RU2684713C2 - Химерный антигенный рецептор - Google Patents
Химерный антигенный рецептор Download PDFInfo
- Publication number
- RU2684713C2 RU2684713C2 RU2016117383A RU2016117383A RU2684713C2 RU 2684713 C2 RU2684713 C2 RU 2684713C2 RU 2016117383 A RU2016117383 A RU 2016117383A RU 2016117383 A RU2016117383 A RU 2016117383A RU 2684713 C2 RU2684713 C2 RU 2684713C2
- Authority
- RU
- Russia
- Prior art keywords
- osteosclerosis
- cells
- bcma
- cell
- car
- Prior art date
Links
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 title claims abstract description 137
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims abstract description 119
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims abstract description 119
- 210000001744 T-lymphocyte Anatomy 0.000 claims abstract description 94
- 125000006850 spacer group Chemical group 0.000 claims abstract description 46
- 101000795167 Homo sapiens Tumor necrosis factor receptor superfamily member 13B Proteins 0.000 claims abstract description 41
- 102100029675 Tumor necrosis factor receptor superfamily member 13B Human genes 0.000 claims abstract description 41
- 210000004180 plasmocyte Anatomy 0.000 claims abstract description 25
- 201000010099 disease Diseases 0.000 claims abstract description 24
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 24
- 239000003446 ligand Substances 0.000 claims abstract description 13
- 230000003834 intracellular effect Effects 0.000 claims abstract description 12
- 102000005962 receptors Human genes 0.000 claims abstract description 11
- 108020003175 receptors Proteins 0.000 claims abstract description 11
- 230000011664 signaling Effects 0.000 claims abstract description 11
- 230000035755 proliferation Effects 0.000 claims abstract description 9
- 230000001939 inductive effect Effects 0.000 claims abstract description 7
- 239000012190 activator Substances 0.000 claims abstract description 6
- 239000003814 drug Substances 0.000 claims abstract description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 3
- 102000001493 Cyclophilins Human genes 0.000 claims abstract description 3
- 108010068682 Cyclophilins Proteins 0.000 claims abstract description 3
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 3
- 239000011575 calcium Substances 0.000 claims abstract description 3
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 57
- 210000000822 natural killer cell Anatomy 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 17
- 208000034578 Multiple myelomas Diseases 0.000 claims description 16
- 208000007452 Plasmacytoma Diseases 0.000 claims description 8
- 102000016611 Proteoglycans Human genes 0.000 claims description 8
- 108010067787 Proteoglycans Proteins 0.000 claims description 8
- 108020004707 nucleic acids Proteins 0.000 claims description 8
- 102000039446 nucleic acids Human genes 0.000 claims description 8
- 150000007523 nucleic acids Chemical class 0.000 claims description 8
- 208000021161 Plasma cell disease Diseases 0.000 claims description 6
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 239000003085 diluting agent Substances 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 208000004346 Smoldering Multiple Myeloma Diseases 0.000 claims description 3
- 208000016025 Waldenstroem macroglobulinemia Diseases 0.000 claims description 3
- 206010002022 amyloidosis Diseases 0.000 claims description 3
- 201000006569 extramedullary plasmacytoma Diseases 0.000 claims description 3
- 201000000564 macroglobulinemia Diseases 0.000 claims description 3
- 208000010721 smoldering plasma cell myeloma Diseases 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 2
- 201000000023 Osteosclerosis Diseases 0.000 claims 29
- 239000013604 expression vector Substances 0.000 claims 5
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 210000004027 cell Anatomy 0.000 description 89
- 108010065323 Tumor Necrosis Factor Ligand Superfamily Member 13 Proteins 0.000 description 63
- 201000000050 myeloid neoplasm Diseases 0.000 description 41
- 108090000623 proteins and genes Proteins 0.000 description 27
- 239000013598 vector Substances 0.000 description 20
- 108010076504 Protein Sorting Signals Proteins 0.000 description 18
- 239000000427 antigen Substances 0.000 description 15
- 102000036639 antigens Human genes 0.000 description 15
- 108091007433 antigens Proteins 0.000 description 15
- 125000003275 alpha amino acid group Chemical group 0.000 description 14
- 102000004169 proteins and genes Human genes 0.000 description 14
- 241000699670 Mus sp. Species 0.000 description 13
- 239000003550 marker Substances 0.000 description 13
- 239000002773 nucleotide Substances 0.000 description 11
- 206010028980 Neoplasm Diseases 0.000 description 10
- 125000003729 nucleotide group Chemical group 0.000 description 10
- 210000003719 b-lymphocyte Anatomy 0.000 description 9
- 201000011510 cancer Diseases 0.000 description 9
- 239000012636 effector Substances 0.000 description 9
- 239000011651 chromium Substances 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 8
- 238000000684 flow cytometry Methods 0.000 description 8
- 238000010186 staining Methods 0.000 description 8
- 102000008070 Interferon-gamma Human genes 0.000 description 7
- 108010074328 Interferon-gamma Proteins 0.000 description 7
- SAZUGELZHZOXHB-UHFFFAOYSA-N acecarbromal Chemical compound CCC(Br)(CC)C(=O)NC(=O)NC(C)=O SAZUGELZHZOXHB-UHFFFAOYSA-N 0.000 description 7
- 230000006378 damage Effects 0.000 description 7
- 238000013461 design Methods 0.000 description 7
- 239000012634 fragment Substances 0.000 description 7
- 229960003130 interferon gamma Drugs 0.000 description 7
- 230000004083 survival effect Effects 0.000 description 7
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 6
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 6
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 description 6
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 6
- 210000001185 bone marrow Anatomy 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 239000006228 supernatant Substances 0.000 description 6
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 102100036922 Tumor necrosis factor ligand superfamily member 13B Human genes 0.000 description 5
- 238000003501 co-culture Methods 0.000 description 5
- 230000001186 cumulative effect Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000008188 pellet Substances 0.000 description 5
- 210000005259 peripheral blood Anatomy 0.000 description 5
- 239000011886 peripheral blood Substances 0.000 description 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 5
- 108090000765 processed proteins & peptides Proteins 0.000 description 5
- 238000010361 transduction Methods 0.000 description 5
- 230000026683 transduction Effects 0.000 description 5
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 description 4
- 238000002965 ELISA Methods 0.000 description 4
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 description 4
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 description 4
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 description 4
- 229910052804 chromium Inorganic materials 0.000 description 4
- 230000001965 increasing effect Effects 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 230000001177 retroviral effect Effects 0.000 description 4
- 230000008685 targeting Effects 0.000 description 4
- 210000003462 vein Anatomy 0.000 description 4
- 208000037914 B-cell disorder Diseases 0.000 description 3
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 3
- 101710181478 Envelope glycoprotein GP350 Proteins 0.000 description 3
- 101000801255 Homo sapiens Tumor necrosis factor receptor superfamily member 17 Proteins 0.000 description 3
- 206010025323 Lymphomas Diseases 0.000 description 3
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 3
- 230000006044 T cell activation Effects 0.000 description 3
- 102100029690 Tumor necrosis factor receptor superfamily member 13C Human genes 0.000 description 3
- 101710178300 Tumor necrosis factor receptor superfamily member 13C Proteins 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 239000011324 bead Substances 0.000 description 3
- 238000003776 cleavage reaction Methods 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 230000035772 mutation Effects 0.000 description 3
- 208000031223 plasma cell leukemia Diseases 0.000 description 3
- 210000003720 plasmablast Anatomy 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 230000007017 scission Effects 0.000 description 3
- 210000000130 stem cell Anatomy 0.000 description 3
- 108010087967 type I signal peptidase Proteins 0.000 description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
- 108010083359 Antigen Receptors Proteins 0.000 description 2
- 102000006306 Antigen Receptors Human genes 0.000 description 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 2
- 108010087819 Fc receptors Proteins 0.000 description 2
- 102000009109 Fc receptors Human genes 0.000 description 2
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 description 2
- 101000830600 Homo sapiens Tumor necrosis factor ligand superfamily member 13 Proteins 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 2
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 description 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 2
- 108010090804 Streptavidin Proteins 0.000 description 2
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 2
- 102100024585 Tumor necrosis factor ligand superfamily member 13 Human genes 0.000 description 2
- 102100033726 Tumor necrosis factor receptor superfamily member 17 Human genes 0.000 description 2
- 108091005906 Type I transmembrane proteins Proteins 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 2
- 230000009089 cytolysis Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 210000001806 memory b lymphocyte Anatomy 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000009126 molecular therapy Methods 0.000 description 2
- 201000006417 multiple sclerosis Diseases 0.000 description 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000001890 transfection Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 230000005945 translocation Effects 0.000 description 2
- 102000003298 tumor necrosis factor receptor Human genes 0.000 description 2
- 239000013603 viral vector Substances 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 108010028006 B-Cell Activating Factor Proteins 0.000 description 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 description 1
- 208000008720 Bone Marrow Neoplasms Diseases 0.000 description 1
- 108091007741 Chimeric antigen receptor T cells Proteins 0.000 description 1
- 108091005941 EBFP Proteins 0.000 description 1
- 108090000331 Firefly luciferases Proteins 0.000 description 1
- 102000004961 Furin Human genes 0.000 description 1
- 108090001126 Furin Proteins 0.000 description 1
- 208000002250 Hematologic Neoplasms Diseases 0.000 description 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 101710160107 Outer membrane protein A Proteins 0.000 description 1
- 208000002774 Paraproteinemias Diseases 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 208000005250 Spontaneous Fractures Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 201000006491 bone marrow cancer Diseases 0.000 description 1
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 description 1
- 229960001467 bortezomib Drugs 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000000139 costimulatory effect Effects 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 210000004443 dendritic cell Anatomy 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 1
- 208000025750 heavy chain disease Diseases 0.000 description 1
- 230000002489 hematologic effect Effects 0.000 description 1
- 102000046935 human TNFRSF17 Human genes 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 210000005104 human peripheral blood lymphocyte Anatomy 0.000 description 1
- 239000012642 immune effector Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 210000000428 immunological synapse Anatomy 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 description 1
- 229960004942 lenalidomide Drugs 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 210000004160 naive b lymphocyte Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 229960004641 rituximab Drugs 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 201000006576 solitary osseous plasmacytoma Diseases 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 102000035160 transmembrane proteins Human genes 0.000 description 1
- 108091005703 transmembrane proteins Proteins 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 239000013638 trimer Substances 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/4214—Receptors for cytokines
- A61K40/4215—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1317929.6 | 2013-10-10 | ||
| GBGB1317929.6A GB201317929D0 (en) | 2013-10-10 | 2013-10-10 | Chimeric antigen receptor |
| PCT/GB2014/053058 WO2015052538A1 (en) | 2013-10-10 | 2014-10-10 | Chimeric antigen receptor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019102382A Division RU2019102382A (ru) | 2013-10-10 | 2014-10-10 | Химерный антигенный рецептор |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2016117383A RU2016117383A (ru) | 2017-11-15 |
| RU2016117383A3 RU2016117383A3 (OSRAM) | 2018-05-22 |
| RU2684713C2 true RU2684713C2 (ru) | 2019-04-11 |
Family
ID=49679854
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019102382A RU2019102382A (ru) | 2013-10-10 | 2014-10-10 | Химерный антигенный рецептор |
| RU2016117383A RU2684713C2 (ru) | 2013-10-10 | 2014-10-10 | Химерный антигенный рецептор |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019102382A RU2019102382A (ru) | 2013-10-10 | 2014-10-10 | Химерный антигенный рецептор |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US10160794B2 (OSRAM) |
| EP (1) | EP3055326B1 (OSRAM) |
| JP (2) | JP6632073B2 (OSRAM) |
| KR (1) | KR20160067177A (OSRAM) |
| CN (1) | CN105658671B (OSRAM) |
| AU (1) | AU2014333564B2 (OSRAM) |
| BR (1) | BR112016007805A2 (OSRAM) |
| CA (1) | CA2926560A1 (OSRAM) |
| CL (1) | CL2016000734A1 (OSRAM) |
| ES (1) | ES2918626T3 (OSRAM) |
| GB (1) | GB201317929D0 (OSRAM) |
| IL (1) | IL244784A0 (OSRAM) |
| MX (1) | MX2016004362A (OSRAM) |
| RU (2) | RU2019102382A (OSRAM) |
| SG (1) | SG11201602414SA (OSRAM) |
| WO (1) | WO2015052538A1 (OSRAM) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201317929D0 (en) * | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Chimeric antigen receptor |
| GB201317928D0 (en) * | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Molecule |
| ES2737690T3 (es) | 2014-02-27 | 2020-01-15 | Ucl Business Ltd | Variantes de APRIL |
| US11385233B2 (en) | 2015-03-05 | 2022-07-12 | Autolus Limited | Methods of depleting malignant T-cells |
| US20230027993A1 (en) | 2014-03-05 | 2023-01-26 | Autolus Limited | Methods |
| GB201403972D0 (en) | 2014-03-06 | 2014-04-23 | Ucl Business Plc | Chimeric antigen receptor |
| CA2945620C (en) | 2014-04-14 | 2022-12-06 | Cellectis | Bcma (cd269) specific chimeric antigen receptors for cancer immunotherapy |
| AU2016212158B2 (en) | 2015-01-26 | 2021-06-03 | Allogene Therapeutics, Inc. | mAb-driven chimeric antigen receptor systems for sorting/depleting engineered immune cells |
| RU2706582C2 (ru) | 2015-04-13 | 2019-11-19 | Пфайзер Инк. | Химерные антигенные рецепторы, нацеленные на антиген созревания B-клеток |
| GB201507108D0 (en) | 2015-04-27 | 2015-06-10 | Ucl Business Plc | Nucleic acid construct |
| GB201507111D0 (en) * | 2015-04-27 | 2015-06-10 | Ucl Business Plc | Nucleic acid construct |
| GB201507115D0 (en) * | 2015-04-27 | 2015-06-10 | Ucl Business Plc | Nucleic Acid Construct |
| EP3466967A1 (en) | 2015-05-18 | 2019-04-10 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| MA42895A (fr) * | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | Cellules modifiées pour thérapie cellulaire adoptive |
| CN108350073B (zh) | 2015-08-03 | 2022-03-18 | 英格玛布有限责任公司 | 针对bcma的单克隆抗体 |
| CN105384825B (zh) * | 2015-08-11 | 2018-06-01 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
| EP3408297A2 (en) | 2016-01-29 | 2018-12-05 | Med Manor Organics, (P) Ltd | A chimeric antigen receptor specific to b-cell maturation antigen, a recombinant expression vector and a method thereof |
| CA3025024A1 (en) | 2016-05-20 | 2017-11-23 | Eli Lilly And Company | Combination therapy with notch and pd-1 or pd-l1 inhibitors |
| KR102497013B1 (ko) | 2016-06-07 | 2023-02-20 | 맥스-델브뤼크-센트럼 퓌어 몰레쿨라레 메디친 | Bcma에 결합하는 키메라 항원 수용체 및 car-t 세포 |
| AU2017306432A1 (en) | 2016-08-02 | 2019-03-21 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
| BR112019007100A2 (pt) | 2016-10-07 | 2019-06-25 | Tcr2 Therapeutics Inc | composições e métodos para reprogramação de receptores de célula t com o uso de proteínas de fusão |
| EP4295918A3 (en) | 2016-11-02 | 2024-03-20 | Bristol-Myers Squibb Company | Bispecific antibody against bcma and cd3 and an immunological drug for combined use in treating multiple myeloma |
| US20190352409A1 (en) | 2016-11-11 | 2019-11-21 | Autolus Limited | Chimeric antigen receptor |
| CA3044593A1 (en) | 2016-11-22 | 2018-05-31 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| AU2017366739B2 (en) | 2016-12-02 | 2023-11-23 | Angeles Therapeutics, Inc. | Synthetic immune receptors and methods of use thereof |
| JP7382829B2 (ja) * | 2017-01-10 | 2023-11-17 | ザ ジェネラル ホスピタル コーポレイション | キメラ抗原受容体を発現するｔ細胞 |
| WO2018151836A1 (en) * | 2017-02-17 | 2018-08-23 | Fred Hutchinson Cancer Research Center | Combination therapies for treatment of bcma-related cancers and autoimmune disorders |
| GB201709508D0 (en) * | 2017-06-15 | 2017-08-02 | Autolus Ltd | Chimeric antigen receptor |
| EP3662055A1 (en) * | 2017-08-02 | 2020-06-10 | Autolus Limited | Cells expressing a chimeric antigen receptor or engineered tcr and comprising a nucleotide sequence which is selectively expressed |
| GB201716728D0 (en) | 2017-10-12 | 2017-11-29 | Autolus Ltd | Cell |
| US11851679B2 (en) | 2017-11-01 | 2023-12-26 | Juno Therapeutics, Inc. | Method of assessing activity of recombinant antigen receptors |
| WO2019090003A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for b-cell maturation antigen (bcma) |
| SG11202003427XA (en) * | 2017-11-06 | 2020-05-28 | Juno Therapeutics Inc | Combination of a cell therapy and a gamma secretase inhibitor |
| CN109971715A (zh) * | 2017-12-28 | 2019-07-05 | 深圳华大生命科学研究院 | 一种扩增特异性car-t细胞的培养方法 |
| EP3737688A4 (en) * | 2018-01-10 | 2021-11-03 | The General Hospital Corporation | IMMUNE CELLS EXPRESSING A CHEMICAL ANTIGENIC RECEPTOR |
| KR102160061B1 (ko) * | 2018-02-01 | 2020-09-29 | 난징 아이에이에스오 바이오테라퓨틱스 컴퍼니, 리미티드 | Bcma에 결합하는 키메릭 항원 수용체(car) 및 그의 용도 |
| CA3094927A1 (en) * | 2018-03-23 | 2019-09-26 | Gavish-Galilee Bio Applications Ltd. | Genetically reprogrammed tregs expressing membrane-bound il-10 |
| GB201807693D0 (en) | 2018-05-11 | 2018-06-27 | Autolus Ltd | Cell |
| JP7398396B2 (ja) | 2018-06-01 | 2023-12-14 | ノバルティス アーゲー | Ｂｃｍａに対する結合分子及びその使用 |
| CA3103610A1 (en) | 2018-06-12 | 2019-12-19 | The Regents Of The University Of California | Single-chain bispecific chimeric antigen receptors for the treatment of cancer |
| TWI838389B (zh) | 2018-07-19 | 2024-04-11 | 美商再生元醫藥公司 | 雙特異性抗-BCMAｘ抗-CD3抗體及其用途 |
| HUE069503T2 (hu) | 2018-09-27 | 2025-03-28 | Autolus Ltd | Kiméra antigénreceptor |
| MA54079A (fr) | 2018-11-01 | 2021-09-08 | Juno Therapeutics Inc | Récepteurs antigéniques chimériques spécifiques du gprc5d (élément d du groupe 5 de classe c des récepteurs couplés à la protéine g) |
| KR20210113169A (ko) | 2018-11-01 | 2021-09-15 | 주노 쎄러퓨티크스 인코퍼레이티드 | Β세포 성숙 항원에 특이적인 키메라 항원 수용체를 이용한 치료 방법 |
| WO2020120982A2 (en) | 2018-12-14 | 2020-06-18 | Autolus Limited | Cell |
| GB201904160D0 (en) | 2019-03-26 | 2019-05-08 | Autolus Ltd | Cell |
| AU2020224160A1 (en) * | 2019-02-21 | 2021-08-26 | John M. LUK | Artificial immunosurveillance chimeric antigen receptor (AI-CAR) and cells expressing the same |
| WO2020183131A1 (en) | 2019-03-08 | 2020-09-17 | Autolus Limited | Compositions and methods comprising engineered chimeric antigen receptor and modulator of car |
| GB201903237D0 (en) | 2019-03-08 | 2019-04-24 | Autolus Ltd | Method |
| PH12021552123A1 (en) | 2019-03-21 | 2022-08-22 | Regeneron Pharma | Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy |
| US20220186232A1 (en) * | 2019-03-26 | 2022-06-16 | Gavish-Galilee Bio Applications Ltd. | Genetically reprogrammed tregs expressing cars |
| GB201904971D0 (en) | 2019-04-08 | 2019-05-22 | Autolus Ltd | Cell |
| GB201906202D0 (en) | 2019-05-02 | 2019-06-19 | Autolus Ltd | Cell |
| CN113784732B (zh) | 2019-05-07 | 2024-03-22 | 亘喜生物科技（上海）有限公司 | 靶向bcma的工程化免疫细胞及其用途 |
| WO2020224605A1 (zh) | 2019-05-07 | 2020-11-12 | 亘喜生物科技（上海）有限公司 | 靶向bcma的工程化免疫细胞及其用途 |
| EP3972998A1 (en) | 2019-05-21 | 2022-03-30 | Novartis AG | Cd19 binding molecules and uses thereof |
| CN110592015A (zh) * | 2019-09-27 | 2019-12-20 | 中国科学院西双版纳热带植物园 | 一种诱导增强cik细胞的滇重楼多糖组合物及其应用 |
| US11883432B2 (en) | 2020-12-18 | 2024-01-30 | Century Therapeutics, Inc. | Chimeric antigen receptor system with adaptable receptor specificity |
| US20240041929A1 (en) | 2022-08-05 | 2024-02-08 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for gprc5d and bcma |
| WO2025076113A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Ionizable cationic lipids with conserved spacing and lipid nanoparticles |
| WO2025076127A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2025160340A2 (en) | 2024-01-26 | 2025-07-31 | Regeneron Pharmaceuticals, Inc. | Combination immunosuppression for inhibiting an immune response and enabling immunogen administration and re-administration |
| US20250242056A1 (en) | 2024-01-26 | 2025-07-31 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for using plasma cell depleting agents and/or b cell depleting agents to suppress host anti-aav antibody response and enable aav transduction and re-dosing |
| WO2025184567A1 (en) | 2024-03-01 | 2025-09-04 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response |
| GB202403564D0 (en) | 2024-03-12 | 2024-04-24 | Autolus Ltd | Method |
| WO2025217452A1 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2025217454A2 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002018620A2 (en) * | 2000-08-15 | 2002-03-07 | Human Genome Sciences, Inc. | Neutrokine-alpha and neutrokine-alpha splice variant |
| EA200200427A1 (ru) * | 1999-10-06 | 2002-12-26 | Байоджен, Инк. | Рецептор april (bcma) и его применения |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU759717B2 (en) * | 1997-09-12 | 2003-04-17 | Apoxis Sa | April- a novel protein with growth effects |
| DK1297013T3 (da) * | 2000-04-27 | 2006-12-27 | Biogen Idec Inc | Anvendelse af TACI som antitumormiddel |
| US20030012783A1 (en) * | 2001-02-20 | 2003-01-16 | Wayne Kindsvogel | Antibodies that bind both BCMA and TACI |
| MXPA04009683A (es) * | 2002-04-09 | 2005-01-11 | Biogen Idec Inc | Metodos para el tratamiento de condiciones relacionadas a tweak. |
| AU2003270715A1 (en) * | 2002-09-19 | 2004-04-08 | Biogen Idec Ma Inc. | Improved methods for preparing highly active april ligand polypeptides |
| JP2008525002A (ja) * | 2004-12-23 | 2008-07-17 | ラボラトワール セローノ ソシエテ アノニム | Ｂｃｍａポリペプチド及びその使用 |
| AT503861B1 (de) | 2006-07-05 | 2008-06-15 | F Star Biotech Forsch & Entw | Verfahren zur manipulation von t-zell-rezeptoren |
| US20100105136A1 (en) | 2006-10-09 | 2010-04-29 | The General Hospital Corporation | Chimeric t-cell receptors and t-cells targeting egfrviii on tumors |
| TWI679212B (zh) * | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | 針對ｂｃｍａ之e3以及ｃｄ３的結合分子 |
| MX394639B (es) * | 2012-04-11 | 2025-03-24 | Us Health | Receptores del antigeno quimerico que seleccionan el antigeno para la maduracion de las celulas b |
| CN103145849B (zh) * | 2013-02-18 | 2014-06-11 | 冯振卿 | 嵌合抗原受体及其用途 |
| GB201317929D0 (en) * | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Chimeric antigen receptor |
| ES2737690T3 (es) | 2014-02-27 | 2020-01-15 | Ucl Business Ltd | Variantes de APRIL |
| US20190352409A1 (en) | 2016-11-11 | 2019-11-21 | Autolus Limited | Chimeric antigen receptor |
| GB201709508D0 (en) | 2017-06-15 | 2017-08-02 | Autolus Ltd | Chimeric antigen receptor |
| EP3737688A4 (en) * | 2018-01-10 | 2021-11-03 | The General Hospital Corporation | IMMUNE CELLS EXPRESSING A CHEMICAL ANTIGENIC RECEPTOR |
-
2013
- 2013-10-10 GB GBGB1317929.6A patent/GB201317929D0/en not_active Ceased
-
2014
- 2014-10-10 WO PCT/GB2014/053058 patent/WO2015052538A1/en not_active Ceased
- 2014-10-10 CN CN201480055657.6A patent/CN105658671B/zh active Active
- 2014-10-10 EP EP14784368.4A patent/EP3055326B1/en active Active
- 2014-10-10 AU AU2014333564A patent/AU2014333564B2/en not_active Ceased
- 2014-10-10 US US15/028,064 patent/US10160794B2/en active Active
- 2014-10-10 CA CA2926560A patent/CA2926560A1/en not_active Abandoned
- 2014-10-10 SG SG11201602414SA patent/SG11201602414SA/en unknown
- 2014-10-10 ES ES14784368T patent/ES2918626T3/es active Active
- 2014-10-10 MX MX2016004362A patent/MX2016004362A/es unknown
- 2014-10-10 RU RU2019102382A patent/RU2019102382A/ru not_active Application Discontinuation
- 2014-10-10 KR KR1020167012121A patent/KR20160067177A/ko not_active Withdrawn
- 2014-10-10 RU RU2016117383A patent/RU2684713C2/ru not_active IP Right Cessation
- 2014-10-10 JP JP2016521314A patent/JP6632073B2/ja active Active
- 2014-10-10 BR BR112016007805A patent/BR112016007805A2/pt not_active Application Discontinuation
-
2016
- 2016-03-28 IL IL244784A patent/IL244784A0/en unknown
- 2016-03-30 CL CL2016000734A patent/CL2016000734A1/es unknown
-
2018
- 2018-10-17 US US16/162,747 patent/US10919951B2/en active Active
-
2019
- 2019-01-10 JP JP2019002499A patent/JP2019052190A/ja not_active Withdrawn
-
2020
- 2020-10-22 US US17/077,782 patent/US20210101959A1/en not_active Abandoned
-
2023
- 2023-05-22 US US18/321,400 patent/US20240076352A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA200200427A1 (ru) * | 1999-10-06 | 2002-12-26 | Байоджен, Инк. | Рецептор april (bcma) и его применения |
| WO2002018620A2 (en) * | 2000-08-15 | 2002-03-07 | Human Genome Sciences, Inc. | Neutrokine-alpha and neutrokine-alpha splice variant |
Non-Patent Citations (5)
| Title |
|---|
| BEITINJANEH A.M. ET AL. Durable responses after donor lymphocyte infusion for patients with residual multiple myeloma following non-myeloablative allogeneic stem cell transplant, Leuk. Lymphoma, 2012, v.53, n.8, p.1525-1529. * |
| CARPENTER R.O. ET AL. B-cell maturation antigen is a promising target for adoptive T-cell therapy of multiple myeloma, Clin. Cancer Res., 2013, v.19, n.8, p.2048-2060. * |
| CARPENTER R.O. ET AL. B-cell maturation antigen is a promising target for adoptive T-cell therapy of multiple myeloma, Clin. Cancer Res., 2013, v.19, n.8, p.2048-2060. KIMBERLEY F.C. ET AL. The design and characterization of receptor-selective APRIL variants, J. Biol. Chem., 2012, v.287, n.44, p.37434-37446. BEITINJANEH A.M. ET AL. Durable responses after donor lymphocyte infusion for patients with residual multiple myeloma following non-myeloablative allogeneic stem cell transplant, Leuk. Lymphoma, 2012, v.53, n.8, p.1525-1529. INGOLD K. ET AL. Identification of proteoglycans as the APRIL-specific binding partners, J. Exp. Med., 2005, v.201, n.9, p.1375-1383. * |
| INGOLD K. ET AL. Identification of proteoglycans as the APRIL-specific binding partners, J. Exp. Med., 2005, v.201, n.9, p.1375-1383. * |
| KIMBERLEY F.C. ET AL. The design and characterization of receptor-selective APRIL variants, J. Biol. Chem., 2012, v.287, n.44, p.37434-37446. * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20160237139A1 (en) | 2016-08-18 |
| GB201317929D0 (en) | 2013-11-27 |
| JP2016538830A (ja) | 2016-12-15 |
| RU2016117383A (ru) | 2017-11-15 |
| IL244784A0 (en) | 2016-04-21 |
| US10919951B2 (en) | 2021-02-16 |
| BR112016007805A2 (pt) | 2017-12-05 |
| US20190100571A1 (en) | 2019-04-04 |
| MX2016004362A (es) | 2016-10-13 |
| US10160794B2 (en) | 2018-12-25 |
| CL2016000734A1 (es) | 2017-05-19 |
| EP3055326B1 (en) | 2022-04-20 |
| CN105658671A (zh) | 2016-06-08 |
| CN105658671B (zh) | 2021-08-27 |
| KR20160067177A (ko) | 2016-06-13 |
| CA2926560A1 (en) | 2015-04-16 |
| JP6632073B2 (ja) | 2020-01-15 |
| HK1222186A1 (en) | 2017-06-23 |
| RU2019102382A (ru) | 2019-02-22 |
| WO2015052538A1 (en) | 2015-04-16 |
| RU2016117383A3 (OSRAM) | 2018-05-22 |
| ES2918626T3 (es) | 2022-07-19 |
| JP2019052190A (ja) | 2019-04-04 |
| EP3055326A1 (en) | 2016-08-17 |
| AU2014333564A1 (en) | 2016-04-28 |
| US20210101959A1 (en) | 2021-04-08 |
| SG11201602414SA (en) | 2016-04-28 |
| AU2014333564B2 (en) | 2018-09-27 |
| US20240076352A1 (en) | 2024-03-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2684713C2 (ru) | Химерный антигенный рецептор | |
| JP6707496B2 (ja) | Ａｐｒｉｌバリアント | |
| RU2731638C2 (ru) | Сигнальная система | |
| CN105848673B (zh) | 细胞 | |
| JP6557657B2 (ja) | 分子 | |
| CA3002774A1 (en) | Programmable universal cell receptors and methods of using the same | |
| US20240139314A1 (en) | Engineered chimeric fusion protein compositions and methods of use thereof | |
| RU2810092C2 (ru) | Химерный антигенный рецептор | |
| HK1222186B (en) | Chimeric antigen receptor | |
| JP2025526383A (ja) | 阻害性キメラ受容体アーキテクチャ |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20201011 |