RU2464277C2 - Антитела и фрагменты антител человека против рецептора фолата альфа для радиоиммунотерапии карциномы яичника - Google Patents

Антитела и фрагменты антител человека против рецептора фолата альфа для радиоиммунотерапии карциномы яичника Download PDF

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RU2464277C2
RU2464277C2 RU2009114161/10A RU2009114161A RU2464277C2 RU 2464277 C2 RU2464277 C2 RU 2464277C2 RU 2009114161/10 A RU2009114161/10 A RU 2009114161/10A RU 2009114161 A RU2009114161 A RU 2009114161A RU 2464277 C2 RU2464277 C2 RU 2464277C2
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antibody
fragment
afra
fab
fragments
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RU2009114161/10A
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Russian (ru)
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RU2009114161A (ru
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Франк МАРТЭН (IT)
Франк МАРТЭН
Маргерита КАТТОЦЦО (IT)
Маргерита КАТТОЦЦО
Джованни МАУРИЦИ (IT)
Джованни МАУРИЦИ
ЧОЧЧО Вито ДИ (IT)
ЧОЧЧО Вито ДИ
Марианджела ФИДЖИНИ (IT)
Марианджела ФИДЖИНИ
Сильвана КАНЕВАРИ (IT)
Сильвана КАНЕВАРИ
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Эдванст Экселерейтер Эпликейшнс С.А.
Иституто Национале Пер Ло Студио Е Ла Кура Дей Тумори
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
RU2009114161/10A 2006-09-15 2007-09-12 Антитела и фрагменты антител человека против рецептора фолата альфа для радиоиммунотерапии карциномы яичника RU2464277C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06019399A EP1900752A1 (en) 2006-09-15 2006-09-15 Human anti-folate receptor alpha antibodies and antibody fragments for the radioimmunotherapy of ovarian carcinoma
EP06019399.2 2006-09-15

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RU2009114161A RU2009114161A (ru) 2010-10-20
RU2464277C2 true RU2464277C2 (ru) 2012-10-20

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RU2009114161/10A RU2464277C2 (ru) 2006-09-15 2007-09-12 Антитела и фрагменты антител человека против рецептора фолата альфа для радиоиммунотерапии карциномы яичника

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US (1) US8388972B2 (enExample)
EP (2) EP1900752A1 (enExample)
JP (1) JP5513114B2 (enExample)
KR (1) KR101497045B1 (enExample)
AU (1) AU2007296899B2 (enExample)
BR (1) BRPI0716811B8 (enExample)
CA (1) CA2662005C (enExample)
ES (1) ES2644423T3 (enExample)
IL (1) IL197300A (enExample)
MX (1) MX2009002711A (enExample)
NZ (1) NZ575093A (enExample)
RU (1) RU2464277C2 (enExample)
WO (1) WO2008031577A1 (enExample)
ZA (1) ZA200901328B (enExample)

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JP2010503386A (ja) 2010-02-04
WO2008031577A1 (en) 2008-03-20
RU2009114161A (ru) 2010-10-20
AU2007296899A1 (en) 2008-03-20
MX2009002711A (es) 2009-06-18
EP2061813A1 (en) 2009-05-27
AU2007296899B2 (en) 2012-09-13
US8388972B2 (en) 2013-03-05
US20100055034A1 (en) 2010-03-04
JP5513114B2 (ja) 2014-06-04
WO2008031577A8 (en) 2009-07-02
NZ575093A (en) 2012-04-27
KR101497045B1 (ko) 2015-02-27
CA2662005A1 (en) 2008-03-20
CA2662005C (en) 2018-01-02
IL197300A0 (en) 2011-08-01
KR20090059114A (ko) 2009-06-10
ES2644423T3 (es) 2017-11-28
ZA200901328B (en) 2010-05-26
EP2061813B1 (en) 2017-07-19
EP1900752A1 (en) 2008-03-19
BRPI0716811B8 (pt) 2021-05-25
IL197300A (en) 2016-02-29
BRPI0716811B1 (pt) 2020-11-24
BRPI0716811A2 (pt) 2013-11-05

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