RU2669922C2 - N-(2-цианогетероциклил)пиразолопиридоны в качестве ингибиторов янус-киназы - Google Patents

N-(2-цианогетероциклил)пиразолопиридоны в качестве ингибиторов янус-киназы Download PDF

Info

Publication number
RU2669922C2
RU2669922C2 RU2015144483A RU2015144483A RU2669922C2 RU 2669922 C2 RU2669922 C2 RU 2669922C2 RU 2015144483 A RU2015144483 A RU 2015144483A RU 2015144483 A RU2015144483 A RU 2015144483A RU 2669922 C2 RU2669922 C2 RU 2669922C2
Authority
RU
Russia
Prior art keywords
amino
dihydro
oxo
pyrazolo
pyridin
Prior art date
Application number
RU2015144483A
Other languages
English (en)
Russian (ru)
Other versions
RU2015144483A (ru
RU2015144483A3 (enExample
Inventor
Кристофер ДИНСМОР
Питер ФУЛЛЕР
Дэвид ГЕРИН
Кристофер Ф. Томпсон
Цинлинь ПУ
Марк Е. СКОТТ
Джейсон Дэвид КАТЦ
Рави КУРУКУЛАСУРИЯ
Джошуа Т. Клоуз
Дэниелл ФОЛКОН
Джейсон Брубейкер
Хунбо ЦЗЭН
Юньфын БАЙ
Цзяньминь Фу
Норман КУН
Юймэй ЛЮ
Чжисян ЧЖЭН
Original Assignee
Мерк Шарп И Доум Корп.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Шарп И Доум Корп. filed Critical Мерк Шарп И Доум Корп.
Publication of RU2015144483A publication Critical patent/RU2015144483A/ru
Publication of RU2015144483A3 publication Critical patent/RU2015144483A3/ru
Application granted granted Critical
Publication of RU2669922C2 publication Critical patent/RU2669922C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
RU2015144483A 2013-03-19 2014-03-19 N-(2-цианогетероциклил)пиразолопиридоны в качестве ингибиторов янус-киназы RU2669922C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361803226P 2013-03-19 2013-03-19
US61/803,226 2013-03-19
PCT/CN2014/000298 WO2014146492A1 (en) 2013-03-19 2014-03-19 N-(2-cyano heterocyclyl)pyrazolo pyridones as janus kinase inhibitors

Publications (3)

Publication Number Publication Date
RU2015144483A RU2015144483A (ru) 2017-04-25
RU2015144483A3 RU2015144483A3 (enExample) 2018-01-30
RU2669922C2 true RU2669922C2 (ru) 2018-10-17

Family

ID=51579321

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2015144483A RU2669922C2 (ru) 2013-03-19 2014-03-19 N-(2-цианогетероциклил)пиразолопиридоны в качестве ингибиторов янус-киназы

Country Status (11)

Country Link
US (1) US9957265B2 (enExample)
EP (1) EP2976338B1 (enExample)
JP (1) JP6322275B2 (enExample)
KR (1) KR20150130311A (enExample)
CN (1) CN105189497B (enExample)
AU (1) AU2014234908B2 (enExample)
BR (1) BR112015023878A2 (enExample)
CA (1) CA2901766A1 (enExample)
MX (1) MX2015013414A (enExample)
RU (1) RU2669922C2 (enExample)
WO (1) WO2014146492A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014146246A1 (en) * 2013-03-19 2014-09-25 Merck Sharp & Dohme Corp. Cycloalkyl nitrile pyrazolo pyridones as janus kinase inhibitors
WO2016061751A1 (en) * 2014-10-22 2016-04-28 Merck Sharp & Dohme Corp. Ethyl n-boc piperidinyl pyrazolo pyridones as janus kinase inhibitors
EP3554499B1 (en) * 2016-12-14 2022-01-26 Merck Sharp & Dohme Corp. Aminopyrazoles as janus kinase inhibitors
CA3129665A1 (en) 2019-03-21 2020-09-24 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN111499592B (zh) * 2020-03-14 2023-06-23 江苏省农用激素工程技术研究中心有限公司 5-氨甲基糖精的合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04139185A (ja) * 1990-09-28 1992-05-13 Taiho Yakuhin Kogyo Kk ピラゾロピリジン誘導体
CN1656079A (zh) * 2002-05-31 2005-08-17 卫材株式会社 吡唑化合物和含有该化合物的药物组合物
RU2453548C2 (ru) * 2006-01-17 2012-06-20 Вертекс Фармасьютикалз Инкорпорейтед Азаиндолы, полезные в качестве ингибиторов янус-киназ

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL352680A1 (en) 1999-06-03 2003-09-08 Knoll Gmbh Benzothiazinone and benzoxazinone compounds
RU2004128943A (ru) * 2002-02-28 2005-04-20 Байота, Инк. (Us) Средства, имитирующие нуклеотиды, и их пролекарственные формы
JP4139185B2 (ja) 2002-10-17 2008-08-27 京セラ株式会社 配線基板の製造方法
US20100105661A1 (en) * 2007-01-12 2010-04-29 Astellas Pharma Inc. Condensed pyridine compound
JP5690823B2 (ja) 2009-07-08 2015-03-25 レオ ファーマ アクティーゼルスカブ Ｊａｋ受容体およびタンパク質チロシンキナーゼ阻害薬としての複素環化合物
CA2792508C (en) 2010-03-10 2018-01-16 Incyte Corporation Piperidin-4-yl azetidine derivatives as jak1 inhibitors
AU2012232658B2 (en) 2011-03-22 2016-06-09 Advinus Therapeutics Limited Substituted fused tricyclic compounds, compositions and medicinal applications thereof
AU2012312303B2 (en) 2011-09-22 2016-09-15 Merck Sharp & Dohme Corp. Cyanomethylpyrazole carboxamides as janus kinase inhibitors
CA2874987A1 (en) * 2012-06-01 2013-12-05 Takeda Pharmaceutical Company Limited Heterocyclic compound
WO2014146246A1 (en) * 2013-03-19 2014-09-25 Merck Sharp & Dohme Corp. Cycloalkyl nitrile pyrazolo pyridones as janus kinase inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04139185A (ja) * 1990-09-28 1992-05-13 Taiho Yakuhin Kogyo Kk ピラゾロピリジン誘導体
CN1656079A (zh) * 2002-05-31 2005-08-17 卫材株式会社 吡唑化合物和含有该化合物的药物组合物
RU2453548C2 (ru) * 2006-01-17 2012-06-20 Вертекс Фармасьютикалз Инкорпорейтед Азаиндолы, полезные в качестве ингибиторов янус-киназ

Also Published As

Publication number Publication date
CN105189497B (zh) 2019-05-03
US20160272633A1 (en) 2016-09-22
JP6322275B2 (ja) 2018-05-09
EP2976338B1 (en) 2018-01-03
CA2901766A1 (en) 2014-09-25
MX2015013414A (es) 2016-02-26
US9957265B2 (en) 2018-05-01
RU2015144483A (ru) 2017-04-25
EP2976338A1 (en) 2016-01-27
JP2016514710A (ja) 2016-05-23
BR112015023878A2 (pt) 2017-07-18
AU2014234908A1 (en) 2015-08-13
EP2976338A4 (en) 2016-08-31
CN105189497A (zh) 2015-12-23
KR20150130311A (ko) 2015-11-23
WO2014146492A1 (en) 2014-09-25
AU2014234908B2 (en) 2017-08-17

Similar Documents

Publication Publication Date Title
JP6110859B2 (ja) ヤヌスキナーゼ阻害剤としてのピラゾールカルボキサミド
JP6412102B2 (ja) ヤヌスキナーゼ阻害剤としてのシクロアルキルニトリルピラゾロピリドン
JP6305510B2 (ja) ヤヌスキナーゼ阻害剤としての非環式シアノエチルピラゾロピリドン
EP3209296B1 (en) Ethyl n-boc piperidinyl pyrazolo pyridones as janus kinase inhibitors
EP2976338B1 (en) N-(2-cyano heterocyclyl)pyrazolo pyridones as janus kinase inhibitors
EP3380474A1 (en) Janus kinases inhibitors, compositions thereof and use thereof
JP2016514709A (ja) ヤヌスキナーゼ阻害剤としてのジェミナル置換シアノエチルピラゾロピリドン
TW202409028A (zh) Lrrk2抑制劑
KR20150130309A (ko) 야누스 키나제 억제제로서의 시클로알킬 니트릴 피라졸로 피리돈
KR20150130310A (ko) 야누스 키나제 억제제로서의 같은자리 치환된 시아노에틸피라졸로 피리돈

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20200320