RU2491952C2 - Способы и фармакологические композиции для заживления ран - Google Patents

Способы и фармакологические композиции для заживления ран Download PDF

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Publication number
RU2491952C2
RU2491952C2 RU2010130763/15A RU2010130763A RU2491952C2 RU 2491952 C2 RU2491952 C2 RU 2491952C2 RU 2010130763/15 A RU2010130763/15 A RU 2010130763/15A RU 2010130763 A RU2010130763 A RU 2010130763A RU 2491952 C2 RU2491952 C2 RU 2491952C2
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RU
Russia
Prior art keywords
insulin
cells
wound
skin
pkc
Prior art date
Application number
RU2010130763/15A
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English (en)
Russian (ru)
Other versions
RU2010130763A (ru
Inventor
Тамар ТЕННЕНБАУМ
Санфорд САМПСОН
Тошио КУРОКИ
Эдди АЛЬТ
Шломзион ШЕН
Original Assignee
Бар-Илан Юнивесити
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from US10/644,775 external-priority patent/US20040037828A1/en
Application filed by Бар-Илан Юнивесити filed Critical Бар-Илан Юнивесити
Publication of RU2010130763A publication Critical patent/RU2010130763A/ru
Application granted granted Critical
Publication of RU2491952C2 publication Critical patent/RU2491952C2/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1858Platelet-derived growth factor [PDGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/30Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45Transferases (2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2010130763/15A 2003-07-15 2004-07-15 Способы и фармакологические композиции для заживления ран RU2491952C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US48690603P 2003-07-15 2003-07-15
US60/486,906 2003-07-15
US10/644,775 US20040037828A1 (en) 2002-07-09 2003-08-21 Methods and pharmaceutical compositions for healing wounds
US10/644,775 2003-08-21

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU2006104617/14A Division RU2359694C2 (ru) 2003-07-15 2004-07-15 Способы и фармакологические композиции для заживления ран

Publications (2)

Publication Number Publication Date
RU2010130763A RU2010130763A (ru) 2012-01-27
RU2491952C2 true RU2491952C2 (ru) 2013-09-10

Family

ID=37134125

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2010130763/15A RU2491952C2 (ru) 2003-07-15 2004-07-15 Способы и фармакологические композиции для заживления ран
RU2008138473/14A RU2404799C2 (ru) 2003-07-15 2008-09-29 Способы и фармакологические композиции для заживления ран

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2008138473/14A RU2404799C2 (ru) 2003-07-15 2008-09-29 Способы и фармакологические композиции для заживления ран

Country Status (6)

Country Link
JP (4) JP4790609B2 (enExample)
CN (2) CN1852722B (enExample)
IL (1) IL173148A (enExample)
NZ (3) NZ545318A (enExample)
RU (2) RU2491952C2 (enExample)
ZA (1) ZA200600235B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040037828A1 (en) * 2002-07-09 2004-02-26 Bar-Ilan University Methods and pharmaceutical compositions for healing wounds
WO2005013885A2 (en) * 2003-08-07 2005-02-17 Healor Ltd. Pharmaceutical compositions and methods for accelerating wound healing
EP2653166A3 (en) * 2007-07-30 2014-08-27 Healor Ltd. Pharmaceutical composition and related methods
WO2012063237A2 (en) * 2010-11-08 2012-05-18 Healor Ltd. Buffered ophthalmic compositions and methods of use thereof
US9283175B2 (en) * 2011-07-28 2016-03-15 Ian S. Zagon Methods and compositions for treatment of epithelial wounds
CN103055304A (zh) * 2013-01-19 2013-04-24 卓阳 一种治疗皮肤溃疡用复方温敏凝胶剂及其制备方法
KR101523503B1 (ko) * 2013-09-17 2015-05-29 강원대학교산학협력단 아디포넥틴으로부터 유래한 펩타이드 및 이를 포함하는 조성물
CN106267163A (zh) * 2015-06-09 2017-01-04 济南博创医药科技有限公司 一种治疗皮肤创伤的药物组合物及其药物制剂
CN108514569A (zh) * 2018-07-09 2018-09-11 广州中医药大学(广州中医药研究院) 斜叶檀香提取物在制备皮肤创伤愈合药物中的应用
CN112316148A (zh) * 2019-08-01 2021-02-05 成都夸常奥普医疗科技有限公司 包含血浆的半流体的应用、包含该半流体和活性成分的药物组合物及其制备方法
CN119801477A (zh) * 2023-10-10 2025-04-11 中国石油化工股份有限公司 一种模拟地层弹性形变的实验装置及其使用方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6537973B1 (en) * 1992-03-16 2003-03-25 Isis Pharmaceuticals, Inc. Oligonucleotide inhibition of protein kinase C

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA892928B (en) * 1988-04-25 1991-01-30 Pro Neuron Inc Pharmaceutical compositions containing deoxyribonucleosides for wound healing
US5591709A (en) * 1991-08-30 1997-01-07 Life Medical Sciences, Inc. Compositions and methods for treating wounds
US5948898A (en) * 1992-03-16 1999-09-07 Isis Pharmaceuticals, Inc. Methoxyethoxy oligonucleotides for modulation of protein kinase C expression
GB9210574D0 (en) * 1992-05-18 1992-07-01 Ca Nat Research Council Biotherapeutic cell-coated microspheres for wound/burn and prothesis implant applications
GB2304047A (en) * 1995-08-09 1997-03-12 Univ Manchester Pharmaceutical compositions containing cytokines
EP1295952A3 (en) * 1996-01-23 2003-07-09 The Board of Trustees of The Leland Stanford Junior University Methods for screening for transdominant effector peptides and RNA molecules
JP2002541195A (ja) * 1999-04-14 2002-12-03 アメリカ合衆国 移植片に対する免疫寛容を誘導するための、免疫毒素および樹状細胞の成熟を阻害する作用剤を含有する組成物
ATE429925T1 (de) * 2000-07-31 2009-05-15 Univ Bar Ilan Methoden und pharmazeutische zusammensetzungen zur wundheilung
GB2369572A (en) * 2000-11-29 2002-06-05 Raft Trustees Ltd Wound treatment composition comprising insulin
US20020119914A1 (en) * 2000-12-26 2002-08-29 Deguang Zhu New uses of insulin and pancreatin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6537973B1 (en) * 1992-03-16 2003-03-25 Isis Pharmaceuticals, Inc. Oligonucleotide inhibition of protein kinase C

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Madibally SV., et al., "Influence of insulin therapy on bum wound healing in rats"J Surg Res. 2003 Feb; 109(2):92-100. Wang HQ., et al., "Overexpression of protein kinase C-alpha in the epidermis of transgenic mice results in striking alterations in phorbol ester-induced inflammation and COX-2, MIP-2 and TNF-alpha expression but not tumor promotion" J Cell Sci. 1999 Oct: 112 (Pt 20):3497-506. Boorsma DM., et al., "IP-10 mRNA expression in cultured keratinocytes is suppressed by inhibition of protein kinase-C and tyrosine kinase and elevation of cAMP" Cytokine. 1999 Jul; 11(7):469-75. Graham MA., et al., "Protein kinase С regulation of comeal endothelial cell proliferation and cell cycle" Invest Ophthalmol Vis Sci. 2000 Dec; 41(13):4124-32. Visnjic D., et al., "Different roles of protein kinase С alpha and delta isoforms in the regulation of neutral sphingomyelinase activity in HL-60 cells." Biochem. J. 1999 Dec 15; 344 Pt 3:921-8. *

Also Published As

Publication number Publication date
IL173148A (en) 2013-02-28
JP2007530426A (ja) 2007-11-01
RU2008138473A (ru) 2010-04-10
JP2011057711A (ja) 2011-03-24
CN101850108A (zh) 2010-10-06
NZ588743A (en) 2012-05-25
ZA200600235B (en) 2007-04-25
JP2011057709A (ja) 2011-03-24
JP4790609B2 (ja) 2011-10-12
RU2404799C2 (ru) 2010-11-27
IL173148A0 (en) 2006-06-11
JP2011057710A (ja) 2011-03-24
RU2010130763A (ru) 2012-01-27
CN1852722A (zh) 2006-10-25
NZ545318A (en) 2009-06-26
NZ573737A (en) 2011-06-30
CN1852722B (zh) 2011-06-08

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20140716