RU2455994C2 - Пиримидиновые производные - Google Patents
Пиримидиновые производные Download PDFInfo
- Publication number
- RU2455994C2 RU2455994C2 RU2009141982/04A RU2009141982A RU2455994C2 RU 2455994 C2 RU2455994 C2 RU 2455994C2 RU 2009141982/04 A RU2009141982/04 A RU 2009141982/04A RU 2009141982 A RU2009141982 A RU 2009141982A RU 2455994 C2 RU2455994 C2 RU 2455994C2
- Authority
- RU
- Russia
- Prior art keywords
- methyl
- indol
- pyrimidin
- ylamino
- phenyl
- Prior art date
Links
- 0 Cc1cc(c(*)c(cc2)Nc3nc(Nc4cccc(*CCNC)c4)ncc3)c2[n]1 Chemical compound Cc1cc(c(*)c(cc2)Nc3nc(Nc4cccc(*CCNC)c4)ncc3)c2[n]1 0.000 description 4
- KVZWYIQMJOZZNJ-UHFFFAOYSA-N CCC(C(C)=C1)c(cc2)c1c(F)c2Nc1ccnc(Nc2ccc(CC(OC)=O)cc2)n1 Chemical compound CCC(C(C)=C1)c(cc2)c1c(F)c2Nc1ccnc(Nc2ccc(CC(OC)=O)cc2)n1 KVZWYIQMJOZZNJ-UHFFFAOYSA-N 0.000 description 1
- PJHKJALVCXSIPC-UHFFFAOYSA-N COc(c(OC)c1)ccc1Nc(nc1Nc(cccc2)c2C(N)=O)ncc1C#N Chemical compound COc(c(OC)c1)ccc1Nc(nc1Nc(cccc2)c2C(N)=O)ncc1C#N PJHKJALVCXSIPC-UHFFFAOYSA-N 0.000 description 1
- GMQPIGJXSZAXSJ-UHFFFAOYSA-N CS(N1CCCC1)(=O)=O Chemical compound CS(N1CCCC1)(=O)=O GMQPIGJXSZAXSJ-UHFFFAOYSA-N 0.000 description 1
- HLRHFJGCNSCEQO-UHFFFAOYSA-N Cc([nH]c1ccc2Nc3ccnc(Nc4cccc(OS(C)(=O)=O)c4)n3)cc1c2F Chemical compound Cc([nH]c1ccc2Nc3ccnc(Nc4cccc(OS(C)(=O)=O)c4)n3)cc1c2F HLRHFJGCNSCEQO-UHFFFAOYSA-N 0.000 description 1
- HTQHYYMBTXZIKS-UHFFFAOYSA-N Cc([nH]c1ccc2Oc3ccnc(Nc(cc4)cnc4OC)n3)cc1c2F Chemical compound Cc([nH]c1ccc2Oc3ccnc(Nc(cc4)cnc4OC)n3)cc1c2F HTQHYYMBTXZIKS-UHFFFAOYSA-N 0.000 description 1
- RGOFWPASXIASRQ-UHFFFAOYSA-N Cc([nH]c1ccc2Oc3nc(Nc4cccc(CC(NCCN5CCOCC5)=O)c4)ncc3)cc1c2F Chemical compound Cc([nH]c1ccc2Oc3nc(Nc4cccc(CC(NCCN5CCOCC5)=O)c4)ncc3)cc1c2F RGOFWPASXIASRQ-UHFFFAOYSA-N 0.000 description 1
- GHSOXRLOYVBTCZ-UHFFFAOYSA-N Cc1cc(c(F)c(cc2)Nc3ccnc(Nc(cn4)ccc4OC)n3)c2[nH]1 Chemical compound Cc1cc(c(F)c(cc2)Nc3ccnc(Nc(cn4)ccc4OC)n3)c2[nH]1 GHSOXRLOYVBTCZ-UHFFFAOYSA-N 0.000 description 1
- MNNRQGVXYHRHOL-UHFFFAOYSA-N Cc1cc(c(F)c(cc2)Nc3ccnc(Nc4cc(OCCN5CCCC5)ccc4)n3)c2[nH]1 Chemical compound Cc1cc(c(F)c(cc2)Nc3ccnc(Nc4cc(OCCN5CCCC5)ccc4)n3)c2[nH]1 MNNRQGVXYHRHOL-UHFFFAOYSA-N 0.000 description 1
- BACKVALOZUOQCN-UHFFFAOYSA-N Cc1cc(c(F)c(cc2)Nc3nc(Nc4cccc(OC5CNCCC5)c4)ncc3)c2[nH]1 Chemical compound Cc1cc(c(F)c(cc2)Nc3nc(Nc4cccc(OC5CNCCC5)c4)ncc3)c2[nH]1 BACKVALOZUOQCN-UHFFFAOYSA-N 0.000 description 1
- CGPBYTHLFCKJHA-UHFFFAOYSA-N Cc1cc(cc(cc2)Nc3nc(NCCN4CCOCC4)ncc3)c2[nH]1 Chemical compound Cc1cc(cc(cc2)Nc3nc(NCCN4CCOCC4)ncc3)c2[nH]1 CGPBYTHLFCKJHA-UHFFFAOYSA-N 0.000 description 1
- HPUAHIWHACKSIR-UHFFFAOYSA-N Cc1cc(cc(cc2)Nc3nc(Nc(cc4Cl)ccc4F)ncc3)c2[nH]1 Chemical compound Cc1cc(cc(cc2)Nc3nc(Nc(cc4Cl)ccc4F)ncc3)c2[nH]1 HPUAHIWHACKSIR-UHFFFAOYSA-N 0.000 description 1
- ZPYJTBCBUVBCKG-UHFFFAOYSA-N Cc1cc(cc(cc2)Nc3nc(Nc4cc(C(NCCN(C)C)=O)ccc4)ncc3)c2[nH]1 Chemical compound Cc1cc(cc(cc2)Nc3nc(Nc4cc(C(NCCN(C)C)=O)ccc4)ncc3)c2[nH]1 ZPYJTBCBUVBCKG-UHFFFAOYSA-N 0.000 description 1
- NODQEOAIZUTCAM-UHFFFAOYSA-N Cc1cc(cc(cc2)Nc3nc(Nc4cc(OCCCN(C)C)ccc4)ncc3)c2[nH]1 Chemical compound Cc1cc(cc(cc2)Nc3nc(Nc4cc(OCCCN(C)C)ccc4)ncc3)c2[nH]1 NODQEOAIZUTCAM-UHFFFAOYSA-N 0.000 description 1
- LSNYNYZOYKHQOG-UHFFFAOYSA-N Cc1cc(cc(cc2)Nc3nc(Nc4cc(OCCO)ccc4)ncc3)c2[nH]1 Chemical compound Cc1cc(cc(cc2)Nc3nc(Nc4cc(OCCO)ccc4)ncc3)c2[nH]1 LSNYNYZOYKHQOG-UHFFFAOYSA-N 0.000 description 1
- SRHOFLLNRAEYQA-UHFFFAOYSA-N Cc1cc2cc(Nc3ccnc(Nc(cc4)ccc4NS(C(F)(F)F)(=O)=O)n3)ccc2[nH]1 Chemical compound Cc1cc2cc(Nc3ccnc(Nc(cc4)ccc4NS(C(F)(F)F)(=O)=O)n3)ccc2[nH]1 SRHOFLLNRAEYQA-UHFFFAOYSA-N 0.000 description 1
- JGPWPSZDUNCWCK-UHFFFAOYSA-N Cc1cc2cc(Nc3ccnc(Nc4cc(C(NC)=O)ccc4)n3)ccc2[nH]1 Chemical compound Cc1cc2cc(Nc3ccnc(Nc4cc(C(NC)=O)ccc4)n3)ccc2[nH]1 JGPWPSZDUNCWCK-UHFFFAOYSA-N 0.000 description 1
- RAFYOROBWBKYGV-UHFFFAOYSA-N Cc1cc2cc(Nc3nc(Nc4cc(CN5CCC(CO)CC5)ccc4)ncc3)ccc2[nH]1 Chemical compound Cc1cc2cc(Nc3nc(Nc4cc(CN5CCC(CO)CC5)ccc4)ncc3)ccc2[nH]1 RAFYOROBWBKYGV-UHFFFAOYSA-N 0.000 description 1
- KNVIGJNYPRGGFL-UHFFFAOYSA-N Cc1cc2cc(Nc3nc(Nc4cc(OCC5CCNCC5)ccc4)ncc3)ccc2[nH]1 Chemical compound Cc1cc2cc(Nc3nc(Nc4cc(OCC5CCNCC5)ccc4)ncc3)ccc2[nH]1 KNVIGJNYPRGGFL-UHFFFAOYSA-N 0.000 description 1
- QMHMOLFIFQJWND-UHFFFAOYSA-N Cc1cc2cc(Nc3nc(Nc4cccc(C(NCCO)=O)c4)ncc3)ccc2[nH]1 Chemical compound Cc1cc2cc(Nc3nc(Nc4cccc(C(NCCO)=O)c4)ncc3)ccc2[nH]1 QMHMOLFIFQJWND-UHFFFAOYSA-N 0.000 description 1
- CORUQLRWPYWRNS-UHFFFAOYSA-N Cc1cc2cc(OCc3nc(Nc4cc(OCCCN5CCOCC5)ccc4)ncc3C#N)ccc2[nH]1 Chemical compound Cc1cc2cc(OCc3nc(Nc4cc(OCCCN5CCOCC5)ccc4)ncc3C#N)ccc2[nH]1 CORUQLRWPYWRNS-UHFFFAOYSA-N 0.000 description 1
- BTTNYQZNBZNDOR-UHFFFAOYSA-N Clc1nc(Cl)ncc1 Chemical compound Clc1nc(Cl)ncc1 BTTNYQZNBZNDOR-UHFFFAOYSA-N 0.000 description 1
- RRHQIRUDDBKIEN-UHFFFAOYSA-N Clc1nccc(Nc(cc2)cc3c2[nH]cn3)n1 Chemical compound Clc1nccc(Nc(cc2)cc3c2[nH]cn3)n1 RRHQIRUDDBKIEN-UHFFFAOYSA-N 0.000 description 1
- BHUSBPXIWBLDIU-UHFFFAOYSA-N N#Cc1cccc(Nc2nccc(Nc3ccc4[nH]cnc4c3)n2)c1 Chemical compound N#Cc1cccc(Nc2nccc(Nc3ccc4[nH]cnc4c3)n2)c1 BHUSBPXIWBLDIU-UHFFFAOYSA-N 0.000 description 1
- WFRXSXUDWCVSPI-UHFFFAOYSA-N Nc1ccc2[nH]cnc2c1 Chemical compound Nc1ccc2[nH]cnc2c1 WFRXSXUDWCVSPI-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91192107P | 2007-04-16 | 2007-04-16 | |
| US60/911,921 | 2007-04-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2009141982A RU2009141982A (ru) | 2011-05-27 |
| RU2455994C2 true RU2455994C2 (ru) | 2012-07-20 |
Family
ID=39854302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009141982/04A RU2455994C2 (ru) | 2007-04-16 | 2008-04-15 | Пиримидиновые производные |
Country Status (17)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2701188C2 (ru) * | 2015-02-27 | 2019-09-25 | Нэнтбайосайенс, Инк. | Производные пиримидина в качестве ингибиторов киназы и их терапевтические применения |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| TW201024281A (en) | 2008-11-24 | 2010-07-01 | Boehringer Ingelheim Int | New compounds |
| AR074210A1 (es) * | 2008-11-24 | 2010-12-29 | Boehringer Ingelheim Int | Derivados de pirimidina como inhibidores de ptk2-quinasa |
| JP2012197231A (ja) * | 2009-08-06 | 2012-10-18 | Oncotherapy Science Ltd | Ｔｔｋ阻害作用を有するピリジンおよびピリミジン誘導体 |
| US8466155B2 (en) * | 2009-10-02 | 2013-06-18 | Boehringer Ingelheim International Gmbh | Pyrimidines |
| CN102070618B (zh) | 2009-11-23 | 2013-08-21 | 和记黄埔医药（上海）有限公司 | 一种化合物及其晶体 |
| US8927547B2 (en) | 2010-05-21 | 2015-01-06 | Noviga Research Ab | Pyrimidine derivatives |
| EP2395001A1 (en) | 2010-05-21 | 2011-12-14 | Chemilia AB | Novel pyrimidine derivatives |
| EP2433636A1 (en) * | 2010-09-27 | 2012-03-28 | Medizinische Universität Wien | Treatment of Malignant Diseases |
| US8785467B2 (en) | 2010-09-30 | 2014-07-22 | Merck Sharp & Dohme Corp. | Alkoxy pyrimidine PDE10 inhibitors |
| US9006241B2 (en) | 2011-03-24 | 2015-04-14 | Noviga Research Ab | Pyrimidine derivatives |
| EP2502924A1 (en) | 2011-03-24 | 2012-09-26 | Chemilia AB | Novel pyrimidine derivatives |
| WO2013054351A1 (en) * | 2011-08-08 | 2013-04-18 | Cadila Healthcare Limited | Heterocyclic compounds |
| EP2711364A1 (en) | 2012-09-21 | 2014-03-26 | Chemilia AB | 4-(Indolyl or benzimidazolyl)amino-2-(2-(indol-3-yl)ethyl)aminopyrimidines useful for the treatment of cancer |
| EP2711365A1 (en) | 2012-09-21 | 2014-03-26 | Chemilia AB | 4-Indazolylamino-2-(2-(indol-3-yl)ethyl)aminopyrimidines useful for the treatment of cancer |
| CN104955459B (zh) | 2012-11-05 | 2019-02-01 | 南特知识产权控股有限责任公司 | 取代的吲哚-5-酚衍生物及其治疗应用 |
| RU2017141536A (ru) * | 2013-03-15 | 2019-02-13 | Нэнтбайосайенс, Инк. | Замещенные производные индол-5-ола и их терапевтические применения |
| CN105601573B (zh) * | 2014-11-24 | 2021-07-02 | 中国科学院上海药物研究所 | 2-氨基嘧啶类化合物及其药物组合物和应用 |
| WO2017190050A1 (en) | 2016-04-28 | 2017-11-02 | Cornell University | Inhibitors of soluble adenylyl cyclase |
| TW202115042A (zh) * | 2019-06-21 | 2021-04-16 | 大陸商江蘇豪森藥業集團有限公司 | 芳基磷氧化物類衍生物抑制劑、其製備方法和應用 |
| CN111004221B (zh) * | 2019-12-13 | 2021-02-02 | 长治学院 | 一种嘧啶/苯并咪唑杂合物、制备方法及医药用途 |
| US20240166635A1 (en) * | 2020-11-27 | 2024-05-23 | Anrui Biomedical Technology (Guangzhou) Co.,Ltd. | Aminoheteroaryl kinase inhibitors |
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| US20030149041A1 (en) * | 1999-12-28 | 2003-08-07 | Pharmacopeia, Inc. | Pyrimidine and triazine kinase inhibitors |
| US6723726B1 (en) * | 1996-07-13 | 2004-04-20 | Smithkline Beecham Corporation | Protein tyrosine kinase inhibitors |
| RU2005108999A (ru) * | 2002-08-30 | 2005-08-27 | Эйсай Ко., Лтд. (JP) | Азотсодержащие ароматические производные |
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- 2008-04-15 BR BRPI0809715-1A patent/BRPI0809715A2/pt not_active Application Discontinuation
- 2008-04-15 PT PT87458816T patent/PT2154967E/pt unknown
- 2008-04-15 EP EP08745881.6A patent/EP2154967B9/en active Active
- 2008-04-15 PL PL08745881T patent/PL2154967T3/pl unknown
- 2008-04-15 SI SI200831203T patent/SI2154967T1/sl unknown
- 2008-04-15 CA CA2684470A patent/CA2684470C/en active Active
- 2008-04-15 ES ES08745881.6T patent/ES2465673T3/es active Active
- 2008-04-15 KR KR1020097023882A patent/KR101424847B1/ko not_active Expired - Fee Related
- 2008-04-15 WO PCT/US2008/060366 patent/WO2008128231A1/en not_active Ceased
- 2008-04-15 HR HRP20140377AT patent/HRP20140377T2/hr unknown
- 2008-04-15 MX MX2009011199A patent/MX2009011199A/es active IP Right Grant
- 2008-04-15 RU RU2009141982/04A patent/RU2455994C2/ru active
- 2008-04-15 DK DK08745881.6T patent/DK2154967T5/en active
- 2008-04-15 TW TW097113595A patent/TWI484960B/zh not_active IP Right Cessation
- 2008-04-15 JP JP2010504191A patent/JP5635398B2/ja not_active Expired - Fee Related
- 2008-04-16 US US12/103,876 patent/US8349859B2/en not_active Expired - Fee Related
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| RU2701188C2 (ru) * | 2015-02-27 | 2019-09-25 | Нэнтбайосайенс, Инк. | Производные пиримидина в качестве ингибиторов киназы и их терапевтические применения |
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| Publication number | Publication date |
|---|---|
| US8349859B2 (en) | 2013-01-08 |
| EP2154967B1 (en) | 2014-03-05 |
| NZ580671A (en) | 2012-03-30 |
| BRPI0809715A2 (pt) | 2019-11-05 |
| CA2684470C (en) | 2016-02-09 |
| EP2154967A4 (en) | 2010-05-19 |
| WO2008128231A1 (en) | 2008-10-23 |
| PL2154967T3 (pl) | 2014-08-29 |
| HRP20140377T2 (hr) | 2015-01-16 |
| JP2010524952A (ja) | 2010-07-22 |
| KR101424847B1 (ko) | 2016-07-08 |
| US8901143B2 (en) | 2014-12-02 |
| CA2684470A1 (en) | 2008-10-23 |
| HRP20140377T1 (en) | 2014-05-23 |
| RU2009141982A (ru) | 2011-05-27 |
| EP2154967A1 (en) | 2010-02-24 |
| JP5635398B2 (ja) | 2014-12-03 |
| PT2154967E (pt) | 2014-06-05 |
| KR20100016592A (ko) | 2010-02-12 |
| TWI484960B (zh) | 2015-05-21 |
| ES2465673T9 (es) | 2014-11-14 |
| DK2154967T5 (en) | 2014-11-17 |
| ES2465673T3 (es) | 2014-06-06 |
| US20130065890A1 (en) | 2013-03-14 |
| SI2154967T1 (sl) | 2014-06-30 |
| AU2008240084A1 (en) | 2008-10-23 |
| TW200848049A (en) | 2008-12-16 |
| MX2009011199A (es) | 2010-03-17 |
| EP2154967B9 (en) | 2014-07-23 |
| DK2154967T3 (da) | 2014-04-07 |
| US20080255172A1 (en) | 2008-10-16 |
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