CN102695524B - 包含与植物病毒衣壳蛋白融合的靶蛋白的病毒样颗粒 - Google Patents

包含与植物病毒衣壳蛋白融合的靶蛋白的病毒样颗粒 Download PDF

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CN102695524B
CN102695524B CN201080041596.XA CN201080041596A CN102695524B CN 102695524 B CN102695524 B CN 102695524B CN 201080041596 A CN201080041596 A CN 201080041596A CN 102695524 B CN102695524 B CN 102695524B
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virus
particle
protein
target protein
plant
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CN102695524A (zh
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V·玉斯博夫
C·E·法兰斯
K·A·穆斯查克
维迪姆·梅特
维兰帝纳·梅特
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Fraunhofer USA Inc
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CN201080041596.XA 2009-09-18 2010-09-16 包含与植物病毒衣壳蛋白融合的靶蛋白的病毒样颗粒 Expired - Fee Related CN102695524B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US24377409P 2009-09-18 2009-09-18
US61/243,774 2009-09-18
US34806910P 2010-05-25 2010-05-25
US61/348,069 2010-05-25
PCT/US2010/049089 WO2011035004A1 (en) 2009-09-18 2010-09-16 Virus like particles comprising target proteins fused to plant viral coat proteins

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CN102695524A CN102695524A (zh) 2012-09-26
CN102695524B true CN102695524B (zh) 2014-07-09

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IN (1) IN2012DN03209A (enExample)
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Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013221187B9 (en) 2012-02-16 2018-01-04 Vlp Therapeutics, Inc. Virus like particle composition
BR112014019755B1 (pt) * 2012-03-22 2022-02-22 Fraunhofer Usa, Inc Partícula do tipo viral; método de produção das partículas do tipo viral; composição imunogênica e uso das partículas do tipo viral
EP3004348B1 (en) * 2013-06-03 2023-03-08 VLP Therapeutics, Inc. Malaria vaccine
TWI676636B (zh) 2013-07-12 2019-11-11 Ｖｌｐ醫療股份有限公司 包含ｐｄ－１抗原或ｐｄ－１配體抗原的類病毒粒子
US10918712B2 (en) 2014-03-03 2021-02-16 Albert Einstein College Of Medicine Passive transfer of immunity using recombinant herpes simplex virus 2 (HSV-2) vaccine vectors
WO2015134368A2 (en) 2014-03-03 2015-09-11 Albert Einstein College Of Medicine Of Yeshiva University Recombinant herpes simplex virus 2 (hsv-2) vaccine vectors
CN106795513B (zh) 2014-08-08 2021-06-11 Vlp治疗公司 包含修饰的包膜蛋白e3的病毒样颗粒
US10385101B2 (en) 2014-08-08 2019-08-20 Vlp Therapeutics, Llc Virus like particle comprising modified envelope protein E3
CA2960102C (en) 2014-09-11 2023-10-24 Vlp Therapeutics, Llc Flavivirus virus like particle
EP4582098A3 (en) * 2015-11-09 2025-12-24 CureVac SE Optimized nucleic acid molecules
US11078240B2 (en) * 2016-11-11 2021-08-03 Fraunhofer Usa Inc. Covalently fused viral coat proteins for the display of target molecules
CN106986943B (zh) * 2017-02-28 2020-12-25 国药中生生物技术研究院有限公司 一种包含北极地松鼠肝炎病毒核心蛋白的重组融合蛋白及其制备方法和应用
WO2019124441A1 (en) 2017-12-20 2019-06-27 Vlp Therapeutics, Llc Alphavirus replicon particle
EP4135847A4 (en) 2020-04-17 2024-05-15 VLP Therapeutics, Inc. Coronavirus vaccine
CA3174651A1 (en) 2020-04-30 2021-11-04 Vlp Therapeutics, Inc. Cytokine immunotherapy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008085147A3 (en) * 2005-12-02 2008-12-18 Dow Global Technologies Inc Novel plant virus particles and methods of inactivation thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977438A (en) * 1988-02-26 1999-11-02 Biosource Technologies, Inc. Production of peptides in plants as viral coat protein fusions
JP2007528727A (ja) * 2004-02-27 2007-10-18 ザ　ダウ　ケミカル　カンパニー 植物細胞における高効率ペプチド生産
BRPI0613625A2 (pt) * 2005-07-19 2011-01-18 Dow Global Technologies Inc vacinas da gripe recombinantes
CA2676481A1 (en) * 2007-01-26 2008-07-31 Folia Biotech Inc. Papaya mosaic virus-based vaccines against salmonella typhi and other enterobacterial pathogens
EP3061462B1 (en) * 2007-07-02 2019-02-27 Etubics Corporation Methods and compositions for producing an adenovirus vector for use with multiple vaccinations
EA034733B1 (ru) * 2008-01-21 2020-03-13 Медикаго Инк. Нуклеиновая кислота для увеличенной экспрессии гемагглютинина вируса гриппа в растении и ее применение

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008085147A3 (en) * 2005-12-02 2008-12-18 Dow Global Technologies Inc Novel plant virus particles and methods of inactivation thereof

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ES2752323T3 (es) 2020-04-06
EP2477650B1 (en) 2019-09-04
EP2477650B8 (en) 2019-10-09
EP2477650A1 (en) 2012-07-25
CA2774640A1 (en) 2011-03-24
BR112012005703A2 (pt) 2020-09-15
RU2571223C2 (ru) 2015-12-20
RU2012114483A (ru) 2013-10-27
WO2011035004A9 (en) 2019-01-24
CN102695524A (zh) 2012-09-26
CA2774640C (en) 2019-11-26
IN2012DN03209A (enExample) 2015-10-23
WO2011035004A1 (en) 2011-03-24

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