CN1852722B - 胰岛素和十四酰化PKCα伪底物用于制备皮肤创伤愈合的药物组合物的用途 - Google Patents

胰岛素和十四酰化PKCα伪底物用于制备皮肤创伤愈合的药物组合物的用途 Download PDF

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Publication number
CN1852722B
CN1852722B CN2004800265295A CN200480026529A CN1852722B CN 1852722 B CN1852722 B CN 1852722B CN 2004800265295 A CN2004800265295 A CN 2004800265295A CN 200480026529 A CN200480026529 A CN 200480026529A CN 1852722 B CN1852722 B CN 1852722B
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China
Prior art keywords
insulin
wound
skin
cells
pkc
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Expired - Fee Related
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CN2004800265295A
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English (en)
Chinese (zh)
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CN1852722A (zh
Inventor
T·藤兰鲍姆
S·森普森
T·库罗基
A·阿尔特
S·沈
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Bar Ilan University
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Bar Ilan University
Healor Ltd
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Priority claimed from US10/644,775 external-priority patent/US20040037828A1/en
Application filed by Bar Ilan University, Healor Ltd filed Critical Bar Ilan University
Publication of CN1852722A publication Critical patent/CN1852722A/zh
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Publication of CN1852722B publication Critical patent/CN1852722B/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2004800265295A 2003-07-15 2004-07-15 胰岛素和十四酰化PKCα伪底物用于制备皮肤创伤愈合的药物组合物的用途 Expired - Fee Related CN1852722B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US48690603P 2003-07-15 2003-07-15
US60/486,906 2003-07-15
US10/644,775 US20040037828A1 (en) 2002-07-09 2003-08-21 Methods and pharmaceutical compositions for healing wounds
US10/644,775 2003-08-21
PCT/IL2004/000640 WO2005007072A2 (en) 2003-07-15 2004-07-15 Methods and pharmaceutical compositions for healing wounds

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN200910217138A Division CN101850108A (zh) 2003-07-15 2004-07-15 用于愈合创伤的方法和药物组合物
CN201310452225.6A Division CN103751211A (zh) 2003-07-15 2004-07-15 用于愈合创伤的方法和药物组合物

Publications (2)

Publication Number Publication Date
CN1852722A CN1852722A (zh) 2006-10-25
CN1852722B true CN1852722B (zh) 2011-06-08

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN2004800265295A Expired - Fee Related CN1852722B (zh) 2003-07-15 2004-07-15 胰岛素和十四酰化PKCα伪底物用于制备皮肤创伤愈合的药物组合物的用途
CN200910217138A Pending CN101850108A (zh) 2003-07-15 2004-07-15 用于愈合创伤的方法和药物组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN200910217138A Pending CN101850108A (zh) 2003-07-15 2004-07-15 用于愈合创伤的方法和药物组合物

Country Status (6)

Country Link
JP (4) JP4790609B2 (enExample)
CN (2) CN1852722B (enExample)
IL (1) IL173148A (enExample)
NZ (3) NZ545318A (enExample)
RU (2) RU2491952C2 (enExample)
ZA (1) ZA200600235B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040037828A1 (en) * 2002-07-09 2004-02-26 Bar-Ilan University Methods and pharmaceutical compositions for healing wounds
WO2005013885A2 (en) * 2003-08-07 2005-02-17 Healor Ltd. Pharmaceutical compositions and methods for accelerating wound healing
EP2653166A3 (en) * 2007-07-30 2014-08-27 Healor Ltd. Pharmaceutical composition and related methods
WO2012063237A2 (en) * 2010-11-08 2012-05-18 Healor Ltd. Buffered ophthalmic compositions and methods of use thereof
US9283175B2 (en) * 2011-07-28 2016-03-15 Ian S. Zagon Methods and compositions for treatment of epithelial wounds
CN103055304A (zh) * 2013-01-19 2013-04-24 卓阳 一种治疗皮肤溃疡用复方温敏凝胶剂及其制备方法
KR101523503B1 (ko) * 2013-09-17 2015-05-29 강원대학교산학협력단 아디포넥틴으로부터 유래한 펩타이드 및 이를 포함하는 조성물
CN106267163A (zh) * 2015-06-09 2017-01-04 济南博创医药科技有限公司 一种治疗皮肤创伤的药物组合物及其药物制剂
CN108514569A (zh) * 2018-07-09 2018-09-11 广州中医药大学(广州中医药研究院) 斜叶檀香提取物在制备皮肤创伤愈合药物中的应用
CN112316148A (zh) * 2019-08-01 2021-02-05 成都夸常奥普医疗科技有限公司 包含血浆的半流体的应用、包含该半流体和活性成分的药物组合物及其制备方法
CN119801477A (zh) * 2023-10-10 2025-04-11 中国石油化工股份有限公司 一种模拟地层弹性形变的实验装置及其使用方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002009639A2 (en) * 2000-07-31 2002-02-07 Bar Ilan University Methods and pharmaceutical compositions for healing wounds
US6737241B2 (en) * 1996-01-23 2004-05-18 Rigel Pharmaceuticals, Inc. Methods for screening for transdominant intracellular effector peptides and RNA molecules

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA892928B (en) * 1988-04-25 1991-01-30 Pro Neuron Inc Pharmaceutical compositions containing deoxyribonucleosides for wound healing
US5591709A (en) * 1991-08-30 1997-01-07 Life Medical Sciences, Inc. Compositions and methods for treating wounds
US5948898A (en) * 1992-03-16 1999-09-07 Isis Pharmaceuticals, Inc. Methoxyethoxy oligonucleotides for modulation of protein kinase C expression
US6537973B1 (en) * 1992-03-16 2003-03-25 Isis Pharmaceuticals, Inc. Oligonucleotide inhibition of protein kinase C
GB9210574D0 (en) * 1992-05-18 1992-07-01 Ca Nat Research Council Biotherapeutic cell-coated microspheres for wound/burn and prothesis implant applications
GB2304047A (en) * 1995-08-09 1997-03-12 Univ Manchester Pharmaceutical compositions containing cytokines
JP2002541195A (ja) * 1999-04-14 2002-12-03 アメリカ合衆国 移植片に対する免疫寛容を誘導するための、免疫毒素および樹状細胞の成熟を阻害する作用剤を含有する組成物
GB2369572A (en) * 2000-11-29 2002-06-05 Raft Trustees Ltd Wound treatment composition comprising insulin
US20020119914A1 (en) * 2000-12-26 2002-08-29 Deguang Zhu New uses of insulin and pancreatin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6737241B2 (en) * 1996-01-23 2004-05-18 Rigel Pharmaceuticals, Inc. Methods for screening for transdominant intracellular effector peptides and RNA molecules
WO2002009639A2 (en) * 2000-07-31 2002-02-07 Bar Ilan University Methods and pharmaceutical compositions for healing wounds

Also Published As

Publication number Publication date
IL173148A (en) 2013-02-28
JP2007530426A (ja) 2007-11-01
RU2008138473A (ru) 2010-04-10
JP2011057711A (ja) 2011-03-24
CN101850108A (zh) 2010-10-06
NZ588743A (en) 2012-05-25
ZA200600235B (en) 2007-04-25
RU2491952C2 (ru) 2013-09-10
JP2011057709A (ja) 2011-03-24
JP4790609B2 (ja) 2011-10-12
RU2404799C2 (ru) 2010-11-27
IL173148A0 (en) 2006-06-11
JP2011057710A (ja) 2011-03-24
RU2010130763A (ru) 2012-01-27
CN1852722A (zh) 2006-10-25
NZ545318A (en) 2009-06-26
NZ573737A (en) 2011-06-30

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20080516

Address after: Israel Matt Gan

Applicant after: Bar-Ilan University

Address before: Israel Matt Gan

Applicant before: Healor Ltd.

C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20110608

Termination date: 20180715

CF01 Termination of patent right due to non-payment of annual fee