RU2642314C2 - Способы избирательной количественной оценки агрегатов а-бета - Google Patents

Способы избирательной количественной оценки агрегатов а-бета Download PDF

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RU2642314C2
RU2642314C2 RU2014130136A RU2014130136A RU2642314C2 RU 2642314 C2 RU2642314 C2 RU 2642314C2 RU 2014130136 A RU2014130136 A RU 2014130136A RU 2014130136 A RU2014130136 A RU 2014130136A RU 2642314 C2 RU2642314 C2 RU 2642314C2
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beta
substrate
aggregates
probes
labeled
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RU2014130136A
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RU2014130136A (ru
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Дитер ВИЛЛЬБОЛЬД
Зузанне Айлен ФУНКЕ
Лэй ВАН-ДИТРИХ
Эва БИРКМАНН
Оливер БАННАХ
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Форшунгсцентрум Юлих Гмбх
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/552—Glass or silica
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
RU2014130136A 2011-12-23 2012-12-21 Способы избирательной количественной оценки агрегатов а-бета RU2642314C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102011057021A DE102011057021A1 (de) 2011-12-23 2011-12-23 Verfahren zur selektiven Quantifizierung von A-Beta-Aggregaten
DE102011057021.7 2011-12-23
PCT/EP2012/076552 WO2013092952A2 (de) 2011-12-23 2012-12-21 Verfahren zur selektiven quantifizierung von a-beta-aggregaten

Publications (2)

Publication Number Publication Date
RU2014130136A RU2014130136A (ru) 2016-02-10
RU2642314C2 true RU2642314C2 (ru) 2018-01-24

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US (1) US20150024512A1 (https=)
EP (1) EP2794655B1 (https=)
JP (2) JP2015502551A (https=)
CN (1) CN104080807A (https=)
BR (1) BR112014015392A2 (https=)
CA (1) CA2858125A1 (https=)
DE (1) DE102011057021A1 (https=)
DK (1) DK2794655T3 (https=)
ES (1) ES2922201T3 (https=)
IL (1) IL232870B (https=)
RU (1) RU2642314C2 (https=)
WO (1) WO2013092952A2 (https=)

Families Citing this family (13)

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DE102013106713A1 (de) 2013-06-26 2014-12-31 Forschungszentrum Jülich GmbH Verfahren zur Ermittlung von Indikatoren zur Bestimmung von Krankheiten
EP3180465B1 (en) * 2014-09-16 2020-04-08 SRI International Libraries of non-natural, dihydroisoquinolinone-based polymers for high-throughput drug screening through fiber-optic array scanning technology
DE102015003404B4 (de) * 2015-03-18 2021-10-07 Forschungszentrum Jülich GmbH Verfahren zur Herstellung eines Standards für den Nachweis von Proteinaggregaten einer Proteinfehlfaltungserkrankung sowie Standard und dessen Verwendung
WO2017138497A1 (ja) * 2016-02-08 2017-08-17 シスメックス株式会社 被検物質の検出方法および被検物質の検出用試薬キット
JP6886854B2 (ja) * 2017-04-13 2021-06-16 シスメックス株式会社 被検物質の情報取得方法
DE102017005543A1 (de) * 2017-06-13 2018-12-13 Forschungszentrum Jülich GmbH Verfahren zum Nachweis von Extrazellulären Vesikeln in einer Probe
DE102017010455A1 (de) * 2017-06-13 2018-12-13 Forschungszentrum Jülich GmbH Verfahren zum Nachweis von Aggregaten biotherapeutischer Substanzen in einer Probe
DE102017010842A1 (de) * 2017-11-23 2019-05-23 Forschungszentrum Jülich GmbH Verfahren zur Quantifizierung von Proteinaggregaten einer Proteinfehlfaltungserkrankung in einer Probe
ES2955992T3 (es) * 2017-12-19 2023-12-11 Chase Therapeutics Corp Método para evaluar una sinucleinopatía
CN111518206B (zh) 2019-02-01 2022-03-29 长春金赛药业有限责任公司 人源化抗Aβ单克隆抗体及其应用
DE102020114278A1 (de) 2020-05-28 2021-12-02 Forschungszentrum Jülich GmbH Bestimmung krankheitsspezifischer Protein-Aggregate in Stuhlproben
DE102020003794A1 (de) * 2020-06-25 2021-12-30 Forschungszentrum Jülich GmbH Verfahren, Verwendung des Verfahrens sowle Kit zum Nachweis von Bioindikatoren in einer Probe
CN116879540B (zh) * 2023-07-13 2024-04-05 香港中文大学（深圳） 一种神经元蛋白聚集体特异性检测试剂盒

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010129276A2 (en) * 2009-04-27 2010-11-11 Case Western Reserve University PYRO-GLUTAMATE Aβ TARGETING AGENTS
RU2432362C2 (ru) * 2005-11-30 2011-10-27 Эбботт Лэборетриз Моноклональные антитела и их применения

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE462454B (sv) * 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
US7427392B1 (en) * 1994-11-14 2008-09-23 Elan Pharmaceuticals, Inc. Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau
WO2005018424A2 (en) * 2003-08-18 2005-03-03 Research Foundation For Mental Hygiene, Inc. Antibodies specific for fibrillar amyloid and a procedure to detect fibrillar amyloid deposits
US7258990B2 (en) * 2004-08-19 2007-08-21 Biocept, Inc. Alleviation of non-specific binding in microarray assays
EA014531B1 (ru) * 2006-02-24 2010-12-30 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Антиамилоидные иммуногенные композиции, способы и применения
WO2008070229A2 (en) * 2006-08-28 2008-06-12 Case Western Reserve University Detection of pathogenic aggregates of protein in a sample by homologous elisa
JPWO2009051220A1 (ja) * 2007-10-19 2011-03-03 イムナス・ファーマ株式会社 Ａβオリゴマーに特異的に結合する抗体およびその利用
CN102089659A (zh) * 2008-05-08 2011-06-08 武田药品工业株式会社 Aβ寡聚物的测定方法
WO2010074083A1 (ja) * 2008-12-24 2010-07-01 コニカミノルタホールディングス株式会社 表面プラズモンおよび蛍光共鳴エネルギー転移を利用した免疫アッセイ
KR20130043088A (ko) * 2010-02-09 2013-04-29 브리스톨-마이어스 스큅 컴퍼니 면역검정 표준물 및 검정내 보정 표준물을 사용한 임상 바이오마커의 측정

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2432362C2 (ru) * 2005-11-30 2011-10-27 Эбботт Лэборетриз Моноклональные антитела и их применения
WO2010129276A2 (en) * 2009-04-27 2010-11-11 Case Western Reserve University PYRO-GLUTAMATE Aβ TARGETING AGENTS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FUNKE et al. "Single particle detection of Abeta aggregates associated with Alzheimer's disease", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 364, 28.12.2007, pages 902-907. *

Also Published As

Publication number Publication date
ES2922201T3 (es) 2022-09-09
EP2794655B1 (de) 2022-04-13
WO2013092952A2 (de) 2013-06-27
IL232870B (en) 2020-06-30
EP2794655A2 (de) 2014-10-29
RU2014130136A (ru) 2016-02-10
CA2858125A1 (en) 2013-06-27
DE102011057021A1 (de) 2013-06-27
JP6625709B2 (ja) 2019-12-25
DK2794655T3 (da) 2022-07-18
IL232870A0 (en) 2014-07-31
WO2013092952A3 (de) 2013-08-29
BR112014015392A2 (pt) 2019-09-24
US20150024512A1 (en) 2015-01-22
JP2015502551A (ja) 2015-01-22
JP2019015738A (ja) 2019-01-31
CN104080807A (zh) 2014-10-01

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