RU2512933C2 - Способ лечения хронической сердечной недостаточности - Google Patents
Способ лечения хронической сердечной недостаточности Download PDFInfo
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- RU2512933C2 RU2512933C2 RU2010151470/14A RU2010151470A RU2512933C2 RU 2512933 C2 RU2512933 C2 RU 2512933C2 RU 2010151470/14 A RU2010151470/14 A RU 2010151470/14A RU 2010151470 A RU2010151470 A RU 2010151470A RU 2512933 C2 RU2512933 C2 RU 2512933C2
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- relaxin
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- A—HUMAN NECESSITIES
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| PCT/US2009/044247 WO2009140657A2 (en) | 2008-05-16 | 2009-05-15 | Method of treating chronic heart failure |
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| RU2010151470A RU2010151470A (ru) | 2012-06-27 |
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| CN102036679A (zh) | 2008-05-16 | 2011-04-27 | 科尔泰拉公司 | 用松弛素治疗与急性心力衰竭相关的呼吸困难 |
| BR112012022654A2 (pt) * | 2010-03-10 | 2016-11-01 | Univ Florida | modulação de aquaporinas com relaxina |
| WO2012072681A1 (en) * | 2010-12-01 | 2012-06-07 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Diagnostic and treatment of chronic heart failure |
| JP2014529293A (ja) * | 2011-07-08 | 2014-11-06 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | レラキシンを放出する融合タンパク質およびその使用 |
| JP6276690B2 (ja) * | 2011-08-04 | 2018-02-07 | ファリス バイオテック ゲーエムベーハー | ヒトリラキシン−２を調製する方法 |
| US10493131B2 (en) | 2011-08-31 | 2019-12-03 | University Of Florida Research Foundation, Incorporated | Materials and methods for modulating activity of bone marrow derived cells |
| US20140364334A1 (en) * | 2011-12-21 | 2014-12-11 | Nuclea Biotechnologies, Inc. | Congestive heart failure biomarkers |
| CN108310396B (zh) | 2012-02-14 | 2022-07-15 | 加利福尼亚大学董事会 | 用于心血管疾病和其它病况的旁分泌基因的全身性递送和受调节的表达 |
| US20140213520A1 (en) * | 2013-01-25 | 2014-07-31 | Cardiorentis Ltd. | Methods of treating cardiovascular indications |
| MX2016005545A (es) * | 2013-11-07 | 2016-10-03 | Shanghai hengrui pharmaceutical co ltd | Analogo de la relaxina humana, composicion farmaceutica del mismo y aplicacion farmaceutica del mismo. |
| US10500227B2 (en) * | 2014-12-03 | 2019-12-10 | University Of Cincinnati | Bioactive gas-encapsulated echogenic liposomes and methods for treating cardiovascular disease |
| WO2017100540A2 (en) | 2015-12-09 | 2017-06-15 | The California Institute For Biomedical Research | Relaxin immunoglobulin fusion proteins and methods of use |
| CN110637027B (zh) | 2017-02-08 | 2024-08-30 | 百时美施贵宝公司 | 包含药代动力学增强子的修饰的松弛素多肽及其用途 |
| CN107335051A (zh) * | 2017-08-18 | 2017-11-10 | 温州医科大学附属第医院 | 一种保护慢性心衰肾功能的药物组合物 |
| US20220008508A1 (en) * | 2018-11-20 | 2022-01-13 | Universität Heidelberg | Relaxin receptor 1 for use in treatment and prevention of heart failure |
| AU2020382102B2 (en) | 2019-11-16 | 2026-02-26 | Relaxera Pharmazeutische Gmbh & Co. Kg | Medical composition for treating cardiac wasting and cachexia |
| CN116406297A (zh) * | 2020-08-05 | 2023-07-07 | 阿斯克肋匹奥生物制药公司 | 治疗心脏疾患和充血性心力衰竭以及施用aav载体的方法 |
| RU2748529C1 (ru) * | 2020-09-01 | 2021-05-26 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр кардиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ кардиологии" Минздрава России) | Способ определения этиологии хронической сердечной недостаточности |
| TW202438534A (zh) * | 2022-12-09 | 2024-10-01 | 瑞典商阿斯特捷利康公司 | 使用異二聚物鬆弛素融合體的給藥方案 |
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| RU2213559C2 (ru) * | 2000-01-26 | 2003-10-10 | Тюменская государственная медицинская академия | Способ лечения больных хронической сердечной недостаточностью на фоне ишемической болезни сердца |
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| US5023321A (en) | 1982-12-13 | 1991-06-11 | Howard Florey Institute Of Experimental Physiology & Medicine | Molecular cloning and characterization of a further gene sequence coding for human relaxin |
| US5166191A (en) * | 1991-08-19 | 1992-11-24 | Genentech, Inc. | Use of relaxin in cardiovascular therapy |
| EP0707650B1 (en) | 1993-06-21 | 2003-05-21 | Genentech, Inc. | Process for producing human relaxin |
| US5811395A (en) | 1995-06-07 | 1998-09-22 | Medical University Of South Carolina | Relaxin analogs and derivatives methods and uses thereof |
| DE10155843A1 (de) * | 2000-11-16 | 2003-01-30 | Immundiagnostik Ag | Verfahren zur Prognose und Diagnose von Herzinsuffizienz |
| US20050113286A1 (en) * | 2002-03-18 | 2005-05-26 | Schreiner George F. | Methods for treating congestive heart failure |
| CN1968717B (zh) * | 2004-03-30 | 2013-08-21 | 延世大学教产学协力团 | 含有松弛素基因的基因送递系统和使用松弛素的药物组合物 |
| US20080077025A1 (en) * | 2005-07-11 | 2008-03-27 | Leticia Delgado-Herrera | Methods for determining how to treat congestive heart failure |
| US8492329B2 (en) | 2007-07-12 | 2013-07-23 | Compugen Ltd. | Bioactive peptides and methods of using same |
| CN102036679A (zh) * | 2008-05-16 | 2011-04-27 | 科尔泰拉公司 | 用松弛素治疗与急性心力衰竭相关的呼吸困难 |
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| RU2213559C2 (ru) * | 2000-01-26 | 2003-10-10 | Тюменская государственная медицинская академия | Способ лечения больных хронической сердечной недостаточностью на фоне ишемической болезни сердца |
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| DSCHIETZIG T, et al. The pregnancy hormone relaxin is a player in human heart failureFASEB J. 2001 Oct;15(12):2187-95. DSCHIETZIG T, et al. Relaxin: a pregnancy hormone as central player of body fluid and circulation homeostasisCell Mol Life Sci. 2003 Apr;60(4):688-700. Кардиология. Национальное руководство. Под ред. Ю.Н.Беленкова и Р.Г.Оганова, М., "ГЭОТАР-Медиа", 2007, с.430,10-16-1041. O,NEIL et al. Recent Advances in the Diagnosis of Heart Failure. Current Cardiology Reports. May 2004, vol.6,No3,pp.205-210 * |
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| EP3150219A1 (en) | 2017-04-05 |
| US20140005112A1 (en) | 2014-01-02 |
| JP2014237648A (ja) | 2014-12-18 |
| JP2011520917A (ja) | 2011-07-21 |
| WO2009140657A3 (en) | 2010-01-07 |
| CN102026649A (zh) | 2011-04-20 |
| EP2288366A2 (en) | 2011-03-02 |
| CA2724535A1 (en) | 2009-11-19 |
| AU2009246112B2 (en) | 2013-05-02 |
| WO2009140657A2 (en) | 2009-11-19 |
| EP2288366A4 (en) | 2012-05-02 |
| CN104815319A (zh) | 2015-08-05 |
| US20110144019A1 (en) | 2011-06-16 |
| MX336145B (es) | 2016-01-08 |
| RU2010151470A (ru) | 2012-06-27 |
| US20160287672A1 (en) | 2016-10-06 |
| BRPI0912559A2 (pt) | 2015-10-13 |
| JP2017061453A (ja) | 2017-03-30 |
| AU2009246112A1 (en) | 2009-11-19 |
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