RU2662713C2 - Пиридопиримидиновое соединение, способ получения, фармацевтическая композиция и применение указанных соединений - Google Patents
Пиридопиримидиновое соединение, способ получения, фармацевтическая композиция и применение указанных соединений Download PDFInfo
- Publication number
- RU2662713C2 RU2662713C2 RU2015140387A RU2015140387A RU2662713C2 RU 2662713 C2 RU2662713 C2 RU 2662713C2 RU 2015140387 A RU2015140387 A RU 2015140387A RU 2015140387 A RU2015140387 A RU 2015140387A RU 2662713 C2 RU2662713 C2 RU 2662713C2
- Authority
- RU
- Russia
- Prior art keywords
- oxa
- azabicyclo
- compound
- title compound
- octanyl
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 172
- -1 Pyridopyrimidine compound Chemical class 0.000 title claims abstract description 72
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 10
- 238000004519 manufacturing process Methods 0.000 title description 3
- 150000003839 salts Chemical class 0.000 claims abstract description 24
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims abstract description 16
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 14
- 230000019491 signal transduction Effects 0.000 claims abstract description 14
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- 230000004064 dysfunction Effects 0.000 claims abstract description 7
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 81
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims description 13
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 13
- 125000000217 alkyl group Chemical group 0.000 claims description 6
- 239000003112 inhibitor Substances 0.000 claims description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
- 239000003937 drug carrier Substances 0.000 claims description 4
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310068888.8A CN103588792B (zh) | 2013-03-04 | 2013-03-04 | 吡啶并嘧啶或嘧啶并嘧啶类化合物、其制备方法、药物组合物及其用途 |
| CN201310068888.8 | 2013-03-04 | ||
| PCT/CN2014/072678 WO2014135028A1 (zh) | 2013-03-04 | 2014-02-28 | 吡啶并嘧啶或嘧啶并嘧啶类化合物、其制备方法、药物组合物及其用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015140387A RU2015140387A (ru) | 2017-03-30 |
| RU2662713C2 true RU2662713C2 (ru) | 2018-07-27 |
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| CN103588792B (zh) | 2013-03-04 | 2016-03-23 | 中国科学院上海药物研究所 | 吡啶并嘧啶或嘧啶并嘧啶类化合物、其制备方法、药物组合物及其用途 |
| CN106008559B (zh) | 2015-03-25 | 2020-10-16 | 中国科学院上海药物研究所 | 取代吡啶并嘧啶类化合物的合成工艺 |
| US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
| CN111148747B (zh) * | 2017-11-07 | 2023-04-04 | 中国科学院上海药物研究所 | 吡啶并嘧啶类化合物的盐型和晶型及其制备方法 |
| CN109867667B (zh) * | 2017-12-05 | 2021-06-11 | 中国药科大学 | 含有吡啶并嘧啶结构的parp和pi3k双靶点抑制剂 |
| CN113825760B (zh) * | 2019-05-06 | 2022-08-19 | 南京明德新药研发有限公司 | 一种mTORC1/2双激酶活性抑制剂的盐型、晶型及其制备方法 |
| EP4161926A4 (en) * | 2020-06-03 | 2024-06-19 | Yumanity Therapeutics, Inc. | PYRIDOPYRIMIDINES AND THEIR METHODS OF USE |
| US20230081426A1 (en) * | 2020-09-18 | 2023-03-16 | Plexxikon Inc. | Compounds and methods for kras modulation and indications therefor |
| WO2022228576A1 (zh) * | 2021-04-30 | 2022-11-03 | 上海医药集团股份有限公司 | 一种靶向蛋白调节剂的化合物及其应用 |
| WO2023018812A1 (en) * | 2021-08-10 | 2023-02-16 | Amgen Inc. | Heterocyclic compounds and methods of use |
| MX2024001894A (es) * | 2021-08-10 | 2024-02-29 | Amgen Inc | Compuestos heterociclicos y metodos de uso. |
| EP4540244A1 (en) * | 2022-06-15 | 2025-04-23 | Mirati Therapeutics, Inc. | Prodrugs of pan-kras inhibitors |
| WO2024057013A1 (en) * | 2022-09-12 | 2024-03-21 | Exscientia Ai Limited | Nlrp3 modulators |
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| RU2448109C2 (ru) * | 2006-08-08 | 2012-04-20 | Чугаи Сейяку Кабусики Кайся | Производное пиримидина в качестве ингибитора pi3k и его применение |
| CN102887895A (zh) * | 2011-07-22 | 2013-01-23 | 山东轩竹医药科技有限公司 | 吡啶并嘧啶类mTOR抑制剂 |
| WO2013016999A1 (zh) * | 2011-08-04 | 2013-02-07 | 江苏豪森药业股份有限公司 | 杂芳基并嘧啶类衍生物、其制备方法和用途 |
| CN103588792A (zh) * | 2013-03-04 | 2014-02-19 | 中国科学院上海药物研究所 | 吡啶并嘧啶或嘧啶并嘧啶类化合物、其制备方法、药物组合物及其用途 |
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| AU2006217744A1 (en) * | 2005-02-25 | 2006-08-31 | Kudos Pharmaceuticals Limited | 2,4-diamino-pyridopyrimidine derivatives and their use as MTOR inhibitors |
| UA96745C2 (en) * | 2005-11-22 | 2011-12-12 | Кудос Фармасьютикалз Лимитед | PYRIDO-, PYRAZO- AND PYRIMIDO-PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS |
| CN101558067B (zh) * | 2006-08-23 | 2014-05-28 | 库多斯药物有限公司 | 作为mtor抑制剂的2-甲基吗啉吡啶并、吡唑并和嘧啶并-嘧啶衍生物 |
| US20080233127A1 (en) * | 2007-03-21 | 2008-09-25 | Wyeth | Imidazolopyrimidine analogs and their use as pi3 kinase and mtor inhibitors |
| WO2010120987A1 (en) * | 2009-04-17 | 2010-10-21 | Wyeth Llc | Ring fused, ureidoaryl- and carbamoylaryl-bridged morpholino-pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2448109C2 (ru) * | 2006-08-08 | 2012-04-20 | Чугаи Сейяку Кабусики Кайся | Производное пиримидина в качестве ингибитора pi3k и его применение |
| CN102887895A (zh) * | 2011-07-22 | 2013-01-23 | 山东轩竹医药科技有限公司 | 吡啶并嘧啶类mTOR抑制剂 |
| WO2013016999A1 (zh) * | 2011-08-04 | 2013-02-07 | 江苏豪森药业股份有限公司 | 杂芳基并嘧啶类衍生物、其制备方法和用途 |
| CN103588792A (zh) * | 2013-03-04 | 2014-02-19 | 中国科学院上海药物研究所 | 吡啶并嘧啶或嘧啶并嘧啶类化合物、其制备方法、药物组合物及其用途 |
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| JP2016510042A (ja) | 2016-04-04 |
| CA2903072A1 (en) | 2014-09-12 |
| US20150368274A1 (en) | 2015-12-24 |
| HK1217197A1 (en) | 2016-12-30 |
| US9796732B2 (en) | 2017-10-24 |
| AU2014225155B2 (en) | 2017-11-23 |
| CA2903072C (en) | 2019-05-07 |
| AU2014225155A1 (en) | 2015-10-15 |
| CN103588792A (zh) | 2014-02-19 |
| EP2966079B1 (en) | 2021-11-24 |
| WO2014135028A1 (zh) | 2014-09-12 |
| EP2966079A1 (en) | 2016-01-13 |
| DK2966079T1 (da) | 2016-05-17 |
| DK2966079T3 (da) | 2022-02-14 |
| EP2966079A4 (en) | 2016-11-09 |
| RU2015140387A (ru) | 2017-03-30 |
| ES2572105T3 (es) | 2022-04-13 |
| DE14760712T1 (de) | 2017-12-14 |
| CN103588792B (zh) | 2016-03-23 |
| ES2572105T1 (es) | 2016-05-30 |
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