RU2649069C2 - Новый способ лечения повреждения спинного мозга с применением фрагмента hmgb1 - Google Patents
Новый способ лечения повреждения спинного мозга с применением фрагмента hmgb1 Download PDFInfo
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- RU2649069C2 RU2649069C2 RU2015119523A RU2015119523A RU2649069C2 RU 2649069 C2 RU2649069 C2 RU 2649069C2 RU 2015119523 A RU2015119523 A RU 2015119523A RU 2015119523 A RU2015119523 A RU 2015119523A RU 2649069 C2 RU2649069 C2 RU 2649069C2
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- hmgb1
- peptide
- amino acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012235786 | 2012-10-25 | ||
JP2012-235786 | 2012-10-25 | ||
PCT/JP2013/078759 WO2014065348A1 (fr) | 2012-10-25 | 2013-10-24 | Nouveau procédé de traitement d'une lésion de la moelle épinière à l'aide d'un fragment hmgb1 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2015119523A RU2015119523A (ru) | 2016-12-20 |
RU2649069C2 true RU2649069C2 (ru) | 2018-04-02 |
Family
ID=50544721
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2015119523A RU2649069C2 (ru) | 2012-10-25 | 2013-10-24 | Новый способ лечения повреждения спинного мозга с применением фрагмента hmgb1 |
Country Status (18)
Country | Link |
---|---|
US (1) | US9688733B2 (fr) |
EP (1) | EP2913059B1 (fr) |
JP (1) | JP6253590B2 (fr) |
KR (1) | KR102146822B1 (fr) |
CN (1) | CN104955470B (fr) |
AU (1) | AU2013335685B2 (fr) |
BR (1) | BR112015008745B1 (fr) |
CA (1) | CA2889299C (fr) |
DK (1) | DK2913059T3 (fr) |
ES (1) | ES2673861T3 (fr) |
HK (2) | HK1212888A1 (fr) |
MX (1) | MX365899B (fr) |
PL (1) | PL2913059T3 (fr) |
RU (1) | RU2649069C2 (fr) |
SG (1) | SG11201503215XA (fr) |
TR (1) | TR201807769T4 (fr) |
WO (1) | WO2014065348A1 (fr) |
ZA (1) | ZA201502829B (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009133943A1 (fr) | 2008-04-30 | 2009-11-05 | 株式会社ジェノミックス | Procédé pour collecter des cellules fonctionnelles in vivo avec une efficacité élevée |
DK3358011T3 (da) | 2011-04-26 | 2020-05-11 | Univ Osaka | Peptid til inducering af regenerering af væv og anvendelse deraf |
JP6253589B2 (ja) | 2012-10-25 | 2017-12-27 | 株式会社ジェノミックス | Hmgb1断片を利用した新規心筋梗塞の治療法 |
WO2018139562A1 (fr) | 2017-01-27 | 2018-08-02 | 株式会社ジェノミックス | Agent thérapeutique pour les cardiomyopathies, l'infarctus du myocarde ancien et l'insuffisance cardiaque chronique |
WO2019107530A1 (fr) | 2017-12-01 | 2019-06-06 | 株式会社ステムリム | Agent thérapeutique pour une maladie inflammatoire de l'intestin |
US20210024594A1 (en) | 2018-02-08 | 2021-01-28 | StemRIM Inc. | Therapeutic Agent for Psoriasis |
BR112021005982A2 (pt) * | 2018-10-05 | 2021-06-29 | StemRIM Inc. | peptídeo possuindo atividade de mobilização de células-tronco mesenquimais |
EP3865179A4 (fr) * | 2018-10-25 | 2022-07-27 | Osaka University | Médicament thérapeutique destiné à un trouble du cartilage |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080214454A1 (en) * | 2001-05-15 | 2008-09-04 | Tracey Kevin J | Use of HMGB fragments as anti-inflammatory agents |
RU2010148785A (ru) * | 2008-04-30 | 2012-06-10 | Дженомикс Ко., Лтд. (Jp) | Фармацевтическое средство для стимуляции функциональной регенерации поврежденной ткани |
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JPS5238680B2 (fr) | 1972-12-27 | 1977-09-30 | ||
US5658894A (en) | 1989-04-23 | 1997-08-19 | The Trustees Of The University Of Pennsylvania | Compositions for inhibiting restenosis |
US5661127A (en) | 1995-05-01 | 1997-08-26 | The Regents Of The University Of California | Peptide compositions with growth factor-like activity |
JP3018313B2 (ja) | 1996-02-23 | 2000-03-13 | 雪印乳業株式会社 | 骨形成促進及び骨吸収防止剤 |
US20040031072A1 (en) | 1999-05-06 | 2004-02-12 | La Rosa Thomas J. | Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement |
US6720340B1 (en) | 1999-07-28 | 2004-04-13 | The Board Of Trustees Of The Leland Stanford Jr. University | Nicotine receptor agonists in stem cell and progenitor cell recruitment |
EP1114862A3 (fr) | 1999-11-17 | 2003-08-06 | Switch Biotech Aktiengesellschaft | Utilitsation des polypeptides ou leurs acids nucléiques pour la diagnose ou traitement des maladies de la peau et leurs utilisation pour l'identification des substances pharmacologiquement actives |
MXPA02008265A (es) | 2000-02-24 | 2004-09-10 | Xcyte Therapies Inc | Concentracion y estimulacion simultanea de calulas. |
JP3421741B2 (ja) | 2000-05-18 | 2003-06-30 | 筑波大学長 | 人工骨髄、血球細胞の増殖方法 |
US20040191246A1 (en) | 2003-02-26 | 2004-09-30 | Connelly Patrick R. | Process for in vivo treatment of specific biological targets in bodily fluid |
ITMI20010562A1 (it) | 2001-03-16 | 2002-09-16 | Marco E Bianchi | Inibitori o antagonisti della proteina hmg1 per il trattamento di disordini vascolari |
EP1390058A2 (fr) | 2001-04-30 | 2004-02-25 | Switch Biotech Aktiengesellschaft | Heterodimere mrp8/mrp14 ou ses composants individuels combines pour le traitement et/ou la prevention de maladies cutanees, de blessures et/ou de troubles de la cicatrisation des blessures caracterises par une quantite reduite d'heterodimeres mrp8/mrp14 |
DE10121254A1 (de) | 2001-04-30 | 2002-11-07 | Switch Biotech Ag | MRP8/MRP14 Heterodimers oder seiner Einzelkomponenten alleine oder in Kombination zur Behandlung und/oder Prävention von Hauterkrankungen, Wunden und/oder Wundheilungsstörungen, die durch eine verringerte Menge an MRP8/MRP14 Heterodimeren gekennzeichnet sind |
US7220723B2 (en) | 2001-05-15 | 2007-05-22 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
CA2447576C (fr) | 2001-05-15 | 2014-04-08 | North Shore-Long Island Jewish Research Institute | Utilisation de fragments de hmg en tant qu'agents anti-inflammatoires |
ITMI20011986A1 (it) | 2001-09-25 | 2003-03-25 | San Raffaele Centro Fond | Metodo e composizione per l'attivazione di cellule presentanti l'antigene |
CN100484569C (zh) | 2001-11-19 | 2009-05-06 | 协和发酵工业株式会社 | 将多潜能干细胞从组织中流通到外周血的药物 |
EP2308963A3 (fr) | 2001-12-07 | 2011-09-21 | Cytori Therapeutics, Inc. | Systèmes pour le traitement des cellules obtenues par liposuccion |
DE60326453D1 (de) | 2002-07-03 | 2009-04-16 | Ct Cardiologico Monzino S P A | Die verwendung von hmgb1 zur behandlung von gewebeverletzungen und/oder zur unterstützung der gewebewiederherstellung |
CA2489860C (fr) | 2002-07-05 | 2015-02-10 | Universite Laval | Utilisation d'un anticorps dirige contre s100a8 ou a1009 en tant qu'inhibiteur de facteur chimiotactique destine a moduler des reactions inflammatoires |
GB0226251D0 (en) | 2002-11-11 | 2002-12-18 | San Raffaele Centro Fond | Acetylated protein |
WO2004046345A2 (fr) | 2002-11-20 | 2004-06-03 | Critical Therapeutics, Inc. | Utilisation de fragments hmgb en tant qu'agents anti-inflammatoires |
CA2512512A1 (fr) | 2003-01-03 | 2004-07-22 | Alcedo Biotech Gmbh | Utilisations de proteines de liaison a l'adn |
CA2520515C (fr) | 2003-03-28 | 2012-08-28 | Universite Laval | Proteine s100 utilisee en tant qu'activateur des neutrophiles pour attenuer la neutropenie dans le traitement du cancer |
US20050014255A1 (en) | 2003-05-29 | 2005-01-20 | Board Of Regents, The University Of Texas System | Stem cells for clinical and commercial uses |
WO2005025604A2 (fr) | 2003-09-10 | 2005-03-24 | The General Hospital Corporation | Utilisation de hmgb et fragments de hmgb pour faire diminuer la reponse immunitaire specifique |
ITRM20040058A1 (it) | 2004-02-03 | 2004-05-03 | Marco E Bianchi | Inibitori ed antagonisti di hmgb1 in grado di regolare la proliferazione delle cellule muscolari lisce ed endoteliali. |
WO2006008779A1 (fr) | 2004-07-20 | 2006-01-26 | Provincia Italiana Della Congregazione Dei Figli Dell'immacolata Concezione-Istituto Dermopatico Dell'immacolata | Utilisation de hmgb1 dans la cicatrisation des plaies |
MX2007001155A (es) | 2004-07-29 | 2007-08-14 | Creabilis Therapeutics Spa | Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1. |
BRPI0514835A (pt) | 2004-09-03 | 2008-06-24 | Creabilis Therapeutics Spa | variante de polipetìdeo de box de domìnio de ligação por alta afinidade de hmbg1 humano e/ou não humano ou de fragmento biologicamente ativo de box-a de hmgb1, molécula de ácido nucléico, uso, composição farmacêutica e dispositivo médico |
KR100593397B1 (ko) | 2004-10-27 | 2006-06-28 | 한국원자력연구소 | 중배엽 줄기세포 및/또는 p 물질을 함유하는 상처 치유또는 상처 치유 촉진제, 또는 세포 치료제 |
WO2006047820A1 (fr) | 2004-11-01 | 2006-05-11 | Newsouth Innovations Pty Limited | Utilisation de la calgranuline a et b pour la stimulation et l'inhibition de la formation de tissus mineralises |
ITRM20050032A1 (it) | 2005-01-21 | 2006-07-22 | Marco E Bianchi | Inibitori ed antagonisti di hmgb1 in grado di inibire la patogenesi e la progressione della malattia aterosclerotica. |
WO2006080434A1 (fr) | 2005-01-27 | 2006-08-03 | Japan Health Sciences Foundation | Feuille cellulaire contenant des cellules souches mesenchymateuses (csm) |
KR101319135B1 (ko) | 2005-03-23 | 2013-10-17 | 바이오세이프 쏘시에떼아노님 | 재생 의약에서 성체 줄기 세포를 비롯한 세포 부분집합의 수집, 처리, 이식을 위한 통합된 기계 장치 |
WO2006114805A2 (fr) | 2005-04-28 | 2006-11-02 | Fondazione Centro San Raffaele Del Monte Tabor | Utilisation des proteines hmgb2 et hmgb3 pour applications medicales |
WO2007015546A1 (fr) | 2005-08-04 | 2007-02-08 | Genomix Co., Ltd | Inducteur de cellules souches mésenchymales, promoteur de régénération tissulaire et méthode de préparation de cellules souches mésenchymales |
WO2007031100A1 (fr) | 2005-09-14 | 2007-03-22 | Ostini, Marco | Immunothérapie active pour inflammation systémique potentiellement mortelle |
US7829097B2 (en) | 2006-02-06 | 2010-11-09 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Use of HMGB1 for protection against ischemia reperfusion injury |
JP4982739B2 (ja) | 2006-06-01 | 2012-07-25 | 国立大学法人 東京医科歯科大学 | ポリグルタミン病の予防・治療剤 |
EP2046834B9 (fr) | 2006-08-11 | 2013-04-10 | Ono Pharmaceutical Co., Ltd. | Anticorps monoclonaux contre le facteur 1 dérivé de cellules stromales (sdf-1) |
WO2008053892A1 (fr) * | 2006-10-30 | 2008-05-08 | Genomix Co., Ltd. | Produit pharmaceutique servant à favoriser la régénération fonctionnelle d'un tissu endommagé |
WO2009133939A1 (fr) | 2008-04-30 | 2009-11-05 | 株式会社ジェノミックス | Agent de recrutement d'une cellule souche pluripotente issue de la moelle osseuse dans la circulation périphérique |
WO2009133943A1 (fr) | 2008-04-30 | 2009-11-05 | 株式会社ジェノミックス | Procédé pour collecter des cellules fonctionnelles in vivo avec une efficacité élevée |
WO2011046570A1 (fr) * | 2009-10-16 | 2011-04-21 | The University Of Medicine And Dentistry Of New Jersey | Procédé de traitement d'une lésion chronique du tissu nerveux à l'aide d'une stratégie de thérapie de cellules |
CA2778759A1 (fr) | 2009-10-28 | 2011-05-05 | Genomix Co., Ltd. | Promoteur de regeneration tissulaire utilisant le recrutement de cellules souches mesenchymateuses de moelle osseuse ou de cellules souches pluripotentes dans le sang |
DK3358011T3 (da) | 2011-04-26 | 2020-05-11 | Univ Osaka | Peptid til inducering af regenerering af væv og anvendelse deraf |
CN102443064A (zh) | 2011-11-03 | 2012-05-09 | 刘誉 | 一种基于凝血酶活性的双靶向作用的嵌合多肽及其应用 |
JP6253589B2 (ja) | 2012-10-25 | 2017-12-27 | 株式会社ジェノミックス | Hmgb1断片を利用した新規心筋梗塞の治療法 |
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2013
- 2013-10-24 ES ES13849823.3T patent/ES2673861T3/es active Active
- 2013-10-24 CA CA2889299A patent/CA2889299C/fr active Active
- 2013-10-24 CN CN201380067951.4A patent/CN104955470B/zh active Active
- 2013-10-24 AU AU2013335685A patent/AU2013335685B2/en active Active
- 2013-10-24 MX MX2015005253A patent/MX365899B/es active IP Right Grant
- 2013-10-24 WO PCT/JP2013/078759 patent/WO2014065348A1/fr active Application Filing
- 2013-10-24 RU RU2015119523A patent/RU2649069C2/ru active
- 2013-10-24 SG SG11201503215XA patent/SG11201503215XA/en unknown
- 2013-10-24 US US14/436,920 patent/US9688733B2/en active Active
- 2013-10-24 EP EP13849823.3A patent/EP2913059B1/fr active Active
- 2013-10-24 DK DK13849823.3T patent/DK2913059T3/en active
- 2013-10-24 JP JP2014543335A patent/JP6253590B2/ja active Active
- 2013-10-24 PL PL13849823T patent/PL2913059T3/pl unknown
- 2013-10-24 TR TR2018/07769T patent/TR201807769T4/tr unknown
- 2013-10-24 BR BR112015008745-0A patent/BR112015008745B1/pt active IP Right Grant
- 2013-10-24 KR KR1020157013591A patent/KR102146822B1/ko active IP Right Grant
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2015
- 2015-04-24 ZA ZA2015/02829A patent/ZA201502829B/en unknown
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2016
- 2016-01-25 HK HK16100783.3A patent/HK1212888A1/zh unknown
- 2016-02-04 HK HK16101298.9A patent/HK1213201A1/zh unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080214454A1 (en) * | 2001-05-15 | 2008-09-04 | Tracey Kevin J | Use of HMGB fragments as anti-inflammatory agents |
RU2010148785A (ru) * | 2008-04-30 | 2012-06-10 | Дженомикс Ко., Лтд. (Jp) | Фармацевтическое средство для стимуляции функциональной регенерации поврежденной ткани |
Non-Patent Citations (1)
Title |
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ESPOSITO E. et al. Melatonin reduces stress-activated/mitogen-activated protein kinases in spinal cord injury, J. Pineal. Res., 2009, v.46, n.1, p.79-86. * |
Also Published As
Publication number | Publication date |
---|---|
DK2913059T3 (en) | 2018-06-25 |
TR201807769T4 (tr) | 2018-06-21 |
US20150274792A1 (en) | 2015-10-01 |
AU2013335685A1 (en) | 2015-05-14 |
SG11201503215XA (en) | 2015-06-29 |
EP2913059A1 (fr) | 2015-09-02 |
JPWO2014065348A1 (ja) | 2016-09-08 |
CA2889299A1 (fr) | 2014-05-01 |
KR20150102957A (ko) | 2015-09-09 |
MX2015005253A (es) | 2015-10-29 |
JP6253590B2 (ja) | 2017-12-27 |
WO2014065348A1 (fr) | 2014-05-01 |
EP2913059B1 (fr) | 2018-04-11 |
BR112015008745B1 (pt) | 2022-08-02 |
HK1213201A1 (zh) | 2016-06-30 |
CN104955470B (zh) | 2017-06-16 |
KR102146822B1 (ko) | 2020-08-21 |
RU2015119523A (ru) | 2016-12-20 |
BR112015008745A2 (pt) | 2017-11-21 |
PL2913059T3 (pl) | 2018-09-28 |
MX365899B (es) | 2019-06-19 |
ES2673861T3 (es) | 2018-06-26 |
CA2889299C (fr) | 2023-02-14 |
CN104955470A (zh) | 2015-09-30 |
EP2913059A4 (fr) | 2016-03-30 |
US9688733B2 (en) | 2017-06-27 |
HK1212888A1 (zh) | 2016-06-24 |
ZA201502829B (en) | 2020-11-25 |
AU2013335685B2 (en) | 2017-10-12 |
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