RU2530775C2 - ПРОИЗВОДНЫЕ 1Н-ПИРАЗОЛО[4,3-c]ИЗОХИНОЛИНОВ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ В ТЕРАПИИ - Google Patents

ПРОИЗВОДНЫЕ 1Н-ПИРАЗОЛО[4,3-c]ИЗОХИНОЛИНОВ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ В ТЕРАПИИ Download PDF

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Publication number
RU2530775C2
RU2530775C2 RU2011147658/04A RU2011147658A RU2530775C2 RU 2530775 C2 RU2530775 C2 RU 2530775C2 RU 2011147658/04 A RU2011147658/04 A RU 2011147658/04A RU 2011147658 A RU2011147658 A RU 2011147658A RU 2530775 C2 RU2530775 C2 RU 2530775C2
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RU
Russia
Prior art keywords
group
pyrazolo
difluorophenyl
isoquinoline
piperidin
Prior art date
Application number
RU2011147658/04A
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English (en)
Russian (ru)
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RU2011147658A (ru
Inventor
Жорж ДЕЛЕТТР
Стефани Депре
Франк Алле
Лоран Шио
Фабьенн Томсон
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Санофи
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Publication date
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Publication of RU2011147658A publication Critical patent/RU2011147658A/ru
Application granted granted Critical
Publication of RU2530775C2 publication Critical patent/RU2530775C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RU2011147658/04A 2009-04-24 2010-04-22 ПРОИЗВОДНЫЕ 1Н-ПИРАЗОЛО[4,3-c]ИЗОХИНОЛИНОВ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ В ТЕРАПИИ RU2530775C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0901995A FR2944792B1 (fr) 2009-04-24 2009-04-24 Derives de 1h-pyrazolo[4,3-c]isoquinoleines, leur preparation et leur application en therapeutique
FR0901995 2009-04-24
PCT/FR2010/050773 WO2010122272A1 (fr) 2009-04-24 2010-04-22 DERIVES DE 1-PYRAZOLO[4,3-c]ISOQUINOLEINES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Publications (2)

Publication Number Publication Date
RU2011147658A RU2011147658A (ru) 2013-05-27
RU2530775C2 true RU2530775C2 (ru) 2014-10-10

Family

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Family Applications (1)

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RU2011147658/04A RU2530775C2 (ru) 2009-04-24 2010-04-22 ПРОИЗВОДНЫЕ 1Н-ПИРАЗОЛО[4,3-c]ИЗОХИНОЛИНОВ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ В ТЕРАПИИ

Country Status (25)

Country Link
US (1) US8461175B2 (enExample)
EP (1) EP2421864B1 (enExample)
JP (1) JP5722880B2 (enExample)
KR (1) KR101675609B1 (enExample)
CN (1) CN102459260B (enExample)
AR (1) AR076393A1 (enExample)
AU (1) AU2010240742B2 (enExample)
BR (1) BRPI1013724A2 (enExample)
CA (1) CA2791947A1 (enExample)
CY (1) CY1115678T1 (enExample)
DK (1) DK2421864T3 (enExample)
ES (1) ES2515240T3 (enExample)
FR (1) FR2944792B1 (enExample)
HR (1) HRP20141058T1 (enExample)
IL (1) IL215733A (enExample)
MX (1) MX2011011246A (enExample)
MY (1) MY156362A (enExample)
PL (1) PL2421864T3 (enExample)
PT (1) PT2421864E (enExample)
RU (1) RU2530775C2 (enExample)
SG (1) SG175338A1 (enExample)
SI (1) SI2421864T1 (enExample)
TW (1) TWI468405B (enExample)
UY (1) UY32575A (enExample)
WO (1) WO2010122272A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4506003A1 (en) 2023-08-07 2025-02-12 S.Yu Yunusov Institute of Chemistry of Plant Substances of the Academy of Sciences of the Republic of Uzbekistan Halogen derivatives of (4´,5´- methylenedioxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline for use in the treatment of leukemia

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109020972B (zh) * 2018-10-08 2021-03-09 广东石油化工学院 一种三唑并[1，5-a]喹啉衍生物的制备方法
WO2023039510A1 (en) * 2021-09-10 2023-03-16 The Trustees Of Columbia University In The City Of New York Gpx4 inhibitors and uses thereof
CN116535356A (zh) * 2023-03-06 2023-08-04 中国药科大学 3-氨基-5-苯基-吡唑类衍生物微管蛋白抑制剂及其制备和医药用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2185255A (en) * 1986-01-14 1987-07-15 Roussel Lab Ltd Pyrazolo-isoquinoline compounds
RU98118998A (ru) * 1996-03-20 2000-10-20 Астра Фармасьютикалз Лтд. Фармацевтически применимые соединения

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10229762A1 (de) * 2002-07-03 2004-01-22 Aventis Pharma Deutschland Gmbh Pyrazoloisoquinolinenderivaten zur Inhibierung von NFkappaB-induzierende Kinase
US7132428B2 (en) * 2003-07-03 2006-11-07 Aventis Pharmaceuticals Inc. Pyrazoloisoquinoline derivative as kinase inhibitors for the treatment of various disorders
CA2531291A1 (en) * 2003-07-03 2005-02-10 Aventis Pharmaceuticals Inc. Pyrazoloisoquinoline derivatives as kinase inhibitors
AU2004259012C1 (en) * 2003-07-23 2012-08-02 Exelixis, Inc. Anaplastic lymphoma kinase modulators and methods of use
AR058223A1 (es) * 2005-11-25 2008-01-23 Palau Pharma Sa Un comuesto de derivados de pirazoloisoquinolina, un procedimiento para l a preparacion de dicho compuesto y una composicion farmaceutica que comprende dicho compuesto

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2185255A (en) * 1986-01-14 1987-07-15 Roussel Lab Ltd Pyrazolo-isoquinoline compounds
RU98118998A (ru) * 1996-03-20 2000-10-20 Астра Фармасьютикалз Лтд. Фармацевтически применимые соединения

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4506003A1 (en) 2023-08-07 2025-02-12 S.Yu Yunusov Institute of Chemistry of Plant Substances of the Academy of Sciences of the Republic of Uzbekistan Halogen derivatives of (4´,5´- methylenedioxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline for use in the treatment of leukemia

Also Published As

Publication number Publication date
UY32575A (es) 2010-11-30
JP5722880B2 (ja) 2015-05-27
TWI468405B (zh) 2015-01-11
BRPI1013724A2 (pt) 2016-04-05
IL215733A0 (en) 2012-01-31
MX2011011246A (es) 2012-02-13
HK1170736A1 (en) 2013-03-08
WO2010122272A1 (fr) 2010-10-28
TW201041887A (en) 2010-12-01
DK2421864T3 (da) 2014-11-10
FR2944792A1 (fr) 2010-10-29
PT2421864E (pt) 2014-10-07
CN102459260A (zh) 2012-05-16
PL2421864T3 (pl) 2014-12-31
SG175338A1 (en) 2011-11-28
FR2944792B1 (fr) 2011-05-20
EP2421864B1 (fr) 2014-08-06
ES2515240T3 (es) 2014-10-29
RU2011147658A (ru) 2013-05-27
HK1167387A1 (en) 2012-11-30
IL215733A (en) 2014-02-27
EP2421864A1 (fr) 2012-02-29
JP2012524766A (ja) 2012-10-18
KR101675609B1 (ko) 2016-11-11
AR076393A1 (es) 2011-06-08
US8461175B2 (en) 2013-06-11
AU2010240742A1 (en) 2011-11-17
SI2421864T1 (sl) 2014-11-28
HRP20141058T1 (hr) 2014-12-19
MY156362A (en) 2016-02-15
KR20120007060A (ko) 2012-01-19
CY1115678T1 (el) 2017-01-25
CN102459260B (zh) 2015-06-10
CA2791947A1 (fr) 2010-10-28
AU2010240742B2 (en) 2015-11-19
US20120115898A1 (en) 2012-05-10

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Effective date: 20180423