JP2015502551A5 - - Google Patents
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- JP2015502551A5 JP2015502551A5 JP2014548051A JP2014548051A JP2015502551A5 JP 2015502551 A5 JP2015502551 A5 JP 2015502551A5 JP 2014548051 A JP2014548051 A JP 2014548051A JP 2014548051 A JP2014548051 A JP 2014548051A JP 2015502551 A5 JP2015502551 A5 JP 2015502551A5
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- JP
- Japan
- Prior art keywords
- aggregate
- seq
- substrate
- aggregates
- standard
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 34
- 239000000523 sample Substances 0.000 claims description 13
- 239000000758 substrate Substances 0.000 claims description 11
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 5
- 239000011521 glass Substances 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 229920002307 Dextran Polymers 0.000 claims description 2
- 239000012925 reference material Substances 0.000 claims description 2
- 238000001514 detection method Methods 0.000 claims 4
- 239000013543 active substance Substances 0.000 claims 3
- 239000007850 fluorescent dye Substances 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 238000000386 microscopy Methods 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 238000011002 quantification Methods 0.000 claims 2
- 125000006850 spacer group Chemical group 0.000 claims 2
- 230000009870 specific binding Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 238000002965 ELISA Methods 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 230000004931 aggregating effect Effects 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 229940000635 beta-alanine Drugs 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 238000012512 characterization method Methods 0.000 claims 1
- 238000001800 confocal fluorescence correlation spectroscopy Methods 0.000 claims 1
- 238000001218 confocal laser scanning microscopy Methods 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000002060 fluorescence correlation spectroscopy Methods 0.000 claims 1
- 238000000799 fluorescence microscopy Methods 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 229920000729 poly(L-lysine) polymer Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 208000007153 proteostasis deficiencies Diseases 0.000 claims 1
- 238000003118 sandwich ELISA Methods 0.000 claims 1
- 238000004621 scanning probe microscopy Methods 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 102100034004 Gamma-adducin Human genes 0.000 description 2
- 101000799011 Homo sapiens Gamma-adducin Proteins 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 239000012634 fragment Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102011057021A DE102011057021A1 (de) | 2011-12-23 | 2011-12-23 | Verfahren zur selektiven Quantifizierung von A-Beta-Aggregaten |
| DE102011057021.7 | 2011-12-23 | ||
| PCT/EP2012/076552 WO2013092952A2 (de) | 2011-12-23 | 2012-12-21 | Verfahren zur selektiven quantifizierung von a-beta-aggregaten |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018189249A Division JP6625709B2 (ja) | 2011-12-23 | 2018-10-04 | Ａβ凝集体の選択的定量化方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015502551A JP2015502551A (ja) | 2015-01-22 |
| JP2015502551A5 true JP2015502551A5 (https=) | 2017-03-02 |
Family
ID=47624003
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014548051A Pending JP2015502551A (ja) | 2011-12-23 | 2012-12-21 | Ａβ凝集体の選択的定量化方法 |
| JP2018189249A Expired - Fee Related JP6625709B2 (ja) | 2011-12-23 | 2018-10-04 | Ａβ凝集体の選択的定量化方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018189249A Expired - Fee Related JP6625709B2 (ja) | 2011-12-23 | 2018-10-04 | Ａβ凝集体の選択的定量化方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20150024512A1 (https=) |
| EP (1) | EP2794655B1 (https=) |
| JP (2) | JP2015502551A (https=) |
| CN (1) | CN104080807A (https=) |
| BR (1) | BR112014015392A2 (https=) |
| CA (1) | CA2858125A1 (https=) |
| DE (1) | DE102011057021A1 (https=) |
| DK (1) | DK2794655T3 (https=) |
| ES (1) | ES2922201T3 (https=) |
| IL (1) | IL232870B (https=) |
| RU (1) | RU2642314C2 (https=) |
| WO (1) | WO2013092952A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102013106713A1 (de) | 2013-06-26 | 2014-12-31 | Forschungszentrum Jülich GmbH | Verfahren zur Ermittlung von Indikatoren zur Bestimmung von Krankheiten |
| EP3180465B1 (en) * | 2014-09-16 | 2020-04-08 | SRI International | Libraries of non-natural, dihydroisoquinolinone-based polymers for high-throughput drug screening through fiber-optic array scanning technology |
| DE102015003404B4 (de) * | 2015-03-18 | 2021-10-07 | Forschungszentrum Jülich GmbH | Verfahren zur Herstellung eines Standards für den Nachweis von Proteinaggregaten einer Proteinfehlfaltungserkrankung sowie Standard und dessen Verwendung |
| WO2017138497A1 (ja) * | 2016-02-08 | 2017-08-17 | シスメックス株式会社 | 被検物質の検出方法および被検物質の検出用試薬キット |
| JP6886854B2 (ja) * | 2017-04-13 | 2021-06-16 | シスメックス株式会社 | 被検物質の情報取得方法 |
| DE102017005543A1 (de) * | 2017-06-13 | 2018-12-13 | Forschungszentrum Jülich GmbH | Verfahren zum Nachweis von Extrazellulären Vesikeln in einer Probe |
| DE102017010455A1 (de) * | 2017-06-13 | 2018-12-13 | Forschungszentrum Jülich GmbH | Verfahren zum Nachweis von Aggregaten biotherapeutischer Substanzen in einer Probe |
| DE102017010842A1 (de) * | 2017-11-23 | 2019-05-23 | Forschungszentrum Jülich GmbH | Verfahren zur Quantifizierung von Proteinaggregaten einer Proteinfehlfaltungserkrankung in einer Probe |
| ES2955992T3 (es) * | 2017-12-19 | 2023-12-11 | Chase Therapeutics Corp | Método para evaluar una sinucleinopatía |
| CN111518206B (zh) | 2019-02-01 | 2022-03-29 | 长春金赛药业有限责任公司 | 人源化抗Aβ单克隆抗体及其应用 |
| DE102020114278A1 (de) | 2020-05-28 | 2021-12-02 | Forschungszentrum Jülich GmbH | Bestimmung krankheitsspezifischer Protein-Aggregate in Stuhlproben |
| DE102020003794A1 (de) * | 2020-06-25 | 2021-12-30 | Forschungszentrum Jülich GmbH | Verfahren, Verwendung des Verfahrens sowle Kit zum Nachweis von Bioindikatoren in einer Probe |
| CN116879540B (zh) * | 2023-07-13 | 2024-04-05 | 香港中文大学（深圳） | 一种神经元蛋白聚集体特异性检测试剂盒 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE462454B (sv) * | 1988-11-10 | 1990-06-25 | Pharmacia Ab | Maetyta foer anvaendning i biosensorer |
| US7427392B1 (en) * | 1994-11-14 | 2008-09-23 | Elan Pharmaceuticals, Inc. | Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau |
| WO2005018424A2 (en) * | 2003-08-18 | 2005-03-03 | Research Foundation For Mental Hygiene, Inc. | Antibodies specific for fibrillar amyloid and a procedure to detect fibrillar amyloid deposits |
| US7258990B2 (en) * | 2004-08-19 | 2007-08-21 | Biocept, Inc. | Alleviation of non-specific binding in microarray assays |
| RU2432362C2 (ru) * | 2005-11-30 | 2011-10-27 | Эбботт Лэборетриз | Моноклональные антитела и их применения |
| EA014531B1 (ru) * | 2006-02-24 | 2010-12-30 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Антиамилоидные иммуногенные композиции, способы и применения |
| WO2008070229A2 (en) * | 2006-08-28 | 2008-06-12 | Case Western Reserve University | Detection of pathogenic aggregates of protein in a sample by homologous elisa |
| JPWO2009051220A1 (ja) * | 2007-10-19 | 2011-03-03 | イムナス・ファーマ株式会社 | Ａβオリゴマーに特異的に結合する抗体およびその利用 |
| CN102089659A (zh) * | 2008-05-08 | 2011-06-08 | 武田药品工业株式会社 | Aβ寡聚物的测定方法 |
| WO2010074083A1 (ja) * | 2008-12-24 | 2010-07-01 | コニカミノルタホールディングス株式会社 | 表面プラズモンおよび蛍光共鳴エネルギー転移を利用した免疫アッセイ |
| US8512677B2 (en) * | 2009-04-27 | 2013-08-20 | Case Western Reserve University | Pyro-glutamate Aβ targeting agents |
| KR20130043088A (ko) * | 2010-02-09 | 2013-04-29 | 브리스톨-마이어스 스큅 컴퍼니 | 면역검정 표준물 및 검정내 보정 표준물을 사용한 임상 바이오마커의 측정 |
-
2011
- 2011-12-23 DE DE102011057021A patent/DE102011057021A1/de not_active Ceased
-
2012
- 2012-12-21 JP JP2014548051A patent/JP2015502551A/ja active Pending
- 2012-12-21 ES ES12818996T patent/ES2922201T3/es active Active
- 2012-12-21 BR BR112014015392A patent/BR112014015392A2/pt not_active IP Right Cessation
- 2012-12-21 CA CA2858125A patent/CA2858125A1/en not_active Abandoned
- 2012-12-21 WO PCT/EP2012/076552 patent/WO2013092952A2/de not_active Ceased
- 2012-12-21 US US14/366,952 patent/US20150024512A1/en not_active Abandoned
- 2012-12-21 EP EP12818996.6A patent/EP2794655B1/de active Active
- 2012-12-21 RU RU2014130136A patent/RU2642314C2/ru not_active IP Right Cessation
- 2012-12-21 CN CN201280064163.5A patent/CN104080807A/zh active Pending
- 2012-12-21 DK DK12818996.6T patent/DK2794655T3/da active
-
2014
- 2014-05-29 IL IL232870A patent/IL232870B/en active IP Right Grant
-
2018
- 2018-10-04 JP JP2018189249A patent/JP6625709B2/ja not_active Expired - Fee Related
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