CN106061975B - 作为抗病毒化合物的吡唑并[1,5-a]嘧啶 - Google Patents

作为抗病毒化合物的吡唑并[1,5-a]嘧啶 Download PDF

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Publication number
CN106061975B
CN106061975B CN201580005612.2A CN201580005612A CN106061975B CN 106061975 B CN106061975 B CN 106061975B CN 201580005612 A CN201580005612 A CN 201580005612A CN 106061975 B CN106061975 B CN 106061975B
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China
Prior art keywords
dimethyl
dimethoxyphenyl
amine
methyl
pyrazolo
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CN201580005612.2A
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Chinese (zh)
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CN106061975A (zh
Inventor
J.维斯特曼
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Kuluowei Co
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Kuluowei Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201580005612.2A 2014-01-22 2015-01-21 作为抗病毒化合物的吡唑并[1,5-a]嘧啶 Active CN106061975B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14152202.9 2014-01-22
EP14152202 2014-01-22
PCT/EP2015/051177 WO2015110491A2 (en) 2014-01-22 2015-01-21 Pyrazolo[1,5-a]pyrimidin-7-amine derivatives useful in therapy

Publications (2)

Publication Number Publication Date
CN106061975A CN106061975A (zh) 2016-10-26
CN106061975B true CN106061975B (zh) 2019-09-24

Family

ID=49989585

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580005612.2A Active CN106061975B (zh) 2014-01-22 2015-01-21 作为抗病毒化合物的吡唑并[1,5-a]嘧啶

Country Status (11)

Country Link
US (1) US9963455B2 (enExample)
EP (1) EP3096762B1 (enExample)
JP (1) JP6509238B2 (enExample)
CN (1) CN106061975B (enExample)
AU (1) AU2015208205B2 (enExample)
BR (1) BR112016016798B1 (enExample)
CA (1) CA2935658C (enExample)
ES (1) ES2954126T3 (enExample)
RU (1) RU2689788C2 (enExample)
WO (1) WO2015110491A2 (enExample)
ZA (1) ZA201605666B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7200126B2 (ja) * 2017-04-05 2023-01-06 キュロヴィル・アクチボラグ 療法において有用なヘテロ芳香族化合物
MA51611A (fr) * 2018-01-17 2021-04-21 Glaxosmithkline Ip Dev Ltd Inhibiteurs de pi4kiiibêta
CN108727386A (zh) * 2018-07-16 2018-11-02 广州医科大学 一种吡唑并嘧啶类化合物及其制备方法和用途
CN118084937A (zh) 2018-08-21 2024-05-28 杏林制药株式会社 双环杂芳族环衍生物
WO2020074160A1 (en) 2018-10-10 2020-04-16 Curovir Ab Condensed pyrimidine or pyridazine derivatives as antiviral agents
AU2019359166B2 (en) 2018-10-10 2024-07-11 Curovir Ab 2,6-dimethyl-N-((pyridin-4-yl)methyl)imidazo(1,2-b)pyridazin-8-amine and 2,5-dimethyl-N-((pyridin-4-yl)methyl)pyrazolo(1,5-a)pyrimidin-7-amine derivatives for treating viral infections
CN109988172B (zh) * 2019-01-10 2020-09-29 石家庄学院 一种吡唑并[1,5-a]嘧啶类杂环化合物及衍生物的合成方法
EP4028131B1 (en) 2019-08-20 2023-11-22 Curovir Ab Heteroaromatic compounds useful in therapy
WO2024184442A1 (en) 2023-03-09 2024-09-12 Curovir Ab Compound and formulation for systemic therapy by oral transmucosal administration

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JP2585462B2 (ja) * 1989-10-25 1997-02-26 株式会社大塚製薬工場 ピラゾロ［１，５―ａ］ピリミジン誘導体
DE69130683T2 (de) * 1991-04-22 1999-05-06 Otsuka Pharmaceutical Factory, Inc., Naruto, Tokushima PYRAZOLO[1,5-a]PYRIMIDINDERIVATE UND SIE ENTHALTENDE ANTIINFLAMMATORISCHE MITTEL
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
PL354675A1 (en) * 1999-09-30 2004-02-09 Neurogen Corporation Certain alkylene diamine-substituted pyrazolo[1,5,-a]-1,5-pyrimidines and pyrazolo[1,5-a]-1,3,5-triazines
US7304068B2 (en) * 2002-05-10 2007-12-04 Smithkline Beecham Corporation Substituted pyrazolo [1,5-A] pyrimidinyls and pharmaceutical uses therefore
US7601724B2 (en) * 2002-09-04 2009-10-13 Schering Corporation Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
NZ539161A (en) * 2002-09-04 2006-05-26 Schering Corp Pyrazolopyrimidines as cyclin dependent kinase inhibitors
GB0519957D0 (en) * 2005-09-30 2005-11-09 Sb Pharmco Inc Chemical compound
WO2010086040A1 (en) * 2009-01-29 2010-08-05 Biomarin Iga, Ltd. Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
RU2543386C2 (ru) * 2010-02-26 2015-02-27 Мицубиси Танабе Фарма Коропорейшн Производные пиразолопиримидина и их применение в качестве ингибиторов pde10
US8633198B1 (en) 2011-09-20 2014-01-21 Nant Holdings Ip, Llc Small molecule inhibitors of influenza A RNA-dependent RNA polymerase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Discovery and characterization of a novel 7-aminopyrazolo[1,5-a ]pyrimidine analog as a potent hepatitis C virus inhibitor;Jong Yeon Hwang，等;《Bioorganic & Medicinal Chemistry Letters》;20121105;第22卷(第24期);第7297-7301页 *

Also Published As

Publication number Publication date
EP3096762B1 (en) 2023-06-28
ZA201605666B (en) 2021-01-27
RU2016134130A3 (enExample) 2018-08-30
CA2935658A1 (en) 2015-07-30
WO2015110491A2 (en) 2015-07-30
ES2954126T3 (es) 2023-11-20
US9963455B2 (en) 2018-05-08
AU2015208205B2 (en) 2019-12-05
CA2935658C (en) 2023-02-21
CN106061975A (zh) 2016-10-26
JP2017503830A (ja) 2017-02-02
EP3096762C0 (en) 2023-06-28
BR112016016798B1 (pt) 2022-06-28
RU2689788C2 (ru) 2019-05-29
WO2015110491A3 (en) 2015-09-17
AU2015208205A1 (en) 2016-08-18
JP6509238B2 (ja) 2019-05-08
EP3096762A2 (en) 2016-11-30
RU2016134130A (ru) 2018-02-26
NZ722290A (en) 2021-08-27
BR112016016798A2 (enExample) 2017-08-08
US20160318937A1 (en) 2016-11-03

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