RU2445318C2 - Высокоаффинные антитела человека к рецептору il-4 человека - Google Patents
Высокоаффинные антитела человека к рецептору il-4 человека Download PDFInfo
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2736732C2 (ru) * | 2015-04-02 | 2020-11-19 | Интервет Интернэшнл Б.В. | Антитела к альфа-рецептору собачьего интерлейкина-4 |
| RU2758091C1 (ru) * | 2018-04-20 | 2021-10-26 | Бейцзин Уиздомаб Байотекнолоджи Ко., Лтд | Антитело против IL-4R и его применение |
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| US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
| AU2003250074B2 (en) | 2002-07-18 | 2010-09-09 | Merus N.V. | Recombinant production of mixtures of antibodies |
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| EP2395017A3 (en) | 2003-05-30 | 2012-12-19 | Merus B.V. | Design and use of paired variable regions of specific binding molecules |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| US7608693B2 (en) * | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| US8092804B2 (en) | 2007-12-21 | 2012-01-10 | Medimmune Limited | Binding members for interleukin-4 receptor alpha (IL-4Rα)-173 |
| EP2604628A3 (en) | 2007-12-21 | 2013-08-21 | Medimmune Limited | Binding members for interleukin-4 receptor alpha (IL-4R) - 173 |
| ES2445193T3 (es) | 2008-06-27 | 2014-02-28 | Merus B.V. | Mamíferos no humanos productores de anticuerpos |
| BRPI0911699B8 (pt) * | 2008-07-25 | 2023-02-28 | Inst Res Biomedicine | vetor, célula, composição farmacêutica, uso de um anticorpo, ou fragmento de ligação a antígeno deste |
| US8871207B2 (en) | 2008-07-25 | 2014-10-28 | Humabs, LLC | Neutralizing anti-influenza A virus antibodies and uses thereof |
| AU2014216019B2 (en) * | 2008-10-29 | 2016-04-21 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to Human IL-4 receptor |
| US20130064834A1 (en) | 2008-12-15 | 2013-03-14 | Regeneron Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia using antibodies to pcsk9 |
| ES2948572T3 (es) | 2009-07-08 | 2023-09-14 | Kymab Ltd | Modelos de roedores y moléculas terapéuticas |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| ES2547142T5 (es) | 2010-02-08 | 2021-12-09 | Regeneron Pharma | Cadena ligera común de ratón |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| MY195217A (en) * | 2010-06-22 | 2023-01-11 | Regeneron Pharma | MICE Expressing An Immunoglobulin Hybrid Light Chain |
| IL315833A (en) * | 2010-08-02 | 2024-11-01 | Regeneron Pharma | Mice producing binding proteins containing VL regions |
| JP5918246B2 (ja) | 2010-10-06 | 2016-05-18 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 抗インターロイキン−４受容体（ｉｌ−４ｒ）抗体を含有する安定化製剤 |
| DK2714738T3 (en) | 2011-05-24 | 2019-01-28 | Zyngenia Inc | MULTIVALENT AND MONOVALENT MULTISPECIFIC COMPLEXES AND THEIR APPLICATIONS |
| CN102830228B (zh) * | 2011-06-15 | 2015-01-21 | 格诺思博生物科技(上海)有限公司 | 定量分析循环肿瘤细胞的试剂及试剂盒 |
| JO3412B1 (ar) * | 2011-06-17 | 2019-10-20 | Regeneron Pharma | أجسام مضادة ل angptl3 واستخداماتها |
| PH12014500089A1 (en) | 2011-07-11 | 2014-02-17 | Ichnos Sciences SA | Antibodies that bind to ox40 and their uses |
| HUE044089T2 (hu) | 2011-07-18 | 2019-09-30 | Inst Res Biomedicine | Neutralizáló anti-influenza A antitestek és alkalmazásaik |
| IL273982B2 (en) | 2011-08-05 | 2023-03-01 | Regeneron Pharma | Humanized mice possess a universal light chain |
| PL4252857T3 (pl) | 2011-09-16 | 2025-03-03 | Regeneron Pharmaceuticals, Inc. | Sposoby redukowania poziomów lipoproteiny(a) poprzez podawanie inhibitora proproteinowej konwertazy subtylizyny keksyny-9 (pcsk9) |
| EP2757875B2 (en) | 2011-09-19 | 2023-03-22 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| CA2791109C (en) | 2011-09-26 | 2021-02-16 | Merus B.V. | Generation of binding molecules |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| SG11201403326VA (en) | 2011-12-20 | 2014-07-30 | Regeneron Pharma | Humanized light chain mice |
| EP2825036B1 (en) | 2012-03-16 | 2018-05-02 | Regeneron Pharmaceuticals, Inc. | Histidine engineered light chain antibodies and genetically modified rodents for generating the same |
| AU2013204581B2 (en) | 2012-03-16 | 2015-06-25 | Regeneron Pharmaceuticals, Inc. | Non-human animals expressing pH-sensitive immunoglobulin sequences |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| RU2664473C2 (ru) | 2012-03-16 | 2018-08-17 | Регенерон Фармасьютикалз, Инк. | ОТЛИЧНЫЕ ОТ ЧЕЛОВЕКА ЖИВОТНЫЕ, ЭКСПРЕССИРУЮЩИЕ ЧУВСТВИТЕЛЬНЫЕ К pН ПОСЛЕДОВАТЕЛЬНОСТИ ИММУНОГЛОБУЛИНОВ |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| CN120383672A (zh) | 2012-04-20 | 2025-07-29 | 美勒斯公司 | 用于产生免疫球蛋白样分子的方法和手段 |
| RU2690675C2 (ru) | 2012-08-21 | 2019-06-05 | Санофи Байотекнолоджи | Способы лечения или предотвращения астмы посредством введения антагониста il-4r |
| TWI682941B (zh) | 2013-02-01 | 2020-01-21 | 美商再生元醫藥公司 | 含嵌合恆定區之抗體 |
| EP2958941B1 (en) | 2013-02-20 | 2019-04-10 | Innate Pharma | A compound that specifically binds to kir3dl2 for use in the treatment of peripheral t cell lymphoma |
| SMT201800435T1 (it) * | 2013-02-20 | 2018-09-13 | Regeneron Pharma | Animali non umani con sequenze della catena pesante dell’immunoglobulina modificate riferimento incrociato a domande correlate |
| CA2907181C (en) | 2013-03-15 | 2023-10-17 | Viktor Roschke | Multivalent and monovalent multispecific complexes and their uses |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US10111953B2 (en) | 2013-05-30 | 2018-10-30 | Regeneron Pharmaceuticals, Inc. | Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9) |
| TWI697334B (zh) | 2013-06-04 | 2020-07-01 | 美商再生元醫藥公司 | 藉由投與ｉｌ-４ｒ抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
| EP3613432B1 (en) | 2013-06-21 | 2025-08-06 | Sanofi Biotechnology | Methods for treating nasal polyposis by administering an il-4r antagonist |
| TWI634900B (zh) | 2013-07-11 | 2018-09-11 | 再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法 |
| ES2993142T3 (en) | 2013-10-01 | 2024-12-23 | Kymab Ltd | Animal models and therapeutic molecules |
| CN113667013B (zh) | 2013-10-02 | 2024-04-09 | 免疫医疗有限责任公司 | 中和抗甲型流感抗体及其用途 |
| US8980273B1 (en) | 2014-07-15 | 2015-03-17 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
| DE202014010499U1 (de) | 2013-12-17 | 2015-10-20 | Kymab Limited | Targeting von humaner PCSK9 zur Cholesterinbehandlung |
| US8986691B1 (en) | 2014-07-15 | 2015-03-24 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
| CA2939034A1 (en) * | 2014-02-19 | 2015-08-27 | Cangene Corporation | Methods of modulating an immune response |
| IL315136A (en) | 2014-02-21 | 2024-10-01 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4rantagonist |
| WO2015130975A1 (en) | 2014-02-28 | 2015-09-03 | Regeneron Pharmaceuticals, Inc. | Methods for treating skin infection by administering an il-4r antagonist |
| BR112016021572A2 (pt) | 2014-03-21 | 2017-10-03 | Regeneron Pharma | Métodos para preparar um animal não humano geneticamente modificado e para produzir proteínas de ligação, hibridoma, ácido nucleico, célula, e, proteína de ligação |
| ES2762640T3 (es) | 2014-03-21 | 2020-05-25 | Regeneron Pharma | Proteínas VL de unión a antígeno que exhiben diferentes características de unión |
| CA2954780A1 (en) | 2014-07-15 | 2016-01-21 | Medimmune, Llc | Neutralizing anti-influenza b antibodies and uses thereof |
| WO2016023916A1 (en) | 2014-08-12 | 2016-02-18 | Kymab Limited | Treatment of disease using ligand binding to targets of interest |
| WO2016071701A1 (en) | 2014-11-07 | 2016-05-12 | Kymab Limited | Treatment of disease using ligand binding to targets of interest |
| MX2017006286A (es) | 2014-11-14 | 2018-01-23 | Sanofi Biotechnology | Metodos para tratar sinusitis cronica con polipos nasales por administracion de un antagonista de il-4r. |
| MX2017011443A (es) | 2015-03-06 | 2018-06-27 | Sorrento Therapeutics Inc | Terapeuticos de anticuerpo que se unen a jag1. |
| EP3271403A1 (en) | 2015-03-19 | 2018-01-24 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| DK3277725T3 (da) | 2015-03-30 | 2021-01-11 | Regeneron Pharma | Konstante tungkædeområder med reduceret binding til FC-gammareceptorer |
| HUE056407T2 (hu) | 2015-06-01 | 2022-02-28 | Medimmune Llc | Neutralizáló influenzaellenes kötõmolekulák és alkalmazásaik |
| CN106699888B (zh) * | 2015-07-28 | 2020-11-06 | 上海昀怡健康科技发展有限公司 | 一种pd-1抗体及其制备方法和应用 |
| TW202440903A (zh) * | 2015-08-04 | 2024-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法（一） |
| CN106939047B (zh) | 2016-01-04 | 2021-08-31 | 江苏怀瑜药业有限公司 | 一种pd-l1抗体及其制备方法 |
| US20190015509A1 (en) | 2016-01-13 | 2019-01-17 | Medimmune, Llc | Method of treating influenza a |
| ES2983475T3 (es) | 2016-02-19 | 2024-10-23 | Regeneron Pharma | Métodos para mejorar la eficacia de una vacuna mediante la administración de un antagonista de IL-4R |
| CN107474134B (zh) * | 2016-06-08 | 2021-07-27 | 苏州康乃德生物医药有限公司 | 用于结合白细胞介素4受体的抗体 |
| EP4442323A3 (en) | 2016-09-01 | 2025-01-01 | Regeneron Pharmaceuticals, Inc. | Methods for preventing or treating allergy by administering an il-4r antagonist |
| US10485844B2 (en) | 2016-09-22 | 2019-11-26 | Regeneron Pharmaceuticals, Inc. | Methods for treating severe atopic dermatitis by administering an IL-4R inhibitor |
| EP4345110A3 (en) | 2016-09-22 | 2024-06-12 | Regeneron Pharmaceuticals, Inc. | Methods for treating severe atopic dermatitis by administering an il-4r inhibitor |
| EP3525820A4 (en) * | 2016-10-17 | 2020-09-16 | Vanderbilt University | ANTIBODIES AGAINST HUMAN RESPIRATORY SYNCYTIAL VIRUS AND THEIR USE METHODS |
| TWI784988B (zh) | 2016-12-01 | 2022-12-01 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
| CN118562004A (zh) | 2016-12-16 | 2024-08-30 | 蓝鳍生物医药公司 | 抗-含cub结构域蛋白1(cdcp1)抗体、抗体药物缀合物及其使用方法 |
| MX2019012171A (es) | 2017-04-13 | 2019-11-25 | Regeneron Pharma | Tratamiento e inhibicion de enfermedades pulmonares inflamatorias en pacientes que tienen alelos de riesgo en los genes que codifican la il33 e il1rl1. |
| WO2019028367A1 (en) | 2017-08-04 | 2019-02-07 | Regeneron Pharmaceuticals, Inc. | METHODS OF TREATING ESOPHAGITIS WITH ACTIVE EOSINOPHILES |
| CN107216388B (zh) * | 2017-08-07 | 2020-05-05 | 广州泰诺迪生物科技有限公司 | 一种治疗丙型肝炎病毒药物的制备方法和用途 |
| KR20250044796A (ko) | 2017-10-30 | 2025-04-01 | 사노피 바이오테크놀로지 | Il-4r 길항제를 투여하여 천식을 치료 또는 예방하는 방법 |
| MA52624A (fr) | 2018-05-13 | 2021-03-24 | Regeneron Pharma | Méthodes de traitement de la dermatite atopique par administration d'un inhibiteur de l'il-4r |
| CN113101364B (zh) * | 2018-05-29 | 2023-12-01 | 康诺亚生物医药科技（成都）有限公司 | 一种自免疫抑制剂的开发和应用 |
| SMT202400300T1 (it) | 2018-07-16 | 2024-09-16 | Regeneron Pharma | Modelli di roditori della sindrome ditra e loro utilizzo |
| ES3028305T3 (en) | 2018-08-24 | 2025-06-18 | Jiangsu Hengrui Medicine Co | Human il-4r binding antibody, antigen binding fragment thereof, and medical use thereof |
| US12216129B2 (en) | 2018-11-09 | 2025-02-04 | Ajou University Industry-Academic Cooperation Foundation | Human antibody having high affinity to human IL-4 receptor alpha |
| CN111494626B (zh) * | 2018-12-25 | 2022-06-21 | 江苏荃信生物医药股份有限公司 | 用于治疗il-4和/或il-13介导的信号转导相关的疾病的药物组合物 |
| EP3935085A1 (en) | 2019-03-06 | 2022-01-12 | Regeneron Pharmaceuticals, Inc. | Il-4/il-13 pathway inhibitors for enhanced efficacy in treating cancer |
| PH12021552123A1 (en) | 2019-03-21 | 2022-08-22 | Regeneron Pharma | Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy |
| BR112021016272A2 (pt) * | 2019-04-08 | 2021-11-09 | Phanes Therapeutics Inc | Receptores de antígeno quimérico anti-dll3 humanizados e usos dos mesmos |
| CN111592597B (zh) | 2019-05-29 | 2022-04-26 | 山东博安生物技术股份有限公司 | 白介素4受体(il-4r)结合蛋白及其用途 |
| JP7592064B2 (ja) | 2019-07-16 | 2024-11-29 | サノフィ・バイオテクノロジー | Ｉｌ－４ｒアンタゴニストを投与することにより喘息を治療するまたは予防するための方法 |
| CN112279914A (zh) * | 2019-07-25 | 2021-01-29 | 苏州丁孚靶点生物技术有限公司 | Il4ra抗体、基因、载体、宿主细胞和il4ra拮抗剂 |
| US11504426B2 (en) | 2019-08-05 | 2022-11-22 | Regeneron Pharmaceuticals, Inc. | Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an IL-4R antagonist |
| AU2020326713A1 (en) | 2019-08-05 | 2022-02-17 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r antagonist |
| EP3992974A1 (en) | 2020-11-02 | 2022-05-04 | Sanofi Biotechnology | Methods for treating digitally-identified il-4/il-13 related disorders |
| BR112022011098A2 (pt) | 2019-12-09 | 2022-09-20 | Sanofi Biotechnology | Métodos para tratamento de distúrbios relacionados a il-4/il-13 digitalmente identificados |
| WO2021167952A2 (en) * | 2020-02-20 | 2021-08-26 | The Feinstein Institutes For Medical Research | Agonist antibodies against endoglin and uses thereof |
| EP4104858A4 (en) | 2020-02-21 | 2023-11-29 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | PHARMACEUTICAL COMPOSITION CONTAINING AN ANTI-IL-4R ANTIBODY AND ITS USE |
| CN115087673B (zh) * | 2020-02-27 | 2025-02-18 | 正大天晴药业集团股份有限公司 | 结合il4r的抗体及其用途 |
| AU2021244266A1 (en) | 2020-03-27 | 2022-12-01 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an IL-4R antagonist |
| CN115942975A (zh) * | 2020-04-10 | 2023-04-07 | 西雅图儿童医院（Dba西雅图儿童研究所） | 白细胞介素-1受体辅助蛋白的特异性结合域和嵌合抗原受体 |
| CN113527485B (zh) | 2020-04-17 | 2024-11-15 | 湖南麦济生物技术股份有限公司 | 抗人白细胞介素-4受体α抗体及其制备方法和应用 |
| CN113549151A (zh) * | 2020-04-24 | 2021-10-26 | 苏州康乃德生物医药有限公司 | 与人IL-4Rα中特定表位结合的抗体及其应用 |
| IL298257A (en) | 2020-05-22 | 2023-01-01 | Regeneron Pharma | Methods for treating eosinophilic esophagitis by administering an il-4r inhibitor |
| CN116348605A (zh) | 2020-07-17 | 2023-06-27 | Gi 医诺微新 | 包含IgE Fc受体α亚基胞外结构域和抗IL-4R抗体的融合蛋白及其应用 |
| KR102697769B1 (ko) | 2020-09-14 | 2024-08-23 | 아주대학교산학협력단 | 인터루킨-4 수용체 알파 서브유닛과 인터루킨-5 수용체 알파 서브유닛에 동시에 결합하는 이중특이항체 및 이의 용도 |
| AU2021357078A1 (en) | 2020-10-05 | 2023-06-15 | Regeneron Pharmaceuticals, Inc. | Methods for treating asthma in pediatric subjects by administering an il-4r antagonist |
| WO2022135441A1 (zh) | 2020-12-22 | 2022-06-30 | 江苏恒瑞医药股份有限公司 | 抗il-4r抗体或其抗原结合片段的复合物及医药用途 |
| US20220220211A1 (en) | 2021-01-08 | 2022-07-14 | Regeneron Pharmaceuticals, Inc. | Methods for treating peanut allergy and enhancing peanut allergen-specific immunotherapy by administering an il-4r antagonist |
| KR20230142724A (ko) | 2021-01-08 | 2023-10-11 | 브리스톨-마이어스 스큅 컴퍼니 | 인자 XIa 억제제에 대한 항체 및 항원 결합 펩티드및 그의 용도 |
| MX2024001189A (es) | 2021-07-26 | 2024-02-27 | Sanofi Biotechnology | Metodos para tratar la urticaria cronica espontanea por administracion de un antagonista de il-4r. |
| TWI876192B (zh) * | 2021-08-05 | 2025-03-11 | 美商美國禮來大藥廠 | 人類介白素-4受體α抗體 |
| AU2022333073A1 (en) | 2021-08-23 | 2024-04-04 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r antagonist |
| CN117615785A (zh) * | 2021-08-26 | 2024-02-27 | 正大天晴药业集团股份有限公司 | 抗il4r抗体的药物组合物及其用途 |
| KR20240099290A (ko) | 2021-10-20 | 2024-06-28 | 사노피 바이오테크놀로지 | Il-4r 길항제를 투여하여 결절성 양진을 치료하는 방법 |
| WO2023130010A1 (en) | 2021-12-30 | 2023-07-06 | Regeneron Pharmaceuticals, Inc. | Methods for attenuating atopic march by administering an il-4/il-13 antagonist |
| MX2024009080A (es) | 2022-01-29 | 2024-07-30 | Shanghai Shengdi Pharmaceutical Co Ltd | Conjugado farmacologico de glucocorticoide. |
| KR20240167717A (ko) | 2022-03-02 | 2024-11-27 | 리제너론 파아마슈티컬스, 인크. | 항체 생산을 위한 세포 배양 방법 |
| US20240199688A1 (en) | 2022-05-02 | 2024-06-20 | Regeneron Pharmaceuticals, Inc. | Methods for reducing lipase activity |
| WO2023215267A1 (en) | 2022-05-02 | 2023-11-09 | Regeneron Pharmaceuticals, Inc. | Anti-interleukin-4 receptor (il-4r) antibody formulations |
| TW202421660A (zh) | 2022-07-08 | 2024-06-01 | 美商再生元醫藥公司 | 藉由投與il-4r拮抗劑來治療嗜伊紅性食道炎的方法 |
| EP4580659A1 (en) | 2022-08-29 | 2025-07-09 | Sanofi Biotechnology | Methods for treating chronic inducible cold urticaria by administering an il-4r antagonist |
| WO2024097714A1 (en) | 2022-11-01 | 2024-05-10 | Regeneron Pharmaceuticals, Inc. | Methods for treating hand and foot dermatitis by administering an il-4r antagonist |
| IL320670A (en) | 2022-11-23 | 2025-07-01 | Regeneron Pharma | Methods for enhancing bone growth by administering an IL-4R antagonist |
| TW202502819A (zh) | 2023-03-22 | 2025-01-16 | 法商賽諾菲生物技術公司 | 藉由投予il-4r拮抗劑治療慢性阻塞性肺病(copd)之方法 |
| KR20250164835A (ko) | 2023-03-27 | 2025-11-25 | 리제너론 파아마슈티컬스, 인크. | Il-4r 길항제를 투여하여 호산구성 위장염을 치료하는 방법 |
| US20250108173A1 (en) | 2023-10-02 | 2025-04-03 | Regeneron Pharmaceuticals, Inc. | Drug delivery device safety system |
| WO2025096932A1 (en) | 2023-11-02 | 2025-05-08 | Regeneron Pharmaceuticals, Inc. | Methods for reducing lipase activity using stress |
| US20250230251A1 (en) | 2023-12-20 | 2025-07-17 | Bristol-Myers Squibb Company | Antibodies targeting il-18 receptor beta (il-18rb) and related methods |
| WO2025221640A1 (en) | 2024-04-15 | 2025-10-23 | Sanofi Biotechnology | Methods for treating chronic rhinosinusitis without nasal polyps by administering an il-4r antagonist |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2162711C2 (ru) * | 1993-09-07 | 2001-02-10 | Смитклайн Бичам Корпорейшн | Рекомбинантные il4-антитела, используемые для лечения нарушений, связанных с действием il4 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US809A (en) | 1838-06-27 | Improved mode of changing the poles of electro-magnets | ||
| US7186A (en) | 1850-03-19 | fetchec | ||
| GB8808015D0 (en) * | 1988-04-06 | 1988-05-05 | Ritter M A | Chemical compounds |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| WO1990005183A1 (en) * | 1988-10-31 | 1990-05-17 | Immunex Corporation | Interleukin-4 receptors |
| NZ255101A (en) | 1992-07-24 | 1997-08-22 | Cell Genesys Inc | A yeast artificial chromosome (yac) vector containing an hprt minigene expressible in murine stem cells and genetically modified rodent therefor |
| US5714146A (en) | 1992-08-26 | 1998-02-03 | Board Of Regents Of The University Of Washington | IL-4 bone therapy |
| EP0604693A1 (en) | 1992-12-29 | 1994-07-06 | Schering-Plough | Monoclonal antibodies against the human interleukin-4 receptor and hybridomas producing the same |
| US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
| US6949245B1 (en) | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
| ES2382891T3 (es) | 2000-05-26 | 2012-06-14 | Immunex Corporation | Uso de anticuerpos IL-4R y sus composiciones |
| US7879328B2 (en) * | 2000-06-16 | 2011-02-01 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| DK1461300T3 (da) * | 2001-11-30 | 2011-10-24 | Biogen Idec Inc | Antistoffer mod kemotaktiske monocytproteiner |
| US20040101920A1 (en) | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
| CA2543982C (en) * | 2003-11-07 | 2013-01-08 | Immunex Corporation | Antibodies that bind interleukin-4 receptor |
| CA2550933A1 (en) * | 2003-12-22 | 2005-07-14 | Amgen Inc. | Methods for identifying functional antibodies |
| ATE395358T1 (de) | 2004-02-27 | 2008-05-15 | Regeneron Pharma | Il-4/il-13-spezifische polypetide und deren therapeutische verwendung |
| US20090098142A1 (en) * | 2004-06-09 | 2009-04-16 | Kasaian Marion T | Methods and compositions for treating and monitoring treatment of IL-13-associated disorders |
| TWI307630B (en) * | 2004-07-01 | 2009-03-21 | Glaxo Group Ltd | Immunoglobulins |
| TW200902555A (en) * | 2005-01-03 | 2009-01-16 | Hoffmann La Roche | Antibodies against IL-13 receptor alpha 1 and uses thereof |
| US7608693B2 (en) * | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
-
2007
- 2007-10-02 CN CN200780036872.1A patent/CN101522716B/zh active Active
- 2007-10-02 MX MX2009003393A patent/MX2009003393A/es active IP Right Grant
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2162711C2 (ru) * | 1993-09-07 | 2001-02-10 | Смитклайн Бичам Корпорейшн | Рекомбинантные il4-антитела, используемые для лечения нарушений, связанных с действием il4 |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2736732C2 (ru) * | 2015-04-02 | 2020-11-19 | Интервет Интернэшнл Б.В. | Антитела к альфа-рецептору собачьего интерлейкина-4 |
| US10858437B2 (en) | 2015-04-02 | 2020-12-08 | Intervet, Inc. | Antibodies to canine interleukin-4 receptor alpha |
| US12180288B2 (en) | 2015-04-02 | 2024-12-31 | Intervet Inc. | Antibodies to canine interleukin-4 receptor alpha |
| RU2758091C1 (ru) * | 2018-04-20 | 2021-10-26 | Бейцзин Уиздомаб Байотекнолоджи Ко., Лтд | Антитело против IL-4R и его применение |
| US11897960B2 (en) | 2018-04-20 | 2024-02-13 | Beijing Wisdomab Biotechnology Co., Ltd | Anti-IL-4R antibody and use thereof |
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