 2692775C2 RU 2017114355 A RU2017114355 A RU 2017114355A RU 2017114355 A RU2017114355 A RU 2017114355A RU 2692775 C2 RU2692775 C2 RU 2692775C2
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methyl
pyrazol
pharmaceutically acceptable
acceptable salt
mmol
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RU2017114355A
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RU2017114355A (ru
RU2017114355A3 (enExample
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Нилл Эндрю АНДЕРСОН
Ян Бакстер КЭМПБЕЛЛ
Мэттью Говард Джеймс КЭМПБЕЛЛ-КРОУФОРД
Эшли Пол ХЭНКОК
Сибл ЛЕММА
Саймон Джон Фосетт Макдоналд
Джон Мартин Притчард
Панайетис Александроу ПРОКОПИОУ
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Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002Heterocyclic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RU2017114355A 2014-09-26 2015-09-22 Производные нафтиридина в качестве антагонистов альфа v бета 6 интегрина для лечения, в частности, фиброзных заболеваний RU2692775C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1417094.8A GB201417094D0 (en) 2014-09-26 2014-09-26 Novel compounds
GB1417094.8 2014-09-26
PCT/EP2015/071782 WO2016046230A1 (en) 2014-09-26 2015-09-22 Naphthyridine derivatives as alpha v beta 6 integrin antagonists for the treatment of e.g. fibrotic diseases

Publications (3)

Publication Number Publication Date
RU2017114355A RU2017114355A (ru) 2018-10-29
RU2017114355A3 RU2017114355A3 (enExample) 2019-01-14
RU2692775C2 true RU2692775C2 (ru) 2019-06-27

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RU2017114355A RU2692775C2 (ru) 2014-09-26 2015-09-22 Производные нафтиридина в качестве антагонистов альфа v бета 6 интегрина для лечения, в частности, фиброзных заболеваний

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US (2) US10144733B2 (enExample)
EP (1) EP3197894B1 (enExample)
JP (1) JP6657196B2 (enExample)
KR (1) KR20170053638A (enExample)
CN (1) CN107074851B (enExample)
AU (1) AU2015320863B2 (enExample)
BR (1) BR112017006242A2 (enExample)
CA (1) CA2962321A1 (enExample)
ES (1) ES2811119T3 (enExample)
GB (1) GB201417094D0 (enExample)
RU (1) RU2692775C2 (enExample)
WO (1) WO2016046230A1 (enExample)

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BR112019009245A2 (pt) 2016-11-08 2019-07-16 Bristol-Myers Squibb Company azol amidas e aminas como inibidores de alfav integrina
WO2018089353A1 (en) 2016-11-08 2018-05-17 Bristol-Myers Squibb Company 3-substituted propionic acids as alpha v integrin inhibitors
EA201991123A1 (ru) 2016-11-08 2019-11-29 ИНДАЗОЛОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ АНТАГОНИСТОВ ИНТЕГРИНА αV
PL3538528T3 (pl) * 2016-11-08 2021-05-31 Bristol-Myers Squibb Company Amidy pirolu jako inhibitory integryny alfa v
EP3558303A4 (en) 2016-12-23 2020-07-29 Pliant Therapeutics, Inc. AMINO ACID COMPOUNDS AND PROCESSES FOR USE
IL316954A (en) 2017-02-28 2025-01-01 Morphic Therapeutic Inc (Alpha-V)(beta-6)integrin inhibitors
EP3760202A1 (en) 2017-02-28 2021-01-06 Morphic Therapeutic, Inc. Inhibitors of (alpha-v)(beta-6) integrin
BR112020008893A2 (pt) 2017-11-07 2020-10-13 Bristol-Myers Squibb Company derivados de pirrolopirazina como inibidores de alfa v integrina
UY38352A (es) 2018-08-29 2020-03-31 Morphic Therapeutic Inc Inhibidores de integrina alfavbeta6
UY38353A (es) 2018-08-29 2020-03-31 Morphic Therapeutic Inc Inhibición de integrina alfavbeta6
WO2020047208A1 (en) 2018-08-29 2020-03-05 Morphic Therapeutic, Inc. Inhibitors of (alpha-v)(beta-6) integrin
GB202010626D0 (en) 2020-07-10 2020-08-26 Univ Nottingham Compound
AU2023232562A1 (en) 2022-03-08 2024-09-05 Equashield Medical Ltd Fluid transfer station in a robotic pharmaceutical preparation system
WO2024129931A1 (en) 2022-12-14 2024-06-20 Alnylam Pharmaceuticals, Inc. ALPHA-V BETA-6(ανβ6) INTEGRIN LIGANDS FOR EXTRAHEPATIC DELIVERY
WO2025259747A2 (en) 2024-06-12 2025-12-18 Alnylam Pharmaceuticals, Inc. Dystrophy myotonic protein kinase (dmpk) irna compositions and methods of use thereof
WO2025259743A1 (en) 2024-06-12 2025-12-18 Alnylam Pharmaceuticals, Inc. Dual conjugate compounds for extrahepatic delivery

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RU2481347C2 (ru) * 2007-08-01 2013-05-10 Валеант Фармасьютикалс Интернэшнл Производные нафтиридина в качестве модуляторов калиевых каналов

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RU2296764C2 (ru) * 2001-11-05 2007-04-10 Новартис Аг Производные нафтиридина, способ их получения и применение
WO2005082889A1 (en) * 2004-02-18 2005-09-09 Janssen Pharmaceutica N.V. Piperidinyl targeting compounds that selectively bind integrins
RU2481347C2 (ru) * 2007-08-01 2013-05-10 Валеант Фармасьютикалс Интернэшнл Производные нафтиридина в качестве модуляторов калиевых каналов

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ES2811119T3 (es) 2021-03-10
EP3197894A1 (en) 2017-08-02
US20170291899A1 (en) 2017-10-12
JP2017528504A (ja) 2017-09-28
KR20170053638A (ko) 2017-05-16
CN107074851B (zh) 2020-01-10
AU2015320863B2 (en) 2018-09-06
AU2015320863A1 (en) 2017-03-09
US20190048005A1 (en) 2019-02-14
CA2962321A1 (en) 2016-03-31
BR112017006242A2 (pt) 2017-12-12
GB201417094D0 (en) 2014-11-12
EP3197894B1 (en) 2020-06-03
RU2017114355A (ru) 2018-10-29
US10513517B2 (en) 2019-12-24
CN107074851A (zh) 2017-08-18
RU2017114355A3 (enExample) 2019-01-14
JP6657196B2 (ja) 2020-03-04
WO2016046230A1 (en) 2016-03-31
US10144733B2 (en) 2018-12-04

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