RU2632191C2 - Аналог оксистерола oxy133 индуцирует остеогенез и сигнальный путь hedgehog и ингибирует липогенез - Google Patents
Аналог оксистерола oxy133 индуцирует остеогенез и сигнальный путь hedgehog и ингибирует липогенез Download PDFInfo
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| US20210338431A1 (en) * | 2015-07-10 | 2021-11-04 | Warsaw Orthopedic, Inc. | Compression resistant implants including an oxysterol and methods of use |
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| US9532994B2 (en) | 2003-08-29 | 2017-01-03 | The Regents Of The University Of California | Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins |
| WO2007098281A2 (en) | 2006-02-27 | 2007-08-30 | Regents Of The University Of California | Oxysterol compounds and the hedgehog pathway |
| JP2011505357A (ja) | 2007-12-03 | 2011-02-24 | ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア | ヘッジホッグシグナル伝達、骨誘導、抗脂肪生成、及びｗｎｔシグナル伝達を活性するためのオキシステロール |
| CN104395331B (zh) | 2012-05-07 | 2016-11-02 | 加利福尼亚大学董事会 | 诱导骨生成和hedgehog 信号传导且抑制脂肪形成的氧固醇类似物氧固醇化合物133 |
| US9683009B2 (en) | 2013-05-02 | 2017-06-20 | The Regents Of The University Of California | Bone-selective osteogenic oxysterol-bone targeting agents |
| CA2945404A1 (en) * | 2014-05-02 | 2015-11-05 | The Regents Of The University Of California | Bone-selective osteogenic oxysterol bisphosphonate analogs |
| US9657052B2 (en) | 2014-12-09 | 2017-05-23 | Warsaw Orthopedic, Inc. | Compounds and methods of making sterols using diols |
| US20180133211A1 (en) * | 2015-05-19 | 2018-05-17 | Mayo Foundation For Medical Education And Research | Methods and materials for promoting bone formation |
| US9987289B2 (en) | 2015-07-10 | 2018-06-05 | Warsaw Orthopedic, Inc. | Slow release oxysterols and methods of use |
| CN107683130B (zh) * | 2015-06-17 | 2022-03-04 | 华沙整形外科股份有限公司 | 包括氧固醇的植入物和使用方法 |
| US9878070B2 (en) * | 2015-06-17 | 2018-01-30 | Warsaw Orthopedic, Inc. | Malleable implants including an oxysterol and methods of use |
| US10632230B2 (en) * | 2015-07-10 | 2020-04-28 | Warsaw Orthopedic, Inc. | Implants having a high drug load of an oxysterol and methods of use |
| US12171909B2 (en) | 2015-07-10 | 2024-12-24 | Warsaw Orthopedic, Inc. | Implants having a drug load of an oxysterol and methods of use |
| US9637514B1 (en) | 2015-10-26 | 2017-05-02 | MAX BioPharma, Inc. | Oxysterols and hedgehog signaling |
| AU2016347052B2 (en) * | 2015-10-27 | 2021-03-25 | Warsaw Orthopedic, Inc. | Implants having a drug load of an oxysterol and methods of use |
| US11090411B2 (en) | 2016-01-28 | 2021-08-17 | Warsaw Orthopedic, Inc. | Electron beam irradiated osteoinductive bone implant |
| US20170275330A1 (en) * | 2016-03-28 | 2017-09-28 | Warsaw Orthopedic, Inc. | Polymorphic forms of an oxysterol and methods of making them |
| US9987290B2 (en) | 2016-03-28 | 2018-06-05 | Warsaw Orthopedic, Inc. | Methods for the separation and detection of an oxysterol |
| CN105924493A (zh) * | 2016-04-23 | 2016-09-07 | 何华琼 | 盐酸布桂嗪的药物组合物及其在生物医药中的应用 |
| US10688222B2 (en) * | 2016-11-21 | 2020-06-23 | Warsaw Orthopedic, Inc. | Lyophilized moldable implants containing an oxysterol |
| US11384114B2 (en) * | 2016-12-09 | 2022-07-12 | Warsaw Orthopedic, Inc. | Polymorphic forms of an oxysterol and methods of making them |
| US10294264B2 (en) | 2017-04-21 | 2019-05-21 | Warsaw Orthopedic, Inc. | Oxysterol-therapeutic agent derivative for bone healing |
| US10434106B2 (en) | 2017-05-19 | 2019-10-08 | Warsaw Orthopedic, Inc. | Oxysterol-statin compounds for bone growth |
| US11464888B2 (en) | 2017-06-12 | 2022-10-11 | Warsaw Orthopedic, Inc. | Moldable formulations containing an oxysterol in an acellular tissue matrix |
| WO2019048898A1 (en) | 2017-09-05 | 2019-03-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ENDOTHELIAL DYSFUNCTION |
| KR102283508B1 (ko) * | 2020-04-17 | 2021-07-29 | 가톨릭대학교 산학협력단 | 골형성 단백질-2를 유효성분으로 포함하는 줄기세포 스페로이드의 골분화 촉진용 조성물 |
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| RU2006103797A (ru) * | 2003-07-09 | 2006-07-27 | Форбз Меди-Тек Инк. (Ca) | Новые соединения и композиции, содержащие стерины и/или станолы и ингибиторы биосинтеза холестерина, и их применение для лечения или предупреждения различных заболеваний и состояний |
| WO2007098281A2 (en) * | 2006-02-27 | 2007-08-30 | Regents Of The University Of California | Oxysterol compounds and the hedgehog pathway |
| WO2009073186A1 (en) * | 2007-12-03 | 2009-06-11 | The Regents Of The University Of California | Oxsterols for activation of hedgehog signaling, osteoinduction, antiadipogenesis, and wnt signaling |
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| GB869007A (en) | 1956-10-03 | 1961-05-25 | Ciba Ltd | New heterocyclically substituted steroids |
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| US12171665B2 (en) * | 2015-07-10 | 2024-12-24 | Warsaw Orthopedic, Inc. | Compression resistant implants including an oxysterol and methods of use |
Also Published As
| Publication number | Publication date |
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| RU2014149164A (ru) | 2016-07-10 |
| AU2013260059B2 (en) | 2017-05-18 |
| HK1207649A1 (en) | 2016-02-05 |
| CN104395331B (zh) | 2016-11-02 |
| EP2847206A4 (en) | 2016-01-20 |
| CN104395331A (zh) | 2015-03-04 |
| US20150118277A1 (en) | 2015-04-30 |
| JP6262723B2 (ja) | 2018-01-17 |
| AU2013260059A1 (en) | 2014-11-27 |
| WO2013169399A1 (en) | 2013-11-14 |
| EP2847206A1 (en) | 2015-03-18 |
| US9717742B2 (en) | 2017-08-01 |
| KR20150013232A (ko) | 2015-02-04 |
| IN2014DN09805A (OSRAM) | 2015-07-31 |
| CA2872751A1 (en) | 2013-11-14 |
| JP2015518493A (ja) | 2015-07-02 |
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