RU2676078C2 - Молекулы, связывающие il-6 - Google Patents

Молекулы, связывающие il-6 Download PDF

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Publication number
RU2676078C2
RU2676078C2 RU2014152006A RU2014152006A RU2676078C2 RU 2676078 C2 RU2676078 C2 RU 2676078C2 RU 2014152006 A RU2014152006 A RU 2014152006A RU 2014152006 A RU2014152006 A RU 2014152006A RU 2676078 C2 RU2676078 C2 RU 2676078C2
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amino acid
antibody
domain
human
binding
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RU2014152006A
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Russian (ru)
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RU2014152006A (ru
Inventor
Кристоф БЛАНХЕТОТ
ХАРД Йоханнес ДЕ
Торстен ДРАЙЕР
ЙОНГЕ Натали ДЕ
ДЕР ВОНИНГ Себастьян Поль ВАН
Никола ОНГЕНА
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Ардженкс Бвба
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • C07K16/248IL-6
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2014152006A 2012-05-23 2013-05-23 Молекулы, связывающие il-6 RU2676078C2 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261650883P 2012-05-23 2012-05-23
US61/650,883 2012-05-23
US201261720102P 2012-10-30 2012-10-30
US61/720,102 2012-10-30
IBPCT/IB2012/056424 2012-11-14
PCT/IB2012/056424 WO2013175276A1 (en) 2012-05-23 2012-11-14 Il-6 binding molecules
PCT/IB2013/054271 WO2013175427A1 (en) 2012-05-23 2013-05-23 Il-6 binding molecules

Publications (2)

Publication Number Publication Date
RU2014152006A RU2014152006A (ru) 2016-07-20
RU2676078C2 true RU2676078C2 (ru) 2018-12-26

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RU2014152006A RU2676078C2 (ru) 2012-05-23 2013-05-23 Молекулы, связывающие il-6

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US (4) US10183995B2 (enExample)
EP (1) EP2852616A1 (enExample)
JP (1) JP6410712B2 (enExample)
KR (1) KR20150063311A (enExample)
CN (1) CN103601806B (enExample)
AU (1) AU2013264779B2 (enExample)
BR (1) BR112014029219B1 (enExample)
CA (1) CA2871148C (enExample)
CL (1) CL2014003167A1 (enExample)
CO (1) CO7240362A2 (enExample)
EC (1) ECSP14029713A (enExample)
IL (1) IL235134B (enExample)
MX (1) MX360163B (enExample)
NZ (1) NZ701370A (enExample)
PE (1) PE20150335A1 (enExample)
RU (1) RU2676078C2 (enExample)
WO (2) WO2013175276A1 (enExample)

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BR112018001853A2 (pt) 2015-07-31 2018-09-25 Astrazeneca Pharmaceuticals Lp métodos para tratamento de um distúrbio e para melhoria do tratamento de um distúrbio
CN105194655A (zh) * 2015-10-21 2015-12-30 胶州市人民中医医院 一种新生儿细菌感染性脑炎的治疗方法
GB201611123D0 (en) * 2016-06-27 2016-08-10 Euremab Srl Anti met antibodiesand uses thereof
SG11201906852XA (en) 2017-02-01 2019-08-27 Univ Yale Treatment of diuretic resistance
SG11202006157VA (en) 2018-01-05 2020-07-29 Corvidia Therapeutics Inc Methods for treating il-6 mediated inflammation without immunosuppression
CN111153998B (zh) * 2020-01-16 2022-06-24 佛山汉腾生物科技有限公司 抗ctla-4纳米抗体及其应用
US20230236199A1 (en) * 2020-04-23 2023-07-27 Eli Lilly And Company Subcutaneous absorption and bioavailability of antibodies
CN113150140B (zh) * 2021-01-25 2022-11-04 山西农业大学 一种sox6二价纳米抗体及其应用
EP4531867A1 (en) * 2022-05-25 2025-04-09 Ayuvis Research, Inc. Novel immunodulating small molecules
CN117186222A (zh) * 2022-05-31 2023-12-08 北京天广实生物技术股份有限公司 Pd-l1结合分子及其用途
CN119331091B (zh) * 2024-11-06 2025-05-13 重庆探生科技有限公司 一种抗人白介素6的单克隆抗体及其应用

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CA2871148A1 (en) 2013-11-28
CO7240362A2 (es) 2015-04-17
PE20150335A1 (es) 2015-03-20
CL2014003167A1 (es) 2015-06-12
BR112014029219B1 (pt) 2022-04-19
CN103601806A (zh) 2014-02-26
IL235134B (en) 2019-12-31
JP2015518857A (ja) 2015-07-06
MX2014014218A (es) 2015-11-23
AU2013264779B2 (en) 2018-03-22
CA2871148C (en) 2020-07-14
AU2013264779A1 (en) 2014-10-30
NZ701370A (en) 2016-11-25
JP6410712B2 (ja) 2018-10-24
CN103601806B (zh) 2019-01-18
RU2014152006A (ru) 2016-07-20
WO2013175276A1 (en) 2013-11-28
US11117959B2 (en) 2021-09-14
MX360163B (es) 2018-10-09
US11827701B2 (en) 2023-11-28
US20240158492A1 (en) 2024-05-16
ECSP14029713A (es) 2015-09-30
EP2852616A1 (en) 2015-04-01
US20190233509A1 (en) 2019-08-01
US20150140011A1 (en) 2015-05-21
BR112014029219A8 (pt) 2019-05-14
US20220073604A1 (en) 2022-03-10
BR112014029219A2 (enExample) 2017-08-15
WO2013175427A1 (en) 2013-11-28
IL235134A0 (en) 2014-12-31
KR20150063311A (ko) 2015-06-09
US10183995B2 (en) 2019-01-22

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