RU2663718C2 - Полипептиды гемагглютининов, а также связанные с ними реагенты и способы - Google Patents

Полипептиды гемагглютининов, а также связанные с ними реагенты и способы Download PDF

Info

Publication number
RU2663718C2
RU2663718C2 RU2013114424A RU2013114424A RU2663718C2 RU 2663718 C2 RU2663718 C2 RU 2663718C2 RU 2013114424 A RU2013114424 A RU 2013114424A RU 2013114424 A RU2013114424 A RU 2013114424A RU 2663718 C2 RU2663718 C2 RU 2663718C2
Authority
RU
Russia
Prior art keywords
polypeptide
binding
glycans
polypeptides
amino acid
Prior art date
Application number
RU2013114424A
Other languages
English (en)
Russian (ru)
Other versions
RU2013114424A (ru
Inventor
Каннан ТАРАКАРАМАН
Картик ВИСВАНАТАН
Рахул РАМАН
Рам САСИСЕКХАРАН
Original Assignee
Массачусетс Инститьют Оф Текнолоджи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Массачусетс Инститьют Оф Текнолоджи filed Critical Массачусетс Инститьют Оф Текнолоджи
Publication of RU2013114424A publication Critical patent/RU2013114424A/ru
Application granted granted Critical
Publication of RU2663718C2 publication Critical patent/RU2663718C2/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
RU2013114424A 2010-10-04 2011-10-04 Полипептиды гемагглютининов, а также связанные с ними реагенты и способы RU2663718C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38963910P 2010-10-04 2010-10-04
US61/389,639 2010-10-04
PCT/US2011/054831 WO2012047941A2 (en) 2010-10-04 2011-10-04 Hemagglutinin polypeptides, and reagents and methods relating thereto

Publications (2)

Publication Number Publication Date
RU2013114424A RU2013114424A (ru) 2014-11-20
RU2663718C2 true RU2663718C2 (ru) 2018-08-08

Family

ID=44860519

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2013114424A RU2663718C2 (ru) 2010-10-04 2011-10-04 Полипептиды гемагглютининов, а также связанные с ними реагенты и способы

Country Status (10)

Country Link
US (2) US10226527B2 (https=)
EP (1) EP2624864B1 (https=)
JP (2) JP6029586B2 (https=)
CN (1) CN103328002B (https=)
AU (1) AU2011312178B2 (https=)
BR (1) BR112013007946B1 (https=)
CA (1) CA2813078A1 (https=)
RU (1) RU2663718C2 (https=)
SG (2) SG10201709806VA (https=)
WO (1) WO2012047941A2 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6029586B2 (ja) 2010-10-04 2016-11-24 マサチューセッツ インスティテュート オブ テクノロジー 血球凝集素ポリペプチド、ならびにそれに関連する試薬および方法
AR083533A1 (es) * 2010-10-22 2013-03-06 Boehringer Ingelheim Vetmed Proteinas de hemaglutinina 5 (h5) para el tratamiento y prevencion de las infecciones de gripe
US11390878B2 (en) 2011-09-30 2022-07-19 Medicago Inc. Increasing protein yield in plants
NZ622731A (en) 2011-09-30 2016-04-29 Medicago Inc Increasing virus-like particle yield in plants
US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
SG11201406769RA (en) 2012-05-10 2014-11-27 Massachusetts Inst Technology Agents for influenza neutralization
US20140335504A1 (en) * 2013-02-07 2014-11-13 Massachusetts Institute Of Technology Human adaptation of h5 influenza
CN105007938A (zh) 2013-03-15 2015-10-28 宾夕法尼亚大学理事会 流感核酸分子和由其制备的疫苗
US12467058B2 (en) 2013-03-28 2025-11-11 Aramis Biotechnologies Inc. Influenza virus-like particle production in plants
ES2803508T3 (es) * 2013-03-28 2021-01-27 Medicago Inc Producción de partículas similares al virus de la gripe en plantas
RU2699982C2 (ru) 2014-01-10 2019-09-11 Медикаго Инк. Энхансерные элементы cpmv
WO2016100926A1 (en) 2014-12-19 2016-06-23 Oregon Health & Science University Synergistic co-administration of computationally optimized broadly reactive antigens for human and avian h5n1 influenza
EP3374390A1 (en) 2015-11-13 2018-09-19 Visterra, Inc. Compositions and methods for treating and preventing influenza
AU2017222564A1 (en) 2016-02-24 2018-09-06 Visterra, Inc. Formulations of antibody molecules to influenza virus
ES2991988T3 (es) 2017-10-30 2024-12-05 Takeda Pharmaceuticals Co Detergentes compatibles con el medio ambiente para la inactivación de virus con envoltura lipídica
US11230593B2 (en) 2019-03-25 2022-01-25 Visterra, Inc. Compositions and methods for treating and preventing influenza
CN110172452B (zh) * 2019-05-21 2021-07-06 广州医科大学 一种高致病性h7n9禽流感病毒、疫苗、检测试剂以及病毒、疫苗的制备方法
JP2022038604A (ja) 2020-08-27 2022-03-10 株式会社Subaru 車両の制御装置

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008112017A2 (en) * 2006-10-10 2008-09-18 The Government Of The United States Of America, As Represented By The Secretary, Department Of Healtand Human Services Avian influenza vaccine
WO2009089121A2 (en) * 2008-01-03 2009-07-16 Massachusetts Institute Of Technology Hemagglutinin polypeptides, and reagents and methods relating thereto

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4270537A (en) 1979-11-19 1981-06-02 Romaine Richard A Automatic hypodermic syringe
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4692411A (en) 1983-09-06 1987-09-08 Ghose Rabindra N Separation of specific biological cells by a biochemical filter
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
CA1283827C (en) 1986-12-18 1991-05-07 Giorgio Cirelli Appliance for injection of liquid formulations
GB8704027D0 (en) 1987-02-20 1987-03-25 Owen Mumford Ltd Syringe needle combination
US4940460A (en) 1987-06-19 1990-07-10 Bioject, Inc. Patient-fillable and non-invasive hypodermic injection device assembly
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
US5698390A (en) 1987-11-18 1997-12-16 Chiron Corporation Hepatitis C immunoassays
US5339163A (en) 1988-03-16 1994-08-16 Canon Kabushiki Kaisha Automatic exposure control device using plural image plane detection areas
FR2638359A1 (fr) 1988-11-03 1990-05-04 Tino Dalto Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
EP0438803B1 (en) 1990-01-26 1997-03-12 Immunomedics, Inc. Vaccines against cancer and infectious diseases
US5190521A (en) 1990-08-22 1993-03-02 Tecnol Medical Products, Inc. Apparatus and method for raising a skin wheal and anesthetizing skin
US5527288A (en) 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
GB9118204D0 (en) 1991-08-23 1991-10-09 Weston Terence E Needle-less injector
SE9102652D0 (sv) 1991-09-13 1991-09-13 Kabi Pharmacia Ab Injection needle arrangement
US5328483A (en) 1992-02-27 1994-07-12 Jacoby Richard M Intradermal injection device with medication and needle guard
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
US5569189A (en) 1992-09-28 1996-10-29 Equidyne Systems, Inc. hypodermic jet injector
US5334144A (en) 1992-10-30 1994-08-02 Becton, Dickinson And Company Single use disposable needleless injector
US5500161A (en) 1993-09-21 1996-03-19 Massachusetts Institute Of Technology And Virus Research Institute Method for making hydrophobic polymeric microparticles
WO1995024176A1 (en) 1994-03-07 1995-09-14 Bioject, Inc. Ampule filling device
US5466220A (en) 1994-03-08 1995-11-14 Bioject, Inc. Drug vial mixing and transfer device
US5599302A (en) 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5730723A (en) 1995-10-10 1998-03-24 Visionary Medical Products Corporation, Inc. Gas pressured needle-less injection device and method
US5893397A (en) 1996-01-12 1999-04-13 Bioject Inc. Medication vial/syringe liquid-transfer apparatus
GB9607549D0 (en) 1996-04-11 1996-06-12 Weston Medical Ltd Spring-powered dispensing device
US5993412A (en) 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus
IT1298087B1 (it) 1998-01-08 1999-12-20 Fiderm S R L Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni
MXPA02012254A (es) 2000-06-23 2003-04-25 American Cyanamid Co Montaje de particulas quimericas semejantes al virus de influenza y del tipo silvestre.
US8592197B2 (en) 2003-07-11 2013-11-26 Novavax, Inc. Functional influenza virus-like particles (VLPs)
JP4980895B2 (ja) * 2004-05-25 2012-07-18 メディミューン，エルエルシー インフルエンザ赤血球凝集素およびノイラミニダーゼ変異体
WO2006108226A1 (en) 2005-04-12 2006-10-19 The University Of Queensland Vaccine delivery system
CA2627105A1 (en) 2005-10-26 2007-05-03 Protelix, Inc. Influenza combinatorial antigen vaccine
US7736642B2 (en) * 2006-02-02 2010-06-15 Globeimmune, Inc. Yeast-based vaccine for inducing an immune response
WO2007130327A2 (en) 2006-05-01 2007-11-15 Technovax, Inc. Influenza virus-like particle (vlp) compositions
WO2007130330A2 (en) 2006-05-01 2007-11-15 Technovax, Inc. Polyvalent influenza virus-like particle (vlp) compositions
EP1998814A4 (en) 2006-05-11 2010-06-16 Novavax Inc NEW VACCINES AGAINST INFLUENZA M2
US20100143406A1 (en) 2006-06-30 2010-06-10 Gale Smith Methods of enhancing protein incorporation into virus like particles
EP2044198A4 (en) 2006-07-27 2010-09-08 Ligocyte Pharmaceuticals Inc CHIMERIC INFLUENZA VIRUS TYPE PARTICLES
CA2657955A1 (en) 2006-07-27 2008-08-07 Ligocyte Pharmaceuticals, Inc. Chimeric virus-like particles
CN104140958A (zh) * 2006-08-09 2014-11-12 米迪缪尼有限公司 流感血凝素和神经氨酸酶变体
CN101501696A (zh) * 2006-08-14 2009-08-05 麻省理工学院 聚糖数据挖掘系统
WO2008073161A2 (en) 2006-08-14 2008-06-19 Massachusetts Institute Of Technology Hemagglutinin polypeptides, and reagents and methods relating thereto
US20090269342A1 (en) 2006-08-14 2009-10-29 Massachusetts Institute Of Technology Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto
AU2007304883B2 (en) 2006-10-04 2013-09-05 The University Of Queensland VLP based vaccine delivery system
US8202967B2 (en) 2006-10-27 2012-06-19 Boehringer Ingelheim Vetmedica, Inc. H5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use
WO2008061243A2 (en) 2006-11-16 2008-05-22 Novavax, Inc. Respiratory syncytial virus-virus like particle (vlps)
EP2111233A2 (en) * 2006-12-29 2009-10-28 Institut Pasteur Of Shanghai Lentivirus pseudotyped with influenza hemagglutinin and methods of use
WO2008148104A1 (en) 2007-05-25 2008-12-04 Novavax, Inc. Novel vlps derived from cells that do not express a viral matrix or core protein
CA2615372A1 (en) 2007-07-13 2009-01-13 Marc-Andre D'aoust Influenza virus-like particles (vlps) comprising hemagglutinin
US20110008838A1 (en) 2007-07-19 2011-01-13 Gale Smith Chimeric varicella zoster virus virus-like particles
WO2009089119A2 (en) 2008-01-03 2009-07-16 Massachusetts Institute Of Technology Decoy influenza therapies
NZ590351A (en) 2008-07-18 2012-11-30 Medicago Inc HA1 domain totally or partially free of N-linked glycosylation operatively linked to a regulatory region
WO2011003100A2 (en) 2009-07-02 2011-01-06 Massachusetts Institute Of Technology Compositions and methods for diagnosing and/or treating influenza infection
JP6029586B2 (ja) 2010-10-04 2016-11-24 マサチューセッツ インスティテュート オブ テクノロジー 血球凝集素ポリペプチド、ならびにそれに関連する試薬および方法
US20140335504A1 (en) 2013-02-07 2014-11-13 Massachusetts Institute Of Technology Human adaptation of h5 influenza

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008112017A2 (en) * 2006-10-10 2008-09-18 The Government Of The United States Of America, As Represented By The Secretary, Department Of Healtand Human Services Avian influenza vaccine
WO2009089121A2 (en) * 2008-01-03 2009-07-16 Massachusetts Institute Of Technology Hemagglutinin polypeptides, and reagents and methods relating thereto

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
AYORA-TALAVERA G. et al. Mutations in H5N1 Influenza Virus Hemagglutinin that Confer Binding to Human Tracheal Airway Epithelium, Plos One, 2009, v.4, n. 11, e7836, p. 1-11. *
CHANDRASEKARAN A. et al. Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin, 2008, Nature Biotechnology, v. 26, n. 01, p. 107-113. *
HU W. Quantifying the effects of mutations on receptor binding specificity of influenza viruses, J. Biomedical Science and Engineering, 2010, v. 3, p. 227-240. *
YANG Z.Y. et al. Immunization by avian H5 influenza hemagglutinin mutants with altered receptor binding specificity, Science, 2007, v. 317, p. 825-828. *
YANG Z.Y. et al. Immunization by avian H5 influenza hemagglutinin mutants with altered receptor binding specificity, Science, 2007, v. 317, p. 825-828. AYORA-TALAVERA G. et al. Mutations in H5N1 Influenza Virus Hemagglutinin that Confer Binding to Human Tracheal Airway Epithelium, Plos One, 2009, v.4, n. 11, e7836, p. 1-11. САМУКОВ В.В. и др. Антигенные свойства синтетических фрагментов тяжелой цепи гемагглютинина вируса гриппа А. Молекулярная генетика. Микробиология и Вирусология, 1988, н.7, стр. 35-39. CHANDRASEKARAN A. et al. Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin, 2008, Nature Biotechnology, v. 26, n. 01, p. 107-113. HU W. Quantifying the effects of mutations on receptor binding specificity of influenza viruses, J. Biomedical Science and Engineering, 2010, v. 3, p. 227-240. *
САМУКОВ В.В. и др. Антигенные свойства синтетических фрагментов тяжелой цепи гемагглютинина вируса гриппа А. Молекулярная генетика. Микробиология и Вирусология, 1988, н.7, стр. 35-39. *

Also Published As

Publication number Publication date
SG10201709806VA (en) 2017-12-28
US10226527B2 (en) 2019-03-12
US20120213819A1 (en) 2012-08-23
CA2813078A1 (en) 2012-04-12
EP2624864B1 (en) 2017-12-06
US20190142931A1 (en) 2019-05-16
EP2624864A2 (en) 2013-08-14
WO2012047941A3 (en) 2013-04-11
JP2016094483A (ja) 2016-05-26
JP6029586B2 (ja) 2016-11-24
JP6143902B2 (ja) 2017-06-07
AU2011312178B2 (en) 2016-05-12
AU2011312178A1 (en) 2013-05-02
CN103328002A (zh) 2013-09-25
SG189236A1 (en) 2013-05-31
CN103328002B (zh) 2020-01-14
WO2012047941A2 (en) 2012-04-12
BR112013007946B1 (pt) 2022-07-12
BR112013007946A2 (pt) 2018-04-17
RU2013114424A (ru) 2014-11-20
JP2013543499A (ja) 2013-12-05

Similar Documents

Publication Publication Date Title
RU2663718C2 (ru) Полипептиды гемагглютининов, а также связанные с ними реагенты и способы
JP2010500880A (ja) ヘマグルチニンポリペプチド、ならびにヘマグルチニンポリペプチドに関連する試薬および方法
US9709567B2 (en) Compositions and methods for diagnosing and/or treating influenza infection
JP2010500880A5 (https=)
AU2011305371B2 (en) Human-adapted HA polypeptides, vaccines, and influenza treatment
US20090269342A1 (en) Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto
AU2014214754B2 (en) Human adaptation of H5 influenza
WO2009089121A2 (en) Hemagglutinin polypeptides, and reagents and methods relating thereto
CN101553502A (zh) 血球凝集素多肽和其相关试剂和方法
HK1218923B (en) Human adaptation of h5 influenza