RU2591823C2 - Новые способы направленного воздействия на раковые стволовые клетки - Google Patents

Новые способы направленного воздействия на раковые стволовые клетки Download PDF

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RU2591823C2
RU2591823C2 RU2012144420/15A RU2012144420A RU2591823C2 RU 2591823 C2 RU2591823 C2 RU 2591823C2 RU 2012144420/15 A RU2012144420/15 A RU 2012144420/15A RU 2012144420 A RU2012144420 A RU 2012144420A RU 2591823 C2 RU2591823 C2 RU 2591823C2
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compound
polymorph
degrees
cancer
peak
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RU2012144420/15A
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Russian (ru)
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RU2012144420A (ru
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Чиан Цзя ЛИ
Дэвид ЛЕДЖЕТТ
Ючжи ЛИ
Вэй Ли
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Бостон Байомедикал, Инк.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
RU2012144420/15A 2010-03-19 2011-03-21 Новые способы направленного воздействия на раковые стволовые клетки RU2591823C2 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US31589010P 2010-03-19 2010-03-19
US31588610P 2010-03-19 2010-03-19
US61/315,890 2010-03-19
US61/315,886 2010-03-19
US32581410P 2010-04-19 2010-04-19
US61/325,814 2010-04-19
PCT/US2011/029283 WO2011116399A1 (en) 2010-03-19 2011-03-21 Novel methods for targeting cancer stem cells

Related Child Applications (1)

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RU2016123004A Division RU2657750C1 (ru) 2010-03-19 2011-03-21 Новые способы направленного воздействия на раковые стволовые клетки

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RU2012144420A RU2012144420A (ru) 2014-04-27
RU2591823C2 true RU2591823C2 (ru) 2016-07-20

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US (2) US9730909B2 (enExample)
EP (1) EP2547205B1 (enExample)
JP (1) JP2013522326A (enExample)
CN (1) CN103025159A (enExample)
AU (1) AU2011227023B2 (enExample)
BR (1) BR112012023660B8 (enExample)
CA (2) CA2946890A1 (enExample)
DK (1) DK2547205T3 (enExample)
ES (1) ES2987670T3 (enExample)
FI (1) FI2547205T3 (enExample)
HR (1) HRP20240658T1 (enExample)
LT (1) LT2547205T (enExample)
PL (1) PL2547205T3 (enExample)
RS (1) RS65536B1 (enExample)
RU (1) RU2591823C2 (enExample)
SI (1) SI2547205T1 (enExample)
SM (1) SMT202400193T1 (enExample)
WO (1) WO2011116399A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105963289B (zh) 2007-09-10 2021-02-26 北京强新生物科技有限公司 一类stat3通路抑制剂和癌干细胞通路抑制剂
HUE066482T2 (hu) * 2010-03-19 2024-08-28 1Globe Biomedical Co Ltd Új eljárások rákõssejtek megcélzására
CN106211758B (zh) * 2013-04-09 2021-03-23 北京强新生物科技有限公司 2-乙酰基萘并[2,3-b]呋喃-4,9-二酮用于治疗癌症的用途
CN106163284A (zh) 2014-02-07 2016-11-23 北京强新生物科技有限公司 3‑取代的羰基萘并[2,3‑b]呋喃衍生物或其药学上可接受的盐
CA2951627A1 (en) 2014-06-09 2015-12-17 Kyoto Pharmaceutical Industries, Ltd. Naphthofuran derivatives as anticancer agent
EA201792288A1 (ru) 2015-04-17 2018-02-28 Бостон Биомедикал, Инк. Способы лечения рака
WO2016168856A1 (en) 2015-04-17 2016-10-20 Boston Biomedical, Inc. Methods for treating cancer
TW201717935A (zh) * 2015-06-03 2017-06-01 波士頓生醫公司 用於治療癌症的組成物和方法
EP3310786B1 (en) 2015-06-16 2021-03-03 Nanophagix LLC Drug delivery and imaging chemical conjugate, formulations and methods of use thereof
WO2017013270A1 (en) 2015-07-23 2017-01-26 Universite De Strasbourg Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy
US20190076392A1 (en) 2016-01-20 2019-03-14 Boston Biomedical, Inc. Methods for treating cancer
JP2019519573A (ja) 2016-06-28 2019-07-11 ボストン バイオメディカル, インコーポレイテッド がんを処置するための方法
WO2018098352A2 (en) 2016-11-22 2018-05-31 Jun Oishi Targeting kras induced immune checkpoint expression
US11299469B2 (en) 2016-11-29 2022-04-12 Sumitomo Dainippon Pharma Oncology, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
JP2020520923A (ja) 2017-05-17 2020-07-16 ボストン バイオメディカル, インコーポレイテッド がんを処置するための方法
US10953369B2 (en) * 2018-03-08 2021-03-23 Georgia Tech Research Corporation Spirocentric compounds and polymers thereof
AU2019357933B2 (en) 2018-10-12 2023-11-23 1Globe Biomedical Co., Ltd. New combination solution for treating chemotherapy refractory cancer
CN111825644B (zh) * 2019-04-18 2023-07-28 中国医学科学院药物研究所 2,3-二氢萘并[2,3-b]呋喃-4,9-二酮类化合物及其制备方法和用途
CN117350965A (zh) * 2023-10-07 2024-01-05 中国原子能科学研究院 对象内放射性微球的指标预估装置

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009036099A1 (en) * 2007-09-10 2009-03-19 Boston Biomedical, Inc. A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors
RU2350606C2 (ru) * 2002-11-15 2009-03-27 Вертекс Фармасьютикалз Инкорпорейтед Диаминотриазолы, пригодные в качестве ингибиторов протеинкиназ

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0402192A1 (fr) 1989-05-31 1990-12-12 BODET, Jean Augustin Article en carton ou matière analogue et procédé de fabrication
JPH04139177A (ja) 1989-12-28 1992-05-13 Dainippon Ink & Chem Inc フラルベンゾキノン誘導体及びその製造方法並びに制癌剤
JPH1121284A (ja) 1997-06-30 1999-01-26 Kotobuki:Kk フラノナフトキノン誘導体及びこれを含有する医薬
US6174913B1 (en) 1998-06-05 2001-01-16 The University Of North Carolina At Chapel Hill Naphtho- and dihydrobenzo-thiophene derivatives as cytotoxic antitumor agents
JP2003525862A (ja) 1999-01-27 2003-09-02 ザ ユニヴァーシティー オブ サウス フロリダ ヒト癌の治療のためのstat3シグナル伝達の阻害
US6482943B1 (en) 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
DK1206436T3 (da) 1999-08-02 2005-02-14 Hoffmann La Roche Retinoider til behandling af emfysem
JP2001097860A (ja) 1999-09-29 2001-04-10 Japan Science & Technology Corp 抗薬剤耐性菌剤と抗クラミジア剤
UA75055C2 (uk) 1999-11-30 2006-03-15 Пфайзер Продактс Інк. Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі
AU2002307217A1 (en) 2001-03-28 2002-10-15 University Of South Florida Materials and methods for treatment of cancer and identification of anti-cancer compounds
GB0117696D0 (en) * 2001-07-20 2001-09-12 Bradford Particle Design Plc Particle information
WO2003045357A1 (en) 2001-11-27 2003-06-05 Transform Pharmaceuticals, Inc. Oral pharmaceutical formulations comprising paclitaxel, derivatives and methods of administration thereof
US20030139466A1 (en) 2001-11-29 2003-07-24 Peritt David L. Methods for pretreating a subject with extracorporeal photopheresis
US7462596B2 (en) 2002-03-15 2008-12-09 Natimmune A/S Pharmaceutical compositions comprising mannose binding lectin
WO2004026253A2 (en) 2002-09-17 2004-04-01 Arqule, Inc. Novel lapacho compounds and methods of use thereof
IS6633A (is) 2002-11-22 2004-05-23 Omega Farma Ehf. Samsetningar af fínasteríð töflum
US20060019256A1 (en) 2003-06-09 2006-01-26 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US20050049207A1 (en) 2003-09-03 2005-03-03 Kaufmann Doug A. Method of treating and preventing cancer
WO2005033048A2 (en) 2003-09-29 2005-04-14 The Johns Hopkins University Wnt pathway antagonists
CN102603565A (zh) 2003-12-11 2012-07-25 得克萨斯州大学系统董事会 治疗细胞增殖疾病的化合物
CA2563305A1 (en) 2004-04-09 2005-11-24 University Of South Florida Combination therapies for cancer and proliferative angiopathies
JP2004224802A (ja) 2004-04-21 2004-08-12 Japan Science & Technology Agency 抗菌剤
KR20070085433A (ko) 2004-11-24 2007-08-27 노파르티스 아게 Jak 저해제들과 bcr-abl, flt-3, fak 또는raf 키나제 저해제들 중 하나 이상의 조합물
WO2006091837A2 (en) 2005-02-25 2006-08-31 The Regent Of The University Of Michigan Small molecule inhibitors of stat3 and the uses thereof
JP2006248978A (ja) 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
CN101142202A (zh) * 2005-03-16 2008-03-12 太日保日本株式会社 抗癌化合物及其中间体和生产方法
JP2006290871A (ja) 2005-03-16 2006-10-26 Taheebo Japan Kk 抗癌性を示す化合物およびその中間体ならびにそれらの製造方法
US20060252073A1 (en) 2005-04-18 2006-11-09 Regents Of The University Of Michigan Compositions and methods for the treatment of cancer
US20070243192A1 (en) 2006-02-21 2007-10-18 Regents Of The University Of Michigan Growth hormone receptor antagonist cancer treatment
ES2533383T3 (es) 2006-03-31 2015-04-09 The Board Of Regents Of The University Of Texas System Fármacos anticancerosos biodisponibles por vía oral relacionados con ácido cafeico
US20070238770A1 (en) 2006-04-05 2007-10-11 Bristol-Myers Squibb Company Process for preparing novel crystalline forms of peliglitazar, novel stable forms produced therein and formulations
WO2008094321A2 (en) 2006-10-04 2008-08-07 Universtiy Of South Florida Akt sensitization of cancer cells
JP4077863B1 (ja) 2007-05-31 2008-04-23 タヒボジャパン株式会社 抗癌活性を有する光学活性2−(1−ヒドロキシエチル)−5−ヒドロキシナフト[2,3−b]フラン−4,9−ジオンの製法
WO2009060282A2 (en) 2007-11-06 2009-05-14 Orchid Research Laboratories Limited Stilbene derivatives as pstat3/il-6 inhibitors
HUE066482T2 (hu) * 2010-03-19 2024-08-28 1Globe Biomedical Co Ltd Új eljárások rákõssejtek megcélzására

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2350606C2 (ru) * 2002-11-15 2009-03-27 Вертекс Фармасьютикалз Инкорпорейтед Диаминотриазолы, пригодные в качестве ингибиторов протеинкиназ
WO2009036099A1 (en) * 2007-09-10 2009-03-19 Boston Biomedical, Inc. A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PINZON-GUZMAN C. et al. "Protein kinase C regulates rod photoreceptor differentiation through modulation of STAT3 signaling." Adv Exp Med Biol. 2010;664:21-8. doi: 10.1007/978-1-4419-1399-9_3, реферат, [найдено 13.03.2015], найдено из PubMed PMID:20237998. LING X et al. "Mesenchymal Stem Cells Overexpressing IFN-β? Inhibit Breast Cancer Growth and Metastases through Stat3 Signaling in a Syngeneic Tumor Model". Cancer Microenviron. 2010 Mar 19;3(1):83-95. doi: 10.1007/s12307-010-0041-8. реферат, [найдено 13.03.2015], найдено из PubMed PMID:21209776. *

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SMT202400193T1 (it) 2024-07-09
EP2547205B1 (en) 2024-03-20
HRP20240658T1 (hr) 2024-08-16
EP2547205A4 (en) 2013-08-14
JP2013522326A (ja) 2013-06-13
US9730909B2 (en) 2017-08-15
AU2011227023A1 (en) 2012-09-27
BR112012023660B1 (pt) 2021-05-18
AU2011227023B2 (en) 2015-05-28
LT2547205T (lt) 2024-06-10
CA2946890A1 (en) 2011-09-22
ES2987670T3 (es) 2024-11-15
RU2012144420A (ru) 2014-04-27
EP2547205A1 (en) 2013-01-23
DK2547205T3 (da) 2024-05-27
BR112012023660A2 (pt) 2015-09-15
BR112012023660B8 (pt) 2021-05-25
CN103025159A (zh) 2013-04-03
RS65536B1 (sr) 2024-06-28
FI2547205T3 (fi) 2024-05-27
US20130028944A1 (en) 2013-01-31
CA2793527A1 (en) 2011-09-22
US20170319537A1 (en) 2017-11-09
WO2011116399A1 (en) 2011-09-22
PL2547205T3 (pl) 2024-07-08
SI2547205T1 (sl) 2024-08-30

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