CN103328002B - 血球凝集素多肽以及与其相关的试剂和方法 - Google Patents

血球凝集素多肽以及与其相关的试剂和方法 Download PDF

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CN103328002B
CN103328002B CN201180057213.2A CN201180057213A CN103328002B CN 103328002 B CN103328002 B CN 103328002B CN 201180057213 A CN201180057213 A CN 201180057213A CN 103328002 B CN103328002 B CN 103328002B
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polypeptide
glycans
binding
polypeptides
glycan
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CN103328002A (zh
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卡纳安·塔拉卡拉曼
卡西克·维斯瓦那坦
拉胡尔·拉曼
拉姆·萨西谢卡尔安
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Massachusetts Institute of Technology
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
CN201180057213.2A 2010-10-04 2011-10-04 血球凝集素多肽以及与其相关的试剂和方法 Active CN103328002B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38963910P 2010-10-04 2010-10-04
US61/389,639 2010-10-04
PCT/US2011/054831 WO2012047941A2 (en) 2010-10-04 2011-10-04 Hemagglutinin polypeptides, and reagents and methods relating thereto

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CN103328002A CN103328002A (zh) 2013-09-25
CN103328002B true CN103328002B (zh) 2020-01-14

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US (2) US10226527B2 (enExample)
EP (1) EP2624864B1 (enExample)
JP (2) JP6029586B2 (enExample)
CN (1) CN103328002B (enExample)
AU (1) AU2011312178B2 (enExample)
BR (1) BR112013007946B1 (enExample)
CA (1) CA2813078A1 (enExample)
RU (1) RU2663718C2 (enExample)
SG (2) SG10201709806VA (enExample)
WO (1) WO2012047941A2 (enExample)

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RU2682752C2 (ru) 2011-09-30 2019-03-21 Медикаго Инк. Повышение выхода вирусоподобных частиц в растениях
US11390878B2 (en) 2011-09-30 2022-07-19 Medicago Inc. Increasing protein yield in plants
AU2013260123A1 (en) 2012-05-10 2014-11-13 Massachusetts Institute Of Technology Agents for influenza neutralization
US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
WO2014124319A2 (en) * 2013-02-07 2014-08-14 Massachusetts Institute Of Technology Human adaptation of h5 influenza
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KR102199018B1 (ko) * 2013-03-28 2021-01-07 메디카고 인코포레이티드 식물에서 인플루엔자 바이러스-유사 입자 생산
US12467058B2 (en) 2013-03-28 2025-11-11 Aramis Biotechnologies Inc. Influenza virus-like particle production in plants
WO2015103704A1 (en) 2014-01-10 2015-07-16 Medicago Inc. Cpmv enhancer elements
WO2016100926A1 (en) * 2014-12-19 2016-06-23 Oregon Health & Science University Synergistic co-administration of computationally optimized broadly reactive antigens for human and avian h5n1 influenza
WO2017083627A1 (en) 2015-11-13 2017-05-18 Visterra, Inc. Compositions and methods for treating and preventing influenza
CA3015347A1 (en) 2016-02-24 2017-08-31 Visterra, Inc. Formulations of antibody molecules to influenza virus
WO2019086463A1 (en) 2017-10-30 2019-05-09 Baxalta GmbH Environmentally compatible detergents for inactivation of lipid-enveloped viruses
EP3946613A1 (en) 2019-03-25 2022-02-09 Visterra, Inc. Compositions and methods for treating and preventing influenza
CN110172452B (zh) * 2019-05-21 2021-07-06 广州医科大学 一种高致病性h7n9禽流感病毒、疫苗、检测试剂以及病毒、疫苗的制备方法
JP7890002B2 (ja) 2020-08-27 2026-07-14 株式会社Subaru 車両の制御装置

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JP2013543499A (ja) 2013-12-05
EP2624864B1 (en) 2017-12-06
AU2011312178A1 (en) 2013-05-02
US20120213819A1 (en) 2012-08-23
SG10201709806VA (en) 2017-12-28
EP2624864A2 (en) 2013-08-14
JP6029586B2 (ja) 2016-11-24
JP6143902B2 (ja) 2017-06-07
RU2013114424A (ru) 2014-11-20
RU2663718C2 (ru) 2018-08-08
AU2011312178B2 (en) 2016-05-12
JP2016094483A (ja) 2016-05-26
US10226527B2 (en) 2019-03-12
WO2012047941A2 (en) 2012-04-12
BR112013007946A2 (pt) 2018-04-17
CA2813078A1 (en) 2012-04-12
SG189236A1 (en) 2013-05-31
US20190142931A1 (en) 2019-05-16
WO2012047941A3 (en) 2013-04-11
BR112013007946B1 (pt) 2022-07-12
CN103328002A (zh) 2013-09-25

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