RU2689788C2 - ПИРАЗОЛО[1,5-а]ПИРИМИДИНЫ В КАЧЕСТВЕ ПРОТИВОВИРУСНЫХ СОЕДИНЕНИЙ - Google Patents

ПИРАЗОЛО[1,5-а]ПИРИМИДИНЫ В КАЧЕСТВЕ ПРОТИВОВИРУСНЫХ СОЕДИНЕНИЙ Download PDF

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Publication number
RU2689788C2
RU2689788C2 RU2016134130A RU2016134130A RU2689788C2 RU 2689788 C2 RU2689788 C2 RU 2689788C2 RU 2016134130 A RU2016134130 A RU 2016134130A RU 2016134130 A RU2016134130 A RU 2016134130A RU 2689788 C2 RU2689788 C2 RU 2689788C2
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RU
Russia
Prior art keywords
dimethoxyphenyl
amine
pyrimidin
methyl
pyrazolo
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RU2016134130A
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English (en)
Russian (ru)
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RU2016134130A (ru
RU2016134130A3 (enExample
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Якоб Вестман
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Куровир Аб
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2016134130A 2014-01-22 2015-01-21 ПИРАЗОЛО[1,5-а]ПИРИМИДИНЫ В КАЧЕСТВЕ ПРОТИВОВИРУСНЫХ СОЕДИНЕНИЙ RU2689788C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14152202.9 2014-01-22
EP14152202 2014-01-22
PCT/EP2015/051177 WO2015110491A2 (en) 2014-01-22 2015-01-21 Pyrazolo[1,5-a]pyrimidin-7-amine derivatives useful in therapy

Publications (3)

Publication Number Publication Date
RU2016134130A RU2016134130A (ru) 2018-02-26
RU2016134130A3 RU2016134130A3 (enExample) 2018-08-30
RU2689788C2 true RU2689788C2 (ru) 2019-05-29

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RU2016134130A RU2689788C2 (ru) 2014-01-22 2015-01-21 ПИРАЗОЛО[1,5-а]ПИРИМИДИНЫ В КАЧЕСТВЕ ПРОТИВОВИРУСНЫХ СОЕДИНЕНИЙ

Country Status (11)

Country Link
US (1) US9963455B2 (enExample)
EP (1) EP3096762B1 (enExample)
JP (1) JP6509238B2 (enExample)
CN (1) CN106061975B (enExample)
AU (1) AU2015208205B2 (enExample)
BR (1) BR112016016798B1 (enExample)
CA (1) CA2935658C (enExample)
ES (1) ES2954126T3 (enExample)
RU (1) RU2689788C2 (enExample)
WO (1) WO2015110491A2 (enExample)
ZA (1) ZA201605666B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3606926T3 (pl) 2017-04-05 2021-11-02 Curovir Ab Heteroaromatyczne związki użyteczne w terapii
JP7133023B2 (ja) * 2018-01-17 2022-09-07 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド Ｐｉ４ｋｉｉｉベータ阻害剤
CN108727386A (zh) * 2018-07-16 2018-11-02 广州医科大学 一种吡唑并嘧啶类化合物及其制备方法和用途
TWI811428B (zh) 2018-08-21 2023-08-11 日商杏林製藥股份有限公司 雙環雜芳香環衍生物
WO2020074160A1 (en) 2018-10-10 2020-04-16 Curovir Ab Condensed pyrimidine or pyridazine derivatives as antiviral agents
EP3864017B1 (en) * 2018-10-10 2023-07-26 Curovir Ab 2,6-dimethyl-n-((pyridin-4-yl)methyl)imidazo[1,2-b]pyridazin-8-amine and 2,5-dimethyl-n-[(pyridin-4-yl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine derivatives for treating viral infections
CN109988172B (zh) * 2019-01-10 2020-09-29 石家庄学院 一种吡唑并[1,5-a]嘧啶类杂环化合物及衍生物的合成方法
WO2021032611A1 (en) 2019-08-20 2021-02-25 Curovir Ab Heteroaromatic compounds useful in therapy
WO2024184442A1 (en) 2023-03-09 2024-09-12 Curovir Ab Compound and formulation for systemic therapy by oral transmucosal administration

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EP0591528A1 (en) * 1991-04-22 1994-04-13 Otsuka Pharmaceutical Factory, Inc. PYRAZOLO 1,5-a]PYRIMIDINE DERIVATIVE AND ANTI-INFLAMMATORY CONTAINING THE SAME
WO2010086040A1 (en) * 2009-01-29 2010-08-05 Biomarin Iga, Ltd. Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
WO2011105628A1 (en) * 2010-02-26 2011-09-01 Mitsubishi Tanabe Pharma Corporation Pyrazolopyrimidine compounds and their use as pde10 inhibitors
US8633198B1 (en) * 2011-09-20 2014-01-21 Nant Holdings Ip, Llc Small molecule inhibitors of influenza A RNA-dependent RNA polymerase

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JP2585462B2 (ja) * 1989-10-25 1997-02-26 株式会社大塚製薬工場 ピラゾロ［１，５―ａ］ピリミジン誘導体
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
PL354675A1 (en) * 1999-09-30 2004-02-09 Neurogen Corporation Certain alkylene diamine-substituted pyrazolo[1,5,-a]-1,5-pyrimidines and pyrazolo[1,5-a]-1,3,5-triazines
WO2003095455A2 (en) * 2002-05-10 2003-11-20 Smithkline Beecham Corporation Substituted pyrazolopyrimidines
DE60313872T2 (de) * 2002-09-04 2008-01-17 Schering Corp. Pyrazoloä1,5-aüpyrimidine als hemmstoffe cyclin-abhängiger kinasen
US7601724B2 (en) 2002-09-04 2009-10-13 Schering Corporation Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
GB0519957D0 (en) * 2005-09-30 2005-11-09 Sb Pharmco Inc Chemical compound

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EP0591528A1 (en) * 1991-04-22 1994-04-13 Otsuka Pharmaceutical Factory, Inc. PYRAZOLO 1,5-a]PYRIMIDINE DERIVATIVE AND ANTI-INFLAMMATORY CONTAINING THE SAME
WO2010086040A1 (en) * 2009-01-29 2010-08-05 Biomarin Iga, Ltd. Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
WO2011105628A1 (en) * 2010-02-26 2011-09-01 Mitsubishi Tanabe Pharma Corporation Pyrazolopyrimidine compounds and their use as pde10 inhibitors
RU2543386C2 (ru) * 2010-02-26 2015-02-27 Мицубиси Танабе Фарма Коропорейшн Производные пиразолопиримидина и их применение в качестве ингибиторов pde10
US8633198B1 (en) * 2011-09-20 2014-01-21 Nant Holdings Ip, Llc Small molecule inhibitors of influenza A RNA-dependent RNA polymerase

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DATABASE REGISTRY[online!], CHEMICAL ABSTRACTS SERVICE, COLUMBIO OHIO,US:25.07.2006 retrieved from STN accesion no.896080-10-7, database accession no.896080-10-7 abstracts. DATABASE REGISTRY[online!], CHEMICAL ABSTRACTS SERVICE, COLUMBIO OHIO,US:25.07.2006 retrieved from STN accesion no.1031626-91-1, database accession no.1031626-91-1, 1031598-41-6 abstracts. DATABASE REGISTRY[online!], CHEMICAL ABSTRACTS SERVICE, COLUMBIO OHIO,US:25.07.2006 retrieved from STN accesion no.890638-53-6, database accession no.890638-53-6 abstracts. DATABASE REGISTRY[online!], CHEMICAL ABSTRACTS SERVICE, COLUMBIO OHIO,US:25.07.2006 retrieved from STN accesion no.950365-69-2, database accession no.950365-69-2 abstracts. *
JONH E.TELLEW et al. Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF 1) receptor antagonist with improved pharmacokinetic properties, Bioorganic & Medicinal Chemistry Letters, 2010, 20, рр.7259-7264. REYNOLDS R C et al. High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv, Tuberculosis, 2012, 92, no.1, рр.72-83. *
M. ARITA et al. Phosphatidylinositol 4-Kinase III Beta Is a Target of Enviroxime-Like Compounds for Antipoliovirus Activity J.OURNAL OF VIROLOGY, Mar. 2011, p. 2364-2372. JONG YEON HWANG et al. Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor. Bioorganic & Medicinal Chemistry Letters, 2012, 22, рр.7897-7301 (см. таблицу 2, соединение 35, реферат. *
Yoon, Jeong-Joong et al. High-throughput screening-based identification of paramyxovirus inhibitors. Journal of Biomolecular Screening, (English), 2008, 13(7), 591-608. *

Also Published As

Publication number Publication date
US20160318937A1 (en) 2016-11-03
JP6509238B2 (ja) 2019-05-08
US9963455B2 (en) 2018-05-08
EP3096762A2 (en) 2016-11-30
CN106061975B (zh) 2019-09-24
RU2016134130A (ru) 2018-02-26
AU2015208205A1 (en) 2016-08-18
CA2935658C (en) 2023-02-21
WO2015110491A3 (en) 2015-09-17
EP3096762C0 (en) 2023-06-28
CA2935658A1 (en) 2015-07-30
CN106061975A (zh) 2016-10-26
RU2016134130A3 (enExample) 2018-08-30
JP2017503830A (ja) 2017-02-02
ES2954126T3 (es) 2023-11-20
ZA201605666B (en) 2021-01-27
EP3096762B1 (en) 2023-06-28
BR112016016798B1 (pt) 2022-06-28
AU2015208205B2 (en) 2019-12-05
BR112016016798A2 (enExample) 2017-08-08
WO2015110491A2 (en) 2015-07-30
NZ722290A (en) 2021-08-27

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