RU2571223C2 - Вирусоподобные частицы, содержащие белки-мишени, слитые с белками оболочки растительных вирусов - Google Patents

Вирусоподобные частицы, содержащие белки-мишени, слитые с белками оболочки растительных вирусов Download PDF

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RU2571223C2
RU2571223C2 RU2012114483/10A RU2012114483A RU2571223C2 RU 2571223 C2 RU2571223 C2 RU 2571223C2 RU 2012114483/10 A RU2012114483/10 A RU 2012114483/10A RU 2012114483 A RU2012114483 A RU 2012114483A RU 2571223 C2 RU2571223 C2 RU 2571223C2
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virus
protein
particle
plant
target protein
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RU2012114483/10A
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Russian (ru)
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RU2012114483A (ru
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Вайдеди ЮСИБОВ
Кристина Е. ФЭРРЕНС
Константин А. МАСЮЧУК
Вадим МЕТТ
Валентина МЕТТ
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Фронхофер Юэсэй Инк.
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
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    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
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    • A61K2039/6075—Viral proteins
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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  • Proteomics, Peptides & Aminoacids (AREA)
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RU2012114483/10A 2009-09-18 2010-09-16 Вирусоподобные частицы, содержащие белки-мишени, слитые с белками оболочки растительных вирусов RU2571223C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US24377409P 2009-09-18 2009-09-18
US61/243,774 2009-09-18
US34806910P 2010-05-25 2010-05-25
US61/348,069 2010-05-25
PCT/US2010/049089 WO2011035004A1 (en) 2009-09-18 2010-09-16 Virus like particles comprising target proteins fused to plant viral coat proteins

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RU2012114483A RU2012114483A (ru) 2013-10-27
RU2571223C2 true RU2571223C2 (ru) 2015-12-20

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RU2012114483/10A RU2571223C2 (ru) 2009-09-18 2010-09-16 Вирусоподобные частицы, содержащие белки-мишени, слитые с белками оболочки растительных вирусов

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US (1) US20120219579A1 (enExample)
EP (1) EP2477650B8 (enExample)
CN (1) CN102695524B (enExample)
BR (1) BR112012005703A2 (enExample)
CA (1) CA2774640C (enExample)
ES (1) ES2752323T3 (enExample)
IN (1) IN2012DN03209A (enExample)
RU (1) RU2571223C2 (enExample)
WO (1) WO2011035004A1 (enExample)

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* Cited by examiner, † Cited by third party
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MX357202B (es) 2012-02-16 2018-06-28 Vlp Therapeutics Llc Composicion de particula tipo virus.
IN2014DN07152A (enExample) * 2012-03-22 2015-04-24 Fraunhofer Usa Inc
SG11201509614SA (en) 2013-06-03 2015-12-30 Vlp Therapeutics Llc Malaria vaccine
TWI676636B (zh) 2013-07-12 2019-11-11 Vlp醫療股份有限公司 包含pd-1抗原或pd-1配體抗原的類病毒粒子
CN106456805B (zh) 2014-03-03 2020-01-10 阿尔伯特爱因斯坦医学院公司 重组单纯疱疹病毒2(hsv-2)疫苗载体
US10918712B2 (en) 2014-03-03 2021-02-16 Albert Einstein College Of Medicine Passive transfer of immunity using recombinant herpes simplex virus 2 (HSV-2) vaccine vectors
US10385101B2 (en) 2014-08-08 2019-08-20 Vlp Therapeutics, Llc Virus like particle comprising modified envelope protein E3
TWI720946B (zh) 2014-08-08 2021-03-11 美商Vlp醫療股份有限公司 包含改質套膜蛋白質e3之類病毒粒子
CA2960102C (en) 2014-09-11 2023-10-24 Vlp Therapeutics, Llc Flavivirus virus like particle
EP3374504B1 (en) * 2015-11-09 2025-03-19 CureVac SE Optimized nucleic acid molecules
WO2018089814A1 (en) * 2016-11-11 2018-05-17 Fraunhofer Usa, Inc. Covalently fused viral coat proteins for the display of target molecules
CN106986943B (zh) * 2017-02-28 2020-12-25 国药中生生物技术研究院有限公司 一种包含北极地松鼠肝炎病毒核心蛋白的重组融合蛋白及其制备方法和应用
KR102823029B1 (ko) 2017-12-20 2025-06-20 브이엘피 테라퓨틱스 인코포레이티드 알파바이러스 레플리콘 입자
TWI891771B (zh) 2020-04-17 2025-08-01 美商Vlp醫療股份有限公司 冠狀病毒疫苗
MX2022013638A (es) 2020-04-30 2023-01-24 Vlp Therapeutics Inc Inmunoterapia con citocina.

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WO2008089569A1 (en) * 2007-01-26 2008-07-31 Folia Biotech Inc. Papaya mosaic virus-based vaccines against salmonella typhi and other enterobacterial pathogens
RU2011105073A (ru) * 2008-07-11 2012-08-20 Медикаго Инк. (Ca) Вирусоподобные частицы (впч) вируса гриппа, содержащие гемагглютинин

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US5977438A (en) * 1988-02-26 1999-11-02 Biosource Technologies, Inc. Production of peptides in plants as viral coat protein fusions
WO2005086667A2 (en) * 2004-02-27 2005-09-22 The Dow Chemical Company High efficiency peptide production in plant cells
JP2009502789A (ja) * 2005-07-19 2009-01-29 ダウ グローバル テクノロジーズ インコーポレイティド 組み換えインフルエンザワクチン
AU2006351933A1 (en) * 2005-12-02 2008-07-17 Dow Global Technologies Inc. Novel plant virus particles and methods of inactivation thereof
ES2725450T3 (es) * 2007-07-02 2019-09-24 Etubics Corp Métodos y composiciones para la producción de un vector adenoviral para su uso en vacunaciones múltiples

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008089569A1 (en) * 2007-01-26 2008-07-31 Folia Biotech Inc. Papaya mosaic virus-based vaccines against salmonella typhi and other enterobacterial pathogens
RU2011105073A (ru) * 2008-07-11 2012-08-20 Медикаго Инк. (Ca) Вирусоподобные частицы (впч) вируса гриппа, содержащие гемагглютинин

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CN102695524A (zh) 2012-09-26
IN2012DN03209A (enExample) 2015-10-23
BR112012005703A2 (pt) 2020-09-15
WO2011035004A9 (en) 2019-01-24
EP2477650A1 (en) 2012-07-25
WO2011035004A1 (en) 2011-03-24
ES2752323T3 (es) 2020-04-06
CA2774640C (en) 2019-11-26
CN102695524B (zh) 2014-07-09
CA2774640A1 (en) 2011-03-24
US20120219579A1 (en) 2012-08-30
RU2012114483A (ru) 2013-10-27
EP2477650B1 (en) 2019-09-04
EP2477650B8 (en) 2019-10-09

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