RU2445967C2 - Method for preventing and treating gastrointestinal diseases in calves - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to veterinary science. A method involves feeding of a hydrolytic preparation. A hydrolytic preparation represents gelatin autoclaved and imbedded in an aqueous solution of an electrically activated anolyte of pH 3.5-4.2 and redox potential +900…+1000 mV.

EFFECT: method enables preserving to 100% calves aged 21 days and younger and increasing their body weight.

Description

The invention relates to the field of agriculture, in particular to veterinary medicine, and can be used for the treatment and prevention of gastrointestinal diseases of young calves.

The cost of a calf at birth, and especially in pedigree farming, is about 4 thousand rubles, the cost of growing before sale is approximately 40 thousand rubles, and its cost in the Russian market ranges from 80 to 120 thousand rubles.

The death of one calf entails damage from 1.5 to 4.5 thousand rubles, the lost profit is from 20 to 80 thousand rubles. Ill calves give growths of 500-800 g less than those that were not sick [1].

Known methods for the prevention and treatment of various diseases of calves with tissue preparations and lysates.

A known method of treating a lysate - collagen of bones, cartilage, when by partial hydrolysis of the collagen contained in the cartilage and bones, get gelatin containing a biologically active substance - chondrolyzate, used in medicine for the treatment of some cases of chronic polyarthritis [2]. The hydrolysis product is administered intramuscularly (up to 15-20 injections every other day). Efficiency is up to 65%.

It is known to use a lysate - gelatin, a hydrolyzed product of cartilage and tendons, in the form of a 10% aqueous sterile solution. The drug is prescribed for bleeding and diarrhea in cattle in the amount of 10.0-30.0 ml per dose. Considering that gelatin in an aqueous solution is a good medium for the growth and development of microbes, only carefully sterile solutions in ampoules are used in medicine [3]. The complexity of the preparation of the drug, the limited release of ampoules and the not so high therapeutic effect do not allow the use of this tool on a large scale.

A known method for the prevention of gastrointestinal diseases of newborn calves using the product of hydrolysis of edible gelatin with 0.1 M citric acid solution, as well as 7% hydrochloric acid and evaporating them together with colostrum (4) (prototype). However, here the complexity and the required thoroughness of the preparation of the colloidal solution restrain its mass application.

It is known to use electroactivated anolyte, a solution obtained by electrolysis of ordinary water, the day of treatment of infectious gastrointestinal diseases [5, 6, 7, 8, 9].

In order to increase the effectiveness of the prevention and treatment of infectious gastrointestinal diseases of calves with a colloidal gelatin solution, it is proposed to use an aqueous solution of electroactivated anolyte with a pH of 3.5-4.2 and a redox potential of +900 mV ... + 1000 mV instead of an acid solution during autoclaving [7, 9].

The product of hydrolysis, gelatin, with anolyte was tested on calves with signs of dyspepsia and weak calves without obvious signs of disease.

4 groups of newborn calves were selected, 10 animals each, according to the analogue principle. The first three groups of calves had signs of dyspepsia, and in the 4th group, the calves were weak, with no obvious signs.

In the first (control) group, the drug was not given, but medication antibiotics generally accepted in the household and various decoctions were used.

In the second experimental group, the product of hydrolysis of edible gelatin with 0.1 M citric acid solution was used and 50 ml of it was evaporated with colostrum 3 times a day. Complete cessation of diarrhea was observed on days 7-8.

In the third experimental group, calves were fed a colloidal gelatin solution with colostrum, during autoclaving, an aqueous solution of electroactivated anolyte with a pH of 3.5-4.2 and a redox potential of + 900 ... + 1000 mV was used.

At the same dosage of drinking, a complete cessation of diarrhea was observed on the 5-6th day.

By the age of one month, the calves of the second and third groups improved the physiological state of the body, the number of red blood cells and hemoglobin in the blood increased. Their live weight in comparison with calves of the first group was 11 and 15% higher. The preservation of calves was 100%, and in the first (control) - 57%.

For prophylactic purposes, newborn weak, but clinically healthy calves of the fourth group were given 50 ml of protein hydrolyzate with anolyte solution 3 times a day before colostrum was fed. Prevention allowed 100% safety in the absence of signs of disease in 100% of calves until the 21st day of life, while the live weight of these calves was 21% higher compared to the first group.

Information sources

1. Oleinik A.V. Gastrointestinal tract disorders in young calves. - Veterinary medicine, No. 1, 2009. - P.6-8.

2. Lagov S.I. The experience of using monolysatotherapy for chronic polyarthritis in transporters. Sat Theoretical foundations and experience of outpatient use of histolysates and gravidan. - M., 1936. - P.187.

3. Brains I.E. Pharmacology. Ed. "Ear". - M., 1969. - P.177.

4. A.S. No. 1515446 dated 06/15/1989. A method for the prevention of gastrointestinal diseases of calves.

5. Electrolysis water treatment for animals. - Inf. Sheet No. 89-057. Ukrainian research institute. - Cherkasy. - MGSTSTI, 1989.

6. Flerov V.N. Sat tasks in applied electrochemistry. - Ed. Graduate School. - M., 1976. - P.14.

7. Kaptur Z.F. Intensive feed preparation technology. - Minsk. - 1939. - S.109-110.

8. Spirina S.I., Vostrikova G.V., Karaseva E.A. The use of electrochemically activated water in poultry farming. - Zootechnics, No. 2, 2001. - P.26.

9. Butko M.P., Frolov B.C., Titanov B.C. The use of electrochemically activated solutions of sodium chloride for the rehabilitation of agricultural facilities. Vetkorm, No. 1, 2007. - P.25-27.

Claims (1)

A method for the prevention and treatment of gastrointestinal diseases of calves, including the evaporation of a hydrolysis preparation, characterized in that gelatin is used as a hydrolysis preparation, which is poured during autoclaving with an aqueous solution of electroactive anolyte with a pH of 3.5-4.2 and a redox potential of + 900 ... +1000 mV.