RU2470657C2 - ПРИМЕНЕНИЕ ЭКСТРАКТОВ ИЛИ ЭКСТРАКТИВНЫХ ВЕЩЕСТВ ИЗ Piper cubeba L. В КАЧЕСТВЕ АКТИВНЫХ ИНГРЕДИЕНТОВ В ЛЕКАРСТВЕННОМ СРЕДСТВЕ ДЛЯ ЛЕЧЕНИЯ РАКОВЫХ ЗАБОЛЕВАНИЙ - Google Patents
ПРИМЕНЕНИЕ ЭКСТРАКТОВ ИЛИ ЭКСТРАКТИВНЫХ ВЕЩЕСТВ ИЗ Piper cubeba L. В КАЧЕСТВЕ АКТИВНЫХ ИНГРЕДИЕНТОВ В ЛЕКАРСТВЕННОМ СРЕДСТВЕ ДЛЯ ЛЕЧЕНИЯ РАКОВЫХ ЗАБОЛЕВАНИЙ Download PDFInfo
- Publication number
- RU2470657C2 RU2470657C2 RU2010109750/15A RU2010109750A RU2470657C2 RU 2470657 C2 RU2470657 C2 RU 2470657C2 RU 2010109750/15 A RU2010109750/15 A RU 2010109750/15A RU 2010109750 A RU2010109750 A RU 2010109750A RU 2470657 C2 RU2470657 C2 RU 2470657C2
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- Russia
- Prior art keywords
- extract
- alcohol
- stage
- cancer
- piper cubeba
- Prior art date
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- 239000000284 extract Substances 0.000 title claims abstract description 123
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- 239000004480 active ingredient Substances 0.000 title claims abstract description 12
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 10
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- 235000013399 edible fruits Nutrition 0.000 claims abstract description 25
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- 244000215068 Acacia senegal Species 0.000 description 2
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1289/07 | 2007-08-16 | ||
| CH01289/07A CH698627B1 (de) | 2007-08-16 | 2007-08-16 | Herstellung und Verwendung von Extrakten oder Extraktivstoffen aus Piper cubeba L. als wirksame Bestandteile in einem Medikament zur Behandlung von Krebserkrankungen. |
| PCT/CH2008/000350 WO2009021347A1 (de) | 2007-08-16 | 2008-08-15 | Verwendung von extrakten oder extraktivstoffen aus piper cubeba l. als wirksame bestandteile in einem medikament zur behandlung von krebserkrankungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2010109750A RU2010109750A (ru) | 2011-09-27 |
| RU2470657C2 true RU2470657C2 (ru) | 2012-12-27 |
Family
ID=38668948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010109750/15A RU2470657C2 (ru) | 2007-08-16 | 2008-08-15 | ПРИМЕНЕНИЕ ЭКСТРАКТОВ ИЛИ ЭКСТРАКТИВНЫХ ВЕЩЕСТВ ИЗ Piper cubeba L. В КАЧЕСТВЕ АКТИВНЫХ ИНГРЕДИЕНТОВ В ЛЕКАРСТВЕННОМ СРЕДСТВЕ ДЛЯ ЛЕЧЕНИЯ РАКОВЫХ ЗАБОЛЕВАНИЙ |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US8404286B2 (enExample) |
| EP (1) | EP2182966B1 (enExample) |
| JP (1) | JP5378379B2 (enExample) |
| KR (1) | KR20100089815A (enExample) |
| CN (1) | CN102065875B (enExample) |
| AU (1) | AU2008286636B2 (enExample) |
| BR (1) | BRPI0815188A2 (enExample) |
| CA (1) | CA2696499A1 (enExample) |
| CH (1) | CH698627B1 (enExample) |
| ES (1) | ES2392310T3 (enExample) |
| PL (1) | PL2182966T3 (enExample) |
| RU (1) | RU2470657C2 (enExample) |
| WO (1) | WO2009021347A1 (enExample) |
| ZA (1) | ZA201000959B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2773173C2 (ru) * | 2017-03-20 | 2022-05-31 | Пьер Фабр Медикамент | Применение олеорезинов копаиферы при патологиях простаты |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI472333B (zh) * | 2008-06-26 | 2015-02-11 | Piramal Entpr Ltd | 治療口腔念珠菌病之口服草本組成物 |
| JP5806231B2 (ja) * | 2009-12-21 | 2015-11-10 | アセフ エス.アー. | 勃起障害の治療における血管拡張剤としてのクベビン、ジベンジルブチルロラクトリンリグナン、その半合成誘導体および合成誘導体、ならびに他のリグナンおよびネオリグナン |
| WO2014027857A1 (ko) * | 2012-08-16 | 2014-02-20 | 부산대학교 산학협력단 | 알파-이소-쿠베벤 또는 알파-이소-쿠베베놀을 유효성분으로 포함하는 감염성 및 염증성 질환의 예방 또는 치료용 조성물 |
| WO2014086379A1 (en) | 2012-12-03 | 2014-06-12 | Alpinia Laudanum Institute Of Phytopharmaceutical Sciences Ag | Lignan compositions |
| FR3085846B1 (fr) * | 2018-09-13 | 2022-01-21 | Robertet Sa | Utilisation d’extrait de p.nigrum, p. cubeba et/ou s. therebentifolius dans des preparations cosmetiques pour favoriser la pousse des poils |
| JP7197908B2 (ja) * | 2019-03-04 | 2022-12-28 | 株式会社ナチュファルマ琉球 | 骨減少性疾患の予防及び/又は治療用組成物 |
| CN114574286B (zh) * | 2022-02-18 | 2024-03-22 | 中国热带农业科学院香料饮料研究所 | 一种具有抗炎活性的胡椒精油及其制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1094813B1 (en) * | 1998-07-13 | 2003-09-10 | Btg International Limited | Use of piperine and derivatives thereof for treating skin pigmentation disorders and skin cancer |
| US20050154215A1 (en) * | 2002-03-25 | 2005-07-14 | Fundacao De Amparo A Pesquisa Do Estado De Sao Pau | Process to obtain dibenzylbutyrolactonic lignans process to obtain synthetic derivatives from lignanes bearing anti-chagas chemoprophylatic and therapeutical activies |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3091962B2 (ja) * | 1998-09-25 | 2000-09-25 | アルプス薬品工業株式会社 | テストステロン−5α−レダクターゼ阻害剤 |
| WO2003047551A1 (en) * | 2001-11-29 | 2003-06-12 | Penwest Pharmaceutical Company | Agglomerated particles including an active agent coprocessed with silicified microcrystalline cellulose |
| US20030228383A1 (en) * | 2002-06-06 | 2003-12-11 | J.B. Chemicals & Pharmaceuticals, Ltd. | Herbal cough formulations and process for the preparation thereof |
| JP2004160165A (ja) * | 2002-09-17 | 2004-06-10 | Pauretsuku:Kk | 生薬成分製剤の造粒方法 |
| EP1581237B1 (en) * | 2002-12-30 | 2007-06-27 | Council of Scientific and Industrial Research | Development of an anti-cough, anti-tussive and throat soothing herbal formulation |
| JP4319417B2 (ja) * | 2003-01-30 | 2009-08-26 | 学校法人近畿大学 | メラニン産生不全症治療剤 |
| US20070248693A1 (en) * | 2003-08-02 | 2007-10-25 | Elizabeth Mazzio | Nutraceutical composition and method of use for treatment / prevention of cancer |
-
2007
- 2007-08-16 CH CH01289/07A patent/CH698627B1/de not_active IP Right Cessation
-
2008
- 2008-08-15 JP JP2010520393A patent/JP5378379B2/ja not_active Expired - Fee Related
- 2008-08-15 CN CN200880111798XA patent/CN102065875B/zh not_active Expired - Fee Related
- 2008-08-15 PL PL08783450T patent/PL2182966T3/pl unknown
- 2008-08-15 AU AU2008286636A patent/AU2008286636B2/en not_active Ceased
- 2008-08-15 WO PCT/CH2008/000350 patent/WO2009021347A1/de not_active Ceased
- 2008-08-15 CA CA2696499A patent/CA2696499A1/en not_active Abandoned
- 2008-08-15 US US12/673,656 patent/US8404286B2/en not_active Expired - Fee Related
- 2008-08-15 ES ES08783450T patent/ES2392310T3/es active Active
- 2008-08-15 KR KR1020107005684A patent/KR20100089815A/ko not_active Ceased
- 2008-08-15 RU RU2010109750/15A patent/RU2470657C2/ru not_active IP Right Cessation
- 2008-08-15 BR BRPI0815188 patent/BRPI0815188A2/pt not_active IP Right Cessation
- 2008-08-15 EP EP08783450A patent/EP2182966B1/de active Active
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2010
- 2010-02-10 ZA ZA201000959A patent/ZA201000959B/xx unknown
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1094813B1 (en) * | 1998-07-13 | 2003-09-10 | Btg International Limited | Use of piperine and derivatives thereof for treating skin pigmentation disorders and skin cancer |
| US20050154215A1 (en) * | 2002-03-25 | 2005-07-14 | Fundacao De Amparo A Pesquisa Do Estado De Sao Pau | Process to obtain dibenzylbutyrolactonic lignans process to obtain synthetic derivatives from lignanes bearing anti-chagas chemoprophylatic and therapeutical activies |
Non-Patent Citations (1)
| Title |
|---|
| A. Chatterjee et al. Spectral properties of Cubebin // Jour. Indian Chem. Soc, Vol.45, no 8, 1968, p.423-725. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2773173C2 (ru) * | 2017-03-20 | 2022-05-31 | Пьер Фабр Медикамент | Применение олеорезинов копаиферы при патологиях простаты |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20100089815A (ko) | 2010-08-12 |
| EP2182966B1 (de) | 2012-08-08 |
| AU2008286636A1 (en) | 2009-02-19 |
| WO2009021347A1 (de) | 2009-02-19 |
| AU2008286636B2 (en) | 2013-10-24 |
| US20110135760A1 (en) | 2011-06-09 |
| JP5378379B2 (ja) | 2013-12-25 |
| CH698627B1 (de) | 2009-09-15 |
| ZA201000959B (en) | 2010-10-27 |
| CN102065875B (zh) | 2013-07-17 |
| RU2010109750A (ru) | 2011-09-27 |
| US9248156B2 (en) | 2016-02-02 |
| BRPI0815188A2 (pt) | 2015-03-31 |
| US20160193272A1 (en) | 2016-07-07 |
| CN102065875A (zh) | 2011-05-18 |
| PL2182966T3 (pl) | 2013-01-31 |
| CA2696499A1 (en) | 2009-02-19 |
| US20130251826A1 (en) | 2013-09-26 |
| ES2392310T3 (es) | 2012-12-07 |
| US8404286B2 (en) | 2013-03-26 |
| JP2010536718A (ja) | 2010-12-02 |
| EP2182966A1 (de) | 2010-05-12 |
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