RU2663718C2 - Полипептиды гемагглютининов, а также связанные с ними реагенты и способы - Google Patents

Полипептиды гемагглютининов, а также связанные с ними реагенты и способы Download PDF

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RU2663718C2
RU2663718C2 RU2013114424A RU2013114424A RU2663718C2 RU 2663718 C2 RU2663718 C2 RU 2663718C2 RU 2013114424 A RU2013114424 A RU 2013114424A RU 2013114424 A RU2013114424 A RU 2013114424A RU 2663718 C2 RU2663718 C2 RU 2663718C2
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polypeptide
binding
glycans
polypeptides
amino acid
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RU2013114424A
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RU2013114424A (ru
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Каннан ТАРАКАРАМАН
Картик ВИСВАНАТАН
Рахул РАМАН
Рам САСИСЕКХАРАН
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Массачусетс Инститьют Оф Текнолоджи
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/145Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
RU2013114424A 2010-10-04 2011-10-04 Полипептиды гемагглютининов, а также связанные с ними реагенты и способы RU2663718C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38963910P 2010-10-04 2010-10-04
US61/389,639 2010-10-04
PCT/US2011/054831 WO2012047941A2 (en) 2010-10-04 2011-10-04 Hemagglutinin polypeptides, and reagents and methods relating thereto

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RU2013114424A RU2013114424A (ru) 2014-11-20
RU2663718C2 true RU2663718C2 (ru) 2018-08-08

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US (2) US10226527B2 (enExample)
EP (1) EP2624864B1 (enExample)
JP (2) JP6029586B2 (enExample)
CN (1) CN103328002B (enExample)
AU (1) AU2011312178B2 (enExample)
BR (1) BR112013007946B1 (enExample)
CA (1) CA2813078A1 (enExample)
RU (1) RU2663718C2 (enExample)
SG (2) SG189236A1 (enExample)
WO (1) WO2012047941A2 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2813078A1 (en) 2010-10-04 2012-04-12 Massachusetts Institute Of Technology Hemagglutinin polypeptides, and reagents and methods relating thereto
AR083533A1 (es) * 2010-10-22 2013-03-06 Boehringer Ingelheim Vetmed Proteinas de hemaglutinina 5 (h5) para el tratamiento y prevencion de las infecciones de gripe
CN103930435A (zh) 2011-09-30 2014-07-16 麦迪卡格公司 增加植物中病毒样颗粒的产率
US11390878B2 (en) 2011-09-30 2022-07-19 Medicago Inc. Increasing protein yield in plants
US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
SG11201406769RA (en) 2012-05-10 2014-11-27 Massachusetts Inst Technology Agents for influenza neutralization
AU2014214754B2 (en) * 2013-02-07 2018-07-12 Massachusetts Institute Of Technology Human adaptation of H5 influenza
KR20150127586A (ko) 2013-03-15 2015-11-17 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 인플루엔자 핵산 분자 및 이로부터 제조된 백신
IL241692B2 (en) 2013-03-28 2023-12-01 Medicago Inc Influenza virus-like particle production in plants
US12467058B2 (en) * 2013-03-28 2025-11-11 Aramis Biotechnologies Inc. Influenza virus-like particle production in plants
ES2864081T3 (es) 2014-01-10 2021-10-13 Medicago Inc Elementos potenciadores de CPMV
EP3233117A4 (en) * 2014-12-19 2018-05-16 Oregon Health & Science University Synergistic co-administration of computationally optimized broadly reactive antigens for human and avian h5n1 influenza
EP3374390A1 (en) 2015-11-13 2018-09-19 Visterra, Inc. Compositions and methods for treating and preventing influenza
JP7104629B2 (ja) 2016-02-24 2022-07-21 ビステラ, インコーポレイテッド インフルエンザウイルスに対する抗体分子の製剤
US12258540B2 (en) 2017-10-30 2025-03-25 Takeda Pharmaceutical Company Limited Environmentally compatible detergents for inactivation of lipid-enveloped viruses
AU2020248404A1 (en) 2019-03-25 2021-09-30 Visterra, Inc. Compositions and methods for treating and preventing influenza
CN110172452B (zh) * 2019-05-21 2021-07-06 广州医科大学 一种高致病性h7n9禽流感病毒、疫苗、检测试剂以及病毒、疫苗的制备方法
JP2022038604A (ja) 2020-08-27 2022-03-10 株式会社Subaru 車両の制御装置

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008112017A2 (en) * 2006-10-10 2008-09-18 The Government Of The United States Of America, As Represented By The Secretary, Department Of Healtand Human Services Avian influenza vaccine
WO2009089121A2 (en) * 2008-01-03 2009-07-16 Massachusetts Institute Of Technology Hemagglutinin polypeptides, and reagents and methods relating thereto

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4270537A (en) 1979-11-19 1981-06-02 Romaine Richard A Automatic hypodermic syringe
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4692411A (en) 1983-09-06 1987-09-08 Ghose Rabindra N Separation of specific biological cells by a biochemical filter
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US4886499A (en) 1986-12-18 1989-12-12 Hoffmann-La Roche Inc. Portable injection appliance
GB8704027D0 (en) 1987-02-20 1987-03-25 Owen Mumford Ltd Syringe needle combination
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US4940460A (en) 1987-06-19 1990-07-10 Bioject, Inc. Patient-fillable and non-invasive hypodermic injection device assembly
US5698390A (en) 1987-11-18 1997-12-16 Chiron Corporation Hepatitis C immunoassays
US5339163A (en) 1988-03-16 1994-08-16 Canon Kabushiki Kaisha Automatic exposure control device using plural image plane detection areas
FR2638359A1 (fr) 1988-11-03 1990-05-04 Tino Dalto Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
EP0438803B1 (en) 1990-01-26 1997-03-12 Immunomedics, Inc. Vaccines against cancer and infectious diseases
US5190521A (en) 1990-08-22 1993-03-02 Tecnol Medical Products, Inc. Apparatus and method for raising a skin wheal and anesthetizing skin
US5527288A (en) 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
GB9118204D0 (en) 1991-08-23 1991-10-09 Weston Terence E Needle-less injector
SE9102652D0 (sv) 1991-09-13 1991-09-13 Kabi Pharmacia Ab Injection needle arrangement
US5328483A (en) 1992-02-27 1994-07-12 Jacoby Richard M Intradermal injection device with medication and needle guard
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
US5569189A (en) 1992-09-28 1996-10-29 Equidyne Systems, Inc. hypodermic jet injector
US5334144A (en) 1992-10-30 1994-08-02 Becton, Dickinson And Company Single use disposable needleless injector
US5500161A (en) 1993-09-21 1996-03-19 Massachusetts Institute Of Technology And Virus Research Institute Method for making hydrophobic polymeric microparticles
WO1995024176A1 (en) 1994-03-07 1995-09-14 Bioject, Inc. Ampule filling device
US5466220A (en) 1994-03-08 1995-11-14 Bioject, Inc. Drug vial mixing and transfer device
US5599302A (en) 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5730723A (en) 1995-10-10 1998-03-24 Visionary Medical Products Corporation, Inc. Gas pressured needle-less injection device and method
US5893397A (en) 1996-01-12 1999-04-13 Bioject Inc. Medication vial/syringe liquid-transfer apparatus
GB9607549D0 (en) 1996-04-11 1996-06-12 Weston Medical Ltd Spring-powered dispensing device
US5993412A (en) 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus
IT1298087B1 (it) 1998-01-08 1999-12-20 Fiderm S R L Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni
CN1196788C (zh) 2000-06-23 2005-04-13 惠氏控股有限公司 野生型和嵌合流感病毒样颗粒(vlp)的装配
US8592197B2 (en) 2003-07-11 2013-11-26 Novavax, Inc. Functional influenza virus-like particles (VLPs)
US7504109B2 (en) * 2004-05-25 2009-03-17 Medimmune, Llc Influenza hemagglutinin and neuraminidase variants
WO2006108226A1 (en) 2005-04-12 2006-10-19 The University Of Queensland Vaccine delivery system
WO2007051036A2 (en) 2005-10-26 2007-05-03 Protelix, Inc. Influenza combinatorial antigen vaccine
SG169375A1 (en) * 2006-02-02 2011-03-30 Globeimmune Inc Yeast-based vaccine for inducing an immune response
US8778353B2 (en) 2006-05-01 2014-07-15 Technovax, Inc. Influenza virus-like particle (VLP) compositions
US9101578B2 (en) 2006-05-01 2015-08-11 Technovax, Inc. Polyvalent influenza virus-like particle (VLP) compositions
WO2008054535A2 (en) 2006-05-11 2008-05-08 Novavax, Inc. Novel influenza m2 vaccines
US20100143406A1 (en) 2006-06-30 2010-06-10 Gale Smith Methods of enhancing protein incorporation into virus like particles
JP5683811B2 (ja) 2006-07-27 2015-03-11 タケダ ヴァクシーンズ, インコーポレイテッド キメラインフルエンザウイルス様粒子
CA2657955A1 (en) 2006-07-27 2008-08-07 Ligocyte Pharmaceuticals, Inc. Chimeric virus-like particles
JP2010500034A (ja) * 2006-08-09 2010-01-07 メッドイミューン バクシーンズ,インコーポレイティド インフルエンザ赤血球凝集素変異体およびノイラミニダーゼ変異体
US20080241918A1 (en) 2006-08-14 2008-10-02 Ram Sasisekharan Hemagglutinin polypeptides, and reagents and methods relating thereto
US20090269342A1 (en) 2006-08-14 2009-10-29 Massachusetts Institute Of Technology Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto
CN101553502A (zh) 2006-08-14 2009-10-07 麻省理工学院 血球凝集素多肽和其相关试剂和方法
AU2007304883B2 (en) 2006-10-04 2013-09-05 The University Of Queensland VLP based vaccine delivery system
US8202967B2 (en) 2006-10-27 2012-06-19 Boehringer Ingelheim Vetmedica, Inc. H5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use
WO2008061243A2 (en) 2006-11-16 2008-05-22 Novavax, Inc. Respiratory syncytial virus-virus like particle (vlps)
MX2009007106A (es) 2006-12-29 2010-04-30 Inst Pasteur Of Shanghai Lentivirus pseudotipificado con hemaglutinina de influenza y metodos de uso.
WO2008148104A1 (en) 2007-05-25 2008-12-04 Novavax, Inc. Novel vlps derived from cells that do not express a viral matrix or core protein
CA2615372A1 (en) 2007-07-13 2009-01-13 Marc-Andre D'aoust Influenza virus-like particles (vlps) comprising hemagglutinin
EP2176427A4 (en) 2007-07-19 2011-10-05 Novavax Inc VIRAL PESUDO-PARTICLES OF THE CHIMÈRE AVIAN INFLUENZA
EP2237787A4 (en) 2008-01-03 2012-03-21 Massachusetts Inst Technology DECOY-INFLUENZA THERAPIES
DK2318530T3 (en) 2008-07-18 2016-10-03 Medicago Inc Ny epitope to immunization against influenza
JP5886194B2 (ja) 2009-07-02 2016-03-16 マサチューセッツ インスティテュート オブ テクノロジー インフルエンザ感染の診断および/または処置のための組成物および方法
CA2813078A1 (en) 2010-10-04 2012-04-12 Massachusetts Institute Of Technology Hemagglutinin polypeptides, and reagents and methods relating thereto
AU2014214754B2 (en) 2013-02-07 2018-07-12 Massachusetts Institute Of Technology Human adaptation of H5 influenza

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008112017A2 (en) * 2006-10-10 2008-09-18 The Government Of The United States Of America, As Represented By The Secretary, Department Of Healtand Human Services Avian influenza vaccine
WO2009089121A2 (en) * 2008-01-03 2009-07-16 Massachusetts Institute Of Technology Hemagglutinin polypeptides, and reagents and methods relating thereto

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
AYORA-TALAVERA G. et al. Mutations in H5N1 Influenza Virus Hemagglutinin that Confer Binding to Human Tracheal Airway Epithelium, Plos One, 2009, v.4, n. 11, e7836, p. 1-11. *
CHANDRASEKARAN A. et al. Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin, 2008, Nature Biotechnology, v. 26, n. 01, p. 107-113. *
HU W. Quantifying the effects of mutations on receptor binding specificity of influenza viruses, J. Biomedical Science and Engineering, 2010, v. 3, p. 227-240. *
YANG Z.Y. et al. Immunization by avian H5 influenza hemagglutinin mutants with altered receptor binding specificity, Science, 2007, v. 317, p. 825-828. *
YANG Z.Y. et al. Immunization by avian H5 influenza hemagglutinin mutants with altered receptor binding specificity, Science, 2007, v. 317, p. 825-828. AYORA-TALAVERA G. et al. Mutations in H5N1 Influenza Virus Hemagglutinin that Confer Binding to Human Tracheal Airway Epithelium, Plos One, 2009, v.4, n. 11, e7836, p. 1-11. САМУКОВ В.В. и др. Антигенные свойства синтетических фрагментов тяжелой цепи гемагглютинина вируса гриппа А. Молекулярная генетика. Микробиология и Вирусология, 1988, н.7, стр. 35-39. CHANDRASEKARAN A. et al. Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin, 2008, Nature Biotechnology, v. 26, n. 01, p. 107-113. HU W. Quantifying the effects of mutations on receptor binding specificity of influenza viruses, J. Biomedical Science and Engineering, 2010, v. 3, p. 227-240. *
САМУКОВ В.В. и др. Антигенные свойства синтетических фрагментов тяжелой цепи гемагглютинина вируса гриппа А. Молекулярная генетика. Микробиология и Вирусология, 1988, н.7, стр. 35-39. *

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Publication number Publication date
RU2013114424A (ru) 2014-11-20
US10226527B2 (en) 2019-03-12
JP2016094483A (ja) 2016-05-26
JP6143902B2 (ja) 2017-06-07
US20190142931A1 (en) 2019-05-16
CN103328002A (zh) 2013-09-25
CA2813078A1 (en) 2012-04-12
BR112013007946A2 (pt) 2018-04-17
SG189236A1 (en) 2013-05-31
US20120213819A1 (en) 2012-08-23
EP2624864A2 (en) 2013-08-14
AU2011312178A1 (en) 2013-05-02
WO2012047941A2 (en) 2012-04-12
WO2012047941A3 (en) 2013-04-11
SG10201709806VA (en) 2017-12-28
BR112013007946B1 (pt) 2022-07-12
JP6029586B2 (ja) 2016-11-24
JP2013543499A (ja) 2013-12-05
EP2624864B1 (en) 2017-12-06
CN103328002B (zh) 2020-01-14
AU2011312178B2 (en) 2016-05-12

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