JP2011520917A - 慢性心不全の治療方法 - Google Patents
慢性心不全の治療方法 Download PDFInfo
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- JP2011520917A JP2011520917A JP2011509781A JP2011509781A JP2011520917A JP 2011520917 A JP2011520917 A JP 2011520917A JP 2011509781 A JP2011509781 A JP 2011509781A JP 2011509781 A JP2011509781 A JP 2011509781A JP 2011520917 A JP2011520917 A JP 2011520917A
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2221—Relaxins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
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- Epidemiology (AREA)
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- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12788908P | 2008-05-16 | 2008-05-16 | |
| US61/127,889 | 2008-05-16 | ||
| US19054508P | 2008-08-28 | 2008-08-28 | |
| US61/190,545 | 2008-08-28 | ||
| US20124008P | 2008-12-08 | 2008-12-08 | |
| US61/201,240 | 2008-12-08 | ||
| PCT/US2009/044247 WO2009140657A2 (en) | 2008-05-16 | 2009-05-15 | Method of treating chronic heart failure |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014129744A Division JP2014237648A (ja) | 2008-05-16 | 2014-06-25 | 慢性心不全の治療方法 |
Publications (2)
| Publication Number | Publication Date |
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| JP2011520917A true JP2011520917A (ja) | 2011-07-21 |
| JP2011520917A5 JP2011520917A5 (https=) | 2012-05-24 |
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| JP2011509781A Withdrawn JP2011520917A (ja) | 2008-05-16 | 2009-05-15 | 慢性心不全の治療方法 |
| JP2014129744A Withdrawn JP2014237648A (ja) | 2008-05-16 | 2014-06-25 | 慢性心不全の治療方法 |
| JP2016190522A Pending JP2017061453A (ja) | 2008-05-16 | 2016-09-29 | 慢性心不全の治療方法 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014129744A Withdrawn JP2014237648A (ja) | 2008-05-16 | 2014-06-25 | 慢性心不全の治療方法 |
| JP2016190522A Pending JP2017061453A (ja) | 2008-05-16 | 2016-09-29 | 慢性心不全の治療方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20110144019A1 (https=) |
| EP (2) | EP3150219A1 (https=) |
| JP (3) | JP2011520917A (https=) |
| CN (2) | CN102026649A (https=) |
| AU (1) | AU2009246112B2 (https=) |
| BR (1) | BRPI0912559A2 (https=) |
| CA (1) | CA2724535A1 (https=) |
| MX (2) | MX2010012502A (https=) |
| RU (1) | RU2512933C2 (https=) |
| WO (1) | WO2009140657A2 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016505065A (ja) * | 2013-01-25 | 2016-02-18 | カーディオレンティス リミテッド | 心血管症候の治療方法 |
| JP2022507693A (ja) * | 2018-11-20 | 2022-01-18 | ウニベルジテート ハイデルベルク | 心不全の治療及び予防における使用のためのリラキシン受容体１ |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102036679A (zh) | 2008-05-16 | 2011-04-27 | 科尔泰拉公司 | 用松弛素治疗与急性心力衰竭相关的呼吸困难 |
| BR112012022654A2 (pt) * | 2010-03-10 | 2016-11-01 | Univ Florida | modulação de aquaporinas com relaxina |
| WO2012072681A1 (en) * | 2010-12-01 | 2012-06-07 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Diagnostic and treatment of chronic heart failure |
| JP2014529293A (ja) * | 2011-07-08 | 2014-11-06 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | レラキシンを放出する融合タンパク質およびその使用 |
| JP6276690B2 (ja) * | 2011-08-04 | 2018-02-07 | ファリス バイオテック ゲーエムベーハー | ヒトリラキシン−２を調製する方法 |
| US10493131B2 (en) | 2011-08-31 | 2019-12-03 | University Of Florida Research Foundation, Incorporated | Materials and methods for modulating activity of bone marrow derived cells |
| US20140364334A1 (en) * | 2011-12-21 | 2014-12-11 | Nuclea Biotechnologies, Inc. | Congestive heart failure biomarkers |
| CN108310396B (zh) | 2012-02-14 | 2022-07-15 | 加利福尼亚大学董事会 | 用于心血管疾病和其它病况的旁分泌基因的全身性递送和受调节的表达 |
| MX2016005545A (es) * | 2013-11-07 | 2016-10-03 | Shanghai hengrui pharmaceutical co ltd | Analogo de la relaxina humana, composicion farmaceutica del mismo y aplicacion farmaceutica del mismo. |
| US10500227B2 (en) * | 2014-12-03 | 2019-12-10 | University Of Cincinnati | Bioactive gas-encapsulated echogenic liposomes and methods for treating cardiovascular disease |
| WO2017100540A2 (en) | 2015-12-09 | 2017-06-15 | The California Institute For Biomedical Research | Relaxin immunoglobulin fusion proteins and methods of use |
| CN110637027B (zh) | 2017-02-08 | 2024-08-30 | 百时美施贵宝公司 | 包含药代动力学增强子的修饰的松弛素多肽及其用途 |
| CN107335051A (zh) * | 2017-08-18 | 2017-11-10 | 温州医科大学附属第医院 | 一种保护慢性心衰肾功能的药物组合物 |
| AU2020382102B2 (en) | 2019-11-16 | 2026-02-26 | Relaxera Pharmazeutische Gmbh & Co. Kg | Medical composition for treating cardiac wasting and cachexia |
| CN116406297A (zh) * | 2020-08-05 | 2023-07-07 | 阿斯克肋匹奥生物制药公司 | 治疗心脏疾患和充血性心力衰竭以及施用aav载体的方法 |
| RU2748529C1 (ru) * | 2020-09-01 | 2021-05-26 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр кардиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ кардиологии" Минздрава России) | Способ определения этиологии хронической сердечной недостаточности |
| TW202438534A (zh) * | 2022-12-09 | 2024-10-01 | 瑞典商阿斯特捷利康公司 | 使用異二聚物鬆弛素融合體的給藥方案 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5023321A (en) | 1982-12-13 | 1991-06-11 | Howard Florey Institute Of Experimental Physiology & Medicine | Molecular cloning and characterization of a further gene sequence coding for human relaxin |
| US5166191A (en) * | 1991-08-19 | 1992-11-24 | Genentech, Inc. | Use of relaxin in cardiovascular therapy |
| EP0707650B1 (en) | 1993-06-21 | 2003-05-21 | Genentech, Inc. | Process for producing human relaxin |
| US5811395A (en) | 1995-06-07 | 1998-09-22 | Medical University Of South Carolina | Relaxin analogs and derivatives methods and uses thereof |
| RU2213559C2 (ru) * | 2000-01-26 | 2003-10-10 | Тюменская государственная медицинская академия | Способ лечения больных хронической сердечной недостаточностью на фоне ишемической болезни сердца |
| DE10155843A1 (de) * | 2000-11-16 | 2003-01-30 | Immundiagnostik Ag | Verfahren zur Prognose und Diagnose von Herzinsuffizienz |
| US20050113286A1 (en) * | 2002-03-18 | 2005-05-26 | Schreiner George F. | Methods for treating congestive heart failure |
| CN1968717B (zh) * | 2004-03-30 | 2013-08-21 | 延世大学教产学协力团 | 含有松弛素基因的基因送递系统和使用松弛素的药物组合物 |
| US20080077025A1 (en) * | 2005-07-11 | 2008-03-27 | Leticia Delgado-Herrera | Methods for determining how to treat congestive heart failure |
| US8492329B2 (en) | 2007-07-12 | 2013-07-23 | Compugen Ltd. | Bioactive peptides and methods of using same |
| CN102036679A (zh) * | 2008-05-16 | 2011-04-27 | 科尔泰拉公司 | 用松弛素治疗与急性心力衰竭相关的呼吸困难 |
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2009
- 2009-05-15 JP JP2011509781A patent/JP2011520917A/ja not_active Withdrawn
- 2009-05-15 EP EP16174665.6A patent/EP3150219A1/en not_active Withdrawn
- 2009-05-15 CN CN2009801176516A patent/CN102026649A/zh active Pending
- 2009-05-15 CA CA2724535A patent/CA2724535A1/en not_active Abandoned
- 2009-05-15 RU RU2010151470/14A patent/RU2512933C2/ru not_active IP Right Cessation
- 2009-05-15 MX MX2010012502A patent/MX2010012502A/es active IP Right Grant
- 2009-05-15 AU AU2009246112A patent/AU2009246112B2/en not_active Ceased
- 2009-05-15 MX MX2012010249A patent/MX336145B/es unknown
- 2009-05-15 BR BRPI0912559A patent/BRPI0912559A2/pt not_active Application Discontinuation
- 2009-05-15 EP EP09747738A patent/EP2288366A4/en not_active Ceased
- 2009-05-15 CN CN201510202983.1A patent/CN104815319A/zh active Pending
- 2009-05-15 US US12/992,667 patent/US20110144019A1/en not_active Abandoned
- 2009-05-15 WO PCT/US2009/044247 patent/WO2009140657A2/en not_active Ceased
-
2013
- 2013-07-11 US US13/939,648 patent/US20140005112A1/en not_active Abandoned
-
2014
- 2014-06-25 JP JP2014129744A patent/JP2014237648A/ja not_active Withdrawn
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2016
- 2016-04-25 US US15/137,054 patent/US20160287672A1/en not_active Abandoned
- 2016-09-29 JP JP2016190522A patent/JP2017061453A/ja active Pending
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| JPN6013038310; Ａｎｎａｌｓ ｏｆ ｔｈｅ Ｎｅｗ Ｙｏｒｋ Ａｃａｄｅｍｙ ｏｆ Ｓｃｉｅｎｃｅｓ Ｖｏｌ．１０４１, 2005, ｐ１９０-１９３ * |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016505065A (ja) * | 2013-01-25 | 2016-02-18 | カーディオレンティス リミテッド | 心血管症候の治療方法 |
| JP2022507693A (ja) * | 2018-11-20 | 2022-01-18 | ウニベルジテート ハイデルベルク | 心不全の治療及び予防における使用のためのリラキシン受容体１ |
| JP7541003B2 (ja) | 2018-11-20 | 2024-08-27 | ウニベルジテート ハイデルベルク | 心不全の治療及び予防における使用のためのリラキシン受容体１ |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2010012502A (es) | 2011-04-11 |
| EP3150219A1 (en) | 2017-04-05 |
| US20140005112A1 (en) | 2014-01-02 |
| JP2014237648A (ja) | 2014-12-18 |
| WO2009140657A3 (en) | 2010-01-07 |
| CN102026649A (zh) | 2011-04-20 |
| EP2288366A2 (en) | 2011-03-02 |
| CA2724535A1 (en) | 2009-11-19 |
| AU2009246112B2 (en) | 2013-05-02 |
| WO2009140657A2 (en) | 2009-11-19 |
| RU2512933C2 (ru) | 2014-04-10 |
| EP2288366A4 (en) | 2012-05-02 |
| CN104815319A (zh) | 2015-08-05 |
| US20110144019A1 (en) | 2011-06-16 |
| MX336145B (es) | 2016-01-08 |
| RU2010151470A (ru) | 2012-06-27 |
| US20160287672A1 (en) | 2016-10-06 |
| BRPI0912559A2 (pt) | 2015-10-13 |
| JP2017061453A (ja) | 2017-03-30 |
| AU2009246112A1 (en) | 2009-11-19 |
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