RU2500679C2 - Кристаллические противогрибковые соединения - Google Patents

Кристаллические противогрибковые соединения Download PDF

Info

Publication number
RU2500679C2
RU2500679C2 RU2009104959/04A RU2009104959A RU2500679C2 RU 2500679 C2 RU2500679 C2 RU 2500679C2 RU 2009104959/04 A RU2009104959/04 A RU 2009104959/04A RU 2009104959 A RU2009104959 A RU 2009104959A RU 2500679 C2 RU2500679 C2 RU 2500679C2
Authority
RU
Russia
Prior art keywords
hfa
characteristic
ray powder
powder diffraction
theta
Prior art date
Application number
RU2009104959/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2009104959A (ru
Inventor
Антонио Кановас ПАРЕДЕС
Джавиер Бартроли ОРПИ
Эллис Молинс ГРАУ
Анна Роиг СЕРРА
Кевин Мейер
Кэйт ЛОРИМЕР
Original Assignee
Палау Фарма, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39082545&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2500679(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP06380225A external-priority patent/EP1887004A1/en
Priority claimed from EP07380186A external-priority patent/EP2009009A1/en
Application filed by Палау Фарма, С.А. filed Critical Палау Фарма, С.А.
Publication of RU2009104959A publication Critical patent/RU2009104959A/ru
Application granted granted Critical
Publication of RU2500679C2 publication Critical patent/RU2500679C2/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
RU2009104959/04A 2006-08-07 2007-08-06 Кристаллические противогрибковые соединения RU2500679C2 (ru)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US83586306P 2006-08-07 2006-08-07
US60/835,863 2006-08-07
EP06380225.0 2006-08-07
EP06380225A EP1887004A1 (en) 2006-08-07 2006-08-07 Crystalline forms of (1R,2R)-7-Chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quinazolin-4(3H)-one
US92940807P 2007-06-26 2007-06-26
EP07380186.2 2007-06-26
EP07380186A EP2009009A1 (en) 2007-06-26 2007-06-26 Crystalline antifungal compounds
US60/929,408 2007-06-26
PCT/US2007/017476 WO2008021049A2 (en) 2006-08-07 2007-08-06 Crystalline antifungal compounds

Publications (2)

Publication Number Publication Date
RU2009104959A RU2009104959A (ru) 2010-08-20
RU2500679C2 true RU2500679C2 (ru) 2013-12-10

Family

ID=39082545

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2009104959/04A RU2500679C2 (ru) 2006-08-07 2007-08-06 Кристаллические противогрибковые соединения

Country Status (17)

Country Link
US (2) US7879867B2 (en, 2012)
EP (2) EP2049504A4 (en, 2012)
JP (3) JP2010513222A (en, 2012)
KR (1) KR20090053903A (en, 2012)
CN (1) CN103232442B (en, 2012)
AR (1) AR062232A1 (en, 2012)
AU (1) AU2007284851B2 (en, 2012)
BR (1) BRPI0716026A2 (en, 2012)
CA (1) CA2658843A1 (en, 2012)
DK (1) DK2650291T3 (en, 2012)
ES (1) ES2652670T3 (en, 2012)
IL (2) IL196722A (en, 2012)
IN (1) IN2014MN01560A (en, 2012)
MX (1) MX2009001208A (en, 2012)
RU (1) RU2500679C2 (en, 2012)
TW (1) TWI426073B (en, 2012)
WO (1) WO2008021049A2 (en, 2012)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006018853A2 (en) 2004-08-19 2006-02-23 Hetero Drugs Limited Novel polymorphs of efavirenz
PE20142329A1 (es) * 2006-04-05 2015-01-30 Opko Health Inc Sales de hidrocloruro de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diazaspiro[4.5]decan-2-ona
ITMI20062449A1 (it) * 2006-12-19 2008-06-20 Dipharma Spa Forma cristallina di rabeprazolo sodico
WO2010138674A1 (en) * 2009-05-29 2010-12-02 Stiefel Laboratories, Inc. Azole antifungal compositions
CA2767785A1 (en) * 2009-07-10 2011-01-13 Evolva Ag Diyne compositions
BR112012003263A2 (pt) * 2009-08-14 2015-09-22 Opko Health Inc formulações intravenosas de antagonistas de neuroquinina-1
US9435692B2 (en) 2014-02-05 2016-09-06 Lam Research Corporation Calculating power input to an array of thermal control elements to achieve a two-dimensional temperature output
US11039620B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11039621B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US9622483B2 (en) 2014-02-19 2017-04-18 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
GB201410407D0 (en) * 2014-06-11 2014-07-23 Univ Dundee And Syngene Internat Ltd Plc And Consejo Superior De Investigaciones Cientificas And Med Treatment of chagas disease
EA025187B1 (ru) * 2015-04-17 2016-11-30 Тагир Аббасели оглы Сулейманов Производное дитиокарбамата 2-((4-(4-метилпиперазин-1-ил)фенил)амино)-2-оксоетил4-этилпиперазин-1-карбодитиоат, обладающее антифунгальной активностью
CN118695852A (zh) 2021-12-22 2024-09-24 帕劳制药有限公司 多颗粒阿巴康唑组合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807854A (en) * 1995-08-02 1998-09-15 J. Uriah & Cia. S.A. Pyrimidone derivatives with antifungal activity
RU2131417C1 (ru) * 1993-09-24 1999-06-10 Такеда Кемикал Индастриз, Лтд. Производные азола, способы их получения и антигрибковое средство
US6653475B2 (en) * 2000-03-07 2003-11-25 J. Uriach & Cia, S.A. Method for preparing pyrimidone derivatives with antifungal activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0293500A1 (en) 1987-06-01 1988-12-07 American Cyanamid Company 3-heteroalkyl-2,4.quinzaoline-diones
GB8819308D0 (en) 1988-08-13 1988-09-14 Pfizer Ltd Triazole antifungal agents
TW218017B (en, 2012) 1992-04-28 1993-12-21 Takeda Pharm Industry Co Ltd
CA2134417A1 (en) 1993-12-22 1995-06-23 Katsumi Itoh Optically active azole derivatives, their production and use
WO1998039305A1 (en) 1997-03-05 1998-09-11 Takeda Chemical Industries, Ltd. Crystalline form of a bis 1,2,4-triazole compound

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2131417C1 (ru) * 1993-09-24 1999-06-10 Такеда Кемикал Индастриз, Лтд. Производные азола, способы их получения и антигрибковое средство
US5807854A (en) * 1995-08-02 1998-09-15 J. Uriah & Cia. S.A. Pyrimidone derivatives with antifungal activity
US6653475B2 (en) * 2000-03-07 2003-11-25 J. Uriach & Cia, S.A. Method for preparing pyrimidone derivatives with antifungal activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BARTROLI, Journal of Medicinal Chemistry, 1998, 41, 1869-1882. *

Also Published As

Publication number Publication date
MX2009001208A (es) 2009-04-14
EP2650291B1 (en) 2017-10-04
JP2014012673A (ja) 2014-01-23
US7879867B2 (en) 2011-02-01
TWI426073B (zh) 2014-02-11
US20080076787A1 (en) 2008-03-27
JP2015193642A (ja) 2015-11-05
RU2009104959A (ru) 2010-08-20
AU2007284851B2 (en) 2013-05-09
TW200823197A (en) 2008-06-01
IN2014MN01560A (en, 2012) 2015-05-08
IL196722A (en) 2016-10-31
CA2658843A1 (en) 2008-02-21
CN103232442A (zh) 2013-08-07
AU2007284851A1 (en) 2008-02-21
WO2008021049A2 (en) 2008-02-21
US20110092702A1 (en) 2011-04-21
IL248216B (en) 2018-03-29
CN103232442B (zh) 2015-01-21
WO2008021049A9 (en) 2008-10-30
ES2652670T3 (es) 2018-02-05
KR20090053903A (ko) 2009-05-28
IL196722A0 (en) 2009-11-18
EP2049504A2 (en) 2009-04-22
AR062232A1 (es) 2008-10-22
EP2650291A1 (en) 2013-10-16
US8258296B2 (en) 2012-09-04
EP2049504A4 (en) 2010-09-22
JP2010513222A (ja) 2010-04-30
BRPI0716026A2 (pt) 2013-08-06
WO2008021049A3 (en) 2008-12-31
DK2650291T3 (en) 2017-10-23

Similar Documents

Publication Publication Date Title
RU2500679C2 (ru) Кристаллические противогрибковые соединения
US10981883B2 (en) Process for the preparation of substituted oxiranes and triazoles
CA2952896C (en) Process for the preparation of substituted oxiranes and triazoles
CN108689951B (zh) 三氮唑化合物及其在农业中的应用
JP6901477B2 (ja) 三置換されているシリルフェノキシヘテロ環及び類似体
WO2010029066A1 (de) Imidazol- und triazolverbindungen, ihre verwendung sowie sie enthaltende mittel
EP2334648A1 (de) Imidazol- und triazolverbindungen, ihre verwendung sowie sie enthaltende mittel
PT2176229E (pt) Nova forma cristalina de 3-(difluorometil)-1-metil-n-(3',4',5'-trifluoro[1,1'-bifenil]-2-il)-1h-pirazole-4-carboxamida
WO2014167428A2 (en) Amorphous 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-n-methylbenzamide
WO2010040718A1 (de) Triazol- und imidazolverbindungen, ihre verwendung sowie sie enthaltende mittel
EP2334649A1 (de) Imidazol- und triazolverbindungen, ihre verwendung sowie sie enthaltende mittel
EP2334654A1 (de) Triazolverbindungen, ihre verwendung sowie sie enthaltende mittel
WO2010029000A1 (de) Triazolverbindungen, ihre verwendung sowie sie enthaltende mittel
WO2010029003A1 (de) Triazolverbindungen, ihre verwendung sowie sie enthaltende mittel
EP2346839A1 (de) Triazol- und imidazolverbindungen, ihre verwendung sowie sie enthaltende mittel
Udupi et al. Design, synthesis and biological activity of certain 3, 4-disubstituted-5-mercapto-1, 2, 4-triazoles and their hydrazino derivatives
AU2016325733A1 (en) Crystalline forms of posaconazole intermediate and process for the preparation of amorphous posaconazole
WO2010031842A1 (de) Imidazol- und triazolverbindungen, ihre verwendung sowie sie enthaltende mittel
CN113666840B (zh) 一种丙硫菌唑中间体的制备方法
CN111406046B (zh) 戊唑醇的多晶型及其制备方法
EP2346835A1 (de) Imidazol- und triazolverbindungen, ihre verwendung sowie sie enthaltende mittel
WO2020174432A1 (en) Dioxane solvate of prothioconazole and process for preparation thereof
US20130303581A1 (en) Polymorphism in 5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoro methyl sulfinyl pyrazole
EP2334655A1 (de) Imidazol- und triazolverbindungen als fungizide
RU2019122565A (ru) СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 7Н-ПИРРОЛО[2,3-d]ПИРИМИДИНА И ИХ СОКРИСТАЛЛОВ